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Image source: the idea of the worm

First, Amazon

Founded in 1994, Amazon is the world’s largest cross-border e-commerce platform. At present, the cross-border e-commerce Amazon’s retail product line covers books, audio-visual products, software, consumer electronics, household appliances, kitchen utensils, food, toys, maternal and child products, cosmetics, daily necessities, sports equipment, clothing, shoes and hats, jewelry and other categories.

Second, AliExpress

AliExpress is Alibaba’s online trading platform for the international market. Founded in 2010, its customers and buyers have covered more than 220 countries and regions, covering 30 first-class industry categories such as clothing, 3C, home and accessories.

Third, ebay

EBay (EBAY Chinese Electronic Bay, Yibei, Yi Bei) is an online auction and shopping website that allows people all over the world to buy and sell goods online. Ebay was founded in San Jose, California on September 4th, 1995 by Pierre Omidyar under the name of Auctionweb. People can sell goods online on ebay.

Fourth, Shopee

Shopee is an e-commerce platform in Southeast Asia and Taiwan, China. In 2015, it was established and headquartered in Singapore, and then expanded to seven major markets: Malaysia, Thailand, Taiwan, China, Indonesia, Viet Nam and the Philippines. Shopee has a variety of goods, including consumer electronics, home, beauty care, maternal and child, clothing and fitness equipment.

V. Coupang

Coupang is the largest cross-border e-commerce platform in Korea, an e-commerce enterprise headquartered in Seoul, the capital of South Korea. Its founder is Bom Kim, and the company was established in 2010. In May 2015, the company’s total financing has reached 1.4 billion US dollars, and Coupang’s valuation has exceeded one trillion won, about 913 million US dollars.

Sixth, Wish

A mobile e-commerce shopping APP in North America. In 2018, Wish supplied more than 200 million products to more than 350 million consumers around the world, with more than 90 million monthly active users and 125,000 active merchants. The daily shipment reached 2 million orders, and the orders mainly came from the United States, Canada, Europe and other regions around the world.

VII. Lazada

Lazada, one of the largest online shopping websites in Southeast Asia. With the support of SamwerBrothers, a German business incubator, Lazada mainly targets users in Indonesia, Malaysia, the Philippines and Thailand. Lazada Group has become the flagship e-commerce platform of Alibaba Group in Southeast Asia since 2016.

Eight, Cdiscount

The largest e-commerce platform in France, established in 1998, belongs to the Casino Group, including the sales of 3C digital, home, gardening, outdoor and entertainment products.

Nine, Ozon

Ozon is a Russian B2C e-commerce platform and the largest online retailer in Russia. It was founded in 1998 and is often called "Russian Amazon" or "Russian Taobao". Ozon has more sales categories than other Russian e-commerce platforms, covering books, electronics, clothing, family, children, beauty, food and pets, sports and other commodity categories, so that sellers have more distribution options.

X. 11th 11street

11th Street ranks among the top three most popular e-commerce websites in Korea, and local platforms in Turkey, Malaysia and Thailand are currently in operation. It is an open platform operated by celcom planesdn.bhd.

(Source: Cross-border compass)

The above content belongs to the author’s personal opinion and does not represent Hugo’s cross-border position! This article is reproduced with the authorization of the original author, and it needs the authorization and consent of the original author. ?

　　August

　　Another batch of laws and regulations concerning people’s livelihood are "new"!

　　A series of new regulations to protect the rights and interests of military personnel will be effective.

　　The abuse of "face brushing" technology will be regulated.

　　The phenomenon of electric vehicles entering the building will be punished.

　　… …

　　Which one do you care about most?

　　Further improve the protection of military rights and interests

　　August 1st is the Army Day of the People’s Liberation Army of China, and a number of new regulations related to the rights and interests of military personnel and their families came into effect.

　　The Law on the Protection of the Status and Rights and Interests of Soldiers in People’s Republic of China (PRC) came into effect on August 1,To stipulate the basic treatment enjoyed by soldiers in terms of salary, housing, medical care, insurance, vacation to visit relatives, education and training, and settlement with the army; We will improve the system of pensions and preferential treatment for servicemen, and make provisions on the policies of praise for martyrs, death pensions and disability pensions, as well as preferential treatment for servicemen’s families and martyrs, servicemen who died in the line of duty, and survivors of deceased servicemen in employment placement, children’s education, assistance and assistance, and judicial services.

　　According to the arrangement of the Department of Veterans Affairs and the Ministry of Finance, starting from August 1st, the disabled people (disabled soldiers, disabled people’s police, disabled state functionaries and disabled militia migrant workers), the "three families" (survivors of martyrs, soldiers who died in the line of duty, survivors of deceased soldiers) and the "three reds" (veterans of the Red Army in rural areas, veterans of the Red Army in the West Road Army in rural areas, and the Red Army lost people) will receive living allowances.

　　In addition, the Regulations on Mass Work in the Army, which came into effect on August 1, has improved the working mechanism of coordinating local support for troops in training and preparing for war, organizing support for the army, implementing the preferential policies for supporting the army, and carrying out activities to create a model of "double support".

　　It is infringement for business premises to collect face information without authorization.

　　The widely criticized compulsory "face brushing" problem also has corresponding new regulations:The new judicial interpretation of the Supreme Law, which came into effect on August 1, regulates the abuse of face recognition technology in business premises.According to the Provisions of the Supreme People’s Court on Several Issues Concerning the Application of Laws in the Trial of Personal Information-related Civil Cases, using face recognition technology for face verification, identification or analysis in hotels, shopping malls, banks, stations, airports, stadiums, entertainment places and other business places and public places in violation of laws and administrative regulations is an act that infringes on the personal rights and interests of natural persons.

　　The judicial interpretation is clear. Property service enterprises or other building managers use face recognition as the only verification method for owners or property users to enter and leave the property service area. If the owners or property users who disagree request them to provide other reasonable verification methods, the people’s courts will support them according to law.

　　Integration of value-added tax, consumption tax and additional tax returns

　　According to the new regulations of State Taxation Administration of The People’s Republic of China,From August 1st, when taxpayers declare value-added tax and consumption tax, they should complete the declaration of urban maintenance and construction tax, education surcharge and local education surcharge.

　　This integration is to integrate the VAT tax return (applicable to general taxpayers), VAT tax return (applicable to small-scale taxpayers) and its attached materials, VAT prepaid tax form and consumption tax return with the Urban Maintenance and Construction Tax Education Fee Additional Local Education Additional Return, and to enable the VAT and Additional Taxes Return (applicable to general taxpayers), VAT and Additional Taxes Return (applicable to small-scale taxpayers) and.

　　The integration of declaration forms will realize the sharing of information on value-added tax, consumption tax and additional taxes and fees, and improve the efficiency of declaration; It is conducive to ensuring the quality of declaration and the timely implementation of preferential policies, and reducing the tax burden of taxpayers.

　　Ask them to provide other reasonable verification methods, and the people’s court will support them according to law.

　　The new fire regulations prohibit battery cars from "entering the building"

　　The Regulations on Fire Safety Management of High-rise Civil Buildings came into effect on August 1st, which stipulated the problem of electric vehicles entering the building.

　　The rules are clear,It is forbidden to park or charge electric bicycles in public halls, evacuation walkways, stairwells and safety exits of high-rise civil buildings.Encourage the establishment of centralized storage and charging places for electric bicycles in high-rise residential quarters.

　　In violation of the above provisions, the fire rescue agency shall order it to make corrections. Refuses to correct, the business units and individuals at more than 2000 yuan to 10000 yuan fine, the non-business units and individuals at 500 yuan above 1000 yuan fine.

　　Pork safety supervision is stricter.

　　The newly revised Regulations on the Management of Pig Slaughtering came into effect on August 1st.The regulations require that the pig slaughtering plant should check the information such as pig quarantine certificate according to law, truthfully record the source, quantity, supplier name and contact information of pigs, and ensure the traceability of the source of pigs. In the process of slaughter, meat quality inspection should be carried out simultaneously with pig slaughter, and the inspection results should be recorded truthfully to ensure that the slaughter process is controllable. The pig slaughtering plant shall truthfully record the name, specifications, quarantine certificate number and other contents of the factory pig products to ensure that the whereabouts of the pig products can be checked.

　　The regulations clearly stipulate that pig slaughtering plants should fulfill their obligations such as reporting and recalling in a timely manner, and take measures such as harmless treatment of recalled pig products to ensure that problem products do not flow into the market.

　　High school military training shall not be less than 7 days.

　　The "Military Training Syllabus for Senior High School Students" was implemented nationwide on August 1st.The "Outline" makes it clear that the military training teaching for senior high school students includes two parts: basic military knowledge and basic military skills, and the teaching time is 7 to 14 days, with a total of 56 class hours in no less than 7 days. Among them, there are 24 hours of basic military knowledge, 12 hours of compulsory training and 12 hours of elective training; There are 88 class hours of basic military skills, 44 class hours of compulsory training and 44 class hours of optional training.

　　(Part of the image source: vision china)

　　CCTV News:On August 29th, the website of Shenyang Municipal Government reported that the epidemic prevention and control headquarters of COVID-19 in Shenyang announced that at present, many cases of people with abnormal nucleic acid test results were found in the regional nucleic acid screening in Shenyang. In order to resolutely and effectively block the spread of the epidemic, effectively protect people’s life safety and health, and reduce the risk of epidemic spread caused by the flow and gathering of people, the relevant measures for strict epidemic prevention and control are hereby announced as follows:

　　First, strict prevention and control measures during regional nucleic acid detection

　　From 0: 00 on August 30 to 24: 00 on September 5, the city continuously carried out regional nucleic acid testing.

　　1. All the people living in Shenyang, before sampling, remain relatively static in their places of residence. According to the unified deployment of the epidemic prevention and control headquarters of each district, county (city) and the organizational arrangement of streets (towns) and communities (villages), nucleic acid testing will be carried out in an orderly manner, and no one will be missed. Only after participating in the nucleic acid sampling can people go to work, go to school and arrange necessary travel.

　　2. The citizens should consciously obey the community (village) organization and on-site management, do personal protection throughout the process, keep a distance of more than 1.5 meters with others, and do not cut in line, talk or gather.

　　3. From now on, the effective time limit of "Liaoshitong" health code will be adjusted from 72 hours to 48 hours. Those who fail to participate in nucleic acid testing within the prescribed time limit will be given a "yellow code" for their health code, and those who cause the spread of the epidemic will be held accountable according to law.

　　4. Shopping malls, supermarkets, hotels, scenic spots, farmers’ markets and other public places with dense personnel, closed space and prone to cluster epidemics shall strictly implement the epidemic prevention and control requirements such as limited quantity and peak shifting, and the number of customers accepted shall not exceed 50% of the maximum carrying capacity.

　　5. Closed public places such as theaters, bath centers, massage parlors, beauty salons, gymnasiums, chess rooms, secret rooms, entertainment halls, cultural centers (stations), Internet cafes, indoor scenic spots, KTV, dance halls, discos, performance venues, and direct sales experience venues are temporarily closed; Night markets, flower and bird markets, and large rural gatherings will be closed in the morning and evening; Restaurants Restaurants are suspended from eating.

　　6. Party and government organs, enterprises and institutions at all levels shall implement "two points and one line", fully implement measures such as nucleic acid detection and health monitoring, and urge them to go to the nearest fever clinic for investigation if abnormal symptoms are found. Advocate qualified citizens to work at home as much as possible and reduce the flow of people.

　　7 welfare institutions, pension institutions, mental health institutions, public security and judicial administrative supervision institutions and other temporary closed management, stop unnecessary visits.

　　8. Primary and secondary schools, kindergartens and off-campus training institutions temporarily stop offline teaching.

　　9. All kinds of public transport vehicles must be disinfected and ventilated, and the drivers and passengers should strictly protect themselves and conduct nucleic acid testing in accordance with industry regulations. Take public transport must strictly check the "four-piece set" (code scanning, temperature measurement, wearing a mask, negative proof of 48-hour nucleic acid test), and the passengers in the car shall not exceed 50% of the rated passenger capacity.

　　10. The city’s long-distance buses and tourist chartered buses (excluding those returning to other cities) are suspended from operation, and the buses and subways (light rail) in the nine urban areas of the city are operating normally during the morning and evening peak hours (6: 00 to 8: 30, 16: 30 to 19: 00), and the interval between vehicles during the peak hours is doubled as that during the daily peak hours.

　　11. Carefully organize large-scale meetings, forums, exhibitions, sales promotions and other personnel gathering activities. If it can be postponed, it will be postponed, and if it can be online, it will be online. In accordance with the principle of "who sponsors who is responsible and who approves who is responsible", the requirements for epidemic prevention and control will be strictly implemented.

　　12. If the wedding is postponed, the funeral is simple, and the banquet is not held, to reduce the gathering time and control the number of people, the participants must strictly implement the "four-piece set".

　　13. Advocate the general public in the city not to leave Shen unless it is necessary. Those who really need to leave Shen must hold a negative nucleic acid test certificate within 48 hours and travel with the green code of "Liaoshitong Health Code".

　　District and county (city) epidemic prevention and control headquarters can formulate specific prevention and control programs in combination with the actual situation.

　　Second, strict normalization of epidemic prevention and control key measures

　　1. Strictly implement the "active filing". Before arriving in Shenyang, all foreign (returning) Shen personnel should download the "Grand Event Link" App, search for "Grand Event Link" by WeChat applet or scan the QR code of "Self-reported by Shen personnel", complete self-reported to local communities (villages) and units one day in advance, report to local communities (villages) and units as soon as they arrive in Shenyang, and implement various control measures according to requirements. The community (village) should do a good job in service to ensure the living needs of residents.

　　2. Strictly "check on landing". At airports, railway stations, passenger stations, highways and other entry channels, they will be reported for inspection, and "landing" nucleic acid testing will be conducted free of charge.

　　3. Strictly implement classified control measures. Strictly implement classified control measures such as centralized isolation, home isolation, home health monitoring and nucleic acid detection for those who come (return) to Shenyang in high, medium and low risk areas outside the territory.

　　4. In high-risk areas, people who really need to go out for medical treatment should be coordinated and arranged by communities (villages) and streets (towns), and a special car should be used for personal protection and closed-loop management.

　　5. In the medium-risk area, "people don’t leave the area and take things at the wrong peak". For those who really need to go out for medical treatment, the community (village) will issue a certificate and make a good audit and registration.

　　6. In low-risk areas, "personal protection, avoiding gathering" shall be implemented, and during the period, going out as little as possible, not gathering, not getting together, and doing personal protection when going out; Strictly implement measures such as booking, peak shifting, current limiting, temperature measurement, registration and wearing masks when entering indoor public places.

　　7. All kinds of units, institutions, public places, residential areas, "nine small places" and other comprehensive applications of "place code" to achieve global coverage, everything must be swept; Strictly check the "four-piece set" for all personnel entering.

　　8. All pharmacies should register the personnel who buy antipyretic, antitussive, antiviral, antibiotic, cold and other drugs with their real names.

　　Third, strictly compact the "four-party responsibility"

　　We will further tighten the "four-party responsibility" of the territories, departments, units and individuals, and strictly implement various prevention and control measures such as "four-piece inspection", reporting of personnel coming (returning) to Shenyang, inspection on landing, site code, employee monitoring and daily ventilation and disinfection in accordance with the requirements of epidemic prevention and control. Places, units and individuals that fail to do a good job in epidemic prevention and control and fail to implement the "four-party responsibility" according to regulations shall be dealt with severely according to law.

　　Citizens and friends, in the face of severe and complicated epidemic situation, let’s tighten the string of epidemic prevention and control together, always do personal protection, adhere to good living habits such as wearing masks, washing hands frequently, often ventilating, using public chopsticks, consciously abide by various epidemic prevention regulations, protect ourselves and defend the city, and love and protect the city as home!

　　This circular shall come into force as of the date of promulgation, and shall be adjusted as the epidemic situation changes.

　　Shoulder-to-shoulder queue, the booming catering industry … … With the optimization and adjustment of epidemic prevention and control policies, offline consumption scenes such as restaurants and restaurants have been restored in an orderly manner, driving related consumption to pick up. According to data released by the National Bureau of Statistics recently, from January to February 2023, the national catering revenue increased by 9.2% year-on-year.

　　Food and beverage consumption demand has been greatly released.

　　Recently, "one table is hard to find" has become a common feeling for many consumers to eat. At the Chaoshan beef shop in Beijing Road, Guangzhou, the "Chaofa" has a long queue, and there are dozens of tables waiting at 6 pm. By the weekend, the average daily number of this store is nearly 1,000 tables. The waiter trotted to serve food and shouted, "It seems that the guests can’t finish receiving it recently."

　　Passenger flow recovery promotes turnover growth. From January to February, 2023, the brands owned by Beijing Huatian increased by about 12% year-on-year. Among them, Tongheju Restaurant and Xinchuan Noodle Restaurant increased by more than 20% year-on-year. In particular, the sales of Tongheju Restaurant and Eryouju in February have exceeded 2019 and returned to normal levels.

　　In order to help the catering industry recover, from January to February, Beijing, Shenzhen and Hangzhou issued special coupons for catering, with obvious results. According to the data of Meituan, after Hangzhou, Ningbo, Shaoxing, Shenzhen, Zhuhai, Dongguan and other cities issued coupons, the year-on-year growth rate of food consumption in restaurants reached double digits. In addition to issuing consumer vouchers, many local governments have also introduced policies to further optimize the business environment, including supporting outbound operations and launching "catering loan" financial products.

　　The "small" of catering reflects the "big" of development. According to the analysis of China Cuisine Association, from January to February, 2023, the growth rate of national catering revenue and catering revenue of units above designated size increased by 0.3 percentage points and 0.1 percentage points respectively compared with the same period of last year. From January to February this year, the national catering revenue accounted for 10.9% of the total retail sales of consumer goods, which was 5.7 percentage points higher than the total retail sales of consumer goods.

　　The relevant person in charge of the China Cuisine Association believes that from January to February, driven by the Spring Festival holiday and the policy of helping enterprises, the demand for catering consumption was greatly released, and the catering market rebounded significantly, which made a good start for the development of the whole year and played a "catalyst" role in boosting consumer confidence in 2023.

　　Customers dine in the Wuyi Hotel in Xi ‘an. Xinhua News Agency reporter Li Jiaxu photo

　　New kinetic energy "combustion-supporting" catering market

　　Potted vegetables and quick-frozen vegetables … … Guangzhou Restaurant accelerated the research and development of new prefabricated dishes and product upgrading, and the revenue of quick-frozen food was once the company’s second largest source of income. The White Paper on the Development of Prefabricated Vegetable Industry in China in 2022 shows that the scale of prefabricated vegetable market in China will reach 419.6 billion yuan in 2022, up by 21.3% year-on-year, and it is estimated that the market scale will exceed one trillion yuan in 2026.

　　Cheng Gang, secretary-general of Guangdong Food and Beverage Service Association, believes that due to the epidemic, people’s consumption behaviors and habits have changed, and many catering entities are "looking for opportunities in danger". Some actively adjust their business methods, including innovating catering products such as prefabricated vegetables, strengthening industrial cross-border integration, overlapping emerging consumption elements, expanding business space, optimizing brand experience and cognition, and finally enhancing consumer trust to activate the market, so as to achieve more stable, sustainable and virtuous development.

　　Including live broadcast, short video, digital channels and social sharing functions to help stimulate consumer demand, attract more passengers and stimulate catering consumption. "We enhance the brand’s popularity by planning videos such as the Fat Story Collection and the food recommendation official shop." Chai Biao, chairman of Feifei Shrimp Village, said that 70% to 80% of the passenger flow in some stores comes from the network platform.

　　More time-honored brands try cross-border innovation, combining eating and drinking with tourism, performance, entertainment, shopping and other formats, and enriching the consumption experience with diverse new scenes. In Shaanxi, there are more and more tourists in Yi Sushe Cultural District of Xi ‘an, which integrates Shaanxi opera performance, time-honored food and new retail of the country. Xi’ an restaurant head office lets customers immerse themselves in the local food culture through the Shaanxi cuisine culture experience museum; Time-honored enterprises turned into "convenience community canteens" and opened a new model of community chain.

　　Jin Wenping, secretary of the Party Committee and chairman of Xi ‘an Catering Co., Ltd. said that the opening of a new chapter of diversified development by time-honored brands is the epitome of the market-oriented reform and exploration of the catering industry with consumer demand as a breakthrough, which is conducive to promoting the development of the industry and enhancing the social and economic benefits of the brand.

　　New measures to stabilize industry confidence

　　"Give priority to restoring and expanding consumption", "Enhance consumption capacity, improve consumption conditions and innovate consumption scenarios" … … We will implement the requirements of the Central Economic Work Conference, and all localities will further clarify policies and stabilize expectations.

　　The policy of benefiting enterprises and benefiting the people continued to increase, boosting food and beverage consumption. For example, Beijing holds a variety of catering activities to promote consumption; Guangzhou has successively introduced catering support policies, with a maximum reward of 1 million yuan for transformed and upgraded catering enterprises and 2 million yuan for enterprises with increased turnover; Wenzhou has introduced ten measures to boost the confidence of catering industry development around reducing the institutional cost of catering industry access.

　　The main body of the catering industry is more confident and the investment layout is accelerated. Not long ago, at the China (Guangzhou) Catering Industry Development Conference and Investment and Financing Cooperation and Exchange Exhibition, hundreds of catering enterprises proposed nearly 1,000 brand catering investment projects, including Guangdong cuisine, Hunan cuisine, Sichuan cuisine, Shandong cuisine and other major domestic cuisines, as well as Japanese cuisine, Southeast Asian cuisine, Central Asian cuisine and other international flavors, with an investment of more than 3 billion yuan.

　　Zhang Yi, the person in charge of Ai Media Consulting, a third-party research institution, said that the expansion of the catering industry shows that confidence has gradually recovered, diversified and tends to middle and high-end projects. The catering industry pursues higher quality brand development and provides better services for consumers.

　　"From banquets, dinners, business receptions, prepared dishes and other aspects, we can see the signal of rapid recovery of the catering industry. New models, new channels and new technologies are constantly emerging, promoting the development of the catering industry to multiple formats and quality. " Chen Jianqi, vice president of Shaanxi Cooking and Catering Industry Association, said that it is also necessary to pay attention to the low threshold, intensified industry competition, low overall profit rate and increasing cost of raw materials and services. Therefore, it is necessary to make further efforts in specialization and industrialization to improve competitiveness.

　　Insiders said that in order to accelerate the comprehensive and steady recovery of the catering industry, it is necessary to continuously improve policy support and guidance, introduce policies to help and promote consumption that are more in line with enterprise needs and market expectations, guide the cultivation of leading enterprises and leading talents, and rationalize the industrial layout. At the same time, it is necessary to promote development and anti-waste, to innovate products and to keep the bottom line of food safety. (Reporter Ding Le, Ning Ji, Cai Xinyi, Li Jiaxu)

　　Why do you still have to queue up for non-parking charges? Provincial Communications Department Responds to Hot Issues in the Use of ETC System

　　On October 28th, it has been 21 days since the electronic toll collection system (ETC system) was opened on expressways in our province. The number of ETC customers has reached 50,681, exceeding the target of reaching 40,000 users before the end of the year. Some bank outlets even cannot handle business immediately because of insufficient hardware stock.

　　Recently, Feng Zhenglin, Vice Minister of the Ministry of Transport, proposed at a special meeting that all provinces (autonomous regions and municipalities) in China will basically be connected to the Internet before the end of 2015. This means that by the end of next year, ETC users in our province will be able to "all-in-one card" nationwide.

　　During the trial operation, the ETC system was impassable and the ETC lane was temporarily closed. On October 29th, the Expressway Monitoring and Settlement Center of the Provincial Communications Department responded to these problems.

　　Q1: Why can’t ETC pass?

　　There may be other vehicles breaking in by mistake.

　　A: This did happen at the beginning of the trial run, mainly because both hardware and software had to have a running-in period. At present, optimization is being carried out to solve the problem.

　　There are three main reasons why the ETC card cannot be used. First, the ETC card has not completed the issuance process, and it must be recharged after the first activation, even if it is only charged with 1 cent. If it is not recharged, the system will display it as an "illegal card". Second, there will be problems between lane and vehicle information interaction. Third, the vehicle without ETC system mistakenly entered ETC lane, and the system sensed that there was a car entering, but another plate of the vehicle was thrown over to take the artificial lane, which kept the ETC lane waiting for reading data. "Although we can debug and manually guide, it is still recommended that drivers who have not installed ETC should not mistakenly enter the ETC lane."

　　Q2: Why is the ETC lane closed?

　　Slow blocking and smooth during peak hours

　　A: ETC lanes have been temporarily closed, mainly concentrated in several gates of Chengdu Ring Expressway, such as connecting Chengguan Road and Chengpeng Road. At present, the utilization efficiency of ETC lane is not high, and the traffic flow is small. In the rush hour, toll station vehicles may even block the main line, which will affect the traffic safety. At this time, the high-speed will start the plan, manually watch the ETC lane, and allow vehicles without ETC system to pass through the ETC channel. This is also a measure to slow down the congestion and ensure smoothness, so drivers can understand. "

　　In addition, there are some special cases, such as Dazhou toll station, which cannot be expanded due to geographical reasons. There are only three lanes in each direction, of which one truck is used, leaving two lanes, so the ETC lane is often closed.

　　Q3: ETC is delayed?

　　OBU devices are in short supply.

　　A: At the beginning of the opening of ETC system, the established goal of Sichuan Provincial Communications Department was to develop 40,000 users by the end of the year, but as of 0: 00 on October 29, the number of ETC users in our province had reached 50,681, with an average increase of 2,100 per day. It is estimated that by the end of this year, ETC users in our province will exceed 100,000. The relevant person in charge of the Expressway Monitoring and Settlement Center of the Provincial Communications Department said, "Due to the rapid growth of users, some bank outlets have no OBU (on-board unit), and we are also urging banks to step up procurement to meet the needs of car owners."

　　At present, the province has opened 417 ETC lanes, covering 208 toll stations, with a coverage rate of 55.5%. This number will rise in the future. As of yesterday, the number of ETC lanes built in our province has reached 500. It is estimated that by next year, the ETC coverage rate of all main toll stations of Sichuan Expressway will reach 100%, and the lanes will not be less than two in and two out, while the ETC coverage rate of all ramp toll stations in the province will reach 90%.

　　Q4: Are there any other services?

　　We plan to launch ETC card in the future.

　　A: We are exploring, for example, the amount of each toll is prompted by bank SMS, and even the historical toll records are queried online. In the future, when the number of ETC users reaches a certain level, we will also open the business of handling ETC cards independently, which is equivalent to that vehicles without OBU (on-board unit) need not give change when passing through artificial lanes, but swipe ETC cards to give money, so as to improve the traffic rate of toll stations.

　　ETC usage reminder

　　1. Do not disassemble the OBU when using it; once disassembled, it will be invalid;

　　2. Vehicles equipped with ETC should not exceed 20 kilometers per hour when passing through the ETC lane, and keep a safe distance from the vehicle in front;

　　3. Ensure that the ETC card is always inserted in the OBU while the vehicle is driving;

　　4. During use, the ETC card and OBU must be in one-to-one correspondence with the vehicle, and the car is dedicated;

　　5. If you can’t get through normally or have questions about the charges, you can call 12122 for consultation. (Reporter Wang Haoye Intern Zhang Yuer)

　　Beijing, June 15th (Reporter Qiu Yu) The last legal holiday in the first half of this year — — Dragon Boat Festival is coming!

　　The college entrance examination is over, the graduation season is here, and the World Cup has begun. This small holiday, is it necessary to let go of yourself?

　　If you plan to travel, you can collect this guide, which will make you have fun and worry-free, and avoid crowds.

　　First of all, people who travel in go on road trip or by bus should pay attention:

　　Dragon boat festival holiday,High speed is not free..

　　Say it again,Normal highway toll collection during Dragon Boat Festival.

　　Trend of congestion during the national high-speed Dragon Boat Festival. Source: 2018 Dragon Boat Festival National Highway Network Travel Forecast Report issued by the Ministry of Communications in conjunction with other institutions.

　　If you want to avoid the headache traffic jam, pay attention to the following peak hours:

　　Ministry of communications estimatesJune 16th is the peak of travel.,9: 00 am to 12: 00 am on the same day is the peak travel time; Especially from 10: 00 to 11: 00, the congestion degree is the highest.

　　June 18th is the peak of return trip.,On the same day, 15: 00 -21: 00 pm was the peak time of return trip, and the peak appeared at 16: 00 -17: 00.

　　Which highway sections are prone to congestion?

　　It is estimated that the highways with high traffic flow include: Hebei section of Jingcheng Expressway, Beijing section and Hebei section of Daguang Expressway, Guangdong section of Guanfo Expressway, Hunan section of Beijing-Hong Kong-Macao Expressway, Jiangsu section, Shanghai section and Zhejiang section of Shenhai Expressway.

　　The expressway around the city with high traffic volume includes: Guangzhou Ring Road, Chengdu Ring Road, Shanghai Ring Road and Hangzhou Ring Road Expressway.

　　Provincial congestion during the Dragon Boat Festival. Source: 2018 Dragon Boat Festival National Highway Network Travel Forecast Report issued by the Ministry of Communications in conjunction with other institutions.

　　The Ministry of Communications predicts that,The high-incidence areas of expressway network in provinces are mainly concentrated in Guangdong, Beijing, Jiangsu, Zhejiang, Hebei and other areas with strong traffic demand or concentrated self-driving tourism.

　　Some people choose to travel by high-speed rail. Have you grabbed the tickets for the following popular routes?

　　Meituan Travel Big Data shows that during the Dragon Boat Festival, the demand for high-speed rail travel is mostly in the province, and the top three popular routes are Guangzhou-Shenzhen, Chengdu-Chongqing and Hefei-Lu ‘an.

　　Jingzhou-Wuhan, Beijing-Tianjin, Chengdu-Xi ‘an, Chengdu-Mianyang, Shenzhen-Xiamen, Wuhan-Yichang and Wuhan-Xiangyang high-speed rail lines are also very popular.

　　Small partners who want to fly can also find cheap air tickets in relatively "unpopular" places.

　　Ctrip data shows thatFly to Fuzhou, Kunming, Guiyang, Quanzhou and overseas destinations such as Sydney and Singapore, and the ticket price is nearly half cheaper than last year’s Dragon Boat Festival.Come and pick up the leak!

　　On the contrary, Beijing, Chengdu and Xi ‘an have become the top three popular destinations in China. It is difficult to see tickets with a discount of less than 20% during hot hours, and some flights only have full-price tickets in economy class.

　　By the way, this year’s Dragon Boat Festival is different from the past, because there is an important event — — World Cup.

　　According to Ctrip data, during the small holiday,The destination with the most obvious price increase is Russia, the host of the 2018 World Cup, with the increase of more than 30% compared with the group and free travel routes.

　　However, the enthusiasm of China tourists has not diminished. During the World Cup, the number of Ctrip Russian tour groups has increased by 60%.

　　In addition, the weather is also a key factor in the journey.

　　According to the forecast of the Central Meteorological Observatory,During the Dragon Boat Festival holiday, there will be a strong rainfall process in the eastern part of southwest China, the lower reaches of Hanshui River and the north-central part of the south of the Yangtze River. There will be heavy rain in some areas and heavy rain in the local area, accompanied by strong convective weather such as short-term thunderstorms or hail.

　　If you want to travel to these places, you’d better prepare rain gear in advance.

　　Refer to the above information, make a good travel plan, and wish you a beautiful Dragon Boat Festival holiday.

　　Finally, I will tell you quietly that it will be more than three months before the next legal holiday is over after this small holiday. So, cherish the holiday and have fun.

As of 17: 00 on April 7, there are 3 high-risk areas and 6 medium-risk areas in China. Recently, I paid attention to the nucleic acid detection. You can check the results with one click here.

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    In recent years, many domestic industrial belts have successively joined the cross-border e-commerce track, and "cross-border e-commerce+industrial belt" has become one of the main forms of foreign trade. In 2024, the domestic industrial belt will face not only the cross-border blue ocean, but also the long-term high-quality sea going. The reporter’s recent visit found that some cross-border e-commerce platforms are helping the industrial belt to expand into a "new blue ocean and new growth pole" through digital means, and promoting the leap of "Made in China" in the international market competitiveness and brand power.

   Cross-border e-commerce empowers industrial belts to expand markets.

    Industrial cluster is an important carrier to promote the high-quality development of regional economy. At present, there are hundreds of light industrial clusters in China, which play an important role in regional economy. In recent years, major cross-border e-commerce platforms have begun to increase cooperation with industrial belts to help local enterprises expand overseas business opportunities more accurately and efficiently through in-depth services.

    In September 2023, Xiyin, a cross-border e-commerce platform, announced the launch of the national 500-city industrial belt plan. Within three years, it will go deep into the national 500-city industrial belt, connect the industrial belt with digital trade and digital flexible supply chain, and provide integrated empowerment from production to market sales to brand growth, helping the industrial belt expand the global market and gain brand promotion. The reporter learned that through the continuous deepening of the 500-city industrial belt going to sea plan under the platform model, the flexible supply chain model of "small single and quick response" produced by Xiyin on demand is splitting from the clothing industry to more industries, helping the industrial belt to go to sea with cross-border e-commerce, and at the same time, empowering this set of capabilities to more industrial belt sellers through platform.

    Going out to sea is not the digestion of excess capacity, but the flexible supply chain makes the market demand and supply more match. By cultivating new models and new formats, the productivity of industrial belts will be improved, and at the same time, small and medium-sized sellers will be realized. In the process of internationalization of China’s manufacturing industry, domestic characteristic industrial belts need to build their own competitive advantages in order to win. With the help of updated digital ideas and digital means, they can realize efficient resource allocation and accelerate innovation, and finally realize the overall capacity transformation and upgrading of industrial belts.

    According to the Insight Report of Cross-border E-commerce Industry 2023 Industry Belt Brand Going to Sea released by Billion Think Tank, "Cross-border E-commerce+Industry Belt" provides a strong impetus for high-quality going to sea. Cross-border e-commerce industrial belts in China have their own characteristics. With the continuous release of policy dividends, many traditional foreign trade industrial belts have achieved global business expansion through cross-border e-commerce.

   From product to brand.

    At present, China’s industrial belt has entered a new stage of intensive brand going out to sea from extensive high-speed growth. Under the background of the state’s support for the development of new foreign trade formats, many traditional foreign trade industrial belts have been actively transformed by relying on cross-border e-commerce channels and digital service tools, further focusing on brand building and global development.

    In the eyes of the industry, one way for the industry to take the brand to the sea is to take the flexible supply chain as the support and embark on the road of brand internationalization through the cross-border e-commerce platform; The other is that trade-oriented businesses transform and upgrade from distributing goods to brands, and build their own brands with the help of cross-border e-commerce platforms.

    Building its own brand and strengthening its brand power are regarded as the inevitable trend of "Made in China". Insiders pointed out that cross-border e-commerce platforms not only empower more industrial belt sellers with flexible supply chain capabilities, but also actively assist industrial belt sellers to build brand power together. The platform helps industrial belt sellers to improve a series of capabilities including product development, market trends, compliance management and supply chain management by empowering them with one-stop services. For the industrial belt, the future is not only the product going out to sea, but also the overall ability and brand power of the industrial belt going out to sea and upgrading. If the industrial belt wants to go to sea, it must achieve high-quality going to sea, and the ultimate benefit will be the comprehensive competitiveness of the whole "Made in China".

    Deng Nan, the seller of wig industry belt, paid attention to the demand of overseas consumers for wigs in his early years. Through the online Xiyin platform, the humble niche products achieved sales of 50,000 US dollars in the first month; Three years later, this number has grown to $2 million.

    "At present, industries driven by cross-border e-commerce platforms are brought out to sea, allowing China’s high-quality supply chain to directly face international consumers, opening up new international markets and promoting industrial upgrading." Zhao Lingyi, chief analyst of Shen Wanhongyuan’s research on commerce and retail, told reporters that the new format of going to sea promoted by "cross-border e-commerce+industrial belt" will further promote the transformation of China’s manufacturing industry into a China brand with independent design concept and strong market competitiveness, thus occupying a more important position in the global value chain.

   Digital innovation drives the development of industrial belt

    Last year, the General Office of the State Council issued an opinion on promoting the stable scale and excellent structure of foreign trade, proposing to support foreign trade enterprises to expand their sales channels and cultivate their own brands through new formats and new models such as cross-border e-commerce, encouraging all localities to combine their industrial and endowment advantages, innovate and build a comprehensive cross-border e-commerce experimental zone, actively develop the "cross-border e-commerce+industrial belt" model, and drive cross-border e-commerce enterprises to export to enterprises.

    Domestic emerging cross-border e-commerce platforms such as Xiyin, AliExpress and Tik Tok Xiaodian have attracted a large number of consumers and sellers through their own characteristics and unique development models, and gradually occupied an important position in the global e-commerce market. In the future, domestic cross-border e-commerce enterprises are expected to fully benefit from the continuous high penetration rate of global e-commerce and the cost-effective advantage of "Made in China" to drive the rapid development of the domestic cross-border e-commerce market. In addition, sellers related to brand going out to sea and manufacturing going out to sea are expected to benefit from the traffic dividend brought by the emerging cross-border e-commerce platform in China.

    "New advantages need to be established in the process of manufacturing internationalization. China’s manufacturing industry must take the road of increasing added value in the future. The added value comes from innovations in design, technology and products, as well as the improvement of brand power. " Hu Qimu, chief researcher of digital economy think tank, said that enterprises can make the supply chain more efficient through digital means, realize personalization and improve overall efficiency at the same time.

    Hu Qimu believes that the "cross-border e-commerce+industrial belt" model is to use digital tools to help businesses continuously optimize the supply chain, solve the problem of production balance through flexible small orders, and then digitally manage the whole process of a large number of fragmented orders, so as to realize flexible and standardized production, improve quality and efficiency, and empower more industrial belts to build new quality productivity and brands to go to sea. (Reporter Gao Shaohua)

Yang Jianfei: Computational Medicine Promotes Accurate Clinical Trials.

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Yang Jianfei, Chief Scientific Officer of Zheyuan Technology

Computational medicine needs to be composed of interdisciplinary teams and platforms. By integrating supercomputing system, AI platform, molecular and clinical data, massive literature and biological information, it can realize effective analysis and calculation of drug development and assist decision-making.

Taking an anti-tumor drug in our pipeline as an example, we read all the literatures of the target disease by using the "TWIRLS stick" of the computational medicine platform, first we have all the scientific knowledge known on the earth at present, and then we analyze the digital twins of patients in the patient database in a data-driven way to obtain the disease mechanism, specific targets and "portraits" of patients.

As we all know, the tumor is heterogeneous in time and space, and the immune system around the tumor is particularly complex. Therefore, only by having an accurate "portrait" of the patient’s tumor and accompanying diagnosis can we enter the stage of accurate clinical trials.

Through the computational medical platform, we established the response mechanism model of CDK4/6 inhibitor, and the effectiveness of this model was verified by the data of TCGA and Chinese patients. Then we put this drug currently used to treat breast cancer on the computational medical platform to study whether it has other applicable diseases. It was found that the model score of chordoma was very high, so we established cooperation with shanghai changzheng hospital and saw that some patients achieved partial remission in the third week after taking the drug. Although this drug has not yet entered the clinical trial stage, as long as it is carried out in accordance with the norms of computational medicine platform, we are confident to achieve truly accurate clinical trials.

Peng Ao: Behind the clinical success rate from 2% to 21%

Peng Ao, Project Management Team Leader of Pfizer China Product Line

The efficiency of Pfizer’s new drug research and development has increased from 2% to 21%. I think we can sum up three experiences. First, accurate positioning, clear their own specific advantages in the field of biology. Pfizer currently focuses on internal medicine, immunity and inflammation, oncology drugs and vaccines. Second, choose the drug mode. At present, more complex and novel molecular entities account for more and more in our pipelines. Thirdly, the decision-making adheres to two principles. First, quantitative POM analysis is carried out in the first and second phase of the experiment, which can help the success rate of the second phase reach 40%; The second is to plan again. If the first direction of clinical research and development fails, then we will transform it and try again in another direction. If there is a very clear biological basis, our success rate can reach 31%.

Ertuglifozin is a SGLT-2 hypoglycemic agent, and a large number of technologies and methods related to computational medicine are used in its research and development, including systematic pharmacological model and Emax Model. Using this model, the highest hypoglycemic effect of the drug can reach 77%. Meta-analysis shows that the drug has the highest hypoglycemic level among similar products. This is a typical case of using model or computational medicine to guide drug research and development.

The US Food and Drug Administration has begun to build a framework for digital health tools. I believe that after the introduction of the framework, the guiding principles of the corresponding rules will also be introduced, which will guide the application of some new drug research and development more specifically and deeply.

Tang Yu: The insights generated by computational medicine need to be verified clinically.

Tang Yu, Executive Director of the Office of Drug Clinical Trial Research Center, Cancer Hospital, China Academy of Medical Sciences

Computational medicine has produced a large number of insights by analyzing massive data, but how to prove that these insights are authentic and can be used in clinical practice through clinical trials?

The first case is to verify the specific answer given by computational medicine to a specific problem, such as verifying whether the first innovative drug under the guidance of AI can treat pancreatic cancer. The second is based on massive data to verify whether the treatment mode formulated by AI for individual patients or groups is better.

In the course of such an experiment, we need to consider several issues:

First, the consistency of the AI model. When we want to prove that an algorithm or an AI-based paradigm can guide medical care, we must ensure the consistency of the paradigm and not make it change irregularly.　

Second, it is necessary to consider whether there is an accessible clinical treatment for a class of patients with more concentrated biological characteristics found by AI model. If there is no targeted treatment, although this model can guide the prognosis of patients, it is difficult to change the existing treatment methods.

Finally, establish a model that can not only explain the results, but also explain the mechanism, so as to better combine human wisdom with the wisdom of computer based on data integration.

At present, we are carrying out an umbrella research design, focusing on soft tissue sarcoma. Although the overall incidence of the disease is not high, there are nearly 100 subtypes. Our anti-vascular targeted drugs have shown excellent effects in individual subtypes, but the overall effect is still not ideal. Therefore, we hope to use Turing Darwin’s laboratory’s in-depth analysis of the whole sarcoma mechanism and digital twin technology to find drugs with ideal curative effect and high accessibility.

Niu gang: the big disease model changes the new paradigm of drug research and development

Niu Gang, Director of Turing Darwin Laboratory

In today’s medical field, we are committed to collecting and utilizing all kinds of disease-related data, looking for clues of logical unity for diseases, and establishing complex and real mechanism portraits. But the key lies in how to understand the so-called mechanism and who is the subject of the complex mechanism?

We have built and trained a brand-new AI method-"Genome Shotgun Damage Assessment Process" (DAGG). By inputting the sequence information of human germ line or tumor genome, AI can translate the sequence gobbledygook that human can’t understand into understandable changes in cell function.

According to the information of genome variation, clinicians can use DAGG to judge whether HER2 gene is amplified in tumor cells of breast cancer patients, so as to further clarify the pathological types of patients and provide clearer and more accurate judgments for patients’ diagnosis and treatment.

With the DAGG method, we can also transform the real patient data into the digital twins of the patient and his disease. With the large-scale accumulation of patients’ digital twins in virtual environment, we conducted a large-scale virtual clinical trial for PD-1/PD-L1 monoclonal antibodies. The results showed that the efficacy of most immunodrugs with indications was not ideal.

Therefore, the virtual clinical trial based on digital twins can replace the original clinical trial results that cost tens of billions of dollars. Based on the curative effect data of a small sample of individual indications, the potential indications of other tumor diseases can be inferred. At the same time, according to the biological mechanism directly suggested by the model, the combination scheme and even new molecules can be rationally designed, which saves many clinical development steps and costs and ensures greater benefits for patients.

Shi Rong: Computational Medicine Helps Accurate Diagnosis and Treatment of Breast Cancer

Shi Rong, Secretary General of Cancer Prevention and Treatment Committee of Wu Jieping Medical Foundation.

Breast cancer is the largest cancer in the world. HER2 is a definite prognostic indicator and a predictive indicator of drug treatment effect for breast cancer, but the tumor heterogeneity of HER2 expression is obvious, and the detection method of HER2 can not meet the demand of anti-HER2 treatment. Therefore, studying the etiology of the germ line carried in the germ line genome is not only helpful to deeply understand the pathogenesis of breast cancer, but also helpful to develop new methods and provide prospective judgment for subsequent treatment.

Recently, the artificial intelligence algorithm DAGG independently developed by the computational medicine team revealed the pathogenesis of breast cancer. It is found that the signal pathway function spectrum (APSP) can be obtained by using the DAGG model based on the germline fingerprint rare coding variation data. According to the difference in the distribution of APSP between patients and people with low etiology, a prediction model can be effectively constructed to evaluate the etiological risk of female individuals, and the HER2-positive and HER2-negative breast cancer patients can be effectively distinguished.

The clinical transformation path of breast cancer based on APSP is divided into three steps. The first step is to guide the clinical treatment plan based on the pathological classification of breast cancer by APSP. The second step, based on APSP, is the extremely early diagnosis of women with breast nodules and breast cancer with familial breast cancer genetic history, so as to reduce the proportion of breast cancer patients who enter advanced and advanced stages at the first diagnosis. The third step, breast cancer risk assessment of healthy population based on APSP, fills the gap of the lack of effective primary prevention measures for breast cancer in the world.

Jiang Min: Virtual clinical trial is a new paradigm in the future.

Jiang Min, Director of the Office of National Drug Clinical Trial Institution of Peking University Cancer Hospital

From a global perspective, there have been exploratory studies on virtual clinical trials, but retrospective cases are the main ones. Regarding whether we can carry out prospective virtual trial design and generate higher-level digital evidence to verify the computer simulation model, so as to better guide clinical research, Peking University Cancer Hospital and the computational medicine team collided from the perspectives of technology and experimental requirements, forming a real landing research.

The two sides jointly carried out a parallel virtual clinical research project by using the digital twin model of patients in computational medicine. The purpose of the research is to explore the relationship between the pathogenesis of tumor and the mechanism of anti-tumor drugs. Through the virtual clinical trial, the curative effect of anti-tumor drugs is predicted, and the characteristics and differences of patients are analyzed, so as to optimize the design of clinical trials. This study compares head-to-head with a real clinical study of registered new drugs to verify the consistency between the predicted results of virtual clinical research and the curative effects of real-world clinical trials.

Virtual clinical trial is a new paradigm in the future. With the support of computational medicine technology, the future clinical trial model may be transformed into more accurate clinical trial design, which will bring a more holistic drug research and development idea, which will bring revolutionary changes to the success rate and effectiveness of clinical trials.

Roundtable Forum I: Cognition and Evaluation of Non-consensus and Subversive Technology

Moderator: Li Lei, Associate Research Fellow of Frontier Science and Education Bureau of China Academy of Sciences.

Roundtable forum site.

Lv Benfu (Professor, School of Economics and Management, Chinese Academy of Sciences)The so-called breakthrough innovation mainly depends on three points. First, whether a brand-new track has been developed; Secondly, on the original track, whether its performance-to-value ratio conforms to the law of ten times speed; Third, whether it belongs to the pattern innovation from 0 to 1 depends on the support of industrial policies.

Gu Chengming (Head of Sanofi Greater China Medical Department)The non-consensus stage is the primary stage. As long as it is accepted by the industry, it is considered as consensus, or it is available, which can solve some problems. However, in the field of drug research and development, if you want to be a First-in-Class, it must be a non-consensus. If you become a consensus, it will be Me too.

Zhang Chunming (Vice President of the Western Research Institute of Computing Technology, Zhongke)From a practical point of view, today’s world structure does not support small steps forward, and we must give full play to the ability of large-scale team operations. In terms of innovation, it is indeed possible for computational medicine to open up a brand-new track, so any government department should carefully evaluate it.

Weng Huajian (deputy head of Changning District, Shanghai)In 2021, I first learned about computational medicine. At that time, we envisaged to set up a life science innovation center between Suzhou and Shanghai, specializing in high-end research and development, focusing on computer +Inside and AI+, so as to give full play to the accumulation of digital economy in Changning, Shanghai in the past 20 years, especially the accumulation advantages of talents and innovation ecology. Therefore, from the perspective of the government, we are full of expectations for disruptive innovation technology in computational medicine.

Roundtable Forum II: Investment Logic from the Perspective of Computational Medicine

Moderator: translated by Hu Ming, partner of Mingde Capital.

Roundtable forum site.

Tian Feng (Minister of Industry Service Department of Shanghai Biomedical Industry Promotion Center)The most noteworthy point of the whole AI+ pharmaceutical industry is to change from logical successful practice to probabilistic successful practice, and finally return to logical successful practice. From the perspective of AI+ diseases, developing virtual clinical trials, I think it can effectively reduce the cost of clinical development and improve the success rate in the future.

Jing Xutian (Managing Director of Wuyuan Capital): AI technology has brought some new algorithms and breakthroughs in computing power. In the past, many AI pharmaceutical companies paid more attention to the field of small molecules with the most data and the most mature data, but today we see that more and more algorithms are actually very suitable for doing some new modal drug discovery.

Zeng Yingzhe (Partner of Linear Capital)Before AI technology, we usually build low-dimensional models to solve high-dimensional problems, but the emergence of AI can solve these high-dimensional problems. With more and more data and more powerful computing power, the prospect of AI pharmaceutical is very broad. At present, we are observing what progress the big language model will bring to AI pharmaceutical. It is exciting that some new progress has been made in the field of molecular characterization algorithms.

Ma Rui (partner of Fengrui Capital)We always overestimate the progress of computational medicine in five years, but underestimate the progress it can bring in ten years. I think that in the next three years, macromolecular protein drugs will basically be subverted by AI, just like AlphaFold in 2021 completely solved the problem of structural prediction of single domain proteins. (Photo courtesy of the organizer)

CCTV News:The State Council Press Office held a series of press conferences on promoting high-quality development on the 29th. China National Intellectual Property Administration introduces new measures for trademark application of service business entities.

As of June this year, the number of valid registered trademarks in China has reached 45.909 million, with an average of one valid trademark for every four business entities.

In order to meet the diversified trademark application needs of business entities, China National Intellectual Property Administration has set up 353 trademark business acceptance windows in 31 provinces (autonomous regions and municipalities) to provide face-to-face application and consulting services.

Hu Wenhui, deputy director of China National Intellectual Property Administration, said: "At the same time, we actively promote the electronic processing of the whole process of trademark business, optimize the user experience of online application, and discount the online application fee. At present, the online application rate of trademark registration application has reached 99.7%."

In addition, China has realized the electronization of trademark certificates to meet the application needs of mutual recognition of electronic certificates throughout the country. Strengthen the sharing of enterprise registration data and trademark registration data, and realize the synchronous acceptance and collaborative processing of enterprise change registration and trademark change application in many places.

China National Intellectual Property Administration: In the first half of the year, the intellectual property business developed steadily.

In addition, China National Intellectual Property Administration introduced on the 29th that in the first half of the year, China’s intellectual property industry developed steadily.

In the first half of this year, China authorized 554,000 invention patents, a year-on-year increase of 28.0%; There were 2.463 million registered trademarks, a year-on-year increase of 22.0%.

Ge Shu, deputy director of China National Intellectual Property Administration Patent Office, said: "The number of patent transfer licenses nationwide reached 252,000, up 35.2% year-on-year. The registered amount of patent and trademark pledge financing reached 419.9 billion yuan, a year-on-year increase of 57%, benefiting more than 20,000 enterprises. "

In addition, China issued the Implementation Plan for the Construction Project of Intellectual Property Protection System, with protection centers and fast rights protection centers covering 28 provinces (autonomous regions and municipalities), and handled 21,000 administrative cases of patent infringement disputes in the first half of the year, and the protection of intellectual property rights continued to increase.