1. Amazon International

Amazon.com is the world’s largest online store, which sells all over the world. Payment methods are usually international credit cards and debit cards. Amazon allows buyers to pay in local currency.

2、eBay

EBay is an online auction and shopping website that allows people all over the world to buy and sell goods online. EBay is a great website for anyone who wants to buy things from foreign countries. However, not all suppliers on eBay ship goods worldwide.

3. Ali Express

AliExpress is a cross-border e-commerce platform built by Alibaba for the international market, and it is called "International Taobao" by the majority of sellers. AliExpress is the third largest English online shopping website in the world, which faces overseas buyers and customers, conducts secured transactions through Alipay international accounts and uses international logistics channels to transport and deliver goods.

4、 Indiamart.com

Indiamart is a well-known trade B2B website in India. Its purpose is to promote cooperation between buyers and suppliers from all over the world and help them trade with each other, thus bringing wide business opportunities to suppliers and rewarding suppliers from all over the world by creating profits. In fact, this is a dropshipping website. People all over the world can order all kinds of things from India and then sell them through dropshipping.

Indiamart doesn’t sell anything directly. Instead, it lists the products of countless manufacturers. Most of these manufacturers can deliver goods on a global scale.

5、KrisShop

KrisShop is an international shopping website, which is sold all over the world. It is actually a duty-free shop from Singapore. KrisShop’s business began with selling all kinds of duty-free goods on Singapore Airlines flights. KrisShop also runs an online store where sellers can order high-quality goods without paying local taxes in various countries.

6、Laphroaig

Laphroaig is one of the top scotch whiskies in the world. They also have an international shopping website, where you can buy high-quality whisky produced by Laphroaig. Laphroaig also offers a wide range of branded clothing, bar requirements and souvenirs. Buyers need to be at least 18 years old to enter the website.

7、Maven POS

If buyers want to buy imported cigarettes, high-grade perfume, cheap wine and other supplies, they can go to Maven POS. This is an online store headquartered in Britain, which can help buyers buy cheap goods from duty-free shops all over the world. Maven POS has also established a cooperative relationship with Dubai Duty Free.

8、Nike

Nike.com comes from the eponymous brand of best-selling sports goods and sportswear. Buyers can buy almost all kinds of sporting goods from Nike.com. Nike.com has business in most countries. This means that you can easily buy Nike products from foreign countries and pay the equivalent in local currency.

9、Coleman

Coleman is an international shopping website for camping and outdoor life lovers, providing more than 10,000 kinds of products, including outdoor lighting, camping supplies, gas appliances and cookers, thermal insulation products, water sports and so on. Coleman accepts international orders and delivers them around the world.

10、 USA.gov

The federal government of the United States also sells many things online. These include souvenirs, collectibles, stamps, coins, books and other various commodities. USA.gov carries out international transportation through the United States Postal Service (USPS).

Discovery Store, an international shopping website, is owned and operated by the world-famous Discovery Channel. People all over the world can order from Discovery Store because they deliver goods all over the world. Discovery Store has a large number of educational toys, clothes, books, stickers, posters, gifts and souvenirs.

11. Royal Mail

For collectors of stamps and souvenirs, Royal Mail operates an international shopping website where buyers can buy some amazing collections. Royal Mail also delivers around the world.

12. Lotte International

Rakuten, a popular online store in Japan, also provides an international shopping website, which is sold all over the world. Buyers only need an international credit card or debit card to pay for shopping.

(Source: cross-border e-commerce BB machine)

The above content belongs to the author’s personal opinion and does not represent Hugo’s position! This article is exclusively authorized by the original author, and the reprint needs the authorization of Hugo. com.

(Source: cross-border e-commerce BB machine)

From AlphaGo’s battle with Ke Jie to OpenAI’s bloody abuse of Dota2 semi-professional players, AI once again stepped onto the stage of history. Since 2012, thanks to the increase in data volume and the substantial increase in computing power due to the emergence of deep learning, artificial intelligence has begun to explode.

However, there are reports that IBM’s medical department has laid off a large number of employees, with a scale of 50%-70%; Then there was news from STAT, an American medical media. STAT got a document from Andrew Norden, then the deputy chief health officer of IBM Watson Health. The report showed that doctors who were using Watson for Oncology(Watson strong criticisms, pointing out that Watson often made inaccurate medical advice, which made IBM Watson fall into the biggest crisis of trust in history. Recently, some media surveys have pointed out that many medical imaging AI products are lying in the hospital "eating ash".

Behind the medical AI carnival is the embarrassment that new technologies frequently encounter the application of landing scenes. Is medical AI a conceptual obscenity or just a capital game? If the technical scene can be realized, then what characteristics of products can be truly accepted by hospitals and avoid the fate of "eating ash"?

At present, the development trend of artificial intelligence is unstoppable. From abroad to China, from capital giants to technology giants, the smart medical industry has been actively deployed. Medical imaging AI is highly favored by capital and is considered to be the first to be commercialized, which is expected to achieve overtaking in corners.

At present, many companies have developed products to assist doctors in different departments, which are accelerating the commercial layout. However, after the carnival from 2017 to the first half of 2018, medical AI companies did not seem to hand over a beautiful answer sheet. It is reported that there are as many as 10 medical AI companies cooperating with the Imaging Department of Run Run Run Shaw Hospital in Zhejiang.

Chai Xiangfei, CEO of Huiyi Huiying, believes that AI medical entrepreneurship is still in its infancy as a whole, and there is still much room for improvement in terms of underlying technology, product creativity and product experience. At present, there are several reasons why medical AI products lie in the hospital and "eat ash":

First, everyone has relatively high expectations for medical AI. At present, the speed requirement of AI medical care and the slow change of the medical industry are the biggest contradictions, and the overall research and development cycle is long. Medical care is a traditional industry, which has many characteristics of the original industry. For example, it may take 10 to 15 years for new drugs to be developed and commercialized, and 5 to 10 years for devices to be developed.

Second, at present, most of the products are actually tried in hospitals, and the usability and friendliness remain to be investigated, and at present, AI’s participation in clinical practice is too shallow and too little. AI company should not only design products with doctors as the center, but also integrate products into doctors’ work scenes, and also conform to doctors’ usage habits to help doctors improve diagnosis efficiency and accuracy; In addition, it is necessary to design products with patients as the center, and truly serving patients and improving their medical experience are the end points of product design, and creating easy-to-use and friendly medical AI products is the key to success. Huiyi Huiying cooperates with well-known medical equipment suppliers at home and abroad, such as GE, Philips, Qixi Medical and Medtronic, and develops customized applications for the application of medical equipment such as imaging equipment and high-value consumables, so that artificial intelligence can empower traditional medical care. For example, Huiyi Huiying provides intelligent report interpretation services to patients on the basis of existing business digital films, which has been welcomed by hospitals and patients in many aspects.

AI technology can master different professional knowledge through data training, and many business fields can benefit. The artificial intelligence medical image is to use the method of image recognition to judge the picture. There may be several kinds of data in medicine, mainly image data and pathological data, and many of them can be solved by image recognition.

Lung nodule screening is an area that most AI imaging companies focus on at present. Although AI can help to find out nodules, AI can’t give a conclusion on further benign and malignant judgment and report opinions. Moreover, the products on the market at present are mostly concentrated on pulmonary nodules, and the homogenization is serious. A top-three hospital may install more than 10 AI companies’ products at the same time, but only one or two are often used. Because there is no feedback from doctors to optimize the products of other companies, the product iteration is slow, and there is a situation of lying in the hospital "eating ash".

There are many public data of pulmonary nodules, and many data sets can be downloaded directly, so a large number of companies have developed pulmonary nodule screening products in the past two years. However, for a wider range of diseases, the research and development of AI products is difficult. It is difficult to obtain data of new diseases, and high-quality data needs experts to cooperate and label, so the research and development cycle of the whole disease AI product is long. In addition, it is not enough to identify images in medical scenes alone, and the clinical value of disease screening and auxiliary diagnosis is limited. To become an indispensable tool for doctors’ daily use, they must be involved in clinical decision-making, and doctors need AI products that can cover all medical processes.

Therefore, products that go deep into more diseases and participate in more medical processes may be supported and affirmed by more hospitals and doctors, which may be the most important competitive advantage of AI imaging companies in the future. At this point, Huiyi Huiying found a new way, reached cooperation with Tsinghua University, Peking University, Stanford University and intel, and set up a joint laboratory of artificial intelligence, hoping to cut in with image data, let AI run through the whole process of imaging department, and realize a closed-loop service from screening to diagnosis to treatment and prognosis.

In 2018, Huiyi Huiying released three commonly used mapping products for screening scenes, such as CT lung nodule detection, chest DR detection and fracture detection. Its training model not only has image information, but also adds many patients’ clinical information, test information and follow-up information. Its AI products can not only locate and label lesions, but also participate in tumor staging and classification, and can provide support for doctors’ treatment decisions.

In April 2019, Huiyi Huiying and 301 Hospital released AORTIST3.0, an artificial intelligence platform for aortic dissection, which well combined the development of new disease models with the whole process coverage of single disease. Through verification, the accuracy of AORTIST3.0 far exceeds that of conventional manual measurement, and it also provides the prognosis prediction results of aortic dilatation and composite endpoint events. The performance of AORTIST3.0 can basically reach the level of accurate judgment and prediction like 301 Hospital, which can reduce the five-year recovery of 40% to 15%, and can go deeper into the medical scene and decision-making process.

Chai Xiangfei said that medical AI has entered the second half, and AI has moved from the 1.0 era to the 2.0 era. The reason for this change is. "In the past 1-2 years, we have focused on improving the diagnostic efficiency for doctors. Today, we find that the real core of medical services is patients. It is very important to take patients as the center and open up the service chain from patients to doctors to hospitals."

At present, Huiyi Huiying is committed to building an online image center, connecting patients, hospitals and doctors, providing a digital, mobile and intelligent image closed-loop service system for the three, and trying to build a platform that can continuously incubate innovative medical services and develop in depth, trying to participate in medical treatment and prognosis follow-up links. At the same time, the most troublesome profit dilemma in the industry was broken by Huiyi Huiying’s full-chain service business model. deus ex jumped out of the curse of burning money. It is reported that Huiyi Huiying has a beautiful income report card and has been regarded as a quasi-unicorn and unicorn by the industry.

The medical field in China faces two difficult problems, one is the lack of medical resources, and the other is the unbalanced distribution of medical resources. According to the data of China Health and Family Planning Statistical Yearbook, among all medical institutions in China, there are 28,261 urban hospitals, and the number of primary medical institutions reaches 927,147, which is 32 times that of urban hospitals.

Statistics on the number of various medical institutions in China in 2016

According to a misdiagnosis data of China Medical Association, the total misdiagnosis rate of clinical medicine in China is 27.8%, among which the average misdiagnosis rate of malignant tumor is 40%, and these misdiagnosis mainly occur in primary medical institutions. The total number of misdiagnosed patients in China exceeds 5,700 every year, which is four times that of the United States.

Guo Na, co-founder and COO of Huiyi Huiying, said: The scarcity and scarcity of high-quality medical resources is a fundamental contradiction. What primary hospitals really lack is diagnostic ability, which is a scarce resource. As an inevitable starting point for graded diagnosis and treatment, artificial intelligence can enable grassroots people to enjoy homogeneous resources and services.

In this regard, Huiyi Huiying has cooperated strategically with China Telecom, China Unicom, Alibaba Cloud, Jiuzhoutong, excellent companies and teams in medical care, IT, cloud computing, big data, artificial intelligence and other dimensions, integrating various resources and its own solid technical foundation, hoping to provide a whole set of services for primary hospitals by taking the medical association as the carrier. Taking the Third Affiliated Hospital of Zhengzhou University as an example, Huiyi Huiying, based on cloud computing, big data and artificial intelligence technology, built a set of intelligent imaging center for the Women and Children’s Union Medical Association, which realized the sharing of medical imaging information and diagnostic information in the medical association, promoted the integration and sharing of medical imaging resources and imaging medical resources, and all women and children’s medical institutions in the medical association could realize the uploading and centralized management of image data, as well as the sharing and reading of image information and diagnostic reports, and finally realized the sinking of high-quality medical resources.

The Third Affiliated Hospital of Zhengzhou University is not a case. It is reported that there are dozens of cases of such medical association imaging center. Guo Na said that in order to further promote the application and popularization of medical AI in primary medical institutions and greatly improve their diagnosis and treatment capabilities, Huiyi Huiying will launch the AI-empowered graded diagnosis and treatment public welfare 100 projects recently, and first provide 100 primary hospitals with free screening services for pulmonary nodules for one year. At present, Huiyi Huiying’s lung nodule screening products can quickly locate and label the lesions, and the automatic recognition accuracy of CT lung nodules exceeds 90%, which helps doctors improve the diagnostic efficiency and reduce the rate of missed diagnosis and misdiagnosis.

Talking about starting from lung nodule screening, Guo Na said that this is based on the current national conditions and future strategic goals. On the one hand, lung cancer can be said to be the first killer of cancer in China. According to the 2013 Annual Report on Cancer Registration in China issued by the National Cancer Registry, there are about 600,000 new cases of lung cancer every year. Lung cancer accounts for 20.48% of all malignant tumors in the city and 27.05% of the mortality. It accounts for 18.05% of the incidence and 22.42% of the mortality of rural malignant tumors, and the incidence and mortality are on the rise. Pulmonary nodule screening can help primary hospitals to provide primary screening services.

On the other hand, the country is vigorously promoting the policy of graded diagnosis and treatment. The medical image cloud platform provided by Huiyi Huiying can provide a good cloud platform support for medical associations and graded diagnosis and treatment, help primary medical institutions and urban hospitals to share data and doctors’ resources, and truly realize "primary examination and superior diagnosis", which can be said to be in response to the call of national graded diagnosis and treatment.

As Chai Xiangfei said, "In the context of insufficient overall medical production capacity, the application of medical artificial intelligence to the grassroots is not only just needed at present, but also the environment is relatively mature. First, using artificial intelligence to help doctors improve the efficiency of diagnosis and liberate doctors from inefficient repetitive work; The second is to help grassroots doctors improve their diagnostic level and reduce the misdiagnosis rate at the grassroots level. Although this road is difficult to walk, we can’t quit because it is difficult. Someone has to do it, and it is valuable to do it. It is worthless not to do it. "

At present, Huiyi Huiying intelligent imaging products have entered more than 1000 hospitals and are widely used in hundreds of medical institutions. It can be said that AI+ primary medical institutions are an excellent pair of "CP", which has achieved a win-win situation for AI medical enterprises, primary medical institutions and primary patients, and has also greatly promoted the development of China’s AI medical industry.

Since the outbreak of COVID-19, Huiyi Huiying has devoted herself to product development, upgrading and implementation. Based on the overall framework of Huiyi Huiying intelligent imaging solution, the algorithm and platform were upgraded for COVID-19 epidemic, and the "Trinity" COVID-19 AI solution was launched, which was helpful for clinical work by effectively combining intelligent auxiliary screening, intelligent remote consultation and digital intelligent film to empower COVID-19 epidemic prevention and control. It has provided scientific and technological assistance to many designated hospitals and shelter hospitals in Beijing, Shanxi, Henan and other places, as well as in the center of Hubei epidemic area. The solution has achieved good feedback in clinical application. The landing application results of Huiyi Huiying COVID-19 AI solution have been reported and affirmed by the top domestic and international media, and also highly praised by the three users in the hospital.

Recently, in the face of the global COVID-19 epidemic, Huiyi Huiying developed and upgraded the artificial intelligence aided diagnosis system in COVID-19 for the rapid COVID-19 epidemic. At present, Huawei has been promoted in Germany, Russia, Thailand, South Africa, Malaysia and other 40+ countries, and has cooperated with 200+ hospitals to provide support for global epidemic prevention and control.

　　[PConline evaluation]Among the newly released Intel and AMD processors, the author Xiao Bian found that the models with K or X suffixes are often more popular among consumers on major e-commerce platforms, but in fact Xiao Bian believes that the processor models without suffix are not as high as those with suffixes, and their performance is not as strong as theirs, but in fact they also have outstanding models. Today, let’s follow Xiaobian to learn about the charm of i7-8700, i5-8600, Ryzen 7 2700 and Ryzen 5 2600.

　　I7-8700 is the second flagship model of the 8th generation Core home platform. Compared with i7-8700K, both specifications are 6 cores and 12 threads, but the frequency setting of i7-8700 is much more conservative, with the basic frequency of 3.2GHz and the maximum turbo frequency of 6 cores of 4.3GHz. The highest core frequency of a single core is 4.6GHz, while the three frequencies of i7-8700K are 3.7GHz, 4.3GHz and 4.7GHz respectively. Thanks to the lower frequency setting, the thermal design power consumption of i7-8700 is only 65W, which is very low. So is it actually a small expert in energy saving and emission reduction? We will have related tests next.

　　The i5-8600 is the second highest rated i5 of the 8th generation Core. It is designed with 6 cores and 6 threads. Compared with the older brother i5-8600K, its basic frequency is 0.5GHz lower, only 3.1GHz, while the highest core frequency and the highest core frequency are 4.1GHz and 4.3GHz, which are consistent with the i5-8600K. Therefore, its thermal design power consumption is only 65W. Compared with i7-8700, its frequency design is more conservative, and it is believed that the power consumption will be further reduced.

　　AMD released the second-generation Ruilong in April this year, but only two processors in the second-generation Ruilong have no suffixes. One is this Ryzen 7 2700, which is also the second flagship model of the second generation Ruilong. Ryzen 7 2700 has a fundamental frequency of 3.2GHz, and the highest acceleration frequency of a single core can reach 4.1GHz, with a wide span. At the same time, its TDP is only 65W, which is very surprising for an 8-core and 16-thread processor. Another surprise is that, unlike the flagship model Ryzen 7 2700X, this processor has only 200 poor reviews on the JD.COM platform. What caused consumers to abandon it? Is it performance or price? Don’t worry, xiaobian will take you to explore the answer in the actual measurement later.

　　Ryzen 5 2600 is another processor without suffix in the second generation Ruilong, and it is also a low-power processor with TDP of only 65W. Ryzen 5 2600 is designed for 6 cores and 12 threads, and is built by Grofonde’s 12nm process. The fundamental frequency is 3.4GHz, and the highest acceleration frequency can reach 3.9GHz.

　　From the chart, we can see the detailed specifications of the four processors to be evaluated today. The models on Intel side generally have higher frequency and built-in nuclear display, while those on AMD side are cheaper and open to overclocking.

　　Next, let’s take a look at the changes of these four processors compared with the previous generation.

　　Due to the change of market competition, the 8th generation Core no longer squeezes toothpaste as before. From the table, we can simply see that the 8th generation Core has improved a lot compared with the previous generation. In the face of Ruilong’s multi-core offensive, first of all, the specifications of the 8 th generation i7 and i5 are compared with the previous generation.There are two more coresAlthough there are more cores, using the updated 14nm++ process can make more cores.The frequencies of i7-8700 and i5-8600 are slightly higher than the previous generation.At the same time, the thermal design power consumption of the processor is still maintained at 65W. In addition, the three-level cache of CPU has been increased a lot to adapt to more cores. In terms of nuclear display, i7-8700 and i5-8600 use HD630 vest nuclear display UHD630, which only improves the frequency by 0.05GHz, which is better than nothing, and the memory support is also upgraded from 2400MHz to 2666MHz.

　　Although the specifications and performance have been improved so much, the starting price of i7-8700 and i5-8600 is not much higher than that of i7-7700 and i5-7600, and now the actual price is only 200~300 yuan, so there is no price increase.The 8th generation of Core is the most conscientious generation in recent years.. A detailed technical analysis on the 8th generation Core canClick here to view past articles.

　　Unlike Intel’s 8th generation Core, which was hastily launched to cope with Ruilong, the 2nd generation Ruilong is obviously the product of AMD’s plan to iterate over the 1st generation Ruilong. The product uses GF’s 12nm process to make up for the shortcomings of the 1st generation Ruilong, but the TDP is still 65W. At the same time, the smarter Precision Boost 2 acceleration technology and XFR2 dynamic spread spectrum technology are used, which can make the core of the processor run at a higher frequency as much as possible, so that the processor is still excellent in applications with poor multi-core optimization.

　　In addition to the low frequency, another area criticized by the first generation Ryzen processor is the memory delay, so the focus of AMD optimization on Zen+ architecture is the cache and memory system. L1 cache delay is reduced by 13%, L2 cache delay is reduced by 34%, L3 cache delay is reduced by 16%, and memory cache delay is also reduced by 11%. At the same time, the frequency supported by the memory controller is improved, reaching 2933MHz.

　　These targeted improvements have greatly improved the second generation Ruilong compared with the first generation Ruilong and made it more mature in more applications. Want to know the detailed technical analysis of the second generation Ruilong canClick here to view past articles..

　　After comparing the improvement of these four processors compared with the previous generation, let’s enter the actual measurement link.

　　As usual, go to the test platform first.

　　In order to make the test results more objective, in addition to the motherboard and processor,We are consistent with other accessories, and the motherboard also uses ROG HERO series motherboards from ASUS, and all of them use the latest BIOS..

AMD platform

　
Willamette

　　In terms of memory, because the highest frequency that the two platforms officially claim to support is different, the memory frequency of the two platforms is not the same.It is 2933MHz on AMD platform and 2666MHz on Intel platform.

　　Memory We use the flame gun memory optimized by Zhiqi for Ryzen. When X.M.P is turned on, it can easily reach the frequency of 3200MHz, and the adaptability of the memory is also very good.

　　When testing, the motherboard BIOS is set to the full default optimal state, and then the memory frequency is changed, and other options remain unchanged.

　　Let’s first test the theoretical performance of the processor. The following tests can detect the processor in different ways.manyThreaded computing performance and single-threaded computing performance.

　　Fritz Chess Benchmark is called chess software in Chinese. You can know your processor’s computing performance by measuring the number of chess steps calculated by the processor per second.

　　WPrime is a software that tests the computing power of computers by calculating prime numbers, and has been widely used in the performance testing of processors all over the world.

　　CPU-Z is a well-known CPU detection software, and it is the most used software to detect CPU. Its own Benchmark can accurately judge the multi-core performance and single-core performance of CPU.The version of CPU-Z adopted this time is 1.85..

　　3Dmark is a software specially designed for measuring the performance of graphics cards by futuremark Company, and it has released 3Dmark99, 3Dmark2001, 3Dmark2003, 3Dmark2005, 3Dmark2006, 3Dmark vantage, 3Dmark 11 and The new 3DMark. Now, 3Dmark is not only a software to measure the performance of graphics cards, but has gradually turned into a software to measure the performance of the whole machine. 3DMark’s test physical score can be basically calculated.Actual game performance of CPU.

　　Summary of CPU theory test:The results of this evaluation are also consistent with the previous evaluation results of Ryzen and Core para-processors. Ryzen is superior in multi-thread testing because of the higher specification of para-processors, and Core processor is stronger in single-thread testing because of its higher frequency.

　　Breakdown, in the comparison between Ryzen 7 2700 and i7-8700, i7-8700 won the chess operation and CPU-Z single-thread test, while Ryzen 7 2700 gained the advantage in the other three tests, and there was not much difference between them in the test, which can be described as a tie, diamond cut diamond.

　　In the comparison between Ryzen 5 2600 and i5-8600, because Ryzen 5 2600 has six more threads than i5-8600, four of the five theoretical tests have won, and most of them have a big lead.

　　Now that the theoretical performance of the processors is known, what is the working efficiency of these four processors in practical application? Next, Xiao Bian will test the performance of the processor in practical application with the software that everyone will use in life.

　　CineBench R15 is a convincing test system for CPU and graphics card. The Cinema 4D special effects software engine developed for film and television industry is used to test a 3D scene picture with high precision, which can support up to 256 logic cores. In addition, the new version also strengthens the investigation of shaders, anti-aliasing, shadows, lighting and reflection blur, and the detection of CPU performance is more accurate.

　　WinRAR is one of the most commonly used compression software. You all know how high it requires the performance of the CPU. The stronger the performance of the CPU, the faster it is pressed and the shorter it takes.

　　Let’s compress a 2.66GB file and see how much time they take.

　　X264 FHD Benchmark can effectively test the floating-point operation performance of CPU and the actual file-changing ability of multimedia audio and video.

　　The testing significance of POV-Ray is similar to that of CineBench R15, and it also represents the 3D rendering performance of CPU. The more pixels rendered per second, the stronger the performance.

　　Video export, like WinRAR above, consumes huge CPU resources, and friends who specialize in video have extremely strong demand for this performance. We will let them export the same video, with the same video parameters and total recording time. There will be two export formats, one is the H.264 format which is more commonly used and should be the most widely used, and the other is the H.265 format which is more efficient in updating compression but has less application scope.

　　Summary of professional software testing:Generally speaking, in the professional application software test, the four processors have their own advantages and disadvantages in the comparison, which is equally divided.

　　To break it down, let’s first look at the comparison between i7-8700 and Ryzen 7 2700. When using CPU for 3D rendering, Ryzen processor will have a greater advantage because there are more cores and threads. Although i7-8700 is stronger in single-core rendering, no one actually uses only one core for rendering, so this project is of little significance. In the aspect of audio and video transcoding, there is not much difference between them when exporting video to H264 code, and i7-8700 is slightly stronger, but i7-8700 has an overwhelming advantage when exporting H.265 code, because in the latest version of X265 decoder, Intel’s native AVX 256-bit instructions are fully optimized, while Ryzen series processors do not have the native AVX 256 instruction set. It must be split into two 128-bit instructions for execution, so the efficiency is much lower. We can see that even the i5-8600 hangs Ryzen 7 2700 in this test. In other tests, there is not much difference between the two.

　　In the comparison between i5-8600 and Ryzen 5 2600, it presents another situation, which is the same as the theoretical test result, because Ryzen 5 2600 has twice as many threads as i5-8600, and it has the upper hand in most application tests, except the H.265 transcoding mentioned above.

　　Therefore, when you buy a processor, you should look at what you will often use in your daily use. If it is 3D rendering, it is wise to choose Ryzen processor. If you often need video transcoding, i7-8700 is obviously a better choice.

　　Of course, the CPU test is inseparable from the game performance. Tomb Raider 10, Wizard 3: wild hunt, Whole Territory Blockade and Ghost Action: Wilderness are selected for the project, all of which have 1080P resolution and the highest special effects. The colorful iGame1080 Flame God of War is selected for the graphics card to ensure that the graphics card will not become a test bottleneck at 1080p resolution.

　　Summary of CPU game performance test;We can clearly see that the optimization of multi-threading in 3A masterpieces is still not very good. The performance of i7-8700 and i5-8600 is not much different, and so are Ryzen 7 2700 and Ryzen 5 2600.

　　Therefore, with higher frequency and stronger ipc, the 8th generation Core won the game performance test, but the gap between the four processors is very small.

　　Since it is impossible to test the power consumption of a certain hardware separately, the following are all the power consumption of the whole machine, which are three application scenarios. The game is fully loaded with the peak power consumption of the whole machine in the process of Tomb Raider 10》Benchmark, while the CPU is fully loaded with Prime95 running FPU baking machine test and the graphics card is empty.

　　In order to ensure the stable operation of the whole machine, we use the MVP P850 power supply of Hangjia, which has passed the 80PLUS white gold medal certification and is located at the top of the power pyramid.

　　We can see that the power consumption of Core is obviously higher than that of Ruilong. After all, the frequency of Core is also higher. Intel will officially set the maximum core frequency and the maximum core frequency of a single core, from which we can know that the full core frequency of i7-8700 is 4.3GHz and that of i5-8600 is 4.1GHz when the CPU is fully loaded.

I5-8600 baking machine

　　The same is true in the actual baking machine, but we can still see some problems. Why is the power consumption of Ryzen 5 2600 higher than that of Ryzen 7 2700? This is actually related to the processor frequency. So what’s the frequency of baking machine in Ryzen processor?

Ryzen 7 2700 baking machine

Ryzen 5 2600 baking machine

　　We can clearly see that the full-core frequency of Ryzen 7 2700 roaster is 3.425GHz, while that of Ryzen 5 2600 roaster is 3.675GHz, which is 0.25GHz higher than that of Ryzen 5 2600, so it is not surprising that the power consumption is relatively high. Therefore, we can draw two conclusions. One is that the accelerated frequency policy of Ryzen 7 2700 will be more conservative than that of Ryzen 5 2600. The other is that for the second generation Ryzen processor, the increase of frequency is more likely to cause the increase of power consumption than the increase of core.

　　In the choice of radiator, in order not to reduce the frequency of the processor, we use the relatively high-end air-cooled overclocking three Donghai hegemony. The radiator is a 6-heat pipe dual-fan radiator, and theoretically four processors with TDP of only 65W should be enough. Let’s take a look at the temperature performance of the four processors under this radiator. The room temperature was 25 degrees Celsius during the test.

　　With the same radiator, the Ryzen 7 2700 with the most cores but the lowest frequency has the best performance. No wonder Acer has stuffed the Ryzen 7 2700 into the notebook, and the excellent temperature performance of Ryzen 7 2700 and Ryzen 5 2600 is also very suitable for DIYer to buy them to assemble high-performance ITX hosts. Let’s take a look at Intel again. Although the thermal design power consumption of the i5-8600 and the i7-8700 is 65W, it can be seen that the temperature difference between them is quite obvious. The performance of the i5-8600 is still normal, while the i7-8700 has a core-wide maximum frequency of 4.3GHz consistent with the i7-8700K, and the temperature reaches a relatively high of 87.Therefore, users who choose i7-8700 should pay attention not to neglect the purchase of radiator just because its thermal design power consumption is only 65W..

　　Based on the above performance tests, including 16 tests of theoretical performance, professional application performance and game performance, we can get the following comprehensive performance ranking chart.

　　I7-8700 won the battle between the second generation Ruilong and the eighth generation Core flagship with a slight advantage, while Ryzen 5 2600 helped the second generation Ruilong regain a city. Of course, our tests in this paper are all carried out at the default frequency, while Ryzen series processors are all frequency-unlocked. In the previous first test of the second generation Ruilong, we have tested that the overclocking ceiling of the second generation Ruilong is between 4.2 and 4.3 GHz, and the performance of Ryzen processor after overclocking is also acceptable.Click here to view past articles..

　　This is the ranking of the four processors in this paper in our new version of PConline CPU ladder diagram. The above picture is a brand-new interactive CPU ladder diagram released by PConline, which includes linked e-commerce price, related original articles, parameter comparison, ranking comparison and performance comparison. Users who need it will collect it soon, and there will be ladder diagrams such as graphics cards and notebook processors released one after another in the future.

　　The PC side canClick here to jump.

　　On the mobile side.Click here to jump.

　　Let’s summarize the situation at Intel first. Because i7-8700 has the same full-core turbo performance as i7-8700K, the performance difference between them at the default frequency will not be very big. Moreover, due to the rising specifications of the 8th generation i7, the heat and power consumption are relatively high. In other words, the cost of overclocking i7-8700K on the radiator, power supply and motherboard will be relatively high. For consumers who are not very keen on the ultimate performance, i7-8700 that can be used with B360 motherboard is undoubtedly a better choice.

　　As for the i5-8600, because of its high pricing, its performance will not be very outstanding compared with Ryzen 5 2600 or its younger brother i5-8500/8400, and its power consumption is also high, and its temperature is high. Xiaobian thinks that the purchase value of this processor is relatively low.

　　On the AMD side, we can see from the above evaluation that Ryzen 7 2700, the sub-flagship, actually has its own advantages in comparison with the 8th generation Core sub-flagship i7-8700, so why is its sales volume so low? This can only blame its big brother Ryzen 7 2700X. Ryzen 7 2700X has stronger performance, and a new belief RGB ghost radiator is presented, but it is only 200 yuan more expensive than Ryzen 7 2700, and most consumers will choose the flagship Ryzen 7 2700X with higher standards. Nevertheless, we can still see an outstanding advantage of Ryzen 7 2700, that is, excellent temperature and power consumption performance, which will be particularly prominent in notebooks or when building ITX hosts. We can expect more manufacturers to directly put this processor into notebooks in the future. However, there are only a few consumers with this demand. We can also foresee that if AMD does not further adjust the price of Ryzen 7 2700, the audience of Ryzen 7 2700 will be very small for a long time to come, and the sales volume will not change much.

The radiators of Ryzen 7 2700 and Ryzen 5 2600 are different, and the materials are better.

　　As for the Ryzen 5 2600, it has gained the upper hand compared with the i5-8600, and it also has certain advantages in temperature and power consumption. More importantly, the Ryzen 5 2600X, which is 200 yuan more expensive than it, does not give away the temptation to believe in the RGB ghost radiator, so this processor has a fair sales volume. When it comes to overclocking, Ryzen 5 2600 can easily exceed 4,0GHz, but whether it can exceed 4,2GHz depends on the face. Although it is 200 yuan cheaper than Ryzen 5 2600X, the highest acceleration frequency of Ryzen 5 2600X single core can reach 4.2GHz. If the temperature and power consumption are not too high, Xiao Bian still recommends everyone to buy Ryzen 5 2600X.

　　In the choice of Ruilong and Core processors, it is necessary to choose according to the needs of the readers. For example, it is more wise for netizens who often use 3D renderers who are very concerned about the temperature of power consumption or to use Ryzen 7 2700 or Ryzen 5 2600 naturally, but for consumers who often need video transcoding, especially H.265 format transcoding, it is more efficient to use i7-8700. Of course, what we discuss in this paper is based on the price of JD.COM’s self-operated platform on July 13th. If the original price of i7-8700 is three or four hundred more expensive than that of Ryzen 7 2700X, its purchase value will be greatly reduced.

　　Dog days are the hottest and most yang-filled stage in a year, and it is also an important time for health preservation. Various health preservation methods circulating on the Internet, such as drinking hot water in the dog days to force out the cold in the body, eating more mutton and ginger to "heat up" and so on, have also made many people follow suit for many years. So, are these health care methods reliable? Recently, shenyang evening news and Shenbao all-media reporters interviewed a number of health experts on related issues. They said that the principle of TCM health care is to conform to nature and pay attention to people, time and local conditions. Many widely spread health care methods are not necessarily scientific and not necessarily suitable for everyone. People should not fall into misunderstanding and blindly follow.

　　A

　　Myth 1: You can’t eat cold drinks and insist on drinking hot water in the dog days.

　　Some people think that drinking hot water in the dog days can force out the cold that has penetrated into the bone marrow for many years, and you can’t touch a cold drink, otherwise it will damage the yang, destroy human immunity and increase the probability of illness. Is this really the case?

　　Expert analysis: Yuan Renjie, director of the Center for Prevention and Treatment of Diseases of the Fourth People’s Hospital of Shenyang, said that cold and heat are a pair of natural attributes, and they also represent yin and yang, such as "cold and heat are signs of yin and yang" in Huangdi Neijing. A healthy body is "yin and yang are secret, and the spirit is the rule." The most controversial thing about health care in the dog days is that the yang is strong in the dog days, and drinking ice drinks, with the attribute of yin, will hurt the yang, causing the imbalance between yin and yang to be a disease, but this statement is too absolute. Some people do have diarrhea and other symptoms when drinking ice drinks. This is because of the different constitutions. People with yang deficiency are inherently yang-deficient, and drinking yin-cold products makes the deficiency of yang more deficient, so they can’t drink it. So for people with peaceful constitutions, it is not bad to drink a small amount of ice drinks to relieve summer heat. In that case, drinking hot water can force out the cold in the body, in fact, this effect is very small. Hot water can ensure the normal operation of yang on people’s body surface, but the cold in the body is accumulated over time, and there are many reasons for its formation. Drinking hot water alone cannot solve the fundamental problem.

　　B

　　Myth 2: Eat more mutton and ginger in "heating with heat"

　　A health post was circulated in a circle of friends: "A bowl of mutton soup in dog days does not require a doctor to prescribe a prescription", saying that eating mutton and drinking mutton soup in dog days can "heat up, sweat and detoxify". In addition, the same is true of "eating radish in winter and ginger in summer, without a doctor prescribing". So, is it really better to eat these hot foods in the dog days?

　　Expert analysis: this statement is not completely correct. If you understand it incorrectly, you will not achieve the purpose of health preservation, but it will be counterproductive. Ginger and mutton are spicy and hot foods, so people with yin deficiency constitution, damp heat constitution constitution and partial qi stagnation constitution should not eat more. However, for some special people, this way of keeping in good health is very suitable. For example, people who eat too much cold and cold food to relieve summer heat are prone to damage the spleen and stomach and consume yang. Proper eating of some foods that are pungent and cold can eliminate these side effects, which is the meaning of "heating with heat". If you don’t have the habit of eating cold food, or have been eating warm food, or are hot people, the "heating with heat" regimen will only "add fuel to the fire" and cause people to get angry.

　　C

　　Myth # 3: Practice in summer, exercise after three days of rain, and keep cool.

　　Many people think that summer is very cool after rain and suitable for exercise, so they will take a walk after rain, or go out for running and fitness, breathe the air after rain and feel comfortable. In fact, going to exercise after the rain in summer will aggravate the moisture in the body.

　　Expert analysis: "Practicing 39 in winter and three volts in summer" is the experience summarized by predecessors in the long-term exercise process, which makes sense. However, for the elderly, "training for three days in summer" is not suitable. The climate in dog days is characterized by high temperature, low air pressure and high humidity. In this weather, summer is the main way to maintain health, and quietness is to nourish the heart, with more quietness and less movement. Middle-aged and elderly people must not exercise excessively in midsummer, because sweating will lead to blood viscosity, blood volume reduction and other cardiovascular and cerebrovascular diseases. Exercise in the dog days must avoid high temperature and be carried out in a cool place and at a cool time. It is advisable to do gymnastics, walking, Tai Chi and other light exercises, as long as you sweat slightly. It is very fresh to exercise the air after rain, but the relative humidity is relatively high, and dampness is also easy to invade the human body, especially when sweating after exercise and the hair is wide open, it is necessary to prevent dampness from invading.

　　D

　　Myth 4: Prevent heatstroke and catch a cold, and always drink Huoxiang Zhengqi water.

　　Many people carry Huoxiang Zhengqi water with them to prevent heatstroke in summer. However, Huoxiang Zhengqi Water is not suitable for everyone. If the physique is not suitable, taking it blindly will only hurt the body.

　　Expert analysis: The main component of Huoxiang Zhengqi Water is Huoxiang, with Atractylodes lancea, Pericarpium Citri Tangerinae, Magnolia Officinalis, Radix Angelicae Dahuricae, Poria, Pericarpium Arecae, Pinellia ternata, etc., which has the functions of relieving exterior dampness, regulating qi and harmonizing middle energizer. It can be used for treating common cold caused by exogenous wind-cold, internal injury and dampness stagnation or summer injury and summer dampness, with symptoms such as headache, heaviness in chest and diaphragm, abdominal distension and pain, vomiting and diarrhea, etc. When taking it, it needs to be accurate in syndrome differentiation, and it is best to take it under the guidance of pharmacists and doctors. Because the medicine is Xinwenfa powder, it is suitable for patients whose dampness is heavier than heat or cold-dampness. If people with heat-toxic reaction eat Huoxiang Zhengqi, it is equivalent to eating backwards, and the medicine will not only be ineffective but also delay the illness.

　　In addition, Zhao Liren, a health expert at Ministry of Human Resources and Social Security Education and Training Center in China, reminded that Huoxiang Zhengqi Water contains a certain amount of ethanol. If you drink a drink containing ethanol after applying cephalosporins, it will lead to "ethanol accumulation" in the body and a disulfiram-like reaction (also known as sulfur-like reaction of abstinence, which is manifested by symptoms such as facial flushing, headache, abdominal pain, sweating, palpitation and dyspnea). Therefore, be careful not to use cephalosporins when taking Huoxiang Zhengqi Water.

　　E

　　Expert advice: mung bean soup after "transformation" has better health care effect.

　　In hot weather, the cool mung bean soup must be the favorite of many people. Then, do you know why mung bean soup can relieve summer heat? How to decoct and match, and the effect of relieving summer heat is better? Let’s listen to the introduction of health expert Zhao Liren.

　　Drinking mung bean water in summer can effectively stimulate appetite and have the effects of clearing away heat, promoting diuresis, relieving summer heat, cooling blood and detoxifying. It has a good auxiliary treatment effect on sore throat, sore mouth, dry stool, dry mouth and bad breath. The heat-clearing power of mung beans lies in the skin, and the detoxification power is included. Therefore, if you just want to cool off the heat, wash the mung beans when cooking the soup, and boil them with strong fire for about 10 minutes. The soup cooked in this way is green and clear, and has the best effect of cooling off the heat.

　　In addition, cooking mung bean soup with other ingredients will also produce good health effects. For example, mung bean double flower soup: choose 100 grams of mung bean and 10 grams of honeysuckle, and decoct them with water. You can also add Coicis Semen for invigorating spleen and eliminating dampness to make Coicis Semen and mung bean soup, and add Lily for nourishing yin and moistening lung to make Lily and mung bean soup. It should be noted that mung beans are cool, and people with weak constitution and cold are not suitable for drinking. In addition, mung bean also has detoxification function. Therefore, if the drugs taken by patients, whether traditional Chinese medicine or western medicine, contain organic phosphorus, calcium, potassium and other components, mung bean will combine with these components to form a precipitate, thus decomposing the efficacy and affecting the treatment. (Reporter Wang Yuzhe)

　　CCTV News:On August 29th, the website of Shenyang Municipal Government reported that the epidemic prevention and control headquarters of COVID-19 in Shenyang announced that at present, many cases of people with abnormal nucleic acid test results were found in the regional nucleic acid screening in Shenyang. In order to resolutely and effectively block the spread of the epidemic, effectively protect people’s life safety and health, and reduce the risk of epidemic spread caused by the flow and gathering of people, the relevant measures for strict epidemic prevention and control are hereby announced as follows:

　　First, strict prevention and control measures during regional nucleic acid detection

　　From 0: 00 on August 30 to 24: 00 on September 5, the city continuously carried out regional nucleic acid testing.

　　1. All the people living in Shenyang, before sampling, remain relatively static in their places of residence. According to the unified deployment of the epidemic prevention and control headquarters of each district, county (city) and the organizational arrangement of streets (towns) and communities (villages), nucleic acid testing will be carried out in an orderly manner, and no one will be missed. Only after participating in the nucleic acid sampling can people go to work, go to school and arrange necessary travel.

　　2. The citizens should consciously obey the community (village) organization and on-site management, do personal protection throughout the process, keep a distance of more than 1.5 meters with others, and do not cut in line, talk or gather.

　　3. From now on, the effective time limit of "Liaoshitong" health code will be adjusted from 72 hours to 48 hours. Those who fail to participate in nucleic acid testing within the prescribed time limit will be given a "yellow code" for their health code, and those who cause the spread of the epidemic will be held accountable according to law.

　　4. Shopping malls, supermarkets, hotels, scenic spots, farmers’ markets and other public places with dense personnel, closed space and prone to cluster epidemics shall strictly implement the epidemic prevention and control requirements such as limited quantity and peak shifting, and the number of customers accepted shall not exceed 50% of the maximum carrying capacity.

　　5. Closed public places such as theaters, bath centers, massage parlors, beauty salons, gymnasiums, chess rooms, secret rooms, entertainment halls, cultural centers (stations), Internet cafes, indoor scenic spots, KTV, dance halls, discos, performance venues, and direct sales experience venues are temporarily closed; Night markets, flower and bird markets, and large rural gatherings will be closed in the morning and evening; Restaurants Restaurants are suspended from eating.

　　6. Party and government organs, enterprises and institutions at all levels shall implement "two points and one line", fully implement measures such as nucleic acid detection and health monitoring, and urge them to go to the nearest fever clinic for investigation if abnormal symptoms are found. Advocate qualified citizens to work at home as much as possible and reduce the flow of people.

　　7 welfare institutions, pension institutions, mental health institutions, public security and judicial administrative supervision institutions and other temporary closed management, stop unnecessary visits.

　　8. Primary and secondary schools, kindergartens and off-campus training institutions temporarily stop offline teaching.

　　9. All kinds of public transport vehicles must be disinfected and ventilated, and the drivers and passengers should strictly protect themselves and conduct nucleic acid testing in accordance with industry regulations. Take public transport must strictly check the "four-piece set" (code scanning, temperature measurement, wearing a mask, negative proof of 48-hour nucleic acid test), and the passengers in the car shall not exceed 50% of the rated passenger capacity.

　　10. The city’s long-distance buses and tourist chartered buses (excluding those returning to other cities) are suspended from operation, and the buses and subways (light rail) in the nine urban areas of the city are operating normally during the morning and evening peak hours (6: 00 to 8: 30, 16: 30 to 19: 00), and the interval between vehicles during the peak hours is doubled as that during the daily peak hours.

　　11. Carefully organize large-scale meetings, forums, exhibitions, sales promotions and other personnel gathering activities. If it can be postponed, it will be postponed, and if it can be online, it will be online. In accordance with the principle of "who sponsors who is responsible and who approves who is responsible", the requirements for epidemic prevention and control will be strictly implemented.

　　12. If the wedding is postponed, the funeral is simple, and the banquet is not held, to reduce the gathering time and control the number of people, the participants must strictly implement the "four-piece set".

　　13. Advocate the general public in the city not to leave Shen unless it is necessary. Those who really need to leave Shen must hold a negative nucleic acid test certificate within 48 hours and travel with the green code of "Liaoshitong Health Code".

　　District and county (city) epidemic prevention and control headquarters can formulate specific prevention and control programs in combination with the actual situation.

　　Second, strict normalization of epidemic prevention and control key measures

　　1. Strictly implement the "active filing". Before arriving in Shenyang, all foreign (returning) Shen personnel should download the "Grand Event Link" App, search for "Grand Event Link" by WeChat applet or scan the QR code of "Self-reported by Shen personnel", complete self-reported to local communities (villages) and units one day in advance, report to local communities (villages) and units as soon as they arrive in Shenyang, and implement various control measures according to requirements. The community (village) should do a good job in service to ensure the living needs of residents.

　　2. Strictly "check on landing". At airports, railway stations, passenger stations, highways and other entry channels, they will be reported for inspection, and "landing" nucleic acid testing will be conducted free of charge.

　　3. Strictly implement classified control measures. Strictly implement classified control measures such as centralized isolation, home isolation, home health monitoring and nucleic acid detection for those who come (return) to Shenyang in high, medium and low risk areas outside the territory.

　　4. In high-risk areas, people who really need to go out for medical treatment should be coordinated and arranged by communities (villages) and streets (towns), and a special car should be used for personal protection and closed-loop management.

　　5. In the medium-risk area, "people don’t leave the area and take things at the wrong peak". For those who really need to go out for medical treatment, the community (village) will issue a certificate and make a good audit and registration.

　　6. In low-risk areas, "personal protection, avoiding gathering" shall be implemented, and during the period, going out as little as possible, not gathering, not getting together, and doing personal protection when going out; Strictly implement measures such as booking, peak shifting, current limiting, temperature measurement, registration and wearing masks when entering indoor public places.

　　7. All kinds of units, institutions, public places, residential areas, "nine small places" and other comprehensive applications of "place code" to achieve global coverage, everything must be swept; Strictly check the "four-piece set" for all personnel entering.

　　8. All pharmacies should register the personnel who buy antipyretic, antitussive, antiviral, antibiotic, cold and other drugs with their real names.

　　Third, strictly compact the "four-party responsibility"

　　We will further tighten the "four-party responsibility" of the territories, departments, units and individuals, and strictly implement various prevention and control measures such as "four-piece inspection", reporting of personnel coming (returning) to Shenyang, inspection on landing, site code, employee monitoring and daily ventilation and disinfection in accordance with the requirements of epidemic prevention and control. Places, units and individuals that fail to do a good job in epidemic prevention and control and fail to implement the "four-party responsibility" according to regulations shall be dealt with severely according to law.

　　Citizens and friends, in the face of severe and complicated epidemic situation, let’s tighten the string of epidemic prevention and control together, always do personal protection, adhere to good living habits such as wearing masks, washing hands frequently, often ventilating, using public chopsticks, consciously abide by various epidemic prevention regulations, protect ourselves and defend the city, and love and protect the city as home!

　　This circular shall come into force as of the date of promulgation, and shall be adjusted as the epidemic situation changes.

　　Shoulder-to-shoulder queue, the booming catering industry … … With the optimization and adjustment of epidemic prevention and control policies, offline consumption scenes such as restaurants and restaurants have been restored in an orderly manner, driving related consumption to pick up. According to data released by the National Bureau of Statistics recently, from January to February 2023, the national catering revenue increased by 9.2% year-on-year.

　　Food and beverage consumption demand has been greatly released.

　　Recently, "one table is hard to find" has become a common feeling for many consumers to eat. At the Chaoshan beef shop in Beijing Road, Guangzhou, the "Chaofa" has a long queue, and there are dozens of tables waiting at 6 pm. By the weekend, the average daily number of this store is nearly 1,000 tables. The waiter trotted to serve food and shouted, "It seems that the guests can’t finish receiving it recently."

　　Passenger flow recovery promotes turnover growth. From January to February, 2023, the brands owned by Beijing Huatian increased by about 12% year-on-year. Among them, Tongheju Restaurant and Xinchuan Noodle Restaurant increased by more than 20% year-on-year. In particular, the sales of Tongheju Restaurant and Eryouju in February have exceeded 2019 and returned to normal levels.

　　In order to help the catering industry recover, from January to February, Beijing, Shenzhen and Hangzhou issued special coupons for catering, with obvious results. According to the data of Meituan, after Hangzhou, Ningbo, Shaoxing, Shenzhen, Zhuhai, Dongguan and other cities issued coupons, the year-on-year growth rate of food consumption in restaurants reached double digits. In addition to issuing consumer vouchers, many local governments have also introduced policies to further optimize the business environment, including supporting outbound operations and launching "catering loan" financial products.

　　The "small" of catering reflects the "big" of development. According to the analysis of China Cuisine Association, from January to February, 2023, the growth rate of national catering revenue and catering revenue of units above designated size increased by 0.3 percentage points and 0.1 percentage points respectively compared with the same period of last year. From January to February this year, the national catering revenue accounted for 10.9% of the total retail sales of consumer goods, which was 5.7 percentage points higher than the total retail sales of consumer goods.

　　The relevant person in charge of the China Cuisine Association believes that from January to February, driven by the Spring Festival holiday and the policy of helping enterprises, the demand for catering consumption was greatly released, and the catering market rebounded significantly, which made a good start for the development of the whole year and played a "catalyst" role in boosting consumer confidence in 2023.

　　Customers dine in the Wuyi Hotel in Xi ‘an. Xinhua News Agency reporter Li Jiaxu photo

　　New kinetic energy "combustion-supporting" catering market

　　Potted vegetables and quick-frozen vegetables … … Guangzhou Restaurant accelerated the research and development of new prefabricated dishes and product upgrading, and the revenue of quick-frozen food was once the company’s second largest source of income. The White Paper on the Development of Prefabricated Vegetable Industry in China in 2022 shows that the scale of prefabricated vegetable market in China will reach 419.6 billion yuan in 2022, up by 21.3% year-on-year, and it is estimated that the market scale will exceed one trillion yuan in 2026.

　　Cheng Gang, secretary-general of Guangdong Food and Beverage Service Association, believes that due to the epidemic, people’s consumption behaviors and habits have changed, and many catering entities are "looking for opportunities in danger". Some actively adjust their business methods, including innovating catering products such as prefabricated vegetables, strengthening industrial cross-border integration, overlapping emerging consumption elements, expanding business space, optimizing brand experience and cognition, and finally enhancing consumer trust to activate the market, so as to achieve more stable, sustainable and virtuous development.

　　Including live broadcast, short video, digital channels and social sharing functions to help stimulate consumer demand, attract more passengers and stimulate catering consumption. "We enhance the brand’s popularity by planning videos such as the Fat Story Collection and the food recommendation official shop." Chai Biao, chairman of Feifei Shrimp Village, said that 70% to 80% of the passenger flow in some stores comes from the network platform.

　　More time-honored brands try cross-border innovation, combining eating and drinking with tourism, performance, entertainment, shopping and other formats, and enriching the consumption experience with diverse new scenes. In Shaanxi, there are more and more tourists in Yi Sushe Cultural District of Xi ‘an, which integrates Shaanxi opera performance, time-honored food and new retail of the country. Xi’ an restaurant head office lets customers immerse themselves in the local food culture through the Shaanxi cuisine culture experience museum; Time-honored enterprises turned into "convenience community canteens" and opened a new model of community chain.

　　Jin Wenping, secretary of the Party Committee and chairman of Xi ‘an Catering Co., Ltd. said that the opening of a new chapter of diversified development by time-honored brands is the epitome of the market-oriented reform and exploration of the catering industry with consumer demand as a breakthrough, which is conducive to promoting the development of the industry and enhancing the social and economic benefits of the brand.

　　New measures to stabilize industry confidence

　　"Give priority to restoring and expanding consumption", "Enhance consumption capacity, improve consumption conditions and innovate consumption scenarios" … … We will implement the requirements of the Central Economic Work Conference, and all localities will further clarify policies and stabilize expectations.

　　The policy of benefiting enterprises and benefiting the people continued to increase, boosting food and beverage consumption. For example, Beijing holds a variety of catering activities to promote consumption; Guangzhou has successively introduced catering support policies, with a maximum reward of 1 million yuan for transformed and upgraded catering enterprises and 2 million yuan for enterprises with increased turnover; Wenzhou has introduced ten measures to boost the confidence of catering industry development around reducing the institutional cost of catering industry access.

　　The main body of the catering industry is more confident and the investment layout is accelerated. Not long ago, at the China (Guangzhou) Catering Industry Development Conference and Investment and Financing Cooperation and Exchange Exhibition, hundreds of catering enterprises proposed nearly 1,000 brand catering investment projects, including Guangdong cuisine, Hunan cuisine, Sichuan cuisine, Shandong cuisine and other major domestic cuisines, as well as Japanese cuisine, Southeast Asian cuisine, Central Asian cuisine and other international flavors, with an investment of more than 3 billion yuan.

　　Zhang Yi, the person in charge of Ai Media Consulting, a third-party research institution, said that the expansion of the catering industry shows that confidence has gradually recovered, diversified and tends to middle and high-end projects. The catering industry pursues higher quality brand development and provides better services for consumers.

　　"From banquets, dinners, business receptions, prepared dishes and other aspects, we can see the signal of rapid recovery of the catering industry. New models, new channels and new technologies are constantly emerging, promoting the development of the catering industry to multiple formats and quality. " Chen Jianqi, vice president of Shaanxi Cooking and Catering Industry Association, said that it is also necessary to pay attention to the low threshold, intensified industry competition, low overall profit rate and increasing cost of raw materials and services. Therefore, it is necessary to make further efforts in specialization and industrialization to improve competitiveness.

　　Insiders said that in order to accelerate the comprehensive and steady recovery of the catering industry, it is necessary to continuously improve policy support and guidance, introduce policies to help and promote consumption that are more in line with enterprise needs and market expectations, guide the cultivation of leading enterprises and leading talents, and rationalize the industrial layout. At the same time, it is necessary to promote development and anti-waste, to innovate products and to keep the bottom line of food safety. (Reporter Ding Le, Ning Ji, Cai Xinyi, Li Jiaxu)

　　Why do you still have to queue up for non-parking charges? Provincial Communications Department Responds to Hot Issues in the Use of ETC System

　　On October 28th, it has been 21 days since the electronic toll collection system (ETC system) was opened on expressways in our province. The number of ETC customers has reached 50,681, exceeding the target of reaching 40,000 users before the end of the year. Some bank outlets even cannot handle business immediately because of insufficient hardware stock.

　　Recently, Feng Zhenglin, Vice Minister of the Ministry of Transport, proposed at a special meeting that all provinces (autonomous regions and municipalities) in China will basically be connected to the Internet before the end of 2015. This means that by the end of next year, ETC users in our province will be able to "all-in-one card" nationwide.

　　During the trial operation, the ETC system was impassable and the ETC lane was temporarily closed. On October 29th, the Expressway Monitoring and Settlement Center of the Provincial Communications Department responded to these problems.

　　Q1: Why can’t ETC pass?

　　There may be other vehicles breaking in by mistake.

　　A: This did happen at the beginning of the trial run, mainly because both hardware and software had to have a running-in period. At present, optimization is being carried out to solve the problem.

　　There are three main reasons why the ETC card cannot be used. First, the ETC card has not completed the issuance process, and it must be recharged after the first activation, even if it is only charged with 1 cent. If it is not recharged, the system will display it as an "illegal card". Second, there will be problems between lane and vehicle information interaction. Third, the vehicle without ETC system mistakenly entered ETC lane, and the system sensed that there was a car entering, but another plate of the vehicle was thrown over to take the artificial lane, which kept the ETC lane waiting for reading data. "Although we can debug and manually guide, it is still recommended that drivers who have not installed ETC should not mistakenly enter the ETC lane."

　　Q2: Why is the ETC lane closed?

　　Slow blocking and smooth during peak hours

　　A: ETC lanes have been temporarily closed, mainly concentrated in several gates of Chengdu Ring Expressway, such as connecting Chengguan Road and Chengpeng Road. At present, the utilization efficiency of ETC lane is not high, and the traffic flow is small. In the rush hour, toll station vehicles may even block the main line, which will affect the traffic safety. At this time, the high-speed will start the plan, manually watch the ETC lane, and allow vehicles without ETC system to pass through the ETC channel. This is also a measure to slow down the congestion and ensure smoothness, so drivers can understand. "

　　In addition, there are some special cases, such as Dazhou toll station, which cannot be expanded due to geographical reasons. There are only three lanes in each direction, of which one truck is used, leaving two lanes, so the ETC lane is often closed.

　　Q3: ETC is delayed?

　　OBU devices are in short supply.

　　A: At the beginning of the opening of ETC system, the established goal of Sichuan Provincial Communications Department was to develop 40,000 users by the end of the year, but as of 0: 00 on October 29, the number of ETC users in our province had reached 50,681, with an average increase of 2,100 per day. It is estimated that by the end of this year, ETC users in our province will exceed 100,000. The relevant person in charge of the Expressway Monitoring and Settlement Center of the Provincial Communications Department said, "Due to the rapid growth of users, some bank outlets have no OBU (on-board unit), and we are also urging banks to step up procurement to meet the needs of car owners."

　　At present, the province has opened 417 ETC lanes, covering 208 toll stations, with a coverage rate of 55.5%. This number will rise in the future. As of yesterday, the number of ETC lanes built in our province has reached 500. It is estimated that by next year, the ETC coverage rate of all main toll stations of Sichuan Expressway will reach 100%, and the lanes will not be less than two in and two out, while the ETC coverage rate of all ramp toll stations in the province will reach 90%.

　　Q4: Are there any other services?

　　We plan to launch ETC card in the future.

　　A: We are exploring, for example, the amount of each toll is prompted by bank SMS, and even the historical toll records are queried online. In the future, when the number of ETC users reaches a certain level, we will also open the business of handling ETC cards independently, which is equivalent to that vehicles without OBU (on-board unit) need not give change when passing through artificial lanes, but swipe ETC cards to give money, so as to improve the traffic rate of toll stations.

　　ETC usage reminder

　　1. Do not disassemble the OBU when using it; once disassembled, it will be invalid;

　　2. Vehicles equipped with ETC should not exceed 20 kilometers per hour when passing through the ETC lane, and keep a safe distance from the vehicle in front;

　　3. Ensure that the ETC card is always inserted in the OBU while the vehicle is driving;

　　4. During use, the ETC card and OBU must be in one-to-one correspondence with the vehicle, and the car is dedicated;

　　5. If you can’t get through normally or have questions about the charges, you can call 12122 for consultation. (Reporter Wang Haoye Intern Zhang Yuer)

    In recent years, many domestic industrial belts have successively joined the cross-border e-commerce track, and "cross-border e-commerce+industrial belt" has become one of the main forms of foreign trade. In 2024, the domestic industrial belt will face not only the cross-border blue ocean, but also the long-term high-quality sea going. The reporter’s recent visit found that some cross-border e-commerce platforms are helping the industrial belt to expand into a "new blue ocean and new growth pole" through digital means, and promoting the leap of "Made in China" in the international market competitiveness and brand power.

   Cross-border e-commerce empowers industrial belts to expand markets.

    Industrial cluster is an important carrier to promote the high-quality development of regional economy. At present, there are hundreds of light industrial clusters in China, which play an important role in regional economy. In recent years, major cross-border e-commerce platforms have begun to increase cooperation with industrial belts to help local enterprises expand overseas business opportunities more accurately and efficiently through in-depth services.

    In September 2023, Xiyin, a cross-border e-commerce platform, announced the launch of the national 500-city industrial belt plan. Within three years, it will go deep into the national 500-city industrial belt, connect the industrial belt with digital trade and digital flexible supply chain, and provide integrated empowerment from production to market sales to brand growth, helping the industrial belt expand the global market and gain brand promotion. The reporter learned that through the continuous deepening of the 500-city industrial belt going to sea plan under the platform model, the flexible supply chain model of "small single and quick response" produced by Xiyin on demand is splitting from the clothing industry to more industries, helping the industrial belt to go to sea with cross-border e-commerce, and at the same time, empowering this set of capabilities to more industrial belt sellers through platform.

    Going out to sea is not the digestion of excess capacity, but the flexible supply chain makes the market demand and supply more match. By cultivating new models and new formats, the productivity of industrial belts will be improved, and at the same time, small and medium-sized sellers will be realized. In the process of internationalization of China’s manufacturing industry, domestic characteristic industrial belts need to build their own competitive advantages in order to win. With the help of updated digital ideas and digital means, they can realize efficient resource allocation and accelerate innovation, and finally realize the overall capacity transformation and upgrading of industrial belts.

    According to the Insight Report of Cross-border E-commerce Industry 2023 Industry Belt Brand Going to Sea released by Billion Think Tank, "Cross-border E-commerce+Industry Belt" provides a strong impetus for high-quality going to sea. Cross-border e-commerce industrial belts in China have their own characteristics. With the continuous release of policy dividends, many traditional foreign trade industrial belts have achieved global business expansion through cross-border e-commerce.

   From product to brand.

    At present, China’s industrial belt has entered a new stage of intensive brand going out to sea from extensive high-speed growth. Under the background of the state’s support for the development of new foreign trade formats, many traditional foreign trade industrial belts have been actively transformed by relying on cross-border e-commerce channels and digital service tools, further focusing on brand building and global development.

    In the eyes of the industry, one way for the industry to take the brand to the sea is to take the flexible supply chain as the support and embark on the road of brand internationalization through the cross-border e-commerce platform; The other is that trade-oriented businesses transform and upgrade from distributing goods to brands, and build their own brands with the help of cross-border e-commerce platforms.

    Building its own brand and strengthening its brand power are regarded as the inevitable trend of "Made in China". Insiders pointed out that cross-border e-commerce platforms not only empower more industrial belt sellers with flexible supply chain capabilities, but also actively assist industrial belt sellers to build brand power together. The platform helps industrial belt sellers to improve a series of capabilities including product development, market trends, compliance management and supply chain management by empowering them with one-stop services. For the industrial belt, the future is not only the product going out to sea, but also the overall ability and brand power of the industrial belt going out to sea and upgrading. If the industrial belt wants to go to sea, it must achieve high-quality going to sea, and the ultimate benefit will be the comprehensive competitiveness of the whole "Made in China".

    Deng Nan, the seller of wig industry belt, paid attention to the demand of overseas consumers for wigs in his early years. Through the online Xiyin platform, the humble niche products achieved sales of 50,000 US dollars in the first month; Three years later, this number has grown to $2 million.

    "At present, industries driven by cross-border e-commerce platforms are brought out to sea, allowing China’s high-quality supply chain to directly face international consumers, opening up new international markets and promoting industrial upgrading." Zhao Lingyi, chief analyst of Shen Wanhongyuan’s research on commerce and retail, told reporters that the new format of going to sea promoted by "cross-border e-commerce+industrial belt" will further promote the transformation of China’s manufacturing industry into a China brand with independent design concept and strong market competitiveness, thus occupying a more important position in the global value chain.

   Digital innovation drives the development of industrial belt

    Last year, the General Office of the State Council issued an opinion on promoting the stable scale and excellent structure of foreign trade, proposing to support foreign trade enterprises to expand their sales channels and cultivate their own brands through new formats and new models such as cross-border e-commerce, encouraging all localities to combine their industrial and endowment advantages, innovate and build a comprehensive cross-border e-commerce experimental zone, actively develop the "cross-border e-commerce+industrial belt" model, and drive cross-border e-commerce enterprises to export to enterprises.

    Domestic emerging cross-border e-commerce platforms such as Xiyin, AliExpress and Tik Tok Xiaodian have attracted a large number of consumers and sellers through their own characteristics and unique development models, and gradually occupied an important position in the global e-commerce market. In the future, domestic cross-border e-commerce enterprises are expected to fully benefit from the continuous high penetration rate of global e-commerce and the cost-effective advantage of "Made in China" to drive the rapid development of the domestic cross-border e-commerce market. In addition, sellers related to brand going out to sea and manufacturing going out to sea are expected to benefit from the traffic dividend brought by the emerging cross-border e-commerce platform in China.

    "New advantages need to be established in the process of manufacturing internationalization. China’s manufacturing industry must take the road of increasing added value in the future. The added value comes from innovations in design, technology and products, as well as the improvement of brand power. " Hu Qimu, chief researcher of digital economy think tank, said that enterprises can make the supply chain more efficient through digital means, realize personalization and improve overall efficiency at the same time.

    Hu Qimu believes that the "cross-border e-commerce+industrial belt" model is to use digital tools to help businesses continuously optimize the supply chain, solve the problem of production balance through flexible small orders, and then digitally manage the whole process of a large number of fragmented orders, so as to realize flexible and standardized production, improve quality and efficiency, and empower more industrial belts to build new quality productivity and brands to go to sea. (Reporter Gao Shaohua)

Yang Jianfei: Computational Medicine Promotes Accurate Clinical Trials.

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Yang Jianfei, Chief Scientific Officer of Zheyuan Technology

Computational medicine needs to be composed of interdisciplinary teams and platforms. By integrating supercomputing system, AI platform, molecular and clinical data, massive literature and biological information, it can realize effective analysis and calculation of drug development and assist decision-making.

Taking an anti-tumor drug in our pipeline as an example, we read all the literatures of the target disease by using the "TWIRLS stick" of the computational medicine platform, first we have all the scientific knowledge known on the earth at present, and then we analyze the digital twins of patients in the patient database in a data-driven way to obtain the disease mechanism, specific targets and "portraits" of patients.

As we all know, the tumor is heterogeneous in time and space, and the immune system around the tumor is particularly complex. Therefore, only by having an accurate "portrait" of the patient’s tumor and accompanying diagnosis can we enter the stage of accurate clinical trials.

Through the computational medical platform, we established the response mechanism model of CDK4/6 inhibitor, and the effectiveness of this model was verified by the data of TCGA and Chinese patients. Then we put this drug currently used to treat breast cancer on the computational medical platform to study whether it has other applicable diseases. It was found that the model score of chordoma was very high, so we established cooperation with shanghai changzheng hospital and saw that some patients achieved partial remission in the third week after taking the drug. Although this drug has not yet entered the clinical trial stage, as long as it is carried out in accordance with the norms of computational medicine platform, we are confident to achieve truly accurate clinical trials.

Peng Ao: Behind the clinical success rate from 2% to 21%

Peng Ao, Project Management Team Leader of Pfizer China Product Line

The efficiency of Pfizer’s new drug research and development has increased from 2% to 21%. I think we can sum up three experiences. First, accurate positioning, clear their own specific advantages in the field of biology. Pfizer currently focuses on internal medicine, immunity and inflammation, oncology drugs and vaccines. Second, choose the drug mode. At present, more complex and novel molecular entities account for more and more in our pipelines. Thirdly, the decision-making adheres to two principles. First, quantitative POM analysis is carried out in the first and second phase of the experiment, which can help the success rate of the second phase reach 40%; The second is to plan again. If the first direction of clinical research and development fails, then we will transform it and try again in another direction. If there is a very clear biological basis, our success rate can reach 31%.

Ertuglifozin is a SGLT-2 hypoglycemic agent, and a large number of technologies and methods related to computational medicine are used in its research and development, including systematic pharmacological model and Emax Model. Using this model, the highest hypoglycemic effect of the drug can reach 77%. Meta-analysis shows that the drug has the highest hypoglycemic level among similar products. This is a typical case of using model or computational medicine to guide drug research and development.

The US Food and Drug Administration has begun to build a framework for digital health tools. I believe that after the introduction of the framework, the guiding principles of the corresponding rules will also be introduced, which will guide the application of some new drug research and development more specifically and deeply.

Tang Yu: The insights generated by computational medicine need to be verified clinically.

Tang Yu, Executive Director of the Office of Drug Clinical Trial Research Center, Cancer Hospital, China Academy of Medical Sciences

Computational medicine has produced a large number of insights by analyzing massive data, but how to prove that these insights are authentic and can be used in clinical practice through clinical trials?

The first case is to verify the specific answer given by computational medicine to a specific problem, such as verifying whether the first innovative drug under the guidance of AI can treat pancreatic cancer. The second is based on massive data to verify whether the treatment mode formulated by AI for individual patients or groups is better.

In the course of such an experiment, we need to consider several issues:

First, the consistency of the AI model. When we want to prove that an algorithm or an AI-based paradigm can guide medical care, we must ensure the consistency of the paradigm and not make it change irregularly.　

Second, it is necessary to consider whether there is an accessible clinical treatment for a class of patients with more concentrated biological characteristics found by AI model. If there is no targeted treatment, although this model can guide the prognosis of patients, it is difficult to change the existing treatment methods.

Finally, establish a model that can not only explain the results, but also explain the mechanism, so as to better combine human wisdom with the wisdom of computer based on data integration.

At present, we are carrying out an umbrella research design, focusing on soft tissue sarcoma. Although the overall incidence of the disease is not high, there are nearly 100 subtypes. Our anti-vascular targeted drugs have shown excellent effects in individual subtypes, but the overall effect is still not ideal. Therefore, we hope to use Turing Darwin’s laboratory’s in-depth analysis of the whole sarcoma mechanism and digital twin technology to find drugs with ideal curative effect and high accessibility.

Niu gang: the big disease model changes the new paradigm of drug research and development

Niu Gang, Director of Turing Darwin Laboratory

In today’s medical field, we are committed to collecting and utilizing all kinds of disease-related data, looking for clues of logical unity for diseases, and establishing complex and real mechanism portraits. But the key lies in how to understand the so-called mechanism and who is the subject of the complex mechanism?

We have built and trained a brand-new AI method-"Genome Shotgun Damage Assessment Process" (DAGG). By inputting the sequence information of human germ line or tumor genome, AI can translate the sequence gobbledygook that human can’t understand into understandable changes in cell function.

According to the information of genome variation, clinicians can use DAGG to judge whether HER2 gene is amplified in tumor cells of breast cancer patients, so as to further clarify the pathological types of patients and provide clearer and more accurate judgments for patients’ diagnosis and treatment.

With the DAGG method, we can also transform the real patient data into the digital twins of the patient and his disease. With the large-scale accumulation of patients’ digital twins in virtual environment, we conducted a large-scale virtual clinical trial for PD-1/PD-L1 monoclonal antibodies. The results showed that the efficacy of most immunodrugs with indications was not ideal.

Therefore, the virtual clinical trial based on digital twins can replace the original clinical trial results that cost tens of billions of dollars. Based on the curative effect data of a small sample of individual indications, the potential indications of other tumor diseases can be inferred. At the same time, according to the biological mechanism directly suggested by the model, the combination scheme and even new molecules can be rationally designed, which saves many clinical development steps and costs and ensures greater benefits for patients.

Shi Rong: Computational Medicine Helps Accurate Diagnosis and Treatment of Breast Cancer

Shi Rong, Secretary General of Cancer Prevention and Treatment Committee of Wu Jieping Medical Foundation.

Breast cancer is the largest cancer in the world. HER2 is a definite prognostic indicator and a predictive indicator of drug treatment effect for breast cancer, but the tumor heterogeneity of HER2 expression is obvious, and the detection method of HER2 can not meet the demand of anti-HER2 treatment. Therefore, studying the etiology of the germ line carried in the germ line genome is not only helpful to deeply understand the pathogenesis of breast cancer, but also helpful to develop new methods and provide prospective judgment for subsequent treatment.

Recently, the artificial intelligence algorithm DAGG independently developed by the computational medicine team revealed the pathogenesis of breast cancer. It is found that the signal pathway function spectrum (APSP) can be obtained by using the DAGG model based on the germline fingerprint rare coding variation data. According to the difference in the distribution of APSP between patients and people with low etiology, a prediction model can be effectively constructed to evaluate the etiological risk of female individuals, and the HER2-positive and HER2-negative breast cancer patients can be effectively distinguished.

The clinical transformation path of breast cancer based on APSP is divided into three steps. The first step is to guide the clinical treatment plan based on the pathological classification of breast cancer by APSP. The second step, based on APSP, is the extremely early diagnosis of women with breast nodules and breast cancer with familial breast cancer genetic history, so as to reduce the proportion of breast cancer patients who enter advanced and advanced stages at the first diagnosis. The third step, breast cancer risk assessment of healthy population based on APSP, fills the gap of the lack of effective primary prevention measures for breast cancer in the world.

Jiang Min: Virtual clinical trial is a new paradigm in the future.

Jiang Min, Director of the Office of National Drug Clinical Trial Institution of Peking University Cancer Hospital

From a global perspective, there have been exploratory studies on virtual clinical trials, but retrospective cases are the main ones. Regarding whether we can carry out prospective virtual trial design and generate higher-level digital evidence to verify the computer simulation model, so as to better guide clinical research, Peking University Cancer Hospital and the computational medicine team collided from the perspectives of technology and experimental requirements, forming a real landing research.

The two sides jointly carried out a parallel virtual clinical research project by using the digital twin model of patients in computational medicine. The purpose of the research is to explore the relationship between the pathogenesis of tumor and the mechanism of anti-tumor drugs. Through the virtual clinical trial, the curative effect of anti-tumor drugs is predicted, and the characteristics and differences of patients are analyzed, so as to optimize the design of clinical trials. This study compares head-to-head with a real clinical study of registered new drugs to verify the consistency between the predicted results of virtual clinical research and the curative effects of real-world clinical trials.

Virtual clinical trial is a new paradigm in the future. With the support of computational medicine technology, the future clinical trial model may be transformed into more accurate clinical trial design, which will bring a more holistic drug research and development idea, which will bring revolutionary changes to the success rate and effectiveness of clinical trials.

Roundtable Forum I: Cognition and Evaluation of Non-consensus and Subversive Technology

Moderator: Li Lei, Associate Research Fellow of Frontier Science and Education Bureau of China Academy of Sciences.

Roundtable forum site.

Lv Benfu (Professor, School of Economics and Management, Chinese Academy of Sciences)The so-called breakthrough innovation mainly depends on three points. First, whether a brand-new track has been developed; Secondly, on the original track, whether its performance-to-value ratio conforms to the law of ten times speed; Third, whether it belongs to the pattern innovation from 0 to 1 depends on the support of industrial policies.

Gu Chengming (Head of Sanofi Greater China Medical Department)The non-consensus stage is the primary stage. As long as it is accepted by the industry, it is considered as consensus, or it is available, which can solve some problems. However, in the field of drug research and development, if you want to be a First-in-Class, it must be a non-consensus. If you become a consensus, it will be Me too.

Zhang Chunming (Vice President of the Western Research Institute of Computing Technology, Zhongke)From a practical point of view, today’s world structure does not support small steps forward, and we must give full play to the ability of large-scale team operations. In terms of innovation, it is indeed possible for computational medicine to open up a brand-new track, so any government department should carefully evaluate it.

Weng Huajian (deputy head of Changning District, Shanghai)In 2021, I first learned about computational medicine. At that time, we envisaged to set up a life science innovation center between Suzhou and Shanghai, specializing in high-end research and development, focusing on computer +Inside and AI+, so as to give full play to the accumulation of digital economy in Changning, Shanghai in the past 20 years, especially the accumulation advantages of talents and innovation ecology. Therefore, from the perspective of the government, we are full of expectations for disruptive innovation technology in computational medicine.

Roundtable Forum II: Investment Logic from the Perspective of Computational Medicine

Moderator: translated by Hu Ming, partner of Mingde Capital.

Roundtable forum site.

Tian Feng (Minister of Industry Service Department of Shanghai Biomedical Industry Promotion Center)The most noteworthy point of the whole AI+ pharmaceutical industry is to change from logical successful practice to probabilistic successful practice, and finally return to logical successful practice. From the perspective of AI+ diseases, developing virtual clinical trials, I think it can effectively reduce the cost of clinical development and improve the success rate in the future.

Jing Xutian (Managing Director of Wuyuan Capital): AI technology has brought some new algorithms and breakthroughs in computing power. In the past, many AI pharmaceutical companies paid more attention to the field of small molecules with the most data and the most mature data, but today we see that more and more algorithms are actually very suitable for doing some new modal drug discovery.

Zeng Yingzhe (Partner of Linear Capital)Before AI technology, we usually build low-dimensional models to solve high-dimensional problems, but the emergence of AI can solve these high-dimensional problems. With more and more data and more powerful computing power, the prospect of AI pharmaceutical is very broad. At present, we are observing what progress the big language model will bring to AI pharmaceutical. It is exciting that some new progress has been made in the field of molecular characterization algorithms.

Ma Rui (partner of Fengrui Capital)We always overestimate the progress of computational medicine in five years, but underestimate the progress it can bring in ten years. I think that in the next three years, macromolecular protein drugs will basically be subverted by AI, just like AlphaFold in 2021 completely solved the problem of structural prediction of single domain proteins. (Photo courtesy of the organizer)

Cctv newsAccording to the WeChat WeChat official account news released by Sanya, on the morning of March 17, 2023, the video of "A tour guide in Sanya suspected that tourists scolded tourists because they didn’t shop" attracted the attention of the media and netizens. The Sanya Municipal Bureau of Tourism and Culture, Radio, Film and Television Sports, the Municipal Comprehensive Administrative Law Enforcement Bureau and other departments attached great importance to it and immediately organized an investigation.

After investigation, the tour group in the video was a four-day and three-night individual tour group received by Hainan Xinxianglian International Travel Service Co., Ltd. (registered at Room B207, Floor 2, Building B, Shengshenghuiyu, No.35 Nansha Road, Longhua District, Haikou City) on February 23, 2023. The tour guide was Yang Moumou (female), and his tour guide card was attached to Hainan Xinhuanyou International Travel Service Co., Ltd. (registered at Floor 4, Blue Sky Plaza, No.19 Heping Avenue, Heping South Street, Meilan District, Haikou City

At present, the Comprehensive Administrative Law Enforcement Bureau of Longhua District of Haikou City has ordered travel agencies to improve the service quality of employees and tour guides; The tour guides involved have made a Record of Investigation and Inquiry, which will be handled according to the law. Citizens and tourists can call the Sanya municipal government service hotline at 0898-12345 immediately if they find illegal business practices in the tourism market. In view of the illegal acts in the tourism market, the relevant departments of our city will severely investigate and deal with them and will never tolerate them.

Comprehensive improvement of tourism market and environment in Sanya City

Work leading group office

March 17, 2023