Beijing, June 15th (Reporter Qiu Yu) The last legal holiday in the first half of this year — — Dragon Boat Festival is coming!

　　The college entrance examination is over, the graduation season is here, and the World Cup has begun. This small holiday, is it necessary to let go of yourself?

　　If you plan to travel, you can collect this guide, which will make you have fun and worry-free, and avoid crowds.

　　First of all, people who travel in go on road trip or by bus should pay attention:

　　Dragon boat festival holiday,High speed is not free..

　　Say it again,Normal highway toll collection during Dragon Boat Festival.

　　Trend of congestion during the national high-speed Dragon Boat Festival. Source: 2018 Dragon Boat Festival National Highway Network Travel Forecast Report issued by the Ministry of Communications in conjunction with other institutions.

　　If you want to avoid the headache traffic jam, pay attention to the following peak hours:

　　Ministry of communications estimatesJune 16th is the peak of travel.,9: 00 am to 12: 00 am on the same day is the peak travel time; Especially from 10: 00 to 11: 00, the congestion degree is the highest.

　　June 18th is the peak of return trip.,On the same day, 15: 00 -21: 00 pm was the peak time of return trip, and the peak appeared at 16: 00 -17: 00.

　　Which highway sections are prone to congestion?

　　It is estimated that the highways with high traffic flow include: Hebei section of Jingcheng Expressway, Beijing section and Hebei section of Daguang Expressway, Guangdong section of Guanfo Expressway, Hunan section of Beijing-Hong Kong-Macao Expressway, Jiangsu section, Shanghai section and Zhejiang section of Shenhai Expressway.

　　The expressway around the city with high traffic volume includes: Guangzhou Ring Road, Chengdu Ring Road, Shanghai Ring Road and Hangzhou Ring Road Expressway.

　　Provincial congestion during the Dragon Boat Festival. Source: 2018 Dragon Boat Festival National Highway Network Travel Forecast Report issued by the Ministry of Communications in conjunction with other institutions.

　　The Ministry of Communications predicts that,The high-incidence areas of expressway network in provinces are mainly concentrated in Guangdong, Beijing, Jiangsu, Zhejiang, Hebei and other areas with strong traffic demand or concentrated self-driving tourism.

　　Some people choose to travel by high-speed rail. Have you grabbed the tickets for the following popular routes?

　　Meituan Travel Big Data shows that during the Dragon Boat Festival, the demand for high-speed rail travel is mostly in the province, and the top three popular routes are Guangzhou-Shenzhen, Chengdu-Chongqing and Hefei-Lu ‘an.

　　Jingzhou-Wuhan, Beijing-Tianjin, Chengdu-Xi ‘an, Chengdu-Mianyang, Shenzhen-Xiamen, Wuhan-Yichang and Wuhan-Xiangyang high-speed rail lines are also very popular.

　　Small partners who want to fly can also find cheap air tickets in relatively "unpopular" places.

　　Ctrip data shows thatFly to Fuzhou, Kunming, Guiyang, Quanzhou and overseas destinations such as Sydney and Singapore, and the ticket price is nearly half cheaper than last year’s Dragon Boat Festival.Come and pick up the leak!

　　On the contrary, Beijing, Chengdu and Xi ‘an have become the top three popular destinations in China. It is difficult to see tickets with a discount of less than 20% during hot hours, and some flights only have full-price tickets in economy class.

　　By the way, this year’s Dragon Boat Festival is different from the past, because there is an important event — — World Cup.

　　According to Ctrip data, during the small holiday,The destination with the most obvious price increase is Russia, the host of the 2018 World Cup, with the increase of more than 30% compared with the group and free travel routes.

　　However, the enthusiasm of China tourists has not diminished. During the World Cup, the number of Ctrip Russian tour groups has increased by 60%.

　　In addition, the weather is also a key factor in the journey.

　　According to the forecast of the Central Meteorological Observatory,During the Dragon Boat Festival holiday, there will be a strong rainfall process in the eastern part of southwest China, the lower reaches of Hanshui River and the north-central part of the south of the Yangtze River. There will be heavy rain in some areas and heavy rain in the local area, accompanied by strong convective weather such as short-term thunderstorms or hail.

　　If you want to travel to these places, you’d better prepare rain gear in advance.

　　Refer to the above information, make a good travel plan, and wish you a beautiful Dragon Boat Festival holiday.

　　Finally, I will tell you quietly that it will be more than three months before the next legal holiday is over after this small holiday. So, cherish the holiday and have fun.

    In recent years, many domestic industrial belts have successively joined the cross-border e-commerce track, and "cross-border e-commerce+industrial belt" has become one of the main forms of foreign trade. In 2024, the domestic industrial belt will face not only the cross-border blue ocean, but also the long-term high-quality sea going. The reporter’s recent visit found that some cross-border e-commerce platforms are helping the industrial belt to expand into a "new blue ocean and new growth pole" through digital means, and promoting the leap of "Made in China" in the international market competitiveness and brand power.

   Cross-border e-commerce empowers industrial belts to expand markets.

    Industrial cluster is an important carrier to promote the high-quality development of regional economy. At present, there are hundreds of light industrial clusters in China, which play an important role in regional economy. In recent years, major cross-border e-commerce platforms have begun to increase cooperation with industrial belts to help local enterprises expand overseas business opportunities more accurately and efficiently through in-depth services.

    In September 2023, Xiyin, a cross-border e-commerce platform, announced the launch of the national 500-city industrial belt plan. Within three years, it will go deep into the national 500-city industrial belt, connect the industrial belt with digital trade and digital flexible supply chain, and provide integrated empowerment from production to market sales to brand growth, helping the industrial belt expand the global market and gain brand promotion. The reporter learned that through the continuous deepening of the 500-city industrial belt going to sea plan under the platform model, the flexible supply chain model of "small single and quick response" produced by Xiyin on demand is splitting from the clothing industry to more industries, helping the industrial belt to go to sea with cross-border e-commerce, and at the same time, empowering this set of capabilities to more industrial belt sellers through platform.

    Going out to sea is not the digestion of excess capacity, but the flexible supply chain makes the market demand and supply more match. By cultivating new models and new formats, the productivity of industrial belts will be improved, and at the same time, small and medium-sized sellers will be realized. In the process of internationalization of China’s manufacturing industry, domestic characteristic industrial belts need to build their own competitive advantages in order to win. With the help of updated digital ideas and digital means, they can realize efficient resource allocation and accelerate innovation, and finally realize the overall capacity transformation and upgrading of industrial belts.

    According to the Insight Report of Cross-border E-commerce Industry 2023 Industry Belt Brand Going to Sea released by Billion Think Tank, "Cross-border E-commerce+Industry Belt" provides a strong impetus for high-quality going to sea. Cross-border e-commerce industrial belts in China have their own characteristics. With the continuous release of policy dividends, many traditional foreign trade industrial belts have achieved global business expansion through cross-border e-commerce.

   From product to brand.

    At present, China’s industrial belt has entered a new stage of intensive brand going out to sea from extensive high-speed growth. Under the background of the state’s support for the development of new foreign trade formats, many traditional foreign trade industrial belts have been actively transformed by relying on cross-border e-commerce channels and digital service tools, further focusing on brand building and global development.

    In the eyes of the industry, one way for the industry to take the brand to the sea is to take the flexible supply chain as the support and embark on the road of brand internationalization through the cross-border e-commerce platform; The other is that trade-oriented businesses transform and upgrade from distributing goods to brands, and build their own brands with the help of cross-border e-commerce platforms.

    Building its own brand and strengthening its brand power are regarded as the inevitable trend of "Made in China". Insiders pointed out that cross-border e-commerce platforms not only empower more industrial belt sellers with flexible supply chain capabilities, but also actively assist industrial belt sellers to build brand power together. The platform helps industrial belt sellers to improve a series of capabilities including product development, market trends, compliance management and supply chain management by empowering them with one-stop services. For the industrial belt, the future is not only the product going out to sea, but also the overall ability and brand power of the industrial belt going out to sea and upgrading. If the industrial belt wants to go to sea, it must achieve high-quality going to sea, and the ultimate benefit will be the comprehensive competitiveness of the whole "Made in China".

    Deng Nan, the seller of wig industry belt, paid attention to the demand of overseas consumers for wigs in his early years. Through the online Xiyin platform, the humble niche products achieved sales of 50,000 US dollars in the first month; Three years later, this number has grown to $2 million.

    "At present, industries driven by cross-border e-commerce platforms are brought out to sea, allowing China’s high-quality supply chain to directly face international consumers, opening up new international markets and promoting industrial upgrading." Zhao Lingyi, chief analyst of Shen Wanhongyuan’s research on commerce and retail, told reporters that the new format of going to sea promoted by "cross-border e-commerce+industrial belt" will further promote the transformation of China’s manufacturing industry into a China brand with independent design concept and strong market competitiveness, thus occupying a more important position in the global value chain.

   Digital innovation drives the development of industrial belt

    Last year, the General Office of the State Council issued an opinion on promoting the stable scale and excellent structure of foreign trade, proposing to support foreign trade enterprises to expand their sales channels and cultivate their own brands through new formats and new models such as cross-border e-commerce, encouraging all localities to combine their industrial and endowment advantages, innovate and build a comprehensive cross-border e-commerce experimental zone, actively develop the "cross-border e-commerce+industrial belt" model, and drive cross-border e-commerce enterprises to export to enterprises.

    Domestic emerging cross-border e-commerce platforms such as Xiyin, AliExpress and Tik Tok Xiaodian have attracted a large number of consumers and sellers through their own characteristics and unique development models, and gradually occupied an important position in the global e-commerce market. In the future, domestic cross-border e-commerce enterprises are expected to fully benefit from the continuous high penetration rate of global e-commerce and the cost-effective advantage of "Made in China" to drive the rapid development of the domestic cross-border e-commerce market. In addition, sellers related to brand going out to sea and manufacturing going out to sea are expected to benefit from the traffic dividend brought by the emerging cross-border e-commerce platform in China.

    "New advantages need to be established in the process of manufacturing internationalization. China’s manufacturing industry must take the road of increasing added value in the future. The added value comes from innovations in design, technology and products, as well as the improvement of brand power. " Hu Qimu, chief researcher of digital economy think tank, said that enterprises can make the supply chain more efficient through digital means, realize personalization and improve overall efficiency at the same time.

    Hu Qimu believes that the "cross-border e-commerce+industrial belt" model is to use digital tools to help businesses continuously optimize the supply chain, solve the problem of production balance through flexible small orders, and then digitally manage the whole process of a large number of fragmented orders, so as to realize flexible and standardized production, improve quality and efficiency, and empower more industrial belts to build new quality productivity and brands to go to sea. (Reporter Gao Shaohua)

Yang Jianfei: Computational Medicine Promotes Accurate Clinical Trials.

　?

Yang Jianfei, Chief Scientific Officer of Zheyuan Technology

Computational medicine needs to be composed of interdisciplinary teams and platforms. By integrating supercomputing system, AI platform, molecular and clinical data, massive literature and biological information, it can realize effective analysis and calculation of drug development and assist decision-making.

Taking an anti-tumor drug in our pipeline as an example, we read all the literatures of the target disease by using the "TWIRLS stick" of the computational medicine platform, first we have all the scientific knowledge known on the earth at present, and then we analyze the digital twins of patients in the patient database in a data-driven way to obtain the disease mechanism, specific targets and "portraits" of patients.

As we all know, the tumor is heterogeneous in time and space, and the immune system around the tumor is particularly complex. Therefore, only by having an accurate "portrait" of the patient’s tumor and accompanying diagnosis can we enter the stage of accurate clinical trials.

Through the computational medical platform, we established the response mechanism model of CDK4/6 inhibitor, and the effectiveness of this model was verified by the data of TCGA and Chinese patients. Then we put this drug currently used to treat breast cancer on the computational medical platform to study whether it has other applicable diseases. It was found that the model score of chordoma was very high, so we established cooperation with shanghai changzheng hospital and saw that some patients achieved partial remission in the third week after taking the drug. Although this drug has not yet entered the clinical trial stage, as long as it is carried out in accordance with the norms of computational medicine platform, we are confident to achieve truly accurate clinical trials.

Peng Ao: Behind the clinical success rate from 2% to 21%

Peng Ao, Project Management Team Leader of Pfizer China Product Line

The efficiency of Pfizer’s new drug research and development has increased from 2% to 21%. I think we can sum up three experiences. First, accurate positioning, clear their own specific advantages in the field of biology. Pfizer currently focuses on internal medicine, immunity and inflammation, oncology drugs and vaccines. Second, choose the drug mode. At present, more complex and novel molecular entities account for more and more in our pipelines. Thirdly, the decision-making adheres to two principles. First, quantitative POM analysis is carried out in the first and second phase of the experiment, which can help the success rate of the second phase reach 40%; The second is to plan again. If the first direction of clinical research and development fails, then we will transform it and try again in another direction. If there is a very clear biological basis, our success rate can reach 31%.

Ertuglifozin is a SGLT-2 hypoglycemic agent, and a large number of technologies and methods related to computational medicine are used in its research and development, including systematic pharmacological model and Emax Model. Using this model, the highest hypoglycemic effect of the drug can reach 77%. Meta-analysis shows that the drug has the highest hypoglycemic level among similar products. This is a typical case of using model or computational medicine to guide drug research and development.

The US Food and Drug Administration has begun to build a framework for digital health tools. I believe that after the introduction of the framework, the guiding principles of the corresponding rules will also be introduced, which will guide the application of some new drug research and development more specifically and deeply.

Tang Yu: The insights generated by computational medicine need to be verified clinically.

Tang Yu, Executive Director of the Office of Drug Clinical Trial Research Center, Cancer Hospital, China Academy of Medical Sciences

Computational medicine has produced a large number of insights by analyzing massive data, but how to prove that these insights are authentic and can be used in clinical practice through clinical trials?

The first case is to verify the specific answer given by computational medicine to a specific problem, such as verifying whether the first innovative drug under the guidance of AI can treat pancreatic cancer. The second is based on massive data to verify whether the treatment mode formulated by AI for individual patients or groups is better.

In the course of such an experiment, we need to consider several issues:

First, the consistency of the AI model. When we want to prove that an algorithm or an AI-based paradigm can guide medical care, we must ensure the consistency of the paradigm and not make it change irregularly.　

Second, it is necessary to consider whether there is an accessible clinical treatment for a class of patients with more concentrated biological characteristics found by AI model. If there is no targeted treatment, although this model can guide the prognosis of patients, it is difficult to change the existing treatment methods.

Finally, establish a model that can not only explain the results, but also explain the mechanism, so as to better combine human wisdom with the wisdom of computer based on data integration.

At present, we are carrying out an umbrella research design, focusing on soft tissue sarcoma. Although the overall incidence of the disease is not high, there are nearly 100 subtypes. Our anti-vascular targeted drugs have shown excellent effects in individual subtypes, but the overall effect is still not ideal. Therefore, we hope to use Turing Darwin’s laboratory’s in-depth analysis of the whole sarcoma mechanism and digital twin technology to find drugs with ideal curative effect and high accessibility.

Niu gang: the big disease model changes the new paradigm of drug research and development

Niu Gang, Director of Turing Darwin Laboratory

In today’s medical field, we are committed to collecting and utilizing all kinds of disease-related data, looking for clues of logical unity for diseases, and establishing complex and real mechanism portraits. But the key lies in how to understand the so-called mechanism and who is the subject of the complex mechanism?

We have built and trained a brand-new AI method-"Genome Shotgun Damage Assessment Process" (DAGG). By inputting the sequence information of human germ line or tumor genome, AI can translate the sequence gobbledygook that human can’t understand into understandable changes in cell function.

According to the information of genome variation, clinicians can use DAGG to judge whether HER2 gene is amplified in tumor cells of breast cancer patients, so as to further clarify the pathological types of patients and provide clearer and more accurate judgments for patients’ diagnosis and treatment.

With the DAGG method, we can also transform the real patient data into the digital twins of the patient and his disease. With the large-scale accumulation of patients’ digital twins in virtual environment, we conducted a large-scale virtual clinical trial for PD-1/PD-L1 monoclonal antibodies. The results showed that the efficacy of most immunodrugs with indications was not ideal.

Therefore, the virtual clinical trial based on digital twins can replace the original clinical trial results that cost tens of billions of dollars. Based on the curative effect data of a small sample of individual indications, the potential indications of other tumor diseases can be inferred. At the same time, according to the biological mechanism directly suggested by the model, the combination scheme and even new molecules can be rationally designed, which saves many clinical development steps and costs and ensures greater benefits for patients.

Shi Rong: Computational Medicine Helps Accurate Diagnosis and Treatment of Breast Cancer

Shi Rong, Secretary General of Cancer Prevention and Treatment Committee of Wu Jieping Medical Foundation.

Breast cancer is the largest cancer in the world. HER2 is a definite prognostic indicator and a predictive indicator of drug treatment effect for breast cancer, but the tumor heterogeneity of HER2 expression is obvious, and the detection method of HER2 can not meet the demand of anti-HER2 treatment. Therefore, studying the etiology of the germ line carried in the germ line genome is not only helpful to deeply understand the pathogenesis of breast cancer, but also helpful to develop new methods and provide prospective judgment for subsequent treatment.

Recently, the artificial intelligence algorithm DAGG independently developed by the computational medicine team revealed the pathogenesis of breast cancer. It is found that the signal pathway function spectrum (APSP) can be obtained by using the DAGG model based on the germline fingerprint rare coding variation data. According to the difference in the distribution of APSP between patients and people with low etiology, a prediction model can be effectively constructed to evaluate the etiological risk of female individuals, and the HER2-positive and HER2-negative breast cancer patients can be effectively distinguished.

The clinical transformation path of breast cancer based on APSP is divided into three steps. The first step is to guide the clinical treatment plan based on the pathological classification of breast cancer by APSP. The second step, based on APSP, is the extremely early diagnosis of women with breast nodules and breast cancer with familial breast cancer genetic history, so as to reduce the proportion of breast cancer patients who enter advanced and advanced stages at the first diagnosis. The third step, breast cancer risk assessment of healthy population based on APSP, fills the gap of the lack of effective primary prevention measures for breast cancer in the world.

Jiang Min: Virtual clinical trial is a new paradigm in the future.

Jiang Min, Director of the Office of National Drug Clinical Trial Institution of Peking University Cancer Hospital

From a global perspective, there have been exploratory studies on virtual clinical trials, but retrospective cases are the main ones. Regarding whether we can carry out prospective virtual trial design and generate higher-level digital evidence to verify the computer simulation model, so as to better guide clinical research, Peking University Cancer Hospital and the computational medicine team collided from the perspectives of technology and experimental requirements, forming a real landing research.

The two sides jointly carried out a parallel virtual clinical research project by using the digital twin model of patients in computational medicine. The purpose of the research is to explore the relationship between the pathogenesis of tumor and the mechanism of anti-tumor drugs. Through the virtual clinical trial, the curative effect of anti-tumor drugs is predicted, and the characteristics and differences of patients are analyzed, so as to optimize the design of clinical trials. This study compares head-to-head with a real clinical study of registered new drugs to verify the consistency between the predicted results of virtual clinical research and the curative effects of real-world clinical trials.

Virtual clinical trial is a new paradigm in the future. With the support of computational medicine technology, the future clinical trial model may be transformed into more accurate clinical trial design, which will bring a more holistic drug research and development idea, which will bring revolutionary changes to the success rate and effectiveness of clinical trials.

Roundtable Forum I: Cognition and Evaluation of Non-consensus and Subversive Technology

Moderator: Li Lei, Associate Research Fellow of Frontier Science and Education Bureau of China Academy of Sciences.

Roundtable forum site.

Lv Benfu (Professor, School of Economics and Management, Chinese Academy of Sciences)The so-called breakthrough innovation mainly depends on three points. First, whether a brand-new track has been developed; Secondly, on the original track, whether its performance-to-value ratio conforms to the law of ten times speed; Third, whether it belongs to the pattern innovation from 0 to 1 depends on the support of industrial policies.

Gu Chengming (Head of Sanofi Greater China Medical Department)The non-consensus stage is the primary stage. As long as it is accepted by the industry, it is considered as consensus, or it is available, which can solve some problems. However, in the field of drug research and development, if you want to be a First-in-Class, it must be a non-consensus. If you become a consensus, it will be Me too.

Zhang Chunming (Vice President of the Western Research Institute of Computing Technology, Zhongke)From a practical point of view, today’s world structure does not support small steps forward, and we must give full play to the ability of large-scale team operations. In terms of innovation, it is indeed possible for computational medicine to open up a brand-new track, so any government department should carefully evaluate it.

Weng Huajian (deputy head of Changning District, Shanghai)In 2021, I first learned about computational medicine. At that time, we envisaged to set up a life science innovation center between Suzhou and Shanghai, specializing in high-end research and development, focusing on computer +Inside and AI+, so as to give full play to the accumulation of digital economy in Changning, Shanghai in the past 20 years, especially the accumulation advantages of talents and innovation ecology. Therefore, from the perspective of the government, we are full of expectations for disruptive innovation technology in computational medicine.

Roundtable Forum II: Investment Logic from the Perspective of Computational Medicine

Moderator: translated by Hu Ming, partner of Mingde Capital.

Roundtable forum site.

Tian Feng (Minister of Industry Service Department of Shanghai Biomedical Industry Promotion Center)The most noteworthy point of the whole AI+ pharmaceutical industry is to change from logical successful practice to probabilistic successful practice, and finally return to logical successful practice. From the perspective of AI+ diseases, developing virtual clinical trials, I think it can effectively reduce the cost of clinical development and improve the success rate in the future.

Jing Xutian (Managing Director of Wuyuan Capital): AI technology has brought some new algorithms and breakthroughs in computing power. In the past, many AI pharmaceutical companies paid more attention to the field of small molecules with the most data and the most mature data, but today we see that more and more algorithms are actually very suitable for doing some new modal drug discovery.

Zeng Yingzhe (Partner of Linear Capital)Before AI technology, we usually build low-dimensional models to solve high-dimensional problems, but the emergence of AI can solve these high-dimensional problems. With more and more data and more powerful computing power, the prospect of AI pharmaceutical is very broad. At present, we are observing what progress the big language model will bring to AI pharmaceutical. It is exciting that some new progress has been made in the field of molecular characterization algorithms.

Ma Rui (partner of Fengrui Capital)We always overestimate the progress of computational medicine in five years, but underestimate the progress it can bring in ten years. I think that in the next three years, macromolecular protein drugs will basically be subverted by AI, just like AlphaFold in 2021 completely solved the problem of structural prediction of single domain proteins. (Photo courtesy of the organizer)

A few years ago, there was a movie called Shopaholic, which told the story of several people who were addicted to shopping. When they saw their favorite items, they couldn’t stop, even if they owed huge credit card debts, they had to take them home. Such people are called shopaholic in English. By analogy, then the "chatter" we are talking about today is talkaholic.

Talkaholic is a person who takes great pleasure in talking. A talkaholic has trouble keeping quiet and listening when other people are around.

Talkaholic refers to someone who likes talking and enjoys it, which is what we call "chattering" Generally, when others are present, it is difficult to talk without listening to others.

Similar words like workaholic and shopaholic are all ended with the same suffix -aholic, which means of an obsessive interest in something.

Both Workaholic and shopaholic, like talkaholic, have the suffix -aholic, which means they are extremely interested in or addicted to something.

For example:

Jane was a talkaholic who gave everyone her opinion whether they asked for it or not.

Jane is a chatty talker. She always gives her opinion whether others want to listen or not.

Related reading

Nevertiree person

"petrify" TV stoned in front of the TV.

App obsession Appiphilia

(Edited by China Daily English Dianjin Helen)

Click to see more English idioms and new words.

1905 movie network news It’s another year of fashion week! On September 15th, local time, in London, England, David Beckham brought a handsome boy and a beautiful woman to his wife’s Victoria fashion brand launch conference. On the same day, Beckham made a handsome appearance in a gray suit; The three sons, Brooklyn Beckham, Romeo Beckham and cruz beckham, all chose casual clothes and sat side by side with their father.

Harper seven beckham, the "Seven Princesses" who has attracted much attention, is dressed in a floral dress with a high ball head, and is full of celebrities. From time to time, Qi Princess, who sits on her father’s lap, has a hot chat with anna wintour, the "devil wears Prada" beside her.

　　From 0: 00 on July 12th to 24: 00 on 14th, Yunnan Menglian Dai, Lahu and Wa Autonomous County carried out a general survey of free nucleic acid detection for all employees, and more than 150,000 people were detected, all of which were negative. Immediately, Menglian County lifted the county’s closed management and resumed normal production and living order. However, when entering and leaving Menglian Card Point, it will continue to strictly enforce that all people leaving Menglian must hold a negative certificate of valid nucleic acid test within 3 days, check their ID cards, scan the code bright (that is, scan Yunnan health code and communication big data travel card), and measure their body temperature without abnormality before they can travel; Personnel from high school risk areas or those who have lived in middle and high risk areas in the past 14 days are suspended from entering Bangladesh. If it is really necessary to enter Bangladesh, negative proof of nucleic acid test within 3 days is required; Persons from other provinces (especially key provinces, cities and districts of telecom fraud) who intend to enter Bangladesh without justifiable reasons (unable to provide valid certificates such as business license, real estate certificate, residence permit, enterprises, institutions and villages (communities)) will be persuaded to return. (CCTV reporter Li Jinsong)

　　China news agency, Beijing, March 1 ST: China’s promotion of a new round of "trade-in" will bring many benefits

　　China News Service reporter Liu Liang

　　The fourth meeting of the Central Financial and Economic Committee held recently proposed to encourage and guide a new round of large-scale equipment renewal and trade-in of consumer goods, and make detailed arrangements for this. According to industry analysts, accelerating product upgrading is an important measure to promote high-quality development, which will not only help promote investment and consumption growth, but also bring many benefits.

　　Realistic consideration of "trade-in"

　　A new round of "trade-in" has long been a policy deployment. At the end of 2023, the Central Economic Work Conference proposed to promote large-scale equipment renewal and trade-in of consumer goods by improving standards such as technology, energy consumption and emissions. The fourth meeting of the Central Financial and Economic Committee will further clarify the deployment.

　　Ma Mao, Vice Chairman of the Presidium of the Board of Directors of China Household Electrical Appliances Service and Maintenance Association, said that a new round of "trade-in" is a realistic need to stimulate investment and consumption. At present, China’s macro-economy is generally in the recovery period after the epidemic, and the trend of recovery has not changed. However, the home appliance industry generally faces some difficulties and challenges, especially the lack of effective demand and the weak willingness of residents to consume and invest in enterprises. Promoting a new round of "trade-in" will help to expand the scale of consumption, improve investment expectations and drive long-term investment growth of enterprises.

　　Promoting the trade-in of the old consumer market and industrial transformation and upgrading complement each other. Wan Zhe, a professor at Beijing Normal University and executive director of China Modern Finance Society, said that at present, China’s new energy industry is developing rapidly, and it is in the forefront of the world in many technologies, products, talents, management and brands. The market share of green, digital and intelligent products and equipment is increasing day by day, which has its own market rules. At this time, it is also in line with the logic of economic development to propose equipment renewal.

　　Multi-point deployment of "trade-in"

　　The meeting made detailed arrangements for the new round of "trade-in". The meeting proposed to adhere to the market-oriented, government guidance, encourage the advanced, eliminate the backward, adhere to the standard guidance, and improve in an orderly manner. In Wan Zhe’s view, the previous trade-in was mostly government-led and financial support, but this time it was carried out in a government-led and enterprise-led way, and the market-oriented tone of letting enterprises "play the leading role" can make the docking between supply and demand more efficient.

　　The meeting also gave "guidance" in specific areas and links, such as promoting the upgrading and technological transformation of various production equipment and service equipment, encouraging the trade-in of traditional consumer goods such as automobiles and household appliances, and promoting the trade-in of durable consumer goods. Promote large-scale recycling, and strengthen the development of "trade-in+recycling" logistics system and new models.

　　Ma Mao pointed out that promoting large-scale recycling and strengthening the development of "trade-in+recycling" logistics system and new model is a very important part of the trade-in work. In recent years, consumers have a certain understanding of trade-in, but there are also some problems, such as not bad, inconvenient and unreasonable depreciation price. Only by unblocking the recycling channels, solving the difficult points in recycling and solving the inconvenience of consumers to "send the old" can we better promote the "replacement".

　　Many advantages of "trade-in"

　　Promoting a new round of "trade-in" will bring many benefits.

　　From the consumer’s point of view, Ma Mao believes that by exchanging old products for new ones, the safety hazards caused by products that have been in service for extended periods can be eliminated for consumers. At the same time, providing consumers with green, intelligent, new technologies and experienced products and services will meet their needs for high-quality life. Furthermore, with the financial support provided by the central finance, local governments and enterprises, consumers will get more consumption benefits.

　　From an industry perspective, the market potential behind it is worthy of attention. Many industry research reports pointed out that "trade-in" will benefit the release of demand for home appliances. For example, according to the Capital Securities Research Report, the number of air conditioners and range hoods in rural areas is much lower than that in urban households. It is expected that a new round of household appliances "trade-in" will promote the implementation of the consumption policy, which will accelerate the increase of the number of range hoods, air conditioners and other categories in rural areas while upgrading the old household appliances. Guotai Junan Research Report predicts that this trade-in policy is expected to promote the valuation of home appliance enterprises.

　　In Ma’s view, a new round of "trade-in" will help enterprises to increase technology investment, eliminate product lines with backward production capacity, and develop more products with new technologies. At the same time, the government policy focuses on guiding and solving the problems encountered by enterprises in the trade-in process, which will facilitate enterprises to better promote trade-in and recycling, and help the country achieve the goal of "double carbon" in the long run. (End)

The Central Meteorological Observatory issued a typhoon red warning at 10: 00 on September 14th:

The center of the 12th typhoon "Meihua" this year (strong typhoon level) is located at 10 o’clock this morning (14th) in the southern part of the East China Sea, about 185km southeast of Xiangshan County, Zhejiang Province, which is 28.1 degrees north latitude and 123.1 degrees east longitude. The maximum wind force near the center is 15 (48m/s), the lowest pressure in the center is 945 hectopascals, and the radius of the seven-level wind circle is 240-3000.

It is estimated that "Meihua" will move to the northwest at a speed of 20-25 kilometers per hour, and its intensity will be maintained or slightly enhanced. It will land in the coastal area from Sanmen to Zhoushan in Zhejiang around the evening of the 14th (strong typhoon level, 42-48 m/s, 14-15); After landing, "Meihua" will continue to move to the northwest, with reduced intensity, passing through Hangzhou Bay, and will land again on the coast from Jiaxing, Zhejiang to Pudong, Shanghai this evening (typhoon level, 35-40m/s, 12-13).

Gale forecast: From 14: 00 on September 14th to 14: 00 on 15th, there will be 6-8 gale in most parts of the East China Sea, most parts of the Yellow Sea, Bohai Sea, Bohai Strait, Changjiang Estuary, Hangzhou Bay, northern Fujian coast, Shandong coast, eastern Zhejiang, Shanghai and eastern Jiangsu, with gusts of 9-11, including the central and western East China Sea, Hangzhou Bay, Changjiang Estuary, central and northern Zhejiang coast, Shanghai coast and eastern Jiangsu. ?

Precipitation forecast: From 14: 00 on September 14th to 14: 00 on September 15th, there will be heavy rains in Liaodong Peninsula, central and eastern Shandong, eastern Anhui, Jiangsu, Shanghai and central and northern Zhejiang, among which, there will be heavy rains in parts of the southern coast of Shandong Peninsula, eastern Jiangsu, Shanghai and northeastern Zhejiang, and heavy rains (250-280mm) in the northeastern Zhejiang.

Defense guide:

1. Relevant departments shall, in accordance with their responsibilities, do a good job in typhoon prevention and emergency rescue.

2. Water operations and passing ships in relevant waters should return to Hong Kong to take shelter from the wind, strengthen port facilities, and prevent ships from anchoring, grounding and collision.

3. Stop large-scale indoor and outdoor gatherings and dangerous outdoor operations such as high altitude.

4. Reinforce or dismantle structures that are easy to be blown by the wind. Personnel should not go out at will. They should stay in windproof and safe places as far as possible, so as to ensure that the elderly and children stay in the safest place at home, and the dangerous people will be transferred in time. When the typhoon center passes by, the wind will decrease or stay still for a period of time. Remember that the strong wind will suddenly blow, and you should continue to stay in a safe place to avoid the wind, and the dangerous people will be transferred in time.

5. Relevant areas should pay attention to prevent flash floods and geological disasters that may be caused by heavy precipitation.

(Editor: Zhang Lin)

When middle-aged people choose a car, they will care about whether a model is mature enough, its appearance should be atmospheric enough, its interior should be exquisite enough, and it should be comfortable enough to drive, whether it is for business or home. I don’t know what you think of domestic cars, but what I want to introduce to you today is domestic cars. Let’s take a look at it next.

Let’s look at the appearance of Seal 06 first. The front face of Seal 06 looks calm and unforgettable. Then the comfortable headlight design is adopted, which can win the love of young people. The car is equipped with LED daytime running lights, automatic opening and closing, adaptive far and near light, delayed closing and so on. Coming to the side of the car body, the size of the car body is 4830MM*1875MM*1495MM. The car adopts moving lines, and the side circumference gives people a very deep feeling. With large-sized thick-walled tires, it gives people a very simple feeling. In the rear part, the rear looks more fashionable, the taillights look very capable, and the overall shape is still very eye-catching.

Coming into the car, Seal 06′ s interior looks calm and the overall visual effect is very distinctive. The steering wheel of the car is well designed, made of leather and avant-garde. Take a look at the central control, with the 15.6-inch touch-sensitive LCD central control screen, which makes the interior design quite layered, and the overall design of the central control is remarkable. The dashboard and the seat are equally eye-catching. The dashboard of the car presents a capable design style and looks very young. The car uses leather seats, equipped with functions such as electric adjustment of auxiliary seats, electric adjustment of seats with memory, and seat proportion tilting, with exquisite materials and comfortable ride.

Looking at the configuration again, Seal 06 is equipped with car networking, driving mode selection, remote control key, Bluetooth key, NFC/RFID key, interior atmosphere light, traction control (ASR/TCS, etc.) and other configurations.

I wonder if you are excited about this car introduced today? As long as you like it, go ahead and buy it.

　　In the past few days, the tension between Palestine and Israel has intensified, and the exchange of fire between the two sides has continued, causing casualties. Nevertheless, the Israeli Prime Minister’s Office announced on the 21st that the government will authorize the construction of 1,000 new houses in the Eli Jewish settlement in the northern West Bank.

　　△ In May this year, Israel started construction in the Homsh settlement in the West Bank.

　　The day before, a shooting incident occurred near the settlement, killing four Israelis. After the shooting incident, Prime Minister Benjamin Netanyahu, Defense Minister Joyaf galante and Finance Minister Bezalel Smout Leah held a meeting and decided to "immediately push forward" this new housing plan.

　　According to the Israel Times, it is unclear whether this move is part of the Israeli government’s existing expansion plan for Jewish settlements in the West Bank. On the 18th, Netanyahu’s government not only announced that it would build 4,560 new houses in the West Bank, but also passed a controversial resolution, giving "almost all" the planning and approval authority for Jewish settlement construction in the West Bank to the far right-wing Smout Lihe.

　　Smout Richer grew up in Jewish settlements in the West Bank. Since he became a politician, he has repeatedly made hate speech against Arabs and supported the expansion of Jewish settlements in a high-profile way. In December, 2022, the camp of Likud leader Netanyahu won the general election, which was greatly contributed by Smout Lihe, whose religious Zionist Party was the second largest political party in the ruling coalition after Likud. Smout Leahy was appointed as finance minister by Netanyahu, and was also in charge of "civil affairs" in the West Bank.

　　According to Israeli media analysis, this move will greatly speed up and simplify the procedures for the construction of Jewish settlements in the West Bank, and at the same time promote some "illegal" settlements to be "legal". Previously, many stages of land planning approval required the authorization of the Minister of National Defense, but now it is "simplified to only one signature of Smout Richer".

　　The so-called "illegal" settlements refer to Jewish settlement facilities built privately without the authorization of the Israeli government or in violation of relevant Israeli laws and regulations. Such facilities are different from the so-called "legal" settlements authorized by the government. However, the international community generally believes that these two types of Jewish settlement construction are in violation of international law.

　　United Nations Secretary-General Kofi antonio guterres said on the 19th that he was "deeply disturbed" by the Israeli government’s expansion of power for Smout Richter. The United Nations Special Envoy for the Middle East, Thor Venesland, warned that Israel’s decision may aggravate the Palestinian-Israeli conflict.

　　Public opinion generally believes that the current tension between Palestine and Israel is heating up again, and the Netanyahu government’s move is tantamount to adding fuel to the fire. On the evening of the 21st, the Israel Defense Forces used drones to launch an air strike on a car in Jenin, a city in the northern West Bank, killing three Palestinians. According to Palestinian media reports, this is the first time since 2005 that the Israeli army has carried out an "assassination operation" with drones in the West Bank.

　　On the 21st, a large number of Jewish settlers also broke into some Palestinian villages and towns in the West Bank and set fire to them, which clashed with local people.

　　The situation in Palestine and Israel is tense, and neighboring countries express concern. The Jordanian Foreign Ministry issued a statement on the 21st, condemning the Israeli government’s plan to build 1,000 new houses in the Eli settlement and warning Israel not to further violate international law, otherwise the "two-state solution" "may be buried forever". The Egyptian Ministry of Foreign Affairs also issued a statement urging that "the bloodshed must be stopped immediately, rather than undermining the regional and international detente".