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　　Why do you still have to queue up for non-parking charges? Provincial Communications Department Responds to Hot Issues in the Use of ETC System

　　On October 28th, it has been 21 days since the electronic toll collection system (ETC system) was opened on expressways in our province. The number of ETC customers has reached 50,681, exceeding the target of reaching 40,000 users before the end of the year. Some bank outlets even cannot handle business immediately because of insufficient hardware stock.

　　Recently, Feng Zhenglin, Vice Minister of the Ministry of Transport, proposed at a special meeting that all provinces (autonomous regions and municipalities) in China will basically be connected to the Internet before the end of 2015. This means that by the end of next year, ETC users in our province will be able to "all-in-one card" nationwide.

　　During the trial operation, the ETC system was impassable and the ETC lane was temporarily closed. On October 29th, the Expressway Monitoring and Settlement Center of the Provincial Communications Department responded to these problems.

　　Q1: Why can’t ETC pass?

　　There may be other vehicles breaking in by mistake.

　　A: This did happen at the beginning of the trial run, mainly because both hardware and software had to have a running-in period. At present, optimization is being carried out to solve the problem.

　　There are three main reasons why the ETC card cannot be used. First, the ETC card has not completed the issuance process, and it must be recharged after the first activation, even if it is only charged with 1 cent. If it is not recharged, the system will display it as an "illegal card". Second, there will be problems between lane and vehicle information interaction. Third, the vehicle without ETC system mistakenly entered ETC lane, and the system sensed that there was a car entering, but another plate of the vehicle was thrown over to take the artificial lane, which kept the ETC lane waiting for reading data. "Although we can debug and manually guide, it is still recommended that drivers who have not installed ETC should not mistakenly enter the ETC lane."

　　Q2: Why is the ETC lane closed?

　　Slow blocking and smooth during peak hours

　　A: ETC lanes have been temporarily closed, mainly concentrated in several gates of Chengdu Ring Expressway, such as connecting Chengguan Road and Chengpeng Road. At present, the utilization efficiency of ETC lane is not high, and the traffic flow is small. In the rush hour, toll station vehicles may even block the main line, which will affect the traffic safety. At this time, the high-speed will start the plan, manually watch the ETC lane, and allow vehicles without ETC system to pass through the ETC channel. This is also a measure to slow down the congestion and ensure smoothness, so drivers can understand. "

　　In addition, there are some special cases, such as Dazhou toll station, which cannot be expanded due to geographical reasons. There are only three lanes in each direction, of which one truck is used, leaving two lanes, so the ETC lane is often closed.

　　Q3: ETC is delayed?

　　OBU devices are in short supply.

　　A: At the beginning of the opening of ETC system, the established goal of Sichuan Provincial Communications Department was to develop 40,000 users by the end of the year, but as of 0: 00 on October 29, the number of ETC users in our province had reached 50,681, with an average increase of 2,100 per day. It is estimated that by the end of this year, ETC users in our province will exceed 100,000. The relevant person in charge of the Expressway Monitoring and Settlement Center of the Provincial Communications Department said, "Due to the rapid growth of users, some bank outlets have no OBU (on-board unit), and we are also urging banks to step up procurement to meet the needs of car owners."

　　At present, the province has opened 417 ETC lanes, covering 208 toll stations, with a coverage rate of 55.5%. This number will rise in the future. As of yesterday, the number of ETC lanes built in our province has reached 500. It is estimated that by next year, the ETC coverage rate of all main toll stations of Sichuan Expressway will reach 100%, and the lanes will not be less than two in and two out, while the ETC coverage rate of all ramp toll stations in the province will reach 90%.

　　Q4: Are there any other services?

　　We plan to launch ETC card in the future.

　　A: We are exploring, for example, the amount of each toll is prompted by bank SMS, and even the historical toll records are queried online. In the future, when the number of ETC users reaches a certain level, we will also open the business of handling ETC cards independently, which is equivalent to that vehicles without OBU (on-board unit) need not give change when passing through artificial lanes, but swipe ETC cards to give money, so as to improve the traffic rate of toll stations.

　　ETC usage reminder

　　1. Do not disassemble the OBU when using it; once disassembled, it will be invalid;

　　2. Vehicles equipped with ETC should not exceed 20 kilometers per hour when passing through the ETC lane, and keep a safe distance from the vehicle in front;

　　3. Ensure that the ETC card is always inserted in the OBU while the vehicle is driving;

　　4. During use, the ETC card and OBU must be in one-to-one correspondence with the vehicle, and the car is dedicated;

　　5. If you can’t get through normally or have questions about the charges, you can call 12122 for consultation. (Reporter Wang Haoye Intern Zhang Yuer)

　　Beijing, June 15th (Reporter Qiu Yu) The last legal holiday in the first half of this year — — Dragon Boat Festival is coming!

　　The college entrance examination is over, the graduation season is here, and the World Cup has begun. This small holiday, is it necessary to let go of yourself?

　　If you plan to travel, you can collect this guide, which will make you have fun and worry-free, and avoid crowds.

　　First of all, people who travel in go on road trip or by bus should pay attention:

　　Dragon boat festival holiday,High speed is not free..

　　Say it again,Normal highway toll collection during Dragon Boat Festival.

　　Trend of congestion during the national high-speed Dragon Boat Festival. Source: 2018 Dragon Boat Festival National Highway Network Travel Forecast Report issued by the Ministry of Communications in conjunction with other institutions.

　　If you want to avoid the headache traffic jam, pay attention to the following peak hours:

　　Ministry of communications estimatesJune 16th is the peak of travel.,9: 00 am to 12: 00 am on the same day is the peak travel time; Especially from 10: 00 to 11: 00, the congestion degree is the highest.

　　June 18th is the peak of return trip.,On the same day, 15: 00 -21: 00 pm was the peak time of return trip, and the peak appeared at 16: 00 -17: 00.

　　Which highway sections are prone to congestion?

　　It is estimated that the highways with high traffic flow include: Hebei section of Jingcheng Expressway, Beijing section and Hebei section of Daguang Expressway, Guangdong section of Guanfo Expressway, Hunan section of Beijing-Hong Kong-Macao Expressway, Jiangsu section, Shanghai section and Zhejiang section of Shenhai Expressway.

　　The expressway around the city with high traffic volume includes: Guangzhou Ring Road, Chengdu Ring Road, Shanghai Ring Road and Hangzhou Ring Road Expressway.

　　Provincial congestion during the Dragon Boat Festival. Source: 2018 Dragon Boat Festival National Highway Network Travel Forecast Report issued by the Ministry of Communications in conjunction with other institutions.

　　The Ministry of Communications predicts that,The high-incidence areas of expressway network in provinces are mainly concentrated in Guangdong, Beijing, Jiangsu, Zhejiang, Hebei and other areas with strong traffic demand or concentrated self-driving tourism.

　　Some people choose to travel by high-speed rail. Have you grabbed the tickets for the following popular routes?

　　Meituan Travel Big Data shows that during the Dragon Boat Festival, the demand for high-speed rail travel is mostly in the province, and the top three popular routes are Guangzhou-Shenzhen, Chengdu-Chongqing and Hefei-Lu ‘an.

　　Jingzhou-Wuhan, Beijing-Tianjin, Chengdu-Xi ‘an, Chengdu-Mianyang, Shenzhen-Xiamen, Wuhan-Yichang and Wuhan-Xiangyang high-speed rail lines are also very popular.

　　Small partners who want to fly can also find cheap air tickets in relatively "unpopular" places.

　　Ctrip data shows thatFly to Fuzhou, Kunming, Guiyang, Quanzhou and overseas destinations such as Sydney and Singapore, and the ticket price is nearly half cheaper than last year’s Dragon Boat Festival.Come and pick up the leak!

　　On the contrary, Beijing, Chengdu and Xi ‘an have become the top three popular destinations in China. It is difficult to see tickets with a discount of less than 20% during hot hours, and some flights only have full-price tickets in economy class.

　　By the way, this year’s Dragon Boat Festival is different from the past, because there is an important event — — World Cup.

　　According to Ctrip data, during the small holiday,The destination with the most obvious price increase is Russia, the host of the 2018 World Cup, with the increase of more than 30% compared with the group and free travel routes.

　　However, the enthusiasm of China tourists has not diminished. During the World Cup, the number of Ctrip Russian tour groups has increased by 60%.

　　In addition, the weather is also a key factor in the journey.

　　According to the forecast of the Central Meteorological Observatory,During the Dragon Boat Festival holiday, there will be a strong rainfall process in the eastern part of southwest China, the lower reaches of Hanshui River and the north-central part of the south of the Yangtze River. There will be heavy rain in some areas and heavy rain in the local area, accompanied by strong convective weather such as short-term thunderstorms or hail.

　　If you want to travel to these places, you’d better prepare rain gear in advance.

　　Refer to the above information, make a good travel plan, and wish you a beautiful Dragon Boat Festival holiday.

　　Finally, I will tell you quietly that it will be more than three months before the next legal holiday is over after this small holiday. So, cherish the holiday and have fun.

As of 17: 00 on April 7, there are 3 high-risk areas and 6 medium-risk areas in China. Recently, I paid attention to the nucleic acid detection. You can check the results with one click here.

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    In recent years, many domestic industrial belts have successively joined the cross-border e-commerce track, and "cross-border e-commerce+industrial belt" has become one of the main forms of foreign trade. In 2024, the domestic industrial belt will face not only the cross-border blue ocean, but also the long-term high-quality sea going. The reporter’s recent visit found that some cross-border e-commerce platforms are helping the industrial belt to expand into a "new blue ocean and new growth pole" through digital means, and promoting the leap of "Made in China" in the international market competitiveness and brand power.

   Cross-border e-commerce empowers industrial belts to expand markets.

    Industrial cluster is an important carrier to promote the high-quality development of regional economy. At present, there are hundreds of light industrial clusters in China, which play an important role in regional economy. In recent years, major cross-border e-commerce platforms have begun to increase cooperation with industrial belts to help local enterprises expand overseas business opportunities more accurately and efficiently through in-depth services.

    In September 2023, Xiyin, a cross-border e-commerce platform, announced the launch of the national 500-city industrial belt plan. Within three years, it will go deep into the national 500-city industrial belt, connect the industrial belt with digital trade and digital flexible supply chain, and provide integrated empowerment from production to market sales to brand growth, helping the industrial belt expand the global market and gain brand promotion. The reporter learned that through the continuous deepening of the 500-city industrial belt going to sea plan under the platform model, the flexible supply chain model of "small single and quick response" produced by Xiyin on demand is splitting from the clothing industry to more industries, helping the industrial belt to go to sea with cross-border e-commerce, and at the same time, empowering this set of capabilities to more industrial belt sellers through platform.

    Going out to sea is not the digestion of excess capacity, but the flexible supply chain makes the market demand and supply more match. By cultivating new models and new formats, the productivity of industrial belts will be improved, and at the same time, small and medium-sized sellers will be realized. In the process of internationalization of China’s manufacturing industry, domestic characteristic industrial belts need to build their own competitive advantages in order to win. With the help of updated digital ideas and digital means, they can realize efficient resource allocation and accelerate innovation, and finally realize the overall capacity transformation and upgrading of industrial belts.

    According to the Insight Report of Cross-border E-commerce Industry 2023 Industry Belt Brand Going to Sea released by Billion Think Tank, "Cross-border E-commerce+Industry Belt" provides a strong impetus for high-quality going to sea. Cross-border e-commerce industrial belts in China have their own characteristics. With the continuous release of policy dividends, many traditional foreign trade industrial belts have achieved global business expansion through cross-border e-commerce.

   From product to brand.

    At present, China’s industrial belt has entered a new stage of intensive brand going out to sea from extensive high-speed growth. Under the background of the state’s support for the development of new foreign trade formats, many traditional foreign trade industrial belts have been actively transformed by relying on cross-border e-commerce channels and digital service tools, further focusing on brand building and global development.

    In the eyes of the industry, one way for the industry to take the brand to the sea is to take the flexible supply chain as the support and embark on the road of brand internationalization through the cross-border e-commerce platform; The other is that trade-oriented businesses transform and upgrade from distributing goods to brands, and build their own brands with the help of cross-border e-commerce platforms.

    Building its own brand and strengthening its brand power are regarded as the inevitable trend of "Made in China". Insiders pointed out that cross-border e-commerce platforms not only empower more industrial belt sellers with flexible supply chain capabilities, but also actively assist industrial belt sellers to build brand power together. The platform helps industrial belt sellers to improve a series of capabilities including product development, market trends, compliance management and supply chain management by empowering them with one-stop services. For the industrial belt, the future is not only the product going out to sea, but also the overall ability and brand power of the industrial belt going out to sea and upgrading. If the industrial belt wants to go to sea, it must achieve high-quality going to sea, and the ultimate benefit will be the comprehensive competitiveness of the whole "Made in China".

    Deng Nan, the seller of wig industry belt, paid attention to the demand of overseas consumers for wigs in his early years. Through the online Xiyin platform, the humble niche products achieved sales of 50,000 US dollars in the first month; Three years later, this number has grown to $2 million.

    "At present, industries driven by cross-border e-commerce platforms are brought out to sea, allowing China’s high-quality supply chain to directly face international consumers, opening up new international markets and promoting industrial upgrading." Zhao Lingyi, chief analyst of Shen Wanhongyuan’s research on commerce and retail, told reporters that the new format of going to sea promoted by "cross-border e-commerce+industrial belt" will further promote the transformation of China’s manufacturing industry into a China brand with independent design concept and strong market competitiveness, thus occupying a more important position in the global value chain.

   Digital innovation drives the development of industrial belt

    Last year, the General Office of the State Council issued an opinion on promoting the stable scale and excellent structure of foreign trade, proposing to support foreign trade enterprises to expand their sales channels and cultivate their own brands through new formats and new models such as cross-border e-commerce, encouraging all localities to combine their industrial and endowment advantages, innovate and build a comprehensive cross-border e-commerce experimental zone, actively develop the "cross-border e-commerce+industrial belt" model, and drive cross-border e-commerce enterprises to export to enterprises.

    Domestic emerging cross-border e-commerce platforms such as Xiyin, AliExpress and Tik Tok Xiaodian have attracted a large number of consumers and sellers through their own characteristics and unique development models, and gradually occupied an important position in the global e-commerce market. In the future, domestic cross-border e-commerce enterprises are expected to fully benefit from the continuous high penetration rate of global e-commerce and the cost-effective advantage of "Made in China" to drive the rapid development of the domestic cross-border e-commerce market. In addition, sellers related to brand going out to sea and manufacturing going out to sea are expected to benefit from the traffic dividend brought by the emerging cross-border e-commerce platform in China.

    "New advantages need to be established in the process of manufacturing internationalization. China’s manufacturing industry must take the road of increasing added value in the future. The added value comes from innovations in design, technology and products, as well as the improvement of brand power. " Hu Qimu, chief researcher of digital economy think tank, said that enterprises can make the supply chain more efficient through digital means, realize personalization and improve overall efficiency at the same time.

    Hu Qimu believes that the "cross-border e-commerce+industrial belt" model is to use digital tools to help businesses continuously optimize the supply chain, solve the problem of production balance through flexible small orders, and then digitally manage the whole process of a large number of fragmented orders, so as to realize flexible and standardized production, improve quality and efficiency, and empower more industrial belts to build new quality productivity and brands to go to sea. (Reporter Gao Shaohua)

Yang Jianfei: Computational Medicine Promotes Accurate Clinical Trials.

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Yang Jianfei, Chief Scientific Officer of Zheyuan Technology

Computational medicine needs to be composed of interdisciplinary teams and platforms. By integrating supercomputing system, AI platform, molecular and clinical data, massive literature and biological information, it can realize effective analysis and calculation of drug development and assist decision-making.

Taking an anti-tumor drug in our pipeline as an example, we read all the literatures of the target disease by using the "TWIRLS stick" of the computational medicine platform, first we have all the scientific knowledge known on the earth at present, and then we analyze the digital twins of patients in the patient database in a data-driven way to obtain the disease mechanism, specific targets and "portraits" of patients.

As we all know, the tumor is heterogeneous in time and space, and the immune system around the tumor is particularly complex. Therefore, only by having an accurate "portrait" of the patient’s tumor and accompanying diagnosis can we enter the stage of accurate clinical trials.

Through the computational medical platform, we established the response mechanism model of CDK4/6 inhibitor, and the effectiveness of this model was verified by the data of TCGA and Chinese patients. Then we put this drug currently used to treat breast cancer on the computational medical platform to study whether it has other applicable diseases. It was found that the model score of chordoma was very high, so we established cooperation with shanghai changzheng hospital and saw that some patients achieved partial remission in the third week after taking the drug. Although this drug has not yet entered the clinical trial stage, as long as it is carried out in accordance with the norms of computational medicine platform, we are confident to achieve truly accurate clinical trials.

Peng Ao: Behind the clinical success rate from 2% to 21%

Peng Ao, Project Management Team Leader of Pfizer China Product Line

The efficiency of Pfizer’s new drug research and development has increased from 2% to 21%. I think we can sum up three experiences. First, accurate positioning, clear their own specific advantages in the field of biology. Pfizer currently focuses on internal medicine, immunity and inflammation, oncology drugs and vaccines. Second, choose the drug mode. At present, more complex and novel molecular entities account for more and more in our pipelines. Thirdly, the decision-making adheres to two principles. First, quantitative POM analysis is carried out in the first and second phase of the experiment, which can help the success rate of the second phase reach 40%; The second is to plan again. If the first direction of clinical research and development fails, then we will transform it and try again in another direction. If there is a very clear biological basis, our success rate can reach 31%.

Ertuglifozin is a SGLT-2 hypoglycemic agent, and a large number of technologies and methods related to computational medicine are used in its research and development, including systematic pharmacological model and Emax Model. Using this model, the highest hypoglycemic effect of the drug can reach 77%. Meta-analysis shows that the drug has the highest hypoglycemic level among similar products. This is a typical case of using model or computational medicine to guide drug research and development.

The US Food and Drug Administration has begun to build a framework for digital health tools. I believe that after the introduction of the framework, the guiding principles of the corresponding rules will also be introduced, which will guide the application of some new drug research and development more specifically and deeply.

Tang Yu: The insights generated by computational medicine need to be verified clinically.

Tang Yu, Executive Director of the Office of Drug Clinical Trial Research Center, Cancer Hospital, China Academy of Medical Sciences

Computational medicine has produced a large number of insights by analyzing massive data, but how to prove that these insights are authentic and can be used in clinical practice through clinical trials?

The first case is to verify the specific answer given by computational medicine to a specific problem, such as verifying whether the first innovative drug under the guidance of AI can treat pancreatic cancer. The second is based on massive data to verify whether the treatment mode formulated by AI for individual patients or groups is better.

In the course of such an experiment, we need to consider several issues:

First, the consistency of the AI model. When we want to prove that an algorithm or an AI-based paradigm can guide medical care, we must ensure the consistency of the paradigm and not make it change irregularly.　

Second, it is necessary to consider whether there is an accessible clinical treatment for a class of patients with more concentrated biological characteristics found by AI model. If there is no targeted treatment, although this model can guide the prognosis of patients, it is difficult to change the existing treatment methods.

Finally, establish a model that can not only explain the results, but also explain the mechanism, so as to better combine human wisdom with the wisdom of computer based on data integration.

At present, we are carrying out an umbrella research design, focusing on soft tissue sarcoma. Although the overall incidence of the disease is not high, there are nearly 100 subtypes. Our anti-vascular targeted drugs have shown excellent effects in individual subtypes, but the overall effect is still not ideal. Therefore, we hope to use Turing Darwin’s laboratory’s in-depth analysis of the whole sarcoma mechanism and digital twin technology to find drugs with ideal curative effect and high accessibility.

Niu gang: the big disease model changes the new paradigm of drug research and development

Niu Gang, Director of Turing Darwin Laboratory

In today’s medical field, we are committed to collecting and utilizing all kinds of disease-related data, looking for clues of logical unity for diseases, and establishing complex and real mechanism portraits. But the key lies in how to understand the so-called mechanism and who is the subject of the complex mechanism?

We have built and trained a brand-new AI method-"Genome Shotgun Damage Assessment Process" (DAGG). By inputting the sequence information of human germ line or tumor genome, AI can translate the sequence gobbledygook that human can’t understand into understandable changes in cell function.

According to the information of genome variation, clinicians can use DAGG to judge whether HER2 gene is amplified in tumor cells of breast cancer patients, so as to further clarify the pathological types of patients and provide clearer and more accurate judgments for patients’ diagnosis and treatment.

With the DAGG method, we can also transform the real patient data into the digital twins of the patient and his disease. With the large-scale accumulation of patients’ digital twins in virtual environment, we conducted a large-scale virtual clinical trial for PD-1/PD-L1 monoclonal antibodies. The results showed that the efficacy of most immunodrugs with indications was not ideal.

Therefore, the virtual clinical trial based on digital twins can replace the original clinical trial results that cost tens of billions of dollars. Based on the curative effect data of a small sample of individual indications, the potential indications of other tumor diseases can be inferred. At the same time, according to the biological mechanism directly suggested by the model, the combination scheme and even new molecules can be rationally designed, which saves many clinical development steps and costs and ensures greater benefits for patients.

Shi Rong: Computational Medicine Helps Accurate Diagnosis and Treatment of Breast Cancer

Shi Rong, Secretary General of Cancer Prevention and Treatment Committee of Wu Jieping Medical Foundation.

Breast cancer is the largest cancer in the world. HER2 is a definite prognostic indicator and a predictive indicator of drug treatment effect for breast cancer, but the tumor heterogeneity of HER2 expression is obvious, and the detection method of HER2 can not meet the demand of anti-HER2 treatment. Therefore, studying the etiology of the germ line carried in the germ line genome is not only helpful to deeply understand the pathogenesis of breast cancer, but also helpful to develop new methods and provide prospective judgment for subsequent treatment.

Recently, the artificial intelligence algorithm DAGG independently developed by the computational medicine team revealed the pathogenesis of breast cancer. It is found that the signal pathway function spectrum (APSP) can be obtained by using the DAGG model based on the germline fingerprint rare coding variation data. According to the difference in the distribution of APSP between patients and people with low etiology, a prediction model can be effectively constructed to evaluate the etiological risk of female individuals, and the HER2-positive and HER2-negative breast cancer patients can be effectively distinguished.

The clinical transformation path of breast cancer based on APSP is divided into three steps. The first step is to guide the clinical treatment plan based on the pathological classification of breast cancer by APSP. The second step, based on APSP, is the extremely early diagnosis of women with breast nodules and breast cancer with familial breast cancer genetic history, so as to reduce the proportion of breast cancer patients who enter advanced and advanced stages at the first diagnosis. The third step, breast cancer risk assessment of healthy population based on APSP, fills the gap of the lack of effective primary prevention measures for breast cancer in the world.

Jiang Min: Virtual clinical trial is a new paradigm in the future.

Jiang Min, Director of the Office of National Drug Clinical Trial Institution of Peking University Cancer Hospital

From a global perspective, there have been exploratory studies on virtual clinical trials, but retrospective cases are the main ones. Regarding whether we can carry out prospective virtual trial design and generate higher-level digital evidence to verify the computer simulation model, so as to better guide clinical research, Peking University Cancer Hospital and the computational medicine team collided from the perspectives of technology and experimental requirements, forming a real landing research.

The two sides jointly carried out a parallel virtual clinical research project by using the digital twin model of patients in computational medicine. The purpose of the research is to explore the relationship between the pathogenesis of tumor and the mechanism of anti-tumor drugs. Through the virtual clinical trial, the curative effect of anti-tumor drugs is predicted, and the characteristics and differences of patients are analyzed, so as to optimize the design of clinical trials. This study compares head-to-head with a real clinical study of registered new drugs to verify the consistency between the predicted results of virtual clinical research and the curative effects of real-world clinical trials.

Virtual clinical trial is a new paradigm in the future. With the support of computational medicine technology, the future clinical trial model may be transformed into more accurate clinical trial design, which will bring a more holistic drug research and development idea, which will bring revolutionary changes to the success rate and effectiveness of clinical trials.

Roundtable Forum I: Cognition and Evaluation of Non-consensus and Subversive Technology

Moderator: Li Lei, Associate Research Fellow of Frontier Science and Education Bureau of China Academy of Sciences.

Roundtable forum site.

Lv Benfu (Professor, School of Economics and Management, Chinese Academy of Sciences)The so-called breakthrough innovation mainly depends on three points. First, whether a brand-new track has been developed; Secondly, on the original track, whether its performance-to-value ratio conforms to the law of ten times speed; Third, whether it belongs to the pattern innovation from 0 to 1 depends on the support of industrial policies.

Gu Chengming (Head of Sanofi Greater China Medical Department)The non-consensus stage is the primary stage. As long as it is accepted by the industry, it is considered as consensus, or it is available, which can solve some problems. However, in the field of drug research and development, if you want to be a First-in-Class, it must be a non-consensus. If you become a consensus, it will be Me too.

Zhang Chunming (Vice President of the Western Research Institute of Computing Technology, Zhongke)From a practical point of view, today’s world structure does not support small steps forward, and we must give full play to the ability of large-scale team operations. In terms of innovation, it is indeed possible for computational medicine to open up a brand-new track, so any government department should carefully evaluate it.

Weng Huajian (deputy head of Changning District, Shanghai)In 2021, I first learned about computational medicine. At that time, we envisaged to set up a life science innovation center between Suzhou and Shanghai, specializing in high-end research and development, focusing on computer +Inside and AI+, so as to give full play to the accumulation of digital economy in Changning, Shanghai in the past 20 years, especially the accumulation advantages of talents and innovation ecology. Therefore, from the perspective of the government, we are full of expectations for disruptive innovation technology in computational medicine.

Roundtable Forum II: Investment Logic from the Perspective of Computational Medicine

Moderator: translated by Hu Ming, partner of Mingde Capital.

Roundtable forum site.

Tian Feng (Minister of Industry Service Department of Shanghai Biomedical Industry Promotion Center)The most noteworthy point of the whole AI+ pharmaceutical industry is to change from logical successful practice to probabilistic successful practice, and finally return to logical successful practice. From the perspective of AI+ diseases, developing virtual clinical trials, I think it can effectively reduce the cost of clinical development and improve the success rate in the future.

Jing Xutian (Managing Director of Wuyuan Capital): AI technology has brought some new algorithms and breakthroughs in computing power. In the past, many AI pharmaceutical companies paid more attention to the field of small molecules with the most data and the most mature data, but today we see that more and more algorithms are actually very suitable for doing some new modal drug discovery.

Zeng Yingzhe (Partner of Linear Capital)Before AI technology, we usually build low-dimensional models to solve high-dimensional problems, but the emergence of AI can solve these high-dimensional problems. With more and more data and more powerful computing power, the prospect of AI pharmaceutical is very broad. At present, we are observing what progress the big language model will bring to AI pharmaceutical. It is exciting that some new progress has been made in the field of molecular characterization algorithms.

Ma Rui (partner of Fengrui Capital)We always overestimate the progress of computational medicine in five years, but underestimate the progress it can bring in ten years. I think that in the next three years, macromolecular protein drugs will basically be subverted by AI, just like AlphaFold in 2021 completely solved the problem of structural prediction of single domain proteins. (Photo courtesy of the organizer)

CCTV News:The State Council Press Office held a series of press conferences on promoting high-quality development on the 29th. China National Intellectual Property Administration introduces new measures for trademark application of service business entities.

As of June this year, the number of valid registered trademarks in China has reached 45.909 million, with an average of one valid trademark for every four business entities.

In order to meet the diversified trademark application needs of business entities, China National Intellectual Property Administration has set up 353 trademark business acceptance windows in 31 provinces (autonomous regions and municipalities) to provide face-to-face application and consulting services.

Hu Wenhui, deputy director of China National Intellectual Property Administration, said: "At the same time, we actively promote the electronic processing of the whole process of trademark business, optimize the user experience of online application, and discount the online application fee. At present, the online application rate of trademark registration application has reached 99.7%."

In addition, China has realized the electronization of trademark certificates to meet the application needs of mutual recognition of electronic certificates throughout the country. Strengthen the sharing of enterprise registration data and trademark registration data, and realize the synchronous acceptance and collaborative processing of enterprise change registration and trademark change application in many places.

China National Intellectual Property Administration: In the first half of the year, the intellectual property business developed steadily.

In addition, China National Intellectual Property Administration introduced on the 29th that in the first half of the year, China’s intellectual property industry developed steadily.

In the first half of this year, China authorized 554,000 invention patents, a year-on-year increase of 28.0%; There were 2.463 million registered trademarks, a year-on-year increase of 22.0%.

Ge Shu, deputy director of China National Intellectual Property Administration Patent Office, said: "The number of patent transfer licenses nationwide reached 252,000, up 35.2% year-on-year. The registered amount of patent and trademark pledge financing reached 419.9 billion yuan, a year-on-year increase of 57%, benefiting more than 20,000 enterprises. "

In addition, China issued the Implementation Plan for the Construction Project of Intellectual Property Protection System, with protection centers and fast rights protection centers covering 28 provinces (autonomous regions and municipalities), and handled 21,000 administrative cases of patent infringement disputes in the first half of the year, and the protection of intellectual property rights continued to increase.

A few years ago, there was a movie called Shopaholic, which told the story of several people who were addicted to shopping. When they saw their favorite items, they couldn’t stop, even if they owed huge credit card debts, they had to take them home. Such people are called shopaholic in English. By analogy, then the "chatter" we are talking about today is talkaholic.

Talkaholic is a person who takes great pleasure in talking. A talkaholic has trouble keeping quiet and listening when other people are around.

Talkaholic refers to someone who likes talking and enjoys it, which is what we call "chattering" Generally, when others are present, it is difficult to talk without listening to others.

Similar words like workaholic and shopaholic are all ended with the same suffix -aholic, which means of an obsessive interest in something.

Both Workaholic and shopaholic, like talkaholic, have the suffix -aholic, which means they are extremely interested in or addicted to something.

For example:

Jane was a talkaholic who gave everyone her opinion whether they asked for it or not.

Jane is a chatty talker. She always gives her opinion whether others want to listen or not.

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(Edited by China Daily English Dianjin Helen)

Click to see more English idioms and new words.

　　General Secretary of the Supreme Leader pointed out at the National Ecological Environmental Protection Conference: "Deepen the application of digital technologies such as artificial intelligence, build a beautiful digital governance system in China, and build a green and intelligent digital ecological civilization." At present, the integration and mutual promotion of digitalization and greening has become an important theme of global development. To promote the intelligent management of ecological environment and the construction of digital ecological civilization with green wisdom, we must adhere to the guidance of Socialism with Chinese characteristics Thought of the Supreme Leader in the new era, comprehensively implement the ecological civilization thought of the Supreme Leader, promote the comprehensive green transformation of economic and social development with digitalization, and provide strong support for the modernization of harmonious coexistence between man and nature.

　　The integration of digitalization and greening has become an important trend in the construction of ecological civilization.

　　Ecological civilization construction covers a wide range and is comprehensive, involving many aspects such as value concept, goal orientation, production and consumption mode, etc. It is a complex systematic project. Promoting the construction of digital ecological civilization can effectively enhance the systematicness and synergy of ecological civilization construction, and promote the formation of scientific and efficient methods and paths to solve ecological environment problems and expand ecological environment governance.

　　As a way of ecological environment governance, digital ecological civilization construction organically embeds big data, 5G, artificial intelligence and other digital technologies into ecological civilization construction, and continuously improves the scientific, refined and intelligent level of ecological civilization construction in the deep integration of digitalization and greening. The key to building digital ecological civilization lies in coordinating the relationship between digitalization and greening, and promoting their mutual promotion and coordinated development. Promoting digital construction, using artificial intelligence and other technologies to discover the laws behind the data, and fully releasing the superposition, aggregation and multiplication effects of digital technology in improving the efficiency, technological improvement and means optimization of ecological environment governance can provide an important engine for ecological environment governance and help to achieve efficient and sustainable ecological environment governance effects. Promoting green development is the proper meaning of building digital ecological civilization. By optimizing the spatial layout of the country, improving the utilization efficiency of resources and energy, strengthening environmental protection and ecological restoration, focusing on solving problems such as environmental pollution and ecological damage in the development process, matching resources, production, consumption and other factors is conducive to the simultaneous advancement of high-quality development and high-level protection.

　　Since the 18th National Congress of the Communist Party of China, under the guidance of the Supreme Leader’s New Era Socialism with Chinese characteristics Thought, especially the Supreme Leader’s Ecological Civilization Thought, China’s digital ecological civilization construction has made great progress, and the level of intelligent management of ecological environment has been significantly improved. In February this year, the CPC Central Committee and the State Council issued the Overall Layout Plan for the Construction of Digital China, which made "positive progress in the construction of digital ecological civilization" as an important goal for the construction of digital China in 2025, and put forward new requirements for the new generation of digital technology to help ecological governance. In the process of promoting the deep integration of digitalization and greening, China’s energy consumption in the whole chain has been significantly reduced, production efficiency and energy efficiency have been continuously improved, and the ecological benefits and economic and social benefits of green mountains have been continuously brought into play. At the same time, we should also realize that the construction of digital ecological civilization in China is still in its infancy, and there are still some problems to be solved in the construction of digital infrastructure, the construction of data standards and norms, the transformation and application of scientific and technological achievements, and the cultivation of digital ecological civilization talents. We should pay more attention to the use of digital technology to innovate the way of ecological civilization construction, constantly promote the deep integration of digitalization and greening, lead greening with digitalization, drive digitalization with greening, focus on strengthening the collection, adaptation, reconstruction and sharing of ecological environment big data, fully release the potential and vitality of ecological environment governance through digital ecological environment technological innovation, and provide strong kinetic energy for building a beautiful China.

　　Provide strong kinetic energy for the modernization of harmonious coexistence between man and nature.

　　The General Secretary of the Supreme Leader stressed: "We must plan development from the height of harmonious coexistence between man and nature, constantly shape new kinetic energy and advantages of development through high-level environmental protection, and strive to build a green and low-carbon circular economy system, effectively reduce the resource and environmental costs of development, and continuously enhance the potential and stamina of development." Building a green and intelligent digital ecological civilization provides strong technical support for accurate identification, real-time tracking of environmental data, timely judgment and systematic solution of ecological problems, and provides strong kinetic energy for promoting a comprehensive green transformation of economic and social development and building a harmonious coexistence between man and nature.

　　Effectively improve the level of intelligent governance of the ecological environment. Building a digital ecological civilization, integrating ecological environment data into digital technologies such as artificial intelligence, and constantly strengthening machine learning and training will not only help to analyze the historical evolution process of ecological environment more scientifically, but also provide important decision-making reference for timely judgment and systematic solution of ecological environment problems in pollution warning, duration prediction and emission reduction effect prediction, and promote the change of decision-making process from "empirical judgment" to "data analysis", making ecological environment governance more "smart" For example, in the Great Protection of the Yangtze River, the relevant departments have established a "data collection and management —" by building a monitoring network of the whole basin’s ecological environment from Qinghai to Shanghai, collecting and sorting out massive ecological environment data in the Yangtze River basin, developing and integrating water quality diagnosis, forecasting and early warning, pollution traceability, scenario simulation and other functions. Data Mining and Simulation — Virtual visualization — Analysis of pollution traceability — The digital management business system of water environment based on intelligent decision-making provides an important technical guarantee for realizing "one river with clear water flowing eastward".

　　Promote the transformation of ecological environment governance to synergy. In the past, due to the insufficient sharing of ecological environment data and information among regions, departments and units, the ecological environment governance has been fragmented to some extent, and the problem of "repeated governance and repeated governance" in some local ecological environment governance is more prominent. Building a digital ecological civilization and building a "network" of ecological environment data will help to break down data barriers, realize data interconnection, and consolidate the data foundation for the transformation of ecological environment governance paradigm from fragmentation and fragmentation to synergy and integrity. For example, in the response to heavily polluted weather, we should follow the general policy of holistic and whole-process collaborative governance, promote the sharing of basic data among relevant government departments, different scientific research institutions and different disciplines, carry out collaborative research on key areas and key issues, and scientifically put forward the timetable and roadmap for continuous improvement of air quality, so as to provide support for the realization of "blue sky, white clouds and twinkling stars".

　　Accelerate the pace of green and low carbon transformation. Digital technology, represented by a new generation of artificial intelligence, is accelerating the evolution of global scientific and technological revolution and industrial transformation, and promoting the reform of global governance system. Digitalization empowers the construction of ecological civilization and has the efficiency of "1+1>2". Intelligent manufacturing technology strengthens the data analysis ability of manufacturing enterprises in process, manufacturing, logistics and other aspects, and reduces the pollutant emission and carbon emission of product manufacturing; Smart energy system explores the data value of energy production, transmission, distribution, storage and other links, monitors and adjusts energy generation in real time, and improves the utilization efficiency of renewable energy; By establishing a carbon inclusive platform for green living, smart cities will count individual emission reductions into individual carbon assets and turn intangible green behaviors into tangible green values. To promote high-quality economic and social development, we need to keep up with the development trend of world science and technology, embrace digital technology, further improve the endogenous driving force of green and low-carbon transformation of production and lifestyle, and make economic and social development have higher green content, lower carbon content and more gold content.

　　Deepen the application of digital technology in the field of ecological environment

　　The construction of digital ecological civilization can focus on platform construction, data mining, digital intelligence integration, policy guarantee and other aspects to form a "network" and a "map", research and develop data value mining algorithms, promote the deep application of digital technology in the field of ecological environment, and give full play to the basic and leading role of digital ecological environment technology in the construction of beautiful China.

　　Improve the stereoscopic intelligence perception of the sky "a net". The collection and transmission of information is the key link in the construction of digital ecological civilization. At present, it is necessary to do a good job in the top-level design of digital ecological civilization infrastructure construction, build a three-dimensional multi-source monitoring and sensing network system for ecological environment, strengthen the application of big data acquisition technologies such as satellite remote sensing, aerial photography of unmanned aerial vehicles, automatic ground monitoring stations, underwater robots and the Internet of Things, continuously expand the accuracy and space-time breadth of monitoring, and build a multi-means comprehensive and fast-responding monitoring network covering various environmental elements of the atmosphere, water, soil, ecology and ocean to realize global monitoring and sensing of ecological environment elements. Strengthen the construction of digital infrastructure that adapts to intelligent decision-making and green development, and build an "information high-speed rail" for the safe and rapid circulation of ecological environment data, laying a solid foundation for the rapid and accurate use of data.

　　Form a "one map" of national ecological environment data. Data is the key to the construction of digital ecological civilization, but fragmented data can’t play its value. To speed up the collection of eco-environmental data, on the one hand, it is necessary to promote the collection and exchange of eco-environmental data, and realize the cross-level communication and cross-departmental sharing of eco-environmental monitoring and monitoring data and their related information. Comprehensively collect environmental data such as environmental quality, pollution sources, sewage outlets, and ecological environment functional zoning, and promote coordinated management, precise management, and overall improvement of regional ecological environment with resource sharing, complementary advantages, and mutual benefit, so that the data can "run" out of great value. At the same time, strengthen data connectivity with natural resources, water conservancy, meteorology, energy, agriculture, forestry, transportation and other fields, and promote multi-source data integration. On the other hand, it is necessary to firmly grasp the standard, improve the standard system for the collection, integration, classification, sharing and application of eco-environmental data, and actively promote the formulation of digital international standards in the field of eco-environment, so as to contribute to building a green "Belt and Road" and building a global ecological civilization.

　　Develop a value mining algorithm for massive data. The model is the golden key to open the data treasure mine. It is necessary to make full use of digital technologies such as augmented reality and artificial intelligence, strengthen large-scale model simulation, form a more comprehensive and scientific understanding of the evolution of ecological environment and the causes of pollution, and provide multi-dimensional data analysis, early warning and forecasting, and traceability for scientific decision-making and precise governance. Using big data analysis, artificial intelligence, visualization and other technologies, we will strengthen the research and development of digital technologies such as intelligent perception and sharing, fusion and deduction, characterization and expression of environmental data, and inject wisdom genes into key areas such as ecological environment monitoring and early warning, integrated protection and system management of grass and sand in mountains, rivers, forests, fields and lakes, comprehensive prevention and control of multi-media environmental pollution, solid waste reduction and resource utilization, new pollutant control, and response to climate change, and continuously enrich the application scenarios of digital technologies in the field of ecological environmental protection.

　　Promote digital technology to be embedded in the whole process of environmental governance. The deep integration of digital technology and environmental governance has greatly improved the modernization level of ecological environmental governance. Give full play to the advantages of digital technology in breaking through the limitation of information time and space, smooth the interactive channels across regions, levels and departments, gather the strength and wisdom of the government, enterprises and the public, promote the formation of a networked and open multi-collaborative governance pattern, and integrate digital technology into the whole business and life-cycle management of ecological environment such as monitoring and evaluation, supervision and law enforcement, so as to improve the efficiency of environmental governance. Leading green development with digital transformation and optimization of ecological environment management, promoting the transformation and upgrading of industries such as steel, coal, electricity, chemicals and building materials, improving green total factor productivity, reducing energy and material consumption in the whole chain, and promoting the organic unity of economic benefits and ecological benefits.

　　Lay a good job in policies, talents and combination boxing. Constantly improve the policy system that is conducive to the deep integration of digital technology and ecological civilization construction, dismantle the barrier between the environmental governance side and the technology supply side, and create an innovative environment where major digital scientific and technological achievements in the ecological environment field are constantly emerging. Strengthen the research on relevant laws, regulations and policies, and strengthen the open sharing of data on the premise of ensuring data security. Cultivate and introduce compound cross-border talents with professional knowledge in digital technology and ecological environment, and form a three-dimensional and high-level echelon of digital technology talents in ecological environment. We will build a scientific research management system and mechanism conducive to the breakthrough of the core technology of digital ecological civilization, establish and improve a market-oriented diversified investment model, and increase support for digital strategic frontiers and applied basic research in the field of ecological environment.

　　(The author is Dean of china environmental science Research Institute)

1905 movie network news It’s another year of fashion week! On September 15th, local time, in London, England, David Beckham brought a handsome boy and a beautiful woman to his wife’s Victoria fashion brand launch conference. On the same day, Beckham made a handsome appearance in a gray suit; The three sons, Brooklyn Beckham, Romeo Beckham and cruz beckham, all chose casual clothes and sat side by side with their father.

Harper seven beckham, the "Seven Princesses" who has attracted much attention, is dressed in a floral dress with a high ball head, and is full of celebrities. From time to time, Qi Princess, who sits on her father’s lap, has a hot chat with anna wintour, the "devil wears Prada" beside her.

Pacific science and technology informationOn August 22nd, Apple’s marketing team did an excellent job in promoting the advantages of its products and chips, even if it meant misleading consumers into believing that they were actually investing in cutting-edge products. Previously, the market generally thought that the iPhone 14 Pro and iPhone 14 Pro Max were equipped with A16 bionic chips manufactured by TSMC in a 4-nanometer process. However, a person familiar with the matter overturned this view. He revealed that Apple internally marked this chip as a 5-nanometer chip, instead of the expected 4 nanometers.

The whistleblower further confirmed that A16 bionic chip was labeled as a 5-nanometer chip inside Apple. This may explain why Apple mentioned in the press release that the M2 Pro and M2 Max chips in the new 14-inch and 16-inch MacBook Pro models are mass-produced on the 5-nanometer process instead of the 4-nanometer process.

On the other hand, Apple’s next-generation A17 bionic chip is determined to adopt TSMC’s most advanced 3 nm process. Due to the transition from 5 nm to 3 nm, the performance leap between A16 and A17 will be huge. It is reported that in the previous benchmark test, compared with the previous generation, A17 bionic chip has improved as much as 31% in single-core and multi-core results.

It is worth noting that this latest news makes the upcoming iPhone 15 Pro and iPhone 15 Pro Max more attractive, because both phones will be equipped with A17 bionic chips. However, the relatively low-priced iPhone 15 and iPhone 15 Plus may use A16 bionic chip.

However, this has also triggered netizens’ speculation, whether A17 is just another product promoted by Apple’s comprehensive marketing promotion, or whether the customized chip is actually designed and mass-produced on a brand-new architecture. Some netizens claimed that TSMC’s 3-nanometer process may only reduce the 5-nanometer nodes, and the real 3-nanometer process should adopt N3E technology. So far, we are disappointed that A16 is not a 4nm component, but this is not surprising, because the company always follows this practice.