Yang Jianfei: Computational Medicine Promotes Accurate Clinical Trials.

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Yang Jianfei, Chief Scientific Officer of Zheyuan Technology

Computational medicine needs to be composed of interdisciplinary teams and platforms. By integrating supercomputing system, AI platform, molecular and clinical data, massive literature and biological information, it can realize effective analysis and calculation of drug development and assist decision-making.

Taking an anti-tumor drug in our pipeline as an example, we read all the literatures of the target disease by using the "TWIRLS stick" of the computational medicine platform, first we have all the scientific knowledge known on the earth at present, and then we analyze the digital twins of patients in the patient database in a data-driven way to obtain the disease mechanism, specific targets and "portraits" of patients.

As we all know, the tumor is heterogeneous in time and space, and the immune system around the tumor is particularly complex. Therefore, only by having an accurate "portrait" of the patient’s tumor and accompanying diagnosis can we enter the stage of accurate clinical trials.

Through the computational medical platform, we established the response mechanism model of CDK4/6 inhibitor, and the effectiveness of this model was verified by the data of TCGA and Chinese patients. Then we put this drug currently used to treat breast cancer on the computational medical platform to study whether it has other applicable diseases. It was found that the model score of chordoma was very high, so we established cooperation with shanghai changzheng hospital and saw that some patients achieved partial remission in the third week after taking the drug. Although this drug has not yet entered the clinical trial stage, as long as it is carried out in accordance with the norms of computational medicine platform, we are confident to achieve truly accurate clinical trials.

Peng Ao: Behind the clinical success rate from 2% to 21%

Peng Ao, Project Management Team Leader of Pfizer China Product Line

The efficiency of Pfizer’s new drug research and development has increased from 2% to 21%. I think we can sum up three experiences. First, accurate positioning, clear their own specific advantages in the field of biology. Pfizer currently focuses on internal medicine, immunity and inflammation, oncology drugs and vaccines. Second, choose the drug mode. At present, more complex and novel molecular entities account for more and more in our pipelines. Thirdly, the decision-making adheres to two principles. First, quantitative POM analysis is carried out in the first and second phase of the experiment, which can help the success rate of the second phase reach 40%; The second is to plan again. If the first direction of clinical research and development fails, then we will transform it and try again in another direction. If there is a very clear biological basis, our success rate can reach 31%.

Ertuglifozin is a SGLT-2 hypoglycemic agent, and a large number of technologies and methods related to computational medicine are used in its research and development, including systematic pharmacological model and Emax Model. Using this model, the highest hypoglycemic effect of the drug can reach 77%. Meta-analysis shows that the drug has the highest hypoglycemic level among similar products. This is a typical case of using model or computational medicine to guide drug research and development.

The US Food and Drug Administration has begun to build a framework for digital health tools. I believe that after the introduction of the framework, the guiding principles of the corresponding rules will also be introduced, which will guide the application of some new drug research and development more specifically and deeply.

Tang Yu: The insights generated by computational medicine need to be verified clinically.

Tang Yu, Executive Director of the Office of Drug Clinical Trial Research Center, Cancer Hospital, China Academy of Medical Sciences

Computational medicine has produced a large number of insights by analyzing massive data, but how to prove that these insights are authentic and can be used in clinical practice through clinical trials?

The first case is to verify the specific answer given by computational medicine to a specific problem, such as verifying whether the first innovative drug under the guidance of AI can treat pancreatic cancer. The second is based on massive data to verify whether the treatment mode formulated by AI for individual patients or groups is better.

In the course of such an experiment, we need to consider several issues:

First, the consistency of the AI model. When we want to prove that an algorithm or an AI-based paradigm can guide medical care, we must ensure the consistency of the paradigm and not make it change irregularly.　

Second, it is necessary to consider whether there is an accessible clinical treatment for a class of patients with more concentrated biological characteristics found by AI model. If there is no targeted treatment, although this model can guide the prognosis of patients, it is difficult to change the existing treatment methods.

Finally, establish a model that can not only explain the results, but also explain the mechanism, so as to better combine human wisdom with the wisdom of computer based on data integration.

At present, we are carrying out an umbrella research design, focusing on soft tissue sarcoma. Although the overall incidence of the disease is not high, there are nearly 100 subtypes. Our anti-vascular targeted drugs have shown excellent effects in individual subtypes, but the overall effect is still not ideal. Therefore, we hope to use Turing Darwin’s laboratory’s in-depth analysis of the whole sarcoma mechanism and digital twin technology to find drugs with ideal curative effect and high accessibility.

Niu gang: the big disease model changes the new paradigm of drug research and development

Niu Gang, Director of Turing Darwin Laboratory

In today’s medical field, we are committed to collecting and utilizing all kinds of disease-related data, looking for clues of logical unity for diseases, and establishing complex and real mechanism portraits. But the key lies in how to understand the so-called mechanism and who is the subject of the complex mechanism?

We have built and trained a brand-new AI method-"Genome Shotgun Damage Assessment Process" (DAGG). By inputting the sequence information of human germ line or tumor genome, AI can translate the sequence gobbledygook that human can’t understand into understandable changes in cell function.

According to the information of genome variation, clinicians can use DAGG to judge whether HER2 gene is amplified in tumor cells of breast cancer patients, so as to further clarify the pathological types of patients and provide clearer and more accurate judgments for patients’ diagnosis and treatment.

With the DAGG method, we can also transform the real patient data into the digital twins of the patient and his disease. With the large-scale accumulation of patients’ digital twins in virtual environment, we conducted a large-scale virtual clinical trial for PD-1/PD-L1 monoclonal antibodies. The results showed that the efficacy of most immunodrugs with indications was not ideal.

Therefore, the virtual clinical trial based on digital twins can replace the original clinical trial results that cost tens of billions of dollars. Based on the curative effect data of a small sample of individual indications, the potential indications of other tumor diseases can be inferred. At the same time, according to the biological mechanism directly suggested by the model, the combination scheme and even new molecules can be rationally designed, which saves many clinical development steps and costs and ensures greater benefits for patients.

Shi Rong: Computational Medicine Helps Accurate Diagnosis and Treatment of Breast Cancer

Shi Rong, Secretary General of Cancer Prevention and Treatment Committee of Wu Jieping Medical Foundation.

Breast cancer is the largest cancer in the world. HER2 is a definite prognostic indicator and a predictive indicator of drug treatment effect for breast cancer, but the tumor heterogeneity of HER2 expression is obvious, and the detection method of HER2 can not meet the demand of anti-HER2 treatment. Therefore, studying the etiology of the germ line carried in the germ line genome is not only helpful to deeply understand the pathogenesis of breast cancer, but also helpful to develop new methods and provide prospective judgment for subsequent treatment.

Recently, the artificial intelligence algorithm DAGG independently developed by the computational medicine team revealed the pathogenesis of breast cancer. It is found that the signal pathway function spectrum (APSP) can be obtained by using the DAGG model based on the germline fingerprint rare coding variation data. According to the difference in the distribution of APSP between patients and people with low etiology, a prediction model can be effectively constructed to evaluate the etiological risk of female individuals, and the HER2-positive and HER2-negative breast cancer patients can be effectively distinguished.

The clinical transformation path of breast cancer based on APSP is divided into three steps. The first step is to guide the clinical treatment plan based on the pathological classification of breast cancer by APSP. The second step, based on APSP, is the extremely early diagnosis of women with breast nodules and breast cancer with familial breast cancer genetic history, so as to reduce the proportion of breast cancer patients who enter advanced and advanced stages at the first diagnosis. The third step, breast cancer risk assessment of healthy population based on APSP, fills the gap of the lack of effective primary prevention measures for breast cancer in the world.

Jiang Min: Virtual clinical trial is a new paradigm in the future.

Jiang Min, Director of the Office of National Drug Clinical Trial Institution of Peking University Cancer Hospital

From a global perspective, there have been exploratory studies on virtual clinical trials, but retrospective cases are the main ones. Regarding whether we can carry out prospective virtual trial design and generate higher-level digital evidence to verify the computer simulation model, so as to better guide clinical research, Peking University Cancer Hospital and the computational medicine team collided from the perspectives of technology and experimental requirements, forming a real landing research.

The two sides jointly carried out a parallel virtual clinical research project by using the digital twin model of patients in computational medicine. The purpose of the research is to explore the relationship between the pathogenesis of tumor and the mechanism of anti-tumor drugs. Through the virtual clinical trial, the curative effect of anti-tumor drugs is predicted, and the characteristics and differences of patients are analyzed, so as to optimize the design of clinical trials. This study compares head-to-head with a real clinical study of registered new drugs to verify the consistency between the predicted results of virtual clinical research and the curative effects of real-world clinical trials.

Virtual clinical trial is a new paradigm in the future. With the support of computational medicine technology, the future clinical trial model may be transformed into more accurate clinical trial design, which will bring a more holistic drug research and development idea, which will bring revolutionary changes to the success rate and effectiveness of clinical trials.

Roundtable Forum I: Cognition and Evaluation of Non-consensus and Subversive Technology

Moderator: Li Lei, Associate Research Fellow of Frontier Science and Education Bureau of China Academy of Sciences.

Roundtable forum site.

Lv Benfu (Professor, School of Economics and Management, Chinese Academy of Sciences)The so-called breakthrough innovation mainly depends on three points. First, whether a brand-new track has been developed; Secondly, on the original track, whether its performance-to-value ratio conforms to the law of ten times speed; Third, whether it belongs to the pattern innovation from 0 to 1 depends on the support of industrial policies.

Gu Chengming (Head of Sanofi Greater China Medical Department)The non-consensus stage is the primary stage. As long as it is accepted by the industry, it is considered as consensus, or it is available, which can solve some problems. However, in the field of drug research and development, if you want to be a First-in-Class, it must be a non-consensus. If you become a consensus, it will be Me too.

Zhang Chunming (Vice President of the Western Research Institute of Computing Technology, Zhongke)From a practical point of view, today’s world structure does not support small steps forward, and we must give full play to the ability of large-scale team operations. In terms of innovation, it is indeed possible for computational medicine to open up a brand-new track, so any government department should carefully evaluate it.

Weng Huajian (deputy head of Changning District, Shanghai)In 2021, I first learned about computational medicine. At that time, we envisaged to set up a life science innovation center between Suzhou and Shanghai, specializing in high-end research and development, focusing on computer +Inside and AI+, so as to give full play to the accumulation of digital economy in Changning, Shanghai in the past 20 years, especially the accumulation advantages of talents and innovation ecology. Therefore, from the perspective of the government, we are full of expectations for disruptive innovation technology in computational medicine.

Roundtable Forum II: Investment Logic from the Perspective of Computational Medicine

Moderator: translated by Hu Ming, partner of Mingde Capital.

Roundtable forum site.

Tian Feng (Minister of Industry Service Department of Shanghai Biomedical Industry Promotion Center)The most noteworthy point of the whole AI+ pharmaceutical industry is to change from logical successful practice to probabilistic successful practice, and finally return to logical successful practice. From the perspective of AI+ diseases, developing virtual clinical trials, I think it can effectively reduce the cost of clinical development and improve the success rate in the future.

Jing Xutian (Managing Director of Wuyuan Capital): AI technology has brought some new algorithms and breakthroughs in computing power. In the past, many AI pharmaceutical companies paid more attention to the field of small molecules with the most data and the most mature data, but today we see that more and more algorithms are actually very suitable for doing some new modal drug discovery.

Zeng Yingzhe (Partner of Linear Capital)Before AI technology, we usually build low-dimensional models to solve high-dimensional problems, but the emergence of AI can solve these high-dimensional problems. With more and more data and more powerful computing power, the prospect of AI pharmaceutical is very broad. At present, we are observing what progress the big language model will bring to AI pharmaceutical. It is exciting that some new progress has been made in the field of molecular characterization algorithms.

Ma Rui (partner of Fengrui Capital)We always overestimate the progress of computational medicine in five years, but underestimate the progress it can bring in ten years. I think that in the next three years, macromolecular protein drugs will basically be subverted by AI, just like AlphaFold in 2021 completely solved the problem of structural prediction of single domain proteins. (Photo courtesy of the organizer)

A few years ago, there was a movie called Shopaholic, which told the story of several people who were addicted to shopping. When they saw their favorite items, they couldn’t stop, even if they owed huge credit card debts, they had to take them home. Such people are called shopaholic in English. By analogy, then the "chatter" we are talking about today is talkaholic.

Talkaholic is a person who takes great pleasure in talking. A talkaholic has trouble keeping quiet and listening when other people are around.

Talkaholic refers to someone who likes talking and enjoys it, which is what we call "chattering" Generally, when others are present, it is difficult to talk without listening to others.

Similar words like workaholic and shopaholic are all ended with the same suffix -aholic, which means of an obsessive interest in something.

Both Workaholic and shopaholic, like talkaholic, have the suffix -aholic, which means they are extremely interested in or addicted to something.

For example:

Jane was a talkaholic who gave everyone her opinion whether they asked for it or not.

Jane is a chatty talker. She always gives her opinion whether others want to listen or not.

Related reading

Nevertiree person

"petrify" TV stoned in front of the TV.

App obsession Appiphilia

(Edited by China Daily English Dianjin Helen)

Click to see more English idioms and new words.

　　General Secretary of the Supreme Leader pointed out at the National Ecological Environmental Protection Conference: "Deepen the application of digital technologies such as artificial intelligence, build a beautiful digital governance system in China, and build a green and intelligent digital ecological civilization." At present, the integration and mutual promotion of digitalization and greening has become an important theme of global development. To promote the intelligent management of ecological environment and the construction of digital ecological civilization with green wisdom, we must adhere to the guidance of Socialism with Chinese characteristics Thought of the Supreme Leader in the new era, comprehensively implement the ecological civilization thought of the Supreme Leader, promote the comprehensive green transformation of economic and social development with digitalization, and provide strong support for the modernization of harmonious coexistence between man and nature.

　　The integration of digitalization and greening has become an important trend in the construction of ecological civilization.

　　Ecological civilization construction covers a wide range and is comprehensive, involving many aspects such as value concept, goal orientation, production and consumption mode, etc. It is a complex systematic project. Promoting the construction of digital ecological civilization can effectively enhance the systematicness and synergy of ecological civilization construction, and promote the formation of scientific and efficient methods and paths to solve ecological environment problems and expand ecological environment governance.

　　As a way of ecological environment governance, digital ecological civilization construction organically embeds big data, 5G, artificial intelligence and other digital technologies into ecological civilization construction, and continuously improves the scientific, refined and intelligent level of ecological civilization construction in the deep integration of digitalization and greening. The key to building digital ecological civilization lies in coordinating the relationship between digitalization and greening, and promoting their mutual promotion and coordinated development. Promoting digital construction, using artificial intelligence and other technologies to discover the laws behind the data, and fully releasing the superposition, aggregation and multiplication effects of digital technology in improving the efficiency, technological improvement and means optimization of ecological environment governance can provide an important engine for ecological environment governance and help to achieve efficient and sustainable ecological environment governance effects. Promoting green development is the proper meaning of building digital ecological civilization. By optimizing the spatial layout of the country, improving the utilization efficiency of resources and energy, strengthening environmental protection and ecological restoration, focusing on solving problems such as environmental pollution and ecological damage in the development process, matching resources, production, consumption and other factors is conducive to the simultaneous advancement of high-quality development and high-level protection.

　　Since the 18th National Congress of the Communist Party of China, under the guidance of the Supreme Leader’s New Era Socialism with Chinese characteristics Thought, especially the Supreme Leader’s Ecological Civilization Thought, China’s digital ecological civilization construction has made great progress, and the level of intelligent management of ecological environment has been significantly improved. In February this year, the CPC Central Committee and the State Council issued the Overall Layout Plan for the Construction of Digital China, which made "positive progress in the construction of digital ecological civilization" as an important goal for the construction of digital China in 2025, and put forward new requirements for the new generation of digital technology to help ecological governance. In the process of promoting the deep integration of digitalization and greening, China’s energy consumption in the whole chain has been significantly reduced, production efficiency and energy efficiency have been continuously improved, and the ecological benefits and economic and social benefits of green mountains have been continuously brought into play. At the same time, we should also realize that the construction of digital ecological civilization in China is still in its infancy, and there are still some problems to be solved in the construction of digital infrastructure, the construction of data standards and norms, the transformation and application of scientific and technological achievements, and the cultivation of digital ecological civilization talents. We should pay more attention to the use of digital technology to innovate the way of ecological civilization construction, constantly promote the deep integration of digitalization and greening, lead greening with digitalization, drive digitalization with greening, focus on strengthening the collection, adaptation, reconstruction and sharing of ecological environment big data, fully release the potential and vitality of ecological environment governance through digital ecological environment technological innovation, and provide strong kinetic energy for building a beautiful China.

　　Provide strong kinetic energy for the modernization of harmonious coexistence between man and nature.

　　The General Secretary of the Supreme Leader stressed: "We must plan development from the height of harmonious coexistence between man and nature, constantly shape new kinetic energy and advantages of development through high-level environmental protection, and strive to build a green and low-carbon circular economy system, effectively reduce the resource and environmental costs of development, and continuously enhance the potential and stamina of development." Building a green and intelligent digital ecological civilization provides strong technical support for accurate identification, real-time tracking of environmental data, timely judgment and systematic solution of ecological problems, and provides strong kinetic energy for promoting a comprehensive green transformation of economic and social development and building a harmonious coexistence between man and nature.

　　Effectively improve the level of intelligent governance of the ecological environment. Building a digital ecological civilization, integrating ecological environment data into digital technologies such as artificial intelligence, and constantly strengthening machine learning and training will not only help to analyze the historical evolution process of ecological environment more scientifically, but also provide important decision-making reference for timely judgment and systematic solution of ecological environment problems in pollution warning, duration prediction and emission reduction effect prediction, and promote the change of decision-making process from "empirical judgment" to "data analysis", making ecological environment governance more "smart" For example, in the Great Protection of the Yangtze River, the relevant departments have established a "data collection and management —" by building a monitoring network of the whole basin’s ecological environment from Qinghai to Shanghai, collecting and sorting out massive ecological environment data in the Yangtze River basin, developing and integrating water quality diagnosis, forecasting and early warning, pollution traceability, scenario simulation and other functions. Data Mining and Simulation — Virtual visualization — Analysis of pollution traceability — The digital management business system of water environment based on intelligent decision-making provides an important technical guarantee for realizing "one river with clear water flowing eastward".

　　Promote the transformation of ecological environment governance to synergy. In the past, due to the insufficient sharing of ecological environment data and information among regions, departments and units, the ecological environment governance has been fragmented to some extent, and the problem of "repeated governance and repeated governance" in some local ecological environment governance is more prominent. Building a digital ecological civilization and building a "network" of ecological environment data will help to break down data barriers, realize data interconnection, and consolidate the data foundation for the transformation of ecological environment governance paradigm from fragmentation and fragmentation to synergy and integrity. For example, in the response to heavily polluted weather, we should follow the general policy of holistic and whole-process collaborative governance, promote the sharing of basic data among relevant government departments, different scientific research institutions and different disciplines, carry out collaborative research on key areas and key issues, and scientifically put forward the timetable and roadmap for continuous improvement of air quality, so as to provide support for the realization of "blue sky, white clouds and twinkling stars".

　　Accelerate the pace of green and low carbon transformation. Digital technology, represented by a new generation of artificial intelligence, is accelerating the evolution of global scientific and technological revolution and industrial transformation, and promoting the reform of global governance system. Digitalization empowers the construction of ecological civilization and has the efficiency of "1+1>2". Intelligent manufacturing technology strengthens the data analysis ability of manufacturing enterprises in process, manufacturing, logistics and other aspects, and reduces the pollutant emission and carbon emission of product manufacturing; Smart energy system explores the data value of energy production, transmission, distribution, storage and other links, monitors and adjusts energy generation in real time, and improves the utilization efficiency of renewable energy; By establishing a carbon inclusive platform for green living, smart cities will count individual emission reductions into individual carbon assets and turn intangible green behaviors into tangible green values. To promote high-quality economic and social development, we need to keep up with the development trend of world science and technology, embrace digital technology, further improve the endogenous driving force of green and low-carbon transformation of production and lifestyle, and make economic and social development have higher green content, lower carbon content and more gold content.

　　Deepen the application of digital technology in the field of ecological environment

　　The construction of digital ecological civilization can focus on platform construction, data mining, digital intelligence integration, policy guarantee and other aspects to form a "network" and a "map", research and develop data value mining algorithms, promote the deep application of digital technology in the field of ecological environment, and give full play to the basic and leading role of digital ecological environment technology in the construction of beautiful China.

　　Improve the stereoscopic intelligence perception of the sky "a net". The collection and transmission of information is the key link in the construction of digital ecological civilization. At present, it is necessary to do a good job in the top-level design of digital ecological civilization infrastructure construction, build a three-dimensional multi-source monitoring and sensing network system for ecological environment, strengthen the application of big data acquisition technologies such as satellite remote sensing, aerial photography of unmanned aerial vehicles, automatic ground monitoring stations, underwater robots and the Internet of Things, continuously expand the accuracy and space-time breadth of monitoring, and build a multi-means comprehensive and fast-responding monitoring network covering various environmental elements of the atmosphere, water, soil, ecology and ocean to realize global monitoring and sensing of ecological environment elements. Strengthen the construction of digital infrastructure that adapts to intelligent decision-making and green development, and build an "information high-speed rail" for the safe and rapid circulation of ecological environment data, laying a solid foundation for the rapid and accurate use of data.

　　Form a "one map" of national ecological environment data. Data is the key to the construction of digital ecological civilization, but fragmented data can’t play its value. To speed up the collection of eco-environmental data, on the one hand, it is necessary to promote the collection and exchange of eco-environmental data, and realize the cross-level communication and cross-departmental sharing of eco-environmental monitoring and monitoring data and their related information. Comprehensively collect environmental data such as environmental quality, pollution sources, sewage outlets, and ecological environment functional zoning, and promote coordinated management, precise management, and overall improvement of regional ecological environment with resource sharing, complementary advantages, and mutual benefit, so that the data can "run" out of great value. At the same time, strengthen data connectivity with natural resources, water conservancy, meteorology, energy, agriculture, forestry, transportation and other fields, and promote multi-source data integration. On the other hand, it is necessary to firmly grasp the standard, improve the standard system for the collection, integration, classification, sharing and application of eco-environmental data, and actively promote the formulation of digital international standards in the field of eco-environment, so as to contribute to building a green "Belt and Road" and building a global ecological civilization.

　　Develop a value mining algorithm for massive data. The model is the golden key to open the data treasure mine. It is necessary to make full use of digital technologies such as augmented reality and artificial intelligence, strengthen large-scale model simulation, form a more comprehensive and scientific understanding of the evolution of ecological environment and the causes of pollution, and provide multi-dimensional data analysis, early warning and forecasting, and traceability for scientific decision-making and precise governance. Using big data analysis, artificial intelligence, visualization and other technologies, we will strengthen the research and development of digital technologies such as intelligent perception and sharing, fusion and deduction, characterization and expression of environmental data, and inject wisdom genes into key areas such as ecological environment monitoring and early warning, integrated protection and system management of grass and sand in mountains, rivers, forests, fields and lakes, comprehensive prevention and control of multi-media environmental pollution, solid waste reduction and resource utilization, new pollutant control, and response to climate change, and continuously enrich the application scenarios of digital technologies in the field of ecological environmental protection.

　　Promote digital technology to be embedded in the whole process of environmental governance. The deep integration of digital technology and environmental governance has greatly improved the modernization level of ecological environmental governance. Give full play to the advantages of digital technology in breaking through the limitation of information time and space, smooth the interactive channels across regions, levels and departments, gather the strength and wisdom of the government, enterprises and the public, promote the formation of a networked and open multi-collaborative governance pattern, and integrate digital technology into the whole business and life-cycle management of ecological environment such as monitoring and evaluation, supervision and law enforcement, so as to improve the efficiency of environmental governance. Leading green development with digital transformation and optimization of ecological environment management, promoting the transformation and upgrading of industries such as steel, coal, electricity, chemicals and building materials, improving green total factor productivity, reducing energy and material consumption in the whole chain, and promoting the organic unity of economic benefits and ecological benefits.

　　Lay a good job in policies, talents and combination boxing. Constantly improve the policy system that is conducive to the deep integration of digital technology and ecological civilization construction, dismantle the barrier between the environmental governance side and the technology supply side, and create an innovative environment where major digital scientific and technological achievements in the ecological environment field are constantly emerging. Strengthen the research on relevant laws, regulations and policies, and strengthen the open sharing of data on the premise of ensuring data security. Cultivate and introduce compound cross-border talents with professional knowledge in digital technology and ecological environment, and form a three-dimensional and high-level echelon of digital technology talents in ecological environment. We will build a scientific research management system and mechanism conducive to the breakthrough of the core technology of digital ecological civilization, establish and improve a market-oriented diversified investment model, and increase support for digital strategic frontiers and applied basic research in the field of ecological environment.

　　(The author is Dean of china environmental science Research Institute)

1905 movie network news It’s another year of fashion week! On September 15th, local time, in London, England, David Beckham brought a handsome boy and a beautiful woman to his wife’s Victoria fashion brand launch conference. On the same day, Beckham made a handsome appearance in a gray suit; The three sons, Brooklyn Beckham, Romeo Beckham and cruz beckham, all chose casual clothes and sat side by side with their father.

Harper seven beckham, the "Seven Princesses" who has attracted much attention, is dressed in a floral dress with a high ball head, and is full of celebrities. From time to time, Qi Princess, who sits on her father’s lap, has a hot chat with anna wintour, the "devil wears Prada" beside her.

In this era of information explosion, the star’s every move is closely watched. Recently, Wang Baoqiang has once again become the focus, and has been involved in the whirlpool of public opinion because of its charity storm and the subsequent’ fraud door’. Why did this actor, who was once considered to be the most human in the entertainment circle, fall into so many controversies? This article will take you to explore the ins and outs of this incident, and let us unveil the truth together.

First, a wonderful beginning: Wang Baoqiang’s "roller coaster" life

Wang Baoqiang’s career is full of ups and downs and glory. From an ordinary farmer to today’s "Billion Film Emperor", he has won numerous applause with his strength. However, in just a few months, he seems to be on the "roller coaster" in the entertainment industry. In October, the news about the collapse of his charity was shocking; Then, in November, there was a "fraud door" with an amount as high as 100 million, which was unbelievable. This series of events seems to imply that Wang Baoqiang is experiencing an unprecedented crisis in the entertainment circle.

Second, the charity storm: people set the fuse for collapse

The cause of the incident originated on October 28th, when a well-known entertainment story revealed that Wang Baoqiang was suspected of charity fraud during the filming of The Octagonal Cage, saying that his image was actually hypocritical. The "little actor"’ s careless complaint quickly triggered a hot discussion among netizens. He not only described the hard life during the filming, but also claimed that Wang Baoqiang’s promise to support school was not fulfilled. For a time, Wang Baoqiang’s "charity design" was hit hard, and many netizens questioned it.

Third, reverse the plot: reveal the true intention of Wang Baoqiang.

With the development of the incident, more truths gradually surfaced. Netizens took the initiative to refute rumors and revealed Wang Baoqiang’s promise to the little actor after the filming. He not only paid 150,000 yuan for each young actor, but also promised to help them finish their studies. Obviously, the opposition did not completely overthrow the true image of Wang Baoqiang, but made things dramatically reversed. More netizens suggested that the careless complaint was not credible, because he already had a considerable economic base, and there were many luxuries in his social account.

Fourth, characterization: Wang Baoqiang’s truth and emotion.

In the entertainment circle, Wang Baoqiang’s truthfulness and simplicity are one of the reasons why he attracts many supporters. Even in the process of his ex-wife Ma Rong absconding with money, Wang Baoqiang still showed his indomitable personality, which made many people feel sympathy for him. In this storm, many supporters have come forward to speak for him, thinking that he has always been a trustworthy person. The hardships of Wang Baoqiang’s childhood life and the story of realizing his dream through hard work later made his image deeply rooted in the minds of many audiences.

V. Fashion and Trend: The Unknown Side of Wang Baoqiang

Although Wang Baoqiang’s recent negative news has dominated the limelight, his performance in the fashion world should not be underestimated. What Wang Baoqiang wears in public often reflects his love for life and his unique understanding of fashion. In the recent red carpet activities, he appeared in a simple but stylish suit and won wide acclaim at the scene. Whether you choose classic black and white collocation or try trendy accessories, Wang Baoqiang can always give people a bright feeling. His fashion concept may not be understood by everyone, but this uniqueness makes him stand out among many stars.

Vi. Hot discussion on social media: the interaction between fans and the public

With the popularity of social media, the interaction between stars and fans has become more frequent. On Wang Baoqiang’s social platform, fans have expressed their views on his events, and the debate between supporters and opponents seems to be endless. Many netizens share their opinions in the comment area, which makes the topic more heated by the coexistence of humor and rationality. It is this kind of interaction that strengthens the connection between Wang Baoqiang and his fans, and also makes this storm the focus of hot discussion on the Internet.

Seven, multi-angle analysis: the opinions of experts and the reactions of ordinary audiences.

For this incident, many industry experts have expressed their views. Some film critics pointed out that the gradual collapse of Wang Baoqiang was not accidental, but the result of the changeable entertainment style and complicated public opinion environment. They believe that once the image of public figures is deeply excavated, it may be greatly reversed. The general audience’s reaction to this incident was polarized. Some viewers said they no longer believed in Wang Baoqiang, while others thought it was just a misunderstanding and needed to give Wang Baoqiang support and understanding.

Eight, the future direction of the event: the story to be continued

Although Wang Baoqiang is facing severe public opinion challenges at present, from the feedback of all parties, things may not have reached the end. With the further development of related events, it will take time to test whether Wang Baoqiang’s personnel structure can be reshaped. No matter how this matter develops, every journey Wang Baoqiang has experienced tells us that the story behind the stars is often more complicated than the characters on the screen.

Generally speaking, this incident in Wang Baoqiang reveals the difficulty and complexity behind the glamorous appearance of the entertainment circle. The construction of a star’s personality requires both talent and hard work, but also persistence and truthfulness. We expect Wang Baoqiang to continue to bring more wonderful works to the audience after the storm, and hope to show a more authentic self in the process.

Editor in charge:

I believe many people have heard the advertisement "Good air conditioner is made by Gree". With the blessing of "Gree mastering core technology", many people will vote for Gree for which brand of air conditioner is good.

If nothing else, let’s talk about the compressor, the core technology of air conditioning. Gree is also the only one among many domestic air conditioning brands with a self-developed Lingda compressor. In the past few decades, Gree has won wide recognition from consumers for its excellent quality and innovative ability.

In 2024, Gree Air Conditioning once again proved its leading position in the market and launched many popular on-hook air conditioners. These three models can be said to beGree’s best three hang-up air conditioners: not only high sales, but also high cost performance, which is recognized by the public.!

First, Gree Yunjia variable frequency air conditioning hangs up.

Gree Yunjia hang-up air conditioner has become a popular choice in the market because of its new level of energy efficiency, variable frequency cooling and heating, self-cleaning and people-friendly price. Equipped with 1.6 rows of condensing copper tubes, electronic expansion valve and 9.8cc Lingda compressor, as well as new energy-efficient frequency conversion technology, it brings users an efficient experience of energy saving, environmental protection and stable operation.

In the hot summer, Yunjia air conditioner’s refrigeration capacity of 1.5 horsepower can easily cope with the high temperature challenge and bring a cool and pleasant environment to the family. At the same time, Yunjia air conditioner adopts variable frequency heating and cooling technology, which can automatically adjust the operating frequency according to the change of indoor temperature, avoiding the discomfort caused by frequent start and stop.

In addition, Yunjia air conditioner has a circulating air volume of 640 m/h, seven adjustable wind speeds and four sleep modes, which ensures the constant and comfortable indoor temperature. Combined with Gree’s triple energy-saving control technology, the energy efficiency of Yunjia air conditioner is as high as 5.27, and the power saving effect is obvious.

In terms of detailed functions, Yunjia air conditioner also has intelligent design such as self-56℃ high temperature cleaning function, independent dehumidification and fluorine deficiency protection, and low noise performance. With a price of less than 3,000 yuan, Gree Yunjia 1.5 air conditioners won the gold list of air conditioners in JD.COM with its excellent price/performance ratio, and remained at the TOP1 of Gree’s sales volume, becoming a hot choice in the market.

Second, Gree Yunjin 3rd Generation Variable Frequency Air Conditioning Hang-up

Gree Yunjin Ⅲ, as an upgrade of Yunjin series, not only maintains the excellent performance and elegant design of the previous generation products, but also carries out various upgrades. Among them, the addition of Gree’s second-generation cold external machine enables it to support 60℃ high-temperature refrigeration and -35℃ low-temperature heating, bringing users a more comprehensive temperature control experience. At the same time, its energy efficiency ratio (APF) is as high as 5.32, and the circulating air volume is increased to 660 m/h, which brings higher cost performance to users.

In terms of performance, Yunjin III is equipped with a new generation of Lingda compressor with a displacement of 10.3CC, combined with a 1.6-row condenser and an electronic expansion valve, and uses a new energy-efficient frequency conversion technology to provide users with a strong and stable refrigeration effect. Its refrigeration capacity of 1.5 horsepower and self-cleaning function at 56℃ ensure the efficient operation of air conditioner and the fresh and healthy indoor air.

In addition, Yunjin ⅲ air conditioner also adopts the closed design of double-layer air deflector, which realizes sufficient air volume and ultra-long air supply distance. At the same time, 7-speed wind speed, 4 sleep modes and automatic wind sweeping function provide users with a more personalized and comfortable experience. Intelligent light-sensitive, anti-direct-blowing and mute design as low as 18dB allow users to enjoy tranquility and comfort while enjoying coolness.

Compared with the best-selling model Yunjia, Gree Yunjin III has a slightly higher price, but its rich configuration and excellent experience make it an ideal choice for users who pursue cost performance. Regardless of performance or design, Yunjin III has demonstrated the excellent quality and innovative ability of Gree brand.

Third, Gree Yunshu Oxygen Fresh Air Air Conditioner hangs up

As a medium and high-end "constant temperature air conditioner" with fresh air function in Gree, Yunshu Oxygen Air Conditioner has shown a very high cost performance in the price range of 4,000 yuan with its fresh air function and excellent refrigeration and heating performance. Whether it is a user who pursues a comfortable quality of life or a family who pays attention to health and environmental protection, Yunshu Oxygen is an ideal choice worthy of in-depth consideration.

Compared with other air-conditioning models of Gree, one of the highlights of Gree Yunshu Oxygen Air-conditioning is that it perfectly combines temperature balancing technology with independent fresh air module. Through the built-in high-quality HEPA filter, it not only can cool and heat, but also has the function of fresh air ventilation, creating a healthier and more comfortable indoor environment for users.

In the aspect of internal machine design, Yunshu oxygen air conditioner is equipped with a 360-degree motion large air deflector, which supports awning air supply and carpet air supply. This design can effectively prevent cold air from blowing directly to the human body, making the blown air softer and more comfortable, and will not cause headache even if it is used for a long time. In the heating mode, hot air can be sent to the ground evenly and naturally rise, forming a carpet heating effect, ensuring that the whole house can feel warm and avoiding the discomfort of being hot at the head and cold at the feet.

The external machine configuration is equally excellent. Yunshu Oxygen Air Conditioning adopts the second-generation Gree cold external machine, equipped with a 10.33cc displacement Lingda compressor and a double-row condenser. This enables it to maintain excellent refrigeration effect in the high temperature environment as high as 60℃, and it can also be started smoothly in the low temperature environment of -35℃, meeting the use requirements in various extreme environments.

In addition to the above three products, Gree has many other excellent on-hook air-conditioning products, such as Gree Yuntian and Gree Yun Xuan Healthy, which also uphold Gree’s consistent spirit of high quality and technological innovation, bringing users a comfortable home environment.

Generally speaking, Gree, as a leading enterprise in the air-conditioning industry, has a wide range of on-hook air-conditioning products with excellent quality. No matter consumers who pursue high efficiency and energy saving or users who pay attention to health and environmental protection, they can find satisfactory products in Gree.

　　Recently, the circle of friends was screened by two pictures of "Qiushui Mountain Villa". One is colored, the other is gray, and it is color that causes everyone to vomit. The gatehouse is painted in yellow wall scarlet letter, and the color is very bright, which is abrupt compared with the color of surrounding buildings. At noon the day before yesterday, the yellow of the gatehouse of Qiushui Villa was covered with new gray. Hangzhou Garden Department said: Qiushui Mountain Villa, as a cultural relic protection site in Hangzhou, should go through filing or approval procedures before implementing protective maintenance or repair. However, they have not reported these refreshes, and the garden department will strengthen its supervision responsibility in the future.

　　Qiushui mountain villa

　　Color changes twice a day.

　　In fact, as early as half a month ago, when the reporter passed Beishan Street, he was attracted by the yellow "Qiushui Villa". Compared with the surrounding red bricks and gray tiles, yellow is really abrupt. At that time, the reporter also had the same guess as passers-by. Maybe this is just the background color. How can the buildings by the West Lake be this color?

　　What the reporter didn’t expect was that two weeks later, the yellow color was still there, and it became online celebrity. Early the day before yesterday, someone in the circle of friends was forwarding two contrasting pictures of "Qiushui Mountain Villa". One was an old photo, and the light gray wall was mottled, revealing a yellowish wall. Behind the four gray characters of Qiushui Villa is a white bottom. The other one, painted bright yellow. The four characters of Qiushui Villa have also been changed to bright red.

　　By 10 o’clock in the morning, these two pictures were in a screen-brushing situation, accompanied by doubts: rhubarb and scarlet were really unacceptable.

　　At noon the day before yesterday, the reporter rushed to Beishan Street. There were already construction workers painting the wall at the entrance of Qiushui Villa. Most of the yellow of the original gatehouse was covered with new gray. A worker said that they were suddenly notified in the morning and asked to paint it gray as soon as possible. After half an hour, the original bright yellow wall turned gray.

　　Xinxin Hotel

　　Painting is not reported.

　　The management of "Qiushui Villa" is Xinxin Hotel. Because of the heavy humidity near the West Lake, the gatehouse of the villa needs to be repainted every two or three years. This painting was also organized by them.

　　The person in charge of Xinxin Hotel emphasized that the gatehouse was originally yellow. This painting is also intended to repair the old. "We checked the historical materials. In those days, Mr. Shi Liangcai bought half a piece of land in Jingguantang to build Qiushui Villa. The gatehouse was painted yellow, perhaps to explain its origin with the temple. So we want to repair the old as before and restore the yellow gatehouse. "

　　Moreover, in the process of scraping off the old coating during construction, it was found that the residual coating inside was yellow.

　　In the eyes of the person in charge of Xinxin Hotel, their starting point was good, but they didn’t expect to "do bad things with good intentions". "Now the yellow with the past yellow is not the same, too bright. We also admit this, and there is indeed a technical deviation. Frankly speaking, our original intention is not wrong, but also to respect history. It’s just that the opinions on the Internet are too concentrated, and everyone still likes the previous gray. " Therefore, Xinxin Hotel temporarily decided to brush it back to gray first. But this is not the final color, and they will invite relevant experts to discuss it again.

　　Suddenly turned yellow, and suddenly turned gray. Some netizens are worried that brushing around can be so capricious? Don’t you need approval or filing? The person in charge of Xinxin Hotel also admitted that they did not report to the relevant departments before the two "refreshes".

　　Garden and cultural department

　　Strengthen supervision responsibility

　　Hangzhou Bureau of Landscape Architecture and Culture said that in order to strengthen the supervision responsibility, they will invite experts to come to the door to make a plan and discuss the next step with Xinxin Hotel as soon as possible.

　　What color is the gatehouse of Qiushui Villa? The reporter went to Hangzhou Archives to inquire. Unfortunately, the archives did not keep the old photos of that year. Zhong Xiangping, a researcher on old buildings in Hangzhou, is an expert on "living maps" and "old houses" in Hangzhou. He told reporters that no one knows whether the earliest background color of the gatehouse of Qiushui Villa is yellow or bluish gray. However, he felt that the original background color, blue brick color, blue gray is more likely. This should also be more in line with everyone’s aesthetics.

　　Color expert

　　New doesn’t mean beauty.

　　"This careless move is likely to erase the best things in Hangzhou." Associate Professor Zhai Yin, a researcher at the Institute of Color Studies of the Chinese Academy of Fine Arts, was very sad when he talked about this matter.

　　"New doesn’t mean beauty! It is a very unconfident behavior for them to brush like this. " Zhai Yin said that the most valuable place in Hangzhou, especially by the West Lake, is the perfect integration of cultural and historical buildings and natural landscapes. "Even if these buildings are to be repaired as old as before, they need to be cautious and cautious, and they should not be casually laid hands on, instead of casually wiping any cement paint. The consequences are really irreparable."

　　Zhai Yin also appealed that in addition to respect and self-confidence, legislation must be accelerated. "Government departments need wisdom to legislate and strengthen management and execution. No matter the color of the landscape of the West Lake or the whole city, they should be treated with caution and study it with scientific methods and aesthetic eyes."

　　The day before yesterday, Xiang Yongdan, deputy mayor of Hangzhou Municipal Government, said that the problems in the renovation of "Qiushui Villa" exposed the shortcomings in the refined management of Hangzhou. All units should attach great importance to and treat the repair of historical buildings carefully in environmental remediation; Seriously implement the strict audit mechanism with the participation of experts. All departments should take this as a mirror, draw inferences from others, respect experts, listen to public opinions and reflect urban culture and characteristics in the renovation of urban housing buildings. Hangzhou is very grateful to the citizens for their enthusiastic participation in urban construction, and hopes that everyone will give more valuable opinions and suggestions on such issues.

　　According to qianjiang evening news.

　　[Global Network News] According to the latest news from the official website of the Nobel Prize, at 17: 30 on October 7, Beijing time, the Karolinska Medical College in Sweden announced that it would jointly award the 2019 Nobel Prize in Physiology or Medicine to William G. Kaelin, Peter J. Ratcliffe and Gregg L. Semenza for their discoveries.

　　The Nobel Prize in Physiology or Medicine was established according to the will of the late Swedish chemist alfred nobel, aiming at commending those who made outstanding discoveries in physiology or medicine in the previous year. The front of the Nobel Prize in Physiology or Medicine is a bust of Nobel, the right is the year of birth and death of Nobel (Roman numerals), and the author’s signature is "E.LINDBERG 1902" in the lower left corner. The design on the back of the medal is the health goddess Xu Guiya in ancient Greek mythology, who is collecting spring water from rocks to quench the thirst of sick girls. The medal is engraved with a Latin sentence, which roughly translates as: New discoveries make life better.

　　The prize was first awarded in 1901, and was selected by Karolinska School of Medical University in Stockholm, Sweden. The award ceremony was held on December 10th every year (the anniversary of Nobel’s death).

　　On October 8, 2015, China scientist Tu Youyou won the 2015 Nobel Prize in Physiology or Medicine, becoming the first Chinese to win the Nobel Prize in Natural Science. Tu Youyou, who has been engaged in the research of combining traditional Chinese medicine with western medicine for many years, creatively developed a new antimalarial drug — — Artemisinin and dihydroartemisinin have achieved 100% inhibition rate against plasmodium, which points out a direction for Chinese medicine to go global.

　　Winners of Nobel Prize in Physiology or Medicine in Recent 5 Years

　　In 2018, American immunologist James Allison and Japanese biologist Tasuku Honjo won the Nobel Prize for their contribution to the discovery of negative immunomodulation therapy for cancer.

　　In 2017, three American scientists, Jeffrey Hall, Michael Rothbash and Michael Young, won prizes for their achievements in studying the molecular mechanism of the biological clock.

　　In 2016, Japanese scientist yoshinori ohsumi won the prize for his achievements in the study of autophagy mechanism.

　　In 2015, Tu Youyou, a female pharmacist in China, William Campbell, an Irish scientist, and Satoshi Omura, a Japanese scientist, won prizes for their achievements in the research on the treatment of parasitic diseases.

　　In 2014, John O’Keefe, a scientist with American and British citizenship, and May-Britt Mo Ze and Edward Mo Ze, two Norwegian scientists, won prizes for their research on finding cells in the brain localization system.

　　Some historical data since the Nobel Prize in Physiology or Medicine was awarded (1901-2018);

　　109 times

　　Since 1901, the Nobel Prize in Physiology or Medicine has been awarded 109 times. It was not issued in 1915, 1916, 1917, 1918, 1921, 1925, 1940, 1941 and 1942. Of the 109 awards, 39 were awarded to a single winner, 33 were shared by two people and 37 were shared by three people.

　　216 people

　　So far, there are 216 winners of the Nobel Prize in Physiology or Medicine, and so far no one has won the prize twice, with an average age of 58. The youngest winner of the Nobel Prize in Physiology or Medicine is Frederick G. Banting, a Canadian surgeon who invented insulin. He was only 32 years old when he was awarded the Prize in Medicine in 1923. The oldest winner was Peyton Rous, an American virologist who discovered tumor-induced virus. He was 87 years old when he won the medical prize in 1966.

　　12 women

　　Of the 216 Nobel Prize winners in Physiology or Medicine, 12 are women. Among them, American cytogeneticist Barabara McClintock is the only winner who won the award alone. The woman scientist who recently won the prize is Tu Youyou from China.

　　family

　　Husband and wife: Gerty Cori and Carl Cori won the Nobel Prize in Physiology or Medicine in 1947; May-Britt Moser and Edvard I. Moser (now divorced) won the 2014 Nobel Prize in Physiology or Medicine.

　　Father and son: Hans von Euler- chelpin(1929 chemistry prize) and Ulf von Euler(1970 medicine prize); Arthur Kornberg (medicine prize in 1959) and Roger D. Kornberg (chemistry prize in 2006).

　　Brothers: Jan Tinbergen(1969 Prize in Economics) and Nikolaas Tinbergen(1973 Prize in Medicine).

　　"Little Plum" in Nobel Prize Circle

　　Sigmund Freud (1856-1939), an Austrian neurologist and founder of psychoanalysis, was nominated for the Nobel Prize in Physiology or Medicine 32 times, but never won the prize. Nobel Prize nominations are kept secret for 50 years.

The new form of microfilm attracts attention. Director: Youth is to dare to do anything.

　　　 Since the fire of "Chopsticks Brothers", "Microfilm", a new film form, has become a "potential stock" that fans and the industry are very optimistic about. The youth microfilm series "Dare" will be made into ten films, each of which will be starred by a "fast girl". The film will be directed by director Tian Meng, cutting-edge director Zhou Nan, director Chen Zhengdao and MV director Xie Dingguo, while director Zhang Yibai will be the producer.

　　　 It is reported that two microfilms starring "Fast Girl" Change Lu and Yu Jiali have been finished. At the press conference that day, directors Zhou Nan and Tian Meng also expressed their views on the films. Director Zhou Nan said that the theme of his film starring Change Lu was "Love and Trust". For Lu Yi’s performance, the director affirmed: "One of the highlights of this film is Change Lu’s performance, which really surprised me, and I am very much looking forward to her future performance;" The specific story is confidential now, but when I showed the clip to Long Danni (the president of Tianyu), she said ‘ You are bold enough ’ . But I think that youth is to dare to do anything, so this film is worth looking forward to. "

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According to the sharing of digital chat stations of well-known people who broke the news, vivo Company is about to launch a new small-screen flagship mobile phone vivo X200. This phone will be equipped with MediaTek’s Tianji 9400 processor, a brand-new Sony super-large bottom main camera and a periscope telephoto camera with triple optical zoom. Compared with other competing products, vivo X200 has certain advantages in battery capacity, battery life and image quality. …