▍ Source: Announcement of Pharmaceutical Companies

▍ Finishing: Cypress Blue-Corn

▍ Industry concentration has been further improved.

In 2019, there were frequent mergers and acquisitions between pharmaceutical companies. Observing these cases, we can find that some of them spun off their subsidiaries and some strengthened their own strengths through acquisitions. In addition, the sale of non-core assets by foreign pharmaceutical companies and the takeover by domestic pharmaceutical companies have also caused industry analysis.

In these cases, some of them have been completed and some are still in progress. Through the inventory of one-year acquisition cases, it seems that the industry is progressing in the direction of increasing concentration.

With the deepening of medical reform, the implementation of policies such as consistency evaluation, quantity procurement and DRG, and the improvement of industry access threshold, SMEs will be acquired more frequently by large enterprises.

Of course, this is just like the plan of "supporting the merger and reorganization of pharmaceutical production enterprises, cultivating a number of large enterprise groups with international competitiveness, and improving the concentration of pharmaceutical industry" in the "Several Opinions on Further Reforming and Improving the Policy of Drug Production, Circulation and Use" issued by the State Council in early 2017.

Suzhou Novartis completed the sale.

On December 21st, Zhejiang Jiuzhou Pharmaceutical Co., Ltd. issued the Announcement on Completion of 100% Equity Delivery of Suzhou Novartis Pharmaceutical Technology Co., Ltd., and formally merged Suzhou Novartis into its subsidiary.

Jiuzhou Pharmaceutical announced on November 30 that the board of directors passed the Proposal on Foreign Investment to Buy 100% Equity of Suzhou Novartis Pharmaceutical Technology Co., Ltd., and estimated to buy 100% equity of Suzhou Novartis held by Novartis Investment with self-raised funds of about 790 million yuan.

According to the data, Suzhou Novartis acquired by Jiuzhou Pharmaceutical Co., Ltd. mainly consists of factory buildings, production lines, process equipment, etc. after divesting the technology and drug development assets held by Novartis.

Fosun Pharma sells assets for 3.6 billion yuan

On December 19th, Shanghai Fosun Pharma (Group) Co., Ltd. issued the Announcement on the Progress of Selling Assets and Foreign Investment, intending to transfer all the limited partnership interests of Healthy Harmony Holdings, L.P. (whose main assets are "United Family" hospitals and clinics) and the management partner of Healthy Harmony Holdings, L.P.. The consideration for this transfer is about US$ 523.15 million (equivalent to about RMB 3.6 billion).

Tasly sells Tasly Medicine Marketing Group.

On December 17th, Tasly announced that it had signed the Framework Agreement with Chongqing Pharmaceutical, and made an agreement on selling the equity of its holding subsidiary Tianjin Tasly Pharmaceutical Marketing Group.

According to the Framework Agreement, Chongqing Pharmaceutical intends to acquire 87.47% of the shares directly and indirectly held by the company and the shares held by other shareholders of Tianshi Marketing by paying cash consideration.

Nanjing pharmaceutical holding enhua herun

On December 13th, Nanjing Pharmaceutical Co., Ltd. issued the Announcement on Completion of Change Registration Procedures for Acquisition of Equity, indicating that the acquisition of Jiangsu Enhua Herun Pharmaceutical Co., Ltd. for 72.24 million yuan has completed the change registration procedures for shareholders and legal representatives. So far, Nanjing Pharmaceutical directly holds 70% equity of Enhua Herun.

China Resources Sanjiu acquires Aonuo Pharmaceutical.

On November 27th, China Resources Sanjiu Pharmaceutical Co., Ltd. issued the Announcement on Acquisition of 100% Equity of Aonuo (China) Pharmaceutical Co., Ltd., and planned to acquire 100% equity of Aonuo (China) Pharmaceutical Co., Ltd. held by Yuheng Pharmaceutical for 1.42 billion yuan.

According to the announcement, the core products of Aonuo Pharmaceutical are calcium zinc gluconate oral solution, vitamin C chewable tablets and Shenzhi Dendrobium granules, and its "Aonuo" and "Jinxin Jinjiute" are well-known brands for children to supplement calcium. China Resources Sanjiu said that the acquisition can improve the category layout of self-diagnosis and treatment (CHC), which can be organically combined with the advantages of China Resources Sanjiu in consumer insight, brand operation and terminal coverage.

Pfizer merged with Mylan.

On November 12th, Mylan and Pfizer officially announced the name of the new company-Via Tris, which was formed by the merger of Mylan and Pfizer’s subsidiary Pfizer Puqiang.

The 2018 financial report shows that Pfizer’s global revenue is $12.5 billion, and the China market contributes $2.4 billion. Mylan is a multinational giant, with a global revenue of 11.434 billion US dollars in 2018, and has not yet started business in China.

Da Shen Lin bought 123 chain pharmacies.

On November 7, Dashenlin Pharmaceutical Group Co., Ltd. issued the Announcement on Acquisition of 51% Equity of Nantong Jianghai Pharmacy Chain Co., Ltd., and plans to acquire 51% equity of Nantong Jianghai Pharmacy Chain Co., Ltd., with the target company including 123 chain pharmacies and the acquisition amount of 120 million yuan.

GSK sells Suzhou factory and Hepudin.

On July 8, Fosun Pharma announced that its holding subsidiary, Chongqing Yaoyou Pharmaceutical Co., Ltd., intends to acquire 100% equity of GlaxoSmithKline Pharmaceutical (Suzhou) Co., Ltd. for no more than RMB 250 million. If the transfer is completed, it will hold the drug registration approval of lamivudine tablets (specification: 0.1g) for the treatment of chronic hepatitis B and the production license and GMP certificate of its production facilities.

On July 9th, GSK China confirmed to Cyberland that both parties expected the transaction to be completed by the end of November.

Sinopharm Holdings acquired Anhui Pharmaceutical Group

On May 8, the official public platform of Sinopharm Holding Anhui Co., Ltd. released a message: Sinopharm Holdings officially signed a contract to acquire Anhui Pharmaceutical Group. According to public information, Anhui Pharmaceutical Group is a large-scale commercial circulation enterprise approved by the Anhui provincial government in December 2002.

China Resources Medicine Acquires Jiangzhong

On April 17, Jiangzhong Pharmaceutical Co., Ltd. announced that the company recently received a notice from the controlling shareholder of the company. With the approval of Jiangxi Provincial Market Supervision Administration, the controlling shareholder completed the industrial and commercial change registration of the enterprise name and business scope on April 8, 2019.

After the change, Jiangxi Jiangzhong Pharmaceutical (Group) Co., Ltd. was changed to China Resources Jiangzhong Pharmaceutical Group Co., Ltd. Jiangzhong Pharmaceutical said in its 2018 annual report that the brand value of "Jiangzhong" was 20.715 billion yuan, ranking 231st among the top 500 Chinese brands and 6th in the pharmaceutical industry. For China Resources Medicine, the acquisition of Jiangzhong Group won brands such as "Jiangzhong" and "Chuyuan".

Bristol-Myers Squibb acquires Xinji.

On January 3rd, Bristol-Myers Squibb announced a $74 billion acquisition of Xinji. According to the agreement between the two parties, Bristol-Myers Squibb will acquire Xinji Company in the form of $74 billion in cash and stock transactions to build a first-class biopharmaceutical giant that can compete with the world’s largest pharmaceutical manufacturer.

In fact, the merger and acquisition of pharmaceutical companies in 2019 is far more than that. By combing the actions of well-known enterprises, the purpose is to find the trend of industry changes under these mergers and acquisitions. In addition, in the announcements of many listed pharmaceutical companies selling assets this year, many properties were thrown out. Some analysts believe that pharmaceutical companies sell houses to survive, but a more rational view should be due to the limited value-added space of real estate.

You may think that you are in good health and there will be no major problems, but you know what? Some people suddenly fell down and never woke up because of temporary excitement or fatigue. This is sudden death, an unpredictable fatal event.

There seems to be nothing wrong. Why did you die suddenly?

Is there any rule of sudden death? Is there any warning? Can we avoid it? To answer these questions, let’s take a look at a recent study.

This study was published in the journal chinese journal of critical care medicine in April, 2020, entitled "Analysis of Epidemiological Characteristics of 5,516 Cases of Autopsy Sudden Death in China". The researchers dissected the bodies of 5516 cases of sudden death and found the following important findings:

1. Emotional excitement and fatigue are the most common causes.

The study found that among the causes of sudden death, emotional excitement accounted for 26%, fatigue accounted for 25%, and blood volume change accounted for 8.95%. Other inducements include drinking, satiety and minor injuries.

2. Heart problem is the main reason.

It was found that among the causes of sudden death, cardiogenic sudden death accounted for 57.76%, pulmonary sudden death accounted for 21.63%, and brain-derived sudden death accounted for 9.21%. Sudden cardiac death is mainly caused by coronary heart disease, myocardial infarction and arrhythmia.

3. There are often some uncomfortable signals before sudden death.

It is found that people with symptoms and signs in sudden death are most often manifested as sudden attack (20.10%), rest and sleep (16.71%), followed by vomiting (7.49%), dyspnea, chest tightness and sweating, dizziness, chest pain, abdominal pain, convulsion, headache, palpitation, cough and disturbance of consciousness.

People with chronic diseases are more prone to sudden death.

It was found that hypertension (37.95%), heart disease (30.02%) and diabetes (23.79%) were the most common among those with past history. Followed by dysplasia, hyperlipidemia, tumor, infection, hyperthyroidism and so on.

5.30 ~ 63 years old is the high incidence age of sudden cardiac death.

People in this age group are at an important stage of their career and family, with high work pressure, fast pace of life, irregular diet, and addiction to cigarettes and good wine, which may easily lead to "three highs" and coronary heart disease.

How to avoid sudden death? Please do the following three points.

From these laws, we can get some enlightenment:

Middle-aged people should pay attention to controlling their emotions!

Do you often get angry and quarrel with others because of some small things? Are you sometimes so excited that you get carried away and even laugh until you cry? You may think these are normal emotional expressions, but you know what? These mood swings may bring fatal danger to your heart!

A media person once witnessed such a tragedy. Her father-in-law was taken to the hospital because of a sudden acute myocardial infarction, and survived after the rescue. However, she found that in her father-in-law’s ward, the other six patients have one thing in common: they are all quick-tempered and short-tempered, and they are emotional, angry and angry when things happen.

She learned a lesson from it: these people are all out of control because of their emotions, which leads to heart problems!

Why is emotional excitement harmful to the heart?

It turns out that when we are angry or excited, the body will secrete a lot of hormones such as adrenaline and cortisol, which will double the blood flow of the heart, strengthen the contractility of the heart and accelerate the heartbeat. At the same time, blood vessels will contract, blood pressure will increase and blood viscosity will increase. In this way, the heart will bear a greater burden, prone to arrhythmia, myocardial ischemia, chest tightness, palpitation and other symptoms. If the duration is too long or the frequency is too high, it may induce serious cardiovascular events such as angina pectoris or myocardial infarction.

Therefore, middle-aged people should learn to adjust their emotions and maintain peace. Don’t vent or suppress things that don’t go your way, but find a suitable way to release the pressure. For example, you can chat with friends, listen to music, do sports and read books. This can not only relax the body and mind, but also enhance the physical fitness, which is beneficial to the heart.

Middle-aged people should rest moderately and avoid overwork!

Are you often so busy with work and family that you even ignore your physical discomfort? You may think it’s your responsibility and responsibility, but you know what? This lifestyle may make your heart stop beating at any time!

Research shows that many sudden deaths have experienced high pressure, long-term and high-intensity working conditions. This kind of work will make your sympathetic nerves overexcited, leading to heart overload, arrhythmia and myocardial ischemia. If the duration is too long or the frequency is too high, it may lead to fatal cardiovascular events such as arrhythmia or myocardial infarction. Some people die suddenly because of working overtime overnight, mood swings and nervous stress, which leads to neurological dysfunction, coronary artery spasm and sudden stop of blood supply to the heart.

Therefore, middle-aged people should arrange their work and rest reasonably, don’t be overworked, and don’t stay up late to hurt themselves. It is necessary to do some aerobic exercise properly to relax and enhance physical fitness. It is necessary to have a regular physical examination to find and treat chronic diseases in time. Keep good living habits and stay away from alcohol, tobacco and greasy food. Only in this way can you protect your heart from the threat of sudden death.

Middle-aged people should pay attention to body signals and seek medical treatment in time!

You may not know that before sudden death, your body actually gave you many warnings. If you can find and deal with it in time, it is possible to avoid the tragedy.

So, what are the signals before sudden death? According to research, the most common symptom before sudden death is chest discomfort, which mainly has the following three manifestations:

Angina pectoris. This is a feeling of pain or oppression in the chest or precordial area, which usually lasts less than 15 minutes and is often accompanied by dysphagia or chest tightness. This is caused by heart ischemia and hypoxia.

Flustered. This is a feeling of rapid or irregular heartbeat, which usually lasts less than 10 minutes and is often accompanied by discomfort such as chest tightness, fatigue and dizziness. This is due to cardiac electrophysiological dysfunction.

Low blood pressure. This is a state in which blood pressure drops below the normal value, which generally lasts less than 5 minutes, and is often accompanied by symptoms such as cold sweat and dyspnea. This is because the pumping function of the heart is weakened.

These signals mostly occur after physical activity, emotional excitement or satiety. If they can be relieved after rest, it means a mild heart problem. However, if it still doesn’t improve after rest, or there are frequent or persistent signals, it means that it is a serious heart problem and needs immediate medical attention.

In addition to these signals, there are some less obvious signals, such as left arm pain, sore throat or toothache. These signals may be nerve reflexes caused by heart problems, which also need attention.

In short, middle-aged people should pay special attention to their physical changes. If there is any chest discomfort, dull pain or fatigue, they should go to the hospital for examination in time and don’t take it lightly. Only early detection and treatment of heart problems can effectively prevent and reduce the risk of sudden death.

Paper materials: Analysis of Epidemiological Characteristics of 5516 Cases of Autopsy Sudden Death in China, chinese journal of critical care medicine Journal in April 2020.

Original title: "Doctors dissected more than 5,000 cases of sudden death and found that people who died suddenly had these rules! 》

Read the original text

　　BEIJING, Beijing, July 27 (Wu Tao) Recently, the General Office of the State Council issued "Guiding Opinions on Establishing Modern Hospital Management System" (hereinafter referred to as "Guiding Opinions"), which made a series of arrangements for establishing modern hospitals. What will the modern hospital be built into? Is it more convenient for people to see a doctor? What changes have been made to the salary of medical staff? Zhongxin. com has combed and summarized this.

　　What will a modern hospital look like?

　　— — Adhere to public welfare and control the scale of special needs services in hospitals

　　The Guiding Opinions pointed out that modern hospitals first adhere to the public welfare of public hospitals, adhere to the people’s health as the center, and put people’s health in a strategic position of giving priority to development. Modern hospitals adhere to the separation of government affairs and management, reasonably define the government’s supervisory responsibilities, and give public hospitals the right to operate and manage independently.

　　The reporter observed that the Guiding Opinions put forward some particularly detailed requirements for modern hospitals. For example, it is necessary to strictly control the bed size, construction standards and large-scale medical equipment in public hospitals, prohibit debt construction and luxury decoration, and gradually compress beds that exceed the scale standards. Control the scale of special services in public hospitals, and the proportion of special services provided shall not exceed 10%.

　　The opinions in the Guidance also suggest that an accountability mechanism should be established for acts such as arbitrary charges and bad practices that have a major social impact, acts that have caused major medical accidents and major safety accidents, serious cases of violation of laws and discipline, and serious violations of the construction of professional ethics.

　　It is worth noting that modern hospitals put forward a series of requirements for the position of dean. The dean should be fully responsible for medical treatment, teaching, scientific research and administrative management. The president’s office meeting is the administrative and business decision-making body of public hospitals, which makes decisions on discussion and research matters. At the same time, the annual and term target responsibility of the president is assessed, which is linked to the president’s salary, appointment and dismissal, rewards and punishments.

　　Wu Ming, a professor at peking university health science center College of Public Health, believes that the Guiding Opinions not only gives public hospitals the right to operate and manage independently, but also promotes the reform of medical insurance payment method, cancels drug addition, adjusts the price of medical services, reduces the price of medical consumables, and the "two-vote system", and establishes an effective competition mechanism in the medical service market to form an effective constraint on public hospitals, so as to ensure that the dean has the right not to be willful.

　　It is more convenient for patients to see a doctor.

　　— — Strengthen the emergency power and smooth the green channel

　　What impact does the establishment of modern hospitals have on patients? First of all, the doctor-patient relationship that everyone is concerned about is mentioned in the Guiding Opinions, for example, promoting the construction of the "three mediations and one insurance" mechanism that organically combines hospital mediation, people’s mediation, judicial mediation and medical risk sharing mechanism, properly resolving medical disputes and building a harmonious doctor-patient relationship.

　　The Guiding Opinions also pointed out that patients’ satisfaction is an aspect of the assessment of medical staff, and the assessment of medical staff is directly related to their salary level and even job appointment and dismissal. City doctors have served at the grassroots or counterpart medical institutions for not less than 1 year before being promoted to the title of attending physician or deputy chief physician.

　　In addition, the "Guiding Opinions" proposes to carry out information-based convenience services such as medical guidance, settlement between clinics, push of inspection results, and settlement of medical treatment in different places. Develop high-quality nursing services and strengthen the services of social workers and volunteers. All these provide better services for people to see a doctor.

　　In addition, tertiary public hospitals should all participate in the construction of medical complexes and play a leading role. Further improve medical services, optimize medical procedures, rationally arrange facilities in consultation areas, scientifically implement appointment diagnosis and treatment, and implement day surgery, telemedicine and multidisciplinary joint diagnosis and treatment models. Strengthen the emergency rescue force and smooth the green passage in front of the hospital.

　　The hospital informatization construction proposed in the Guiding Opinions is also closely related to the convenience of people seeking medical treatment. Zhang Wei, secretary of the Party Committee of west china hospital, analyzed that the Guiding Opinions put forward the effective docking of medical insurance, budget management, drug electronic supervision and other systems, and well designed and implemented medical services, medical quality and safety, internal audit and other systems, so as to minimize the burden of patients seeking medical treatment and the repeated work of medical staff caused by information and communication barriers and cumbersome workflow.

　　How to change the salary of medical staff?

　　— — Do not set revenue targets, and shall not be linked to the business income of the department.

　　Will the salary of medical staff change in the process of establishing modern hospitals? How to change? Presumably this is a problem that many people care about. According to the Guiding Opinions, public hospitals should make independent distribution within the approved total salary, reflecting post differences, taking into account the balance of disciplines, and achieving more work and more rewards.

　　According to the relevant regulations, hospitals can explore the implementation of target annual salary system and agreed salary. The salary of medical personnel shall not be linked to the business income of drugs, sanitary materials, inspection and testing. It is strictly forbidden to set income-generating targets for medical staff.

　　The Guiding Opinions also show that public hospitals should establish a public welfare-oriented assessment and evaluation mechanism, regularly organize public hospital performance assessment and dean’s annual and term target responsibility assessment, and the assessment results are linked to financial subsidies, medical insurance payment, total performance salary and dean’s salary, appointment and dismissal, rewards and punishments, etc. The assessment results will also be linked to the employment of medical staff, promotion of professional titles and personal salary.

　　Wang Hufeng, director of the Medical Reform Research Center of Renmin University of China, analyzed that it is an important aspect to establish a modern hospital management system to grant public hospitals autonomy in salary distribution and management under the framework of laws and regulations. "Only in this way can the enthusiasm of managers and medical staff be fully mobilized, so that medical institutions can provide quality services and efficient services." Wang Hufeng said. (End)

　　The artificial meat company has just listed in the United States, and the artificial milk has come. Recently, Mike Shedlock, a columnist of MishTalk, a global economic research website, introduced artificial milk that is more environmentally friendly, healthier and more expensive. This makes many people lament that with artificial milk, the problems existing in milk can finally be solved.

　　Rumors about milk have never been broken. "Milk causes cancer", "Milk is not suitable for Chinese’s physique" and "Milk will send mankind to the grave" … … Are these terrible stories about milk circulating on the Internet true?

　　Rumor 1: Hormones in milk can cause cancer.

　　An article entitled "Milk sends human beings to the grave" was once heated up, causing widespread panic among the masses. According to the article, milk contains the hormone IGF-1. Women who drink too much will suffer from breast cancer and ovarian cancer, while men are prone to prostate cancer.

　　"The full name of IGF-1 is called insulin-like growth factor No.1, which has a similar effect to insulin, mainly regulating people’s blood sugar and promoting people’s growth and development. Judging from the current experimental or scientific evidence, it does not indicate that it has a carcinogenic effect. " Li Yajun, a professor at the School of Life Sciences of Guizhou Normal University, said in an interview with the Science and Technology Daily reporter.

　　In this regard, some experts have explained that IGF-1 is a protein with important physiological functions, which exists widely in human body. Milk does contain this hormone substance, but the content is very small. Previously, an epidemiological survey showed that IGF-1 seems to have a certain relationship with prostate cancer and other cancers, but so far there is no evidence that IGF-1 is the direct cause of cancer. "Having a certain relationship" does not mean that it will directly induce cancer. In addition, the amount of IGF-1 obtained by drinking milk is insignificant compared with the amount of IGF-1 contained in the human body itself. Moreover, IGF-1 in milk has no biological activity in human body after heating, digestion and absorption, let alone causing cancer.

　　In 2017, Song Xiaomei and other scholars from the School of Chemistry and Environmental Sciences of Hebei University published a paper pointing out that the main argument of "milk carcinogenesis" comes from some epidemiological research results (especially for prostate cancer), but it often avoids intake, which is misleading to people who generally lack systematic health knowledge. Its argument is mainly the view of the China Health Survey Report compiled by Cornell University, the main purpose of which is to advocate people in Europe and America to change their bad eating habits mainly based on animal foods. However, the intake of dairy products by Chinese residents is far from the highest intake in European and American epidemiological studies (more than 600 grams per day), even lower than the recommended daily intake of 300 grams in the Dietary Guidelines for China Residents (2016).

　　Proverbs 2: Chinese was born unfit to drink milk.

　　In life, we often hear the saying that Chinese is mainly vegetarian, and its constitution is peaceful and cool, so it is useless to digest the cold and wet food such as milk. Therefore, more than 60% of Chinese people have diarrhea when drinking milk, which is because milk hurts spleen yang.

　　In this regard, Li Yajun said that for a long time, the academic community thought that milk was flat and sweet and did not belong to cold food. Many people in Chinese will have diarrhea when drinking milk, not because the milk is cold or the milk hurts spleen yang, but because the milk contains lactose, and these people lack enzymes to decompose lactose, which is reflected in the fact that they will not have diarrhea when drinking yogurt or soothing milk with lactose decomposed.

　　Adults in China drink less milk, and the body’s ability to decompose lactose will decrease — — Lactases that decompose lactose in the intestine are "unemployed" one after another, which leads to the basic shutdown of the "factory" that produces lactase. The lack of lactase in most people is caused by "using it and discarding it", rather than congenital lack of this gene. The vast majority of Chinese do not have congenital lactase deficiency, that is to say, Chinese is not born unfit to drink milk, just because he usually drinks too little. For non-congenital lactose deficiency, the ability to digest lactose can be restored through gradual adaptation.

　　Rumor 3: Drinking milk leads to various skin diseases.

　　Some people, especially infants, are prone to eczema after drinking milk, so there is a saying on the Internet: Never drink milk, which will lead to skin diseases such as eczema.

　　"This is a chronic allergic problem of food. Some people will be allergic and acne when drinking milk, but it cannot be proved that this food is inedible, because there are always a few allergic people. In fact, many people in life have different allergens, such as eggs, beef, seafood and even all kinds of fruits. We can’t say that everyone should not eat these things just because a few people are allergic. This is typical and a bit ridiculous. " Fan Zhihong, an associate professor in the Department of Nutrition and Food Safety, College of Food Science, China Agricultural University, said.

　　Li Yajun also said that this statement is not accurate. It is not milk itself that causes allergies, but some people may be allergic to protein contained in milk, so drinking milk will cause skin diseases, but this does not mean that there is something wrong with milk. Just like many people are allergic to pollen and seafood, there are various allergens. As individuals, it is good to avoid contact as much as possible in life. But it doesn’t mean that what is bad for this person is not good for others to eat.

　　Proverbs 4 Casein can increase the prevalence of many diseases.

　　An article entitled "The Great Harm of Milk! The online article "Milk, Meat, Fish and Eggs", which is suggested to be completely fasted, has far-reaching influence and makes many people have doubts about eating milk. The article points out that the research by Professor Campbell of Cornell University in the United States shows that protein in milk, especially casein, is a very strong cancer promoter, and it can increase the incidence of heart disease, diabetes, kidney calculi and hypertension. Li Piao, editor of the rumor mill of the shell network and an agronomy major, once said that Professor Campbell’s research on the carcinogenesis of casein in milk "is not the mainstream view in academic circles, and there is no stronger evidence to prove that milk can increase the risk of cancer". According to reports, Campbell’s experiment was to induce cancerous cells in rats by high dose of aflatoxin (a strong carcinogen), but it could not be directly concluded that casein had the same effect on healthy people. Moreover, Campbell also made it clear in an interview with the media that his research does not mean that dairy products can cause cancer.

　　Fan Zhihong said that this statement is purely a rumor, because existing studies have proved that casein in milk not only does not increase the risk of the above diseases, but is beneficial to the prevention of hypertension and stroke. A study of 64,191 women in China found that the intake of calcium, magnesium and dairy products was negatively correlated with the risk of diabetes. The nutritional epidemiological study of Institute of Nutrition of Chinese Academy of Sciences also found that the intake of dairy products was negatively correlated with waist circumference, systolic blood pressure and diastolic blood pressure, glycosylated hemoglobin content, high-density lipoprotein cholesterol, body mass index (BMI) and blood sugar.

　　In Li Yajun’s view, not only milk, but also human milk contains casein. Casein in dairy products is a kind of high-quality protein, which contains eight kinds of amino acids needed by human body, especially the combination of casein and calcium, which is beneficial to promote the absorption of calcium by human body. Reporter Fu Lili

　　CCTV News:In response to the news reported by the US media on the 14th that the Ukrainian Southern Design Bureau sold missile engines to North Korea, the Ukrainian side voiced for two consecutive days, firmly denying the incident and suggesting that Russia was behind the scenes. In this regard, Russia also responded strongly: criticizing Ukraine for wanting to "shabu-shabu".

RD-250 engine

　　On 14th, The New York Times quoted a military expert as saying that North Korea successfully tested an intercontinental ballistic missile last month, probably because it bought missile engines from Ukrainian enterprises in the arms black market. A research report published by the Institute for International Strategic Studies in London, UK, further pointed out: "No other country can develop from having medium-range missiles to having intercontinental ballistic missiles in such a short time. This speed means that North Korea has obtained a high-performance liquid fuel engine from abroad, and only the RD-250 engine manufactured by the Southern Design Bureau of Ukraine meets the external characteristics of North Korea’s new engine. "

　　In this regard, the Ukrainian side voiced for two consecutive days and denied the incident.

　　Ukrainian Prime Minister Groisman said that this is aimed at sowing dissension against Ukraine. I believe the statement of the National Security and National Defense Commission, and I can assure you that there is no such thing at all.

　　The Southern Design Bureau of Ukraine was established in 1954, and its full name is the Southern Machinery Manufacturing Scientific Research and Production Consortium, located in Dnepropetrovsk, Ukraine. Its original purpose was to design ballistic missiles for dropping nuclear warheads. After the American media reported, the Southern Design Bureau has issued a statement that Ukraine has not provided military missile engines to any country since its independence in 1991.

　　The Ukrainian Space Agency hinted that Russia was behind the scenes.

　　The Ukrainian National Space Agency further issued a statement, suggesting that Russia is behind the scenes.

　　Yuri Radcenco, head of the Ukrainian National Space Agency, said that this kind of engine was produced in Ukraine before 2001 and was widely used in two projects, namely "Cyclone 2" and "Cyclone 3", which were supplied by the Southern Machinery Factory for Russian projects, but not produced for Ukraine itself.

　　When this statement came out, it was immediately countered by the Russian side.

　　The host of Russia’s first channel reported that what they mean is that Russia disassembled the "Cyclone" missile into components and gave the most precious engine to North Korea without feeling distressed. That’s ridiculous!

　　On 15th, the general manager of Southern Design Bureau suggested that RD-250 could be "copied" by 3D printing technology to meet the demand of North Korea. In this regard, Russian Deputy Prime Minister Dmitry rogozin said categorically that this is absolutely impossible.

　　Russian Deputy Prime Minister Dmitry rogozin said that some portraits can be reproduced, but the engine is the most advanced technical structure, which requires not only detailed technical documents, but also test stands and various tests. Strictly speaking, what is needed most is professionals who know everything about engines, so this time either the technical documents were leaked or someone sold them directly.

　　Just as the two sides were at loggerheads, a piece of news disclosed by the British Reuters on the 16th was quite a "rescue". According to Reuters, Pyongyang may already have the ability to manufacture missile engines, and it does not need to rely on the support of other countries at all.

　　A reporter from Reuters, UK, said that the research of the London Institute for International Strategic Studies was only based on the measurement of the engine photos released by North Korea, and there was a heated discussion among experts who had been concerned about the North Korean nuclear issue. Some experts’ judgments were consistent with the assessment of American intelligence agencies, that is, North Korea may have the ability to independently develop and build missile engines.

　　Lead: Some time ago, a video on INS attracted millions of people to watch and like it, because a sheep was saved by the prince. He is.The Second Prince of Dubai, currently the Crown Prince of Dubai-Sheikh haman dan. At the same time, he is also calledWang Zizhong’s Daniel Wu, worth hundreds of billions, owns 200 Rolls Royce and 20 private jets, and is also restricted from entering the country because he is too handsome. …

　　It’s really a prince! The thing is this-

　　One day, a sheep was trapped in a net and bumped around. As a result, I bumped into the prince who went out with his entourage.

　　The prince chased it for several kilometers, put it down with light anesthesia, and then helped it untie the net cover and treat it carefully.

　　The whole process fascinated millions of netizens and called him "the real bond." Because the prince looks like this-

　　His identity is the Second Prince of Dubai, and he is currently the Crown Prince of Dubai-Sheikh haman dan.

　　Haman dan, born in 1982, has an incomparable handsome appearance, and she was as beautiful as a doll when she was a child.

　　All along the way, I was honored by off the charts.

　　It is said that he wanted to go to Saudi Arabia, and the local police restricted him from entering the country for fear that he would be too handsome and cause chaos. . . . . .

　　His handsome, even in the eyes of foreign media, is very famous, and he even describes him with "shock", "everyone loves him" and "perfection". It is also a frequent visitor to the list of "the sexiest royal family members in the world".

　　At the same time, he is the most powerful man in Dubai and the richest prince in the world.

　　Then how rich is he? It is estimated that his family assets exceed 100 billion dollars, which is only a conservative estimate.

　　His uncle’s assets alone are about 76000000000 RMB. Let’s count them, nine hundred and seventy-six billion RMB. When the prince succeeds as chief, the whole Dubai will be his.

　　With so much money, how can we spend it?

　　Of course, it is to satisfy your hobbies!

　　First of all, we should build our own exclusive racecourse, select all the most precious breeds, and the most expensive BMW with a price of 3 million dollars. From then on, the favorite thing to do is to stay with horses. (little pin suddenly feels that people are not as good as horses. )

　　Because the whole family likes horses, we have to order a Boeing 747 to transport horses. . . . . .

　　When I was free, I sent five private jets to find all kinds of horse racing masters around the world as sparring partners. This is Prince Charming.

　　Secondly, cool luxury cars are also to be collected. His garage is full of privately-made limited editions. The family alone has more than 200 Rolls Royce cars and gold sports cars.

　　"The original color is not good-looking, so design and customize it yourself."

　　It is also necessary to spend 96 million RMB to buy a unique royal license plate for the car ~

　　"It’s so special! Buy another one! "

　　Running around the world every day, how can you not have a private jet? So with the concerted efforts of Qi Xin, their family bought more than 20 planes!

　　During the Dubai Air Show, Prince spent $15 billion to buy 40 Boeing aircraft to improve Dubai’s aviation business.

　　When you go out to sea, you should also have a super yacht ~

　　In addition to the expensive sea, land and air equipment, the prince also has his own pet-African lion.

　　Well, there are leopards, white tigers, elephants and peacocks. . . You can open a zoo at home.

　　Rich and willful, he can’t catch up with the stars.

　　At that time, Jackie Chan filmed Kung Fu Yoga in Dubai. As a fan of Jackie Chan’s eldest brother, how could he not support it? With a wave of his hand, the prince lent 70 luxury cars for free, among which three supercars were the most expensive in the world.

　　These limited-edition luxury cars cost millions of dollars to change the bumper casually, but who let the other side love beans? The prince said: hit it casually, and there is a spare if it is damaged. . .

　　Although there is endless money, haman dan has been diligent and low-key since childhood, and he is gifted and intelligent. After finishing his private school in Dubai, he went to the Royal Military Academy in Sandhurst, England, and became an alumnus with William and Prince Harry.

　　Haman dan, who is docile and low-key, was met by chance in the London underground. Netizens don’t forget to send greetings: does a famous person like you take the subway himself?

　　As the super online celebrity of ins, haman dan is also an all-round prince.

　　He loves sports: gliding, surfing, diving, skydiving, football and volleyball. . . No, he won’t.

　　Can go to heaven.

　　Can hike glaciers.

　　Turning around and underwater, the "Prince’s Water Story" was truly staged.

　　Water sports are also amazing.

　　You can shoot a live-action version of The Prince of Tennis.

　　Every moment is a big movie.

　　What he is best at is equestrian. When attending the Royal Jockey Club, he looks like a handsome man coming out of an oil painting.

　　He is also a frequent visitor to equestrian events. In 2006, he represented the UAE in the 15th Asian Games and won the gold medal.

　　He also won the championship in the endurance race that was very affordable.

　　In addition, he also called on the UAE to regain the traditional aristocratic movement-Falcon.

　　Haman dan is a falcon expert, and he himself, like an eagle, is hard to tame and loves freedom and adventure.

　　Haman dan likes photography. In order to train more people to play photography with him, he founded the Hamdan International Photography Award, with a prize of several hundred thousand dollars.

　　And he himself is also a young literary man who loves to travel and take photos. He is simply the most frequent travel blogger who updates ins.

　　Welcome the first sunshine in Paris in the morning.

　　Shuttle through the valleys of the Faroe Islands.

　　Sitting in a tree in Canada overlooking the forest.

　　He is photographing the scenery, and he is someone else’s scenery.

　　He traveled all over the world, experienced different cultures and captured the beauty of the world with his lens.

　　Under his lens, he is always full of love for animals and care for the environment. Before he became a prince, he was more valuable as a natural guardian.

　　But his favorite place is Dubai.

　　After all, the prince’s perspective on Dubai is different from ours, so he must fly to see it.

　　Such a beautiful angle must be seen by everyone.

　　His favorite photo is the Burj Khalifa opposite his home.

　　And the Dubai Financial Street downstairs.

　　What you must do every day is to stand on the balcony at home, look out at Dubai under the clouds and gently say good morning to the world!

　　On holidays, it is a greeting like a screen.

　　This year’s once-in-a-century "blue moon", the prince waited at home earlier and shouted excitedly: The moon is too big tonight.

　　Because there are many clouds in Dubai’s high-rise buildings, aircraft routes often rub shoulders with clouds. The prince said again, please change the course of the plane, or the clouds will not be beautiful.

　　Think this is the whole life of the prince? NO！

　　Haman dan is also an affectionate poet, who often publishes poems under the pseudonym of Fazza.

　　In private, he is also a warm man, and he is crazy about pets. Children of nephews, nephews, friends. . . It’s basically a child’s pet.

　　I believe many people will ask: he has a mine at home, has an extraordinary appearance, is friendly and versatile, and with the identity of the Crown Prince, he is definitely not single, right?

　　In this regard, Xiao pin loudly emphasized three times: single! Single! Single!

　　In the polygamous UAE royal family, haman dan is legendary. Not only is it very exclusive, but it also opposes polygamy. There is another romantic past on me.

　　According to the royal custom, all princes have appointed engagement, and haman dan also has an engagement partner appointed by his father.

　　But haman dan canceled her engagement early because she had a goddess in her heart. But under the protection of haman dan, no one knows who this woman is until now, because she refuses to marry into the royal family!

　　I have to let Xiao pin sigh that this is a fairy tale plot. Besides, I am willing to marry the prince instead of her. . .

　　Some people say that this is an era of "everything is born in red". With the development of Internet, Internet celebrities have been born, and "online celebrity" industry and "online celebrity" economy have emerged. Many teenagers even set "online celebrity" as their most desirable career in the future.

　　Objectively speaking, "online celebrity" is not a scourge. In this era, standing on the Internet, pigs can fly, not to mention the "online celebrity" with something to watch and speculation. The atomization of society, the madness of entertainment, the diversity of values and the division of public opinion … … It provides the best soil for the prosperity and popularity of online celebrity. "online celebrity" can also be "the most beautiful" with three views and integrity; But once it falls into the "vanity fair" of eyeball economy, at this time, the "online celebrity" economy will be easily possessed with a little eye-catching.

　　At present, "online celebrity" is full of chaos, involving drugs, violence, vulgarity, pornography, scams and rumors … … It’s hard to say, especially the live webcast. In 2016, webcasting in China developed rapidly, with more than 400 webcasting platforms in China. Some large-scale webcasting platforms have over 100 million registered users and over 10 million monthly active users. However, vulgarity, pornography and other content have been repeatedly banned. On August 27th, CCTV took "Webcast ‘ Huang ’ With ‘ Black ’ " A 15-minute special report was made on the topic. Famous live broadcast platforms such as Cat Pup, Yingke, Panda TV, Tiger Tooth and so on were impressively listed because of spreading vulgar pornographic content and cheating and interest bundling. For the sake of being red, it’s really quite a fight: the bottom line of the law is gone, and the underwear of morality is no longer worn. A few "online celebrity" use network technology as the engine to reverse civilized society for hundreds of years — — Either physical temptation, crazy racing, or obscene conversation, each of them goes further and further on the road of selling three customs.

　　When shame becomes the joke of vulgarity, it’s not just children’s career aspirations that "online celebrity" brings bad effects. First, it ruthlessly dispels the core values and positive energy of this society. In Entertainment to Death, Pozmann has long expressed his warning and anxiety about the rampant pan-entertainment culture. If everything is deconstructed by the "online celebrity" culture, the boundaries between right and wrong are vague, the beauty and ugliness are unclear, how to have fun, and how to be "out of position", then online carnival will become another kind of spiritual ecstasy.

　　Secondly, it provides an imposing model for bourgeois thinking such as quick success and instant benefit, mercenary and so on, and promotes and revives money worship and kitsch, which should have become rats crossing the street. Overnight fame, once profiteering, impetuous mentality in the "online celebrity" nouveau riche thinking interpretation of an alternative "peak of life." Gentle and honest civic rationality, resolute and sonorous public order and good customs will all encounter persistent provocations in the realization thinking of "online celebrity" economy.

　　In addition, the "online celebrity" line, which caters blindly and only exaggerates, is also mocking the spirit and style of Chinese culture; Especially in public events and public interests, the mysterious voices and extreme words of a few "online celebrity" have harmed the security and stability of social order.

　　For all kinds of "online celebrity" chaos at present, the supervision and platform should be managed, and the "online celebrity" should be self-respecting and self-reliant. Whether it is the tangible online celebrity Convention or the intangible force of rules, if the "online celebrity" and the platform can abide by the bottom line of morality and civilization, abide by the "red line" of laws and regulations, and take the initiative to assume social responsibilities under the temptation of immediate interests, they will be able to draw a new sky in the territory of "online celebrity" in China. In a word, online celebrity should not be reduced to vulgar "pronoun", and self-control and self-cleaning should become the "standard" of "online celebrity" phenomenon.

　　On November 20 th, because CPI, PPI and initial application data all supported the Fed’s expectation of raising interest rates, the major indexes of US stocks all recorded three consecutive weekly gains last Wednesday, and the Dow rose 1.94%. The Nasdaq rose by 2.37%; The S&P 500 index rose 2.24%.

　　However, it is worth noting that although the market seems to usher in a "sweet period", the Fed has been warning about risks, and some officials still stressed that the possibility of further interest rate hikes is not ruled out, which also suppressed the gains of US stocks to some extent.

　　Among them, Boston Fed President Collins said that the possibility of further interest rate hikes will not be ruled out; Chicago Fed President goolsbee believes that inflation has improved, but it is still too high, and will make every effort to beat inflation; San Francisco Fed President Daley continued to reiterate that the Fed is not sure whether inflation can reach the target of 2% and should be patient in the face of economic uncertainty; Federal Reserve Vice Chairman Barr reiterated the Fed’s concern about hedge fund basis trading.

　　As for the advice to the market, Michael Hartnett, chief investment strategist of Bank of America, said that after experiencing an "epic rebound", investors should sell these risky assets as technical and macroeconomic unfavorable factors are accumulating.

　　JackMcIntyre, portfolio manager of Brandywine Global, said that the recent increase in the stock market is amazing enough, and we need to find the next catalyst. The peak of the third quarter earnings report has passed, and the Federal Reserve will definitely stay put in December. The stock market needs to find new guidance, such as November inflation data.

　　For the past weekend, the global focus has undoubtedly focused on OpenAI, the initiator of this wave of AI. Last Friday, it was announced that CEO Altman had left, his ability was questioned, CTO took over temporarily, and the president subsequently resigned; Employees questioned whether to seize power, but the chief scientist denied it, saying it was to ensure the construction of AGI； for the benefit of all mankind; A big reversal in just 24 hours: It is said that the board of directors negotiated to restore Altman’s position, but the negotiations were blocked. He hoped to replace the existing directors and posted a message suggesting that he would return.

　　There is also news that Microsoft CEO Satya Nadella has been contacting Altman and promised to support him no matter what measures he takes next.

　　This wave of huge earthquakes at the top of OpenAI can be described as a realistic version of the "Gongdou" drama. However, from the perspective of influence, CEO Altman plays a vital role in OpenAI and even the entire AI industry. If Altman leaves, where will OpenAI go, and whether its major shareholder Microsoft will be affected, and if Altman joins other enterprises, whether the existing pattern in the AI field will change again, we will wait and see.

　　In other news, OPEC+ may cut production by up to 1 million barrels per day, and Saudi Arabia will at least extend its voluntary production reduction until next spring, and international oil prices will rise sharply.

　　Looking at this week, the minutes of the Federal Reserve’s monetary policy meeting in November can not be ignored. Although the market has priced the expectation of not raising interest rates, the minutes of the meeting may reveal the differences among members to some extent and how some members may vote next. And if the US economic data continues to weaken, it may overwhelm the contents revealed in the minutes of the meeting.

　　NVIDIA, the leader of AI, will announce its latest results, and its revenue in the third quarter is expected to reach 16 billion US dollars, up 170% year-on-year. Wall Street analysts believe that NVIDIA’s revenue in the third quarter will reach $16.1 billion, exceeding expectations. They also expect the company’s revenue in the fourth quarter to be around $17.7 billion (up 193% year-on-year). If the company’s performance or outlook falls short of expectations, the chill may strike again.

　　It is worth noting that the US stock market will usher in the Thanksgiving holiday this Thursday, so the market may enter a dull one.

　　[Market Review]

　　The three major indexes of US stocks all recorded three consecutive weekly gains. The Dow rose 1.94% last week; The Nasdaq rose by 2.37%; The S&P 500 index rose by 2.24%.

　　[One-week preview]

　　[Weekend Highlights]

　　OpenAI high-rise earthquake!

　　Last Friday, it was announced that CEO Altman had left, his ability was questioned, CTO took over temporarily, and the president subsequently resigned; Employees questioned whether to seize power, but the chief scientist denied it, saying it was to ensure the construction of AGI； for the benefit of all mankind; A big reversal in just 24 hours: It is said that the board of directors negotiated to restore Altman’s position, but the negotiations were blocked. He hoped to replace the existing directors and posted a message suggesting that he would return.

　　The San Francisco Declaration of APEC Leaders in 2023 (Abstract) was released.

　　China Merchants Securities believes that the main consensus of the 2023 APEC Summit is: trade, numbers and tolerance. The summit also emphasized the opportunity of green market and the rapid growth of China’s "new three kinds" exports of new energy vehicles, lithium batteries and photovoltaic products. The advantages of China’s new energy industry chain can effectively reduce the green financial expenditure of various economies in the process of global low-carbon transformation and the supply-side price pressure in the process of transformation. During the summit, China and the United States reached a consensus on further substantially increasing international flights, expanding educational and cultural exchanges, setting up an anti-drug cooperation working group and establishing an intergovernmental dialogue on artificial intelligence, which will promote dialogue and cooperation between the two countries in more fields such as science and technology, economy and trade, humanities and education.

　　The Fed continues to warn of risks internally.

　　Boston Fed President Collins said that the possibility of further interest rate hikes will not be ruled out; Chicago Fed President goolsbee believes that inflation has improved, but it is still too high, and will make every effort to beat inflation; San Francisco Fed President Daley continued to reiterate that the Fed is not sure whether inflation can reach the target of 2% and should be patient in the face of economic uncertainty; Federal Reserve Vice Chairman Barr reiterated the Fed’s concern about hedge fund basis trading.

　　OPEC+ will cut production by up to 1 million barrels per day, and Saudi Arabia will at least extend its voluntary production reduction until next spring.

　　These motions may be put forward at this weekend’s OPEC+ meeting. On hearing the news, the international crude oil rose more than 4%, and the oil distribution reached the psychological integer of $80. However, the oil price plunged by nearly 5% on Thursday, hitting a four-month low. After Big bounce on Friday, the crude oil continued to fall for four weeks, mainly due to the surge in non-OPEC supply and the growing concern about global oil cooling.

　　Meta reorganizes RAI team to fully bet on generative AI.

　　A spokesperson for Meta recently revealed that Meta has dissolved its ResponsibleAI(RAI) department, which is committed to supervising the safety of artificial intelligence projects when they are developed and deployed. The spokesman said that most members of the RAI team have been reassigned to the company’s Generative AI product department, while others will now work in the AI infrastructure team.

　　Everything Network: MasterCard brand RMB bank card will be launched as soon as possible.

　　According to CCTV news, after obtaining the bank card clearing business license issued by the People’s Bank of China, Wanshiwanglian Information Technology (Beijing) Co., Ltd. said today (November 19) that the People’s Bank of China and the State Financial Supervision and Administration Bureau have reviewed and approved the application for opening a bank card clearing institution submitted by Wanshiwanglian. The company will introduce MasterCard brand RMB bank cards to the market as soon as possible, and lay an omni-channel acquiring network to support cardholders to spend money at more than 100 million merchants at home and abroad. Everything Network will actively build a safe, convenient and intelligent new payment ecology and become a new force on the road of high-quality development of China market.

　　Tesla FSD is about to enter China, and everything is ready.

　　According to TecbWeb, an overseas source said that Tesla FSD is about to enter China, and everything is ready. However, Tesla has not announced the public relations news. In October, many car bloggers in China broke the news that the new Model 3 will use FSD after many confirmations, and it is expected that the road test will be carried out in China soon.

　　[financial calendar]

"Overhead Generation": How far are we from the real world?

Brush the sense of existence in the WeChat movement, find love in online novels, and achieve "the glory of the king" &hellip in the game; … When Wifi becomes the "underlying demand", real life is constantly being "binarized". In the overhead world of "I share, therefore I am", people are more closely connected and convenient; But in reality, people are increasingly alienated, lonely and anxious. This is your life and mine. Is it really "overhead"? How far are we from the real world?

Youth stuffed with net articles and "eat chicken"

At 2: 30 in the morning, Hu Xin, a "post-90 s" youth, sent a team invitation in the "Eat Chicken" group. Within ten minutes, three group friends responded quickly. Near three o’clock, the whole city was silent, but four young people lit up their screens and put on headphones in their respective corners, once again immersed in the game world.

"Eat Chicken", which Hu Xin and his teammates are keen on, is a mobile phone game that has recently become popular among young people. A variety of game circles are more magical than the so-called "magic capital" that these young people live in. "All kinds of game groups are day and night." Hu Xin told reporters who talked for half a month that in the dozen game groups she formed or joined, there were many late-night drinks and team brushing games; It is not uncommon to take screenshots all night.

In the daytime, another group of people "took over" to discuss raiders and cheats. In reality, these young people who play tricks online and chat for hours every day have different careers, and they live far apart, so they may never meet for the rest of their lives. But in the game, they fight side by side every day, share jargon that only people in the circle understand, and become the most like-minded playmates.

Hu Xin is regarded as an ashes player among his peers, from simple "eliminating pleasure" to once-popular "the glory of the king" and "Master of Yin and Yang", and then to the newly-popular "Jump" and "Eat Chicken". "What makes people addicted is not a specific game, but the feeling of being immersed in another world. Whether you lose your job today, break up, or have no money to pay the rent, all the troubles in reality can be forgotten. " She said.

"Even if it is not a game, it is also other virtual entertainment. My hobby is going to Jinjiang to catch up with online articles, and one of my roommates spends an hour or two brushing Tik Tok every night, without brushing or sleeping. " Wu Li, a graduate student, said.

Jinjiang and Tik Tok, which Wu Li and her roommate are keen on, are in the limelight in the online world and short video apps. According to reports, Tik Tok, a short video software launched in 2016, has now played more than 100 million videos per day. Jinjiang Literature City, which is known as "the largest female literature base in the world", is an evergreen tree in the "literary circle" — — It claims that there are 2.2 million daily registered fixed users, and more than 10,000 registered users are added every day.

Wu Li is a staunch member of these 2.2 million people. She has a history of pursuing literature for nearly 10 years, and she talks about "crossing", "Xian Xia" and "fantasy", which sounds like a few treasures to laymen. Wu Li said that online platforms such as Jinjiang will launch lists of TOP100 and TOP200 hits on a monthly and quarterly basis. When I am most obsessed, the list of books on the list can be read before the next update.

"It’s really getting up, eating, and lighting a flashlight. Several times, I took the subway and used my mobile phone to chase the text. I sat in the station, fell back and took the subway in the opposite direction, and then chased the text. As a result, I passed the station. " Wu Li said.

Lu Songsen, an 80-year-old special-grade teacher in Jiangsu Province, said with emotion that today’s students are inseparable from mobile phones and social networks. They chat and joke online, instead of going out to play in groups like children used to.

According to statistics on the Internet, as of 2012, all players have spent a total of 5.92 million years on the online game World of Warcraft, which is equivalent to the evolution of the entire human species.

It seems to be stuffed, but it is actually overhead.

Like a miserly businessman, the Internet has given convenience to a generation of young people, but at the same time, it is also quietly asking for it in its own way. Some young people who deeply "touch the net" find that with the deepening of "secondary element", their connection with the real world has been gradually overhead.

— — Virtual beauty, reality a chicken feather. Huang Yu, who works in a logistics company, summed up the pleasure brought by the game as "a sense of accomplishment in sharp contrast with reality". Even though I am not as capable as you in real life, I KO you more times in the game and rank higher than you.

Others like "life in a circle of friends" "I can’t help but send a circle of friends for 3 seconds every day, and I want to see who has commented." Zhao Xinzhi, who works in a public institution, has become accustomed to the life of "taking photos before meals and taking selfies must be beautiful". In her opinion, whether it is true or not, as long as it is a "winner in life" in the circle of friends.

— — Virtual social overhead emotional needs. More and more young people are addicted to ambiguous virtual friendship and love. Shanghai Doumeng Technology once conducted a user survey for 1,000 post-90s generation, asking: Who are your real friends among classmates, friends and relatives and gay friends who met through online reading? Results More than 90% people choose people they know in the virtual world, because they firmly believe that people in the virtual world know their joys and sorrows better.

Wu Li also found that the "literary circle" around him is almost equal to the single circle. As a little girl in her twenties, the single rate who is keen on reading online novels exceeds 70%. This ratio is significantly higher than other girls of the same age and environment.

The high single rate of women who pursue literature is not only because reading books consumes social time. More importantly, online texts and online dramas will create a set of "pink world" with a strong sense of substitution. Girls who are used to seeing all kinds of overbearing presidents and black-bellied affectionate heroes can easily live in this world where perfect men are ready to save ugly ducklings and girls everywhere, but they don’t care about the real world.

"The virtual world really fills the emotional needs of young girls and makes us less eager for love and family." Wu Li described that many girls around him hold the view that money can be earned by themselves and life can be lived by themselves. If you can’t find a better person than the online man, why should you fall in love?

— — The more noisy the online life is, the more lonely the real life is. Lei Gang, a young man born after 1985, lives in Nanjing. Every day, his family is like this: he goes home for dinner on weekdays, puts on his headset to play games, and his wife watches TV and brushes online dramas in the living room. Under the same roof, sometimes I can’t say two words in one night.

"I also feel that it has always been so bad, but it is difficult for both parties not to play or watch at the same time. The later, the more difficult it is to find another lifestyle. "

Lei Gang said that not only the couple, but also their parents and colleagues are more or less troubled by spending more time on the screen and less real face-to-face communication. At family gatherings, each family grabs a red envelope with his mobile phone, and the old man has no chance to talk to his children. Colleagues chat enthusiastically in QQ group every day, but once they meet, they are like strangers, and they don’t know what to say to each other. "Social networks make people thousands of miles away close at hand, but at the same time, people who are close at hand are increasingly alienated."

In recent years, there is a kind of "phone phobia" which is especially suitable for WeChat and QQ communication, but it is a "symptom" when the phone rings. Although there is no accurate conclusion yet, some followers believe that from "fear of meeting" to "fear of voice", the real communication and emotional ties between people are being dissolved and evacuated.

What is overhead is not only reality, but also the mind.

"The Internet provides an exit to escape from reality at any time. In the virtual space, it is easier for people to build their ideal selves, and social interaction becomes simpler, more friendly and more arbitrary." Dong Yizhi, a lawyer in the field of Internet investment finance, believes that many of the words spoken on social networks are for himself. Brushing the track and showing the daily life every day is actually brushing the sense of existence. The reason for this may be that it is difficult to find like-minded people in real organizations, or some real demands cannot be met in time.

"In this seemingly overhead world, people can vent their unconscious tension and anxiety." Dr. Tao Xinhua, the first supervisor of the psychological consultation registration system of the Chinese Psychological Association, said that the impact of scientific and technological innovations such as the Internet on people’s lives has two sides: on the one hand, it better meets people’s living needs, on the other hand, when the needs are over-satisfied and uncontrolled, it will destroy life.

"This is not the result of technological innovation such as the Internet ‘ Side effects ’ However, scientific and technological progress has disrupted the balance of people’s lives, and they are not used to and adapt to the rapid development of science and technology. " Tao Xinhua said.

Lu Songsen, an old teacher, is very worried about the younger generation, especially underage children. Because of the lack of interaction with nature, the immune function will not develop completely. "The overhead of the real world is essentially the disconnection between knowledge and people’s literacy, the disconnection between young individuals and society, and the disconnection between knowledge and action, which makes children unprepared and have insufficient ability to adapt to and cope with the rapid development of science and technology."

As Turkel expressed in the book Group Loneliness, scientific and technological innovations such as the Internet have brought us this new type of loneliness, but this is not the fault of the Internet. On the contrary, the real problem is that we are not fully prepared for the arrival of the Internet.

"People’s desires are infinite, but their abilities are ultimately limited. What is important is to find the true self in their hearts and find their own position in real life." The interviewed experts suggested that it is more important than anything to go out for a walk and play, to embrace nature again in the real world, to establish a thick and intimate social relationship, and to plan a healthy lifestyle to adapt to the new era.

After all, everyone’s specific life is unique, which can’t be replaced by others, and it is impossible to make up for it in the future. Just as Ready Player One, a popular movie recently, said, return to reality and don’t escape, because reality is the only real existence. After all, "the game is always virtual, and only in the real world can you have a full meal." (Talk to reporter Pan Wei and Wang Jue for half a month)

link

Frontier science issues

What is the ecological mechanism of cross-species transmission of coronaviruses?

　　At present, COVID-19 is raging around the world. Virologists have repeatedly warned that cross-species transmission of coronaviruses is a high probability event. The background situation of wild animals such as bats carrying coronaviruses and how wild animals break through ecological and physiological barriers to cause cross-species transmission and infection are still unclear at the scientific level. This question is of great significance for revealing the cross-species transmission mechanism of coronaviruses and preventing future epidemics caused by coronaviruses.

Question 2: How will the attractive force wave reveal the mysteries of the universe?

　　Since the first direct detection of attractive force waves in 2015, attractive force waves have rapidly become a hotspot in the frontier research of basic physics and astrophysics in the world, and it is expected that there will be a historical opportunity for major breakthroughs in the origin of the universe in more than ten years. Attractive force waves open a new window for observing the universe. By observing the generation and distribution of attractive force wave sources in the universe, it is expected to answer the deep scientific questions left over from the standard model of general relativity and particle physics, thereby deepening the understanding of nature.

Question 3: How does Earth’s material evolve and circulate?

　　The earth’s materials are mainly divided into rocks and minerals. People’s understanding of the evolution and circulation of magmatic rocks and metamorphic rocks in the earth’s historical period is blurred due to the lack of comprehensive analysis of big data. Using the comprehensive analysis of big data platforms and deep-time big data systems on the earth, it is possible to establish a connection between the basic course and special events of mineral evolution and planetary geological evolution, clarify the evolution law and coupling relationship of planetary earth and its multiple circles from the perspective of mineral evolution, and answer the basic scientific questions about how planetary earth evolves and whether there is a co-evolution relationship between various circles of the earth.

Question 4: What will a fifth-generation nuclear energy system look like?

　　In 2000, the Fourth Generation Nuclear Energy System International Forum initiated by the US Department of Energy divided the development of nuclear energy into four generations. At present, the research on the fifth generation nuclear energy system is still in the exploratory and exchange stage, and there is no mature concept definition and goal definition, and there is little talk about its realization path. If it can promote the implementation and final realization of the concept of the fifth generation nuclear energy system, it can reform the concept of nuclear energy development, the model of nuclear energy development, the concept of nuclear energy application, and support the deep decarbonization of the energy system; lead the world in nuclear energy innovation, and help China become the world’s nuclear energy innovation highland.

What is the scientific principle of special energy field-assisted manufacturing?

　　With the continued demand for lightweight and safety in aerospace, transportation, and other fields, high-strength materials, including ultra-high-strength steels, light alloys, composites, and intermetallic compounds, are applied to complex components. As material strength increases, manufacturing difficulty increases significantly, and forming defects are more difficult to control. Existing research shows that special energy field-assisted forming technology has great potential in improving the manufacturing challenges of high-strength and difficult-to-deform materials.

Question 6: How can digital transportation infrastructure promote the coordinated development of autonomous driving and vehicles?

　　In the future, the large-scale social operation of autonomous vehicles will inevitably appear, which will be a change for the transportation system, and the road transportation system is facing the challenge of evolution and replacement. For the research on new road infrastructure to support the social operation of autonomous driving, our country is still in its infancy, and there is no ready-made advanced technology and experience abroad to learn from. It is necessary to transfer the support of autonomous driving research to the research of intelligent supply on the infrastructure side and the research of comprehensive integrated landing application in a timely manner.

Question 7: What is the mechanism of traditional Chinese medicine that regulates human immune function?

　　Although the basic research of immunology has made remarkable achievements and medicine is also developing by leaps and bounds, it is still insufficient in the prevention and treatment of many difficult and serious diseases. Autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and ankylosing spondylitis still plague patients. The occurrence, development, and outcome of these major and difficult diseases are closely related to immunity. Traditional Chinese medicine can act on the body at multiple levels, targets, and pathways, regulate the body’s immune function, and has important application value in disease prevention and treatment.

Question 8: What is the biological basis of plant apomixis?

　　Non-fusion reproduction is a kind of reproductive method that propagates asexually through seeds, which can make hybrid varieties produce cloned seeds, keep the characters of hybrid offspring from separating, and thus permanently fix ** advantages. However, due to the complexity of the mechanism of non-fusion reproduction, despite the efforts of scientists from many countries for nearly a century, its formation mechanism is still unclear, and it has not been successfully applied to crop breeding.

Question 9: How to optimize the water carrying capacity of our country in a changing environment and achieve a healthy regional water balance?

　　At present, the construction of ecological civilization in our country has entered an accelerated period and a critical period, which puts forward higher requirements for the intensive utilization and strict protection of water resources. Studying the scientific issue of water resources carrying capacity and water balance optimization under changing conditions is conducive to deepening the understanding of the factors of regional water cycle in our country and their evolution laws, improving the evaluation method of water resources carrying capacity, clarifying the index significance of water balance status for water resources carrying capacity, clarifying the occurrence mechanism of many water problems and ecological environment problems, and providing important theoretical and technical support for summarizing the economic and social development and ecological protection models that are compatible with water resources carrying capacity, and effectively protecting and restoring the ecological environment.

Question 10: How to establish a theoretical and technical foundation for virtual twins and develop demonstration applications?

　　Virtual twin is a process and method for describing and modeling the characteristics, behavior, formation process and performance of physical entities and intelligent entity objects in the real world using digital technologies such as sensors, Internet of Things, virtual reality, artificial intelligence, etc. on the basis of digital twin, also known as virtual twin technology. It is based on digital twin, but focuses more on modeling and simulation of intelligent entities or living beings. How to realize the interaction and integration of manufacturing the physical world and the information world is one of the core bottlenecks currently faced by the practice of intelligent manufacturing concepts and goals at home and abroad.

Engineering problems

Question 1: How to develop new pathways and technologies for novel immune cells in tumor treatment?

　　Immune cell technology is the hope for human to completely cure tumors, and it is one of the hot areas pursued by cutting-edge medicine and capital around the world. As a key node cell linking cellular immunity and humoral immunity, dendritic cells (DC) can mobilize the entire immune system, resist the invasion of pathogens and promote the clearance of tumor cells, becoming a key research direction of new immune cell therapies. The new DC amplification technology can realize the standardization and mass production of DC vaccines, which can significantly reduce the preparation cost and serve more cancer patients, with obvious economic and social benefits.

Question 2: Why has the integrated design of horizontal take-off and landing combined power vehicles become the new focus of aerospace technology?

　　水平起降组合动力运载器具有快速、廉价、可靠的特点，可成为低成本天地往返运输工具。水平起降组合动力运载器一体化设计技术是支撑未来航天运输系统发展与应用的核心技术之一，是未来先进航天运输系统的重要支撑技术之一。

●问题3：如何实现农业重大入侵生物的前瞻性风险预警和即时控制？

　　农业有害生物入侵不仅仅是简单的植物病虫害或动物疫情问题，入侵生物的发生流行不仅危害食品安全和农业生产，造成巨大的直接经济损失，还可能对人类健康构成越来越大甚至是灾难性的威胁，对外交、经济和社会产生巨大影响。因此，站在国际化、全球化视角，从科学研究和专业技术层面，开展农业入侵生物跨境传播预警及防减技术合作的协同攻关，将有力解决入侵生物疫情的源头治理和联防联控关键技术难题，保障社会稳定与公共安全。

●问题4：信息化条件下国家关键基础设施如何防范重大电磁威胁？

　　强电磁脉冲一旦对金融、能源、电力等领域的关键信息基础设施产生影响，将可能导致交通中断、金融紊乱、电力瘫痪等重大事故。开展此项研究，对确保关键基础设施电磁安全、保护经济建设成果、提升关键基础设施容灾抗毁能力具有重要意义。

●问题5：硅光技术能否促成光电子和微电子的融合？

　　信息光电子芯片已然成为“数字化新基建”的核心和基石，也是全球信息通信价值链的关键领域和网络强国建设的“国之重器”。硅基光电子芯片技术既可应用于芯片级光互连，又适用于长距离光纤通信，可实现全功能光电子集成，具有极高的通用性和兼容性，是微电子和光电子两大产业公认的发展方向。利用国内现有微电子产业资源和互补金属氧化物半导体（CMOS）制造平台，建立健全硅光产业链，可以有效提升我国信息光电子的制造能力，缓解光电子芯片制造工艺的“卡脖子”困境，为我国信息化新基建提供有力支撑。

Question 6: How to solve the problem of on-line defect detection in integrated circuit manufacturing process?

　　The field of integrated circuits is currently the main battlefield of international science and technology competition and the focus of the game between major powers. For integrated circuit defect detection technology and equipment, on the one hand, the most advanced technology and equipment are monopolized by a few developed countries; on the other hand, the defect online detection technology of 7 nanometers and below nodes around the world is still immature, and the equipment gap is still huge. Whoever takes the lead in mastering the corresponding key technologies will have the dominance in the future. This is both an opportunity and a challenge for our country.

Question 7: How can unmanned vehicles achieve high-precision intelligent navigation under conditions where satellites are not available?

　　Special unmanned vehicles represented by unmanned rescue vehicles, unmanned mining vehicles, and unmanned transport vehicles are the core unmanned equipment for completing modern operations, emergency rescue and disaster relief. In order to improve the emergency rescue and joint operation capabilities of unmanned vehicles, its navigation system is required to have functions such as high-precision positioning, autonomous obstacle avoidance, intelligent path planning and guidance. Therefore, it is necessary to study high-precision and fully autonomous navigation methods and to solve the problem of inertia-based intelligent navigation for unmanned vehicles.

● Question 8: How to achieve the unity of "large-scale", "low energy consumption" and "high stability" in the large-scale production of hydrogen by electrolysis of water from renewable energy sources?

　　The development of high-efficiency and low-cost renewable energy and hydrogen energy technologies is a timely response to the country’s major needs, and it is also a high-quality solution for reducing carbon emissions and mitigating climate change globally. However, the current level of development of hydrogen electrolysis technology limits the conversion efficiency and industrialization process of renewable energy into chemical energy. Breakthrough in high-efficiency, low-cost, and large-scale hydrogen electrolysis technology can greatly promote the utilization and development of renewable energy and hydrogen energy.

Question 9: How to break through the intelligent construction and engineering health protection technology of the expressway into Tibet?

　　The lithology of the Qinghai-Tibet Plateau is complex and changeable, the neotectonic movement is intense, the deep and large active faults are widely distributed, the glaciers, permafrost and mountain disaster groups (chains) are developed, and there are "significant terrain height difference", "strong plate activity", "frequent mountain disasters", "sensitive permafrost environment" four geological environmental characteristics, as well as "high frequency freeze-thaw cycle", "severe wet and dry alternation" and "extreme cold and hypoxia" three climatic and environmental characteristics. The series of engineering and technical problems brought about by this are the key technical factors restricting the development of high-speed transportation in Tibet.