National Medical Products Administration announces the fourth batch of typical cases of drug safety special rectification. Since the beginning of 2022, in order to implement the decision-making arrangements of the CPC Central Committee and the State Council on strengthening drug safety, National Medical Products Administration has organized nationwide drug safety special rectification actions with strict investigation of illegal activities and strict control of risks as the main line. Local drug regulatory authorities continued to strengthen supervision and law enforcement, severely cracked down on illegal acts endangering drug safety, investigated and dealt with a number of illegal cases, and earnestly safeguarded people’s health and drug safety. The fourth batch of typical cases of drug safety special rectification is now announced. I. Hao Cheng Oxygen Factory in Tieling Economic Development Zone failed to comply with good manufacturing practice’s case in drug production activities [Brief Introduction to the case] In March 2022, Liaoning Drug Administration found in its daily supervision and inspection that Hao Cheng Oxygen Factory in Tieling Economic Development Zone had a serious violation of the good manufacturing practice. After investigation, the company’s quality management system is not perfect, and there are behaviors such as production, inspection, inspection and recheck that are not in accordance with the regulations, and the person in charge of the enterprise, the person in charge of production management and the quality authorized person fail to perform the corresponding management duties. The above-mentioned behavior of the company violated the first paragraph of Article 43 of the Drug Administration Law and the sixth paragraph of Article 69 of the Measures for the Supervision and Administration of Drug Production. In August 2022, Liaoning Drug Administration ordered the company to suspend production and business for rectification in accordance with Article 126 of the Drug Administration Law and Articles 4, 6 and 9 of the Provisions on the Application of Administrative Punishment Discretion of Liaoning Food and Drug Administration.An administrative penalty of 100,000 yuan will be imposed, and the legal representative, the person in charge of production management and the quality authorized person of the company will be given an administrative penalty of confiscation of income and fines from their own units during the illegal act. [Typical significance] Oxygen is the key substance for human metabolism. Medical oxygen is mainly used for oxygen inhalation in patients with hypoxia in clinic, especially in emergency situations. High-purity oxygen can be used to save patients’ lives. China has strict requirements on the production management, quality control, storage and release of medical oxygen. In this case, the key personnel of the enterprise failed to perform the corresponding management responsibilities, and the enterprise did not comply with the good manufacturing practice to organize production, so the product quality was difficult to guarantee, which brought potential hidden dangers to the public’s safe and effective drug use. The drug regulatory authorities conscientiously implement the requirements of the "double punishment system", and at the same time, impose corresponding administrative penalties on the relevant responsible personnel of the enterprise according to law, which is of great significance to urge enterprises to implement the main responsibility and compact the post responsibilities of relevant employees. II. Case of Wei Motao’s Illegal Acquisition of Drugs [Brief Introduction to the Case] In December 2021, the Fengtai District Market Supervision Administration of Beijing and the Fengtai Branch of the Beijing Municipal Public Security Bureau jointly inspected and found that Wei Motao bought drugs such as Niaoduqing granules and acarbose tablets from individuals around Fengtai District through cash transactions and on-the-spot settlement. Wei Motao’s above behavior violated the provisions of Article 22 of the Measures for the Supervision and Administration of Drug Circulation. In August 2022,According to Article 115 of the Drug Administration Law, Item 1 and Item 4 of Article 17 of the Provisions of Beijing Food and Drug Administration on the Application of Administrative Punishment Discretion (Trial) and Item 3 of Article 152 of Beijing Drug Administration Discretion Benchmark (Trial), Beijing Fengtai Market Supervision Administration imposed an administrative penalty on the party concerned, which included confiscation of the drugs involved and a fine of 1.6 million yuan. [Typical Significance] China implements a strict licensing system for drug business activities, and illegal acquisition of drugs is prohibited. In this case, criminals used the price difference between the purchased medical insurance drugs and the drugs sold normally to obtain high profits, which not only seriously disrupted the order of drug management, but also caused the illegal purchase of drugs to be out of formal management, and the storage conditions of drugs could not be guaranteed, and the related drugs were re-circulated to patients, which brought great hidden dangers to the public’s drug safety. Strict investigation and punishment by drug regulatory authorities in accordance with the law has a positive demonstration role in effectively curbing related illegal activities, which is conducive to standardizing the order of drug circulation and effectively ensuring the safety of people’s medication. Iii. Case of Kangjian Store of Shi ‘antang Pharmaceutical Chain Co., Ltd. in Jining City [Brief Introduction to the Case] In 2021, Jining Municipal Market Supervision Administration of Shandong Province and Qufu Municipal Market Supervision Administration jointly inspected and sampled Kangjian Store of Shi ‘antang Pharmaceutical Chain Co., Ltd. in Jining City within the jurisdiction of Qufu City, and found that the drugs sold in this store, such as "Special Effects on Muscular Pain" and "Pain Eliminating Roots", contained diclofenac sodium and other ingredients and were identified as counterfeit drugs.Qufu Municipal Market Supervision Administration transferred the case to Qufu Municipal Public Security Bureau for investigation. In June 2022, the People’s Court of Qufu City, Shandong Province convicted the person in charge of the store of selling counterfeit drugs, sentenced him to criminal detention and fined him. In October, 2022, according to Articles 116 and 118 of the Drug Administration Law, Jining Municipal Market Supervision Administration imposed an administrative penalty on the store to revoke its Drug Business License, and imposed an administrative penalty on the person in charge of the store to ban drug production and business activities for life. [Typical Significance] As a special commodity for treating diseases and saving lives, the quality and safety of drugs are directly related to the public’s health and life safety. We must strictly guard against and strictly control the drug safety risks, and resolutely prevent and eliminate the damage caused by counterfeit and inferior drugs to people’s lives and health. The parties in this case sell fake drugs, which is extremely harmful to society. The judicial organs sentenced the relevant responsible persons to criminal detention and fined them according to law, and the drug regulatory authorities imposed administrative penalties on the parties concerned and banned the relevant responsible persons according to law, which reflected the determination to resolutely implement the "four strictest" requirements for drug safety. This case is a typical case of execution linkage between the drug regulatory authorities and the public security and judicial departments, which embodies a good working mechanism of information exchange and close cooperation between the administrative departments and the public security and judicial departments, and reflects the efficient law enforcement joint force of execution convergence, which has reference significance for the drug regulatory authorities at all levels and the public security and judicial departments to share information and jointly crack down on illegal acts.IV. Case of Guangzhou Dameikang Medical Device Co., Ltd. Failing to fulfill the obligation of registered agent [Brief Introduction to the case] According to the case clue assigned by National Medical Products Administration, in June 2022, Guangdong Provincial Drug Administration filed an investigation on Guangzhou Dameikang Medical Device Co., Ltd. for allegedly failing to fulfill the obligation of registered agent of overseas medical devices. Upon investigation, the party concerned, as the import registration agent of medical devices, failed to fulfill the obligation to inform the registrant of the need to supplement the notarized letter of ISO certificate, product label and authenticity statement for the change of production address during the process of assisting the registrant to apply for the registration of imported medical devices in National Medical Products Administration, and Yin Moumou, the registration Commissioner of the party concerned, forged a false notarized letter through photo editing software without authorization and submitted it to National Medical Products Administration as registration correction materials. In November 2021, the parties have assisted the registrant to apply for withdrawing the application for registration of medical devices involved. The above-mentioned behavior of the parties violates the provisions of Paragraph 4 of Article 14, Paragraph 5 and Paragraph 2 of Paragraph 1 of Article 20 of the Regulations on the Supervision and Administration of Medical Devices (Order No.739 of the State Council). In August, 2022, Guangdong Drug Administration ordered the parties concerned to correct the above-mentioned illegal acts according to the first paragraph of Article 98 of the Regulations on the Supervision and Administration of Medical Devices (the State Council Order No.739), and imposed an administrative penalty of a fine of 120,000 yuan on the parties concerned, and imposed an administrative penalty of banning the production and operation of medical devices for five years on its responsible person Yin Moumou.[Typical Significance] Applicants for medical device registration should ensure that the submitted materials are legal, true, accurate, complete and traceable. An overseas applicant shall designate an enterprise legal person in China as an agent to handle the relevant medical device registration matters. The agent shall assist the registrant to fulfill the legal obligations according to law, and assist the overseas registrant to fulfill the corresponding legal responsibilities. Since the launch of the special rectification campaign for drug safety, drug regulatory authorities at all levels have severely cracked down on the fraudulent registration of medical devices. This case is the first case of fraudulent registration of medical devices involving medical device agents. Guangdong Provincial Drug Administration has imposed administrative penalties on the parties who are fined and the responsible personnel who are forbidden to engage in the production and business activities of medical devices for five years, investigated the legal responsibilities of the parties according to law, and strictly implemented the punishment for illegal acts to meet the requirements of people, thus forming a powerful deterrent, which is conducive to standardizing the registration behavior of medical devices and ensuring the safety and effectiveness of medical devices. V. Case of Ningbo Jingbo Rehabilitation Aids Co., Ltd. producing Class II medical devices without permission [Brief Introduction to the case] On March 4, 2022, Ningbo Municipal Market Supervision Administration of Zhejiang Province inspected Ningbo Jingbo Rehabilitation Aids Co., Ltd. After investigation, the party involved was suspected of producing scoliosis orthosis without permission, which was not registered according to law. The value of the goods involved was 264,000 yuan, and the illegal income was 264,000 yuan. The parties’ unauthorized production of Class II medical devices that are not registered according to law violates the Regulations on the Supervision and Administration of Medical Devices (the State Council Decree No.739? Number)Paragraph 1 of Article 16 and paragraph 1 of Article 32 stipulate that. On August 3, 2022, Ningbo Municipal Market Supervision Administration issued the Regulations on the Supervision and Administration of Medical Devices (the State Council Decree No.739? No.) Items 1 and 2 of the first paragraph of Article 81 and the Guiding Opinions on Standardizing the Discretion of Administrative Punishment in Market Supervision and Management (Guo Shi Jian Law [2019] No.244) stipulate that it is decided to give the parties a mitigated punishment, and impose an administrative penalty of confiscation of illegal income of 264,000 yuan and a fine of 1.32 million yuan. [Typical Significance] With the development of economy and society, rehabilitation therapy has become a new growth point in the medical field. Adolescent idiopathic scoliosis occurs frequently, and its treatment process and the legality of medical devices used have also become the focus of people’s attention. During the investigation and handling of the case, the supervision department deeply understood the causes, diagnosis points, treatment methods and imaging features of scoliosis, and extracted the electronic data of patients’ radiation images from PACS system by using technical methods, so as to find the breakthrough direction of case handling, thus uncovering the hidden rules of unlicensed production of medical devices in the field of medical rehabilitation and infringing on patients’ rights and interests. The handling of this case highlights the determination of the drug regulatory authorities to make key breakthroughs and overcome difficulties in the light of new illegal acts of medical devices, maintains the order of production and use of medical devices, and effectively guarantees the safety of public equipment. VI. Suzhou Weishijian Medical Instruments and Equipment Import and Export Co., Ltd. operates unregistered Class III medical devices and medical devices without Chinese instructions and labels [Brief Introduction] In June 2022,Law enforcement officers of gusu district Market Supervision Administration in Suzhou, Jiangsu Province inspected Suzhou Weishijian Medical Instruments and Equipment Import and Export Co., Ltd. according to the investigation clues. After investigation, the parties involved were suspected of operating unregistered imported medical devices such as intraocular lighting probes and ultra-emulsion wave cutting machines without Chinese instructions and labels, involving a value of 20,988.73 yuan. The parties’ operation of unregistered Class III medical devices and medical devices without Chinese instructions and labels violates the Regulations on the Supervision and Administration of Medical Devices (the State Council Decree No.739? Number) the provisions of the first paragraph of article thirty-ninth, second paragraph third and fifty-fifth. In September, 2022, the gusu district Municipal Market Supervision Administration of Suzhou City issued the Regulations on the Supervision and Administration of Medical Devices (the State Council Decree No.739? ) Article 88 (2), Article 81 (1) and Article 13 (1) of the Provisions on the Application of Administrative Punishment Discretion in Suzhou Market Supervision and Management (Trial) stipulate that the parties concerned shall be given a lighter punishment, and they shall be given an administrative penalty of confiscation of illegal income, confiscation of 104 unlicensed medical devices and a fine of 358,819.68 yuan. 【 Typical 】 According to the Regulations on the Supervision and Administration of Medical Devices (the State Council Decree No.739th? No.) Article 55 stipulates that medical device trading enterprises and users shall not operate or use medical devices that are not registered or filed according to law, have no certificates, or are expired, invalid or eliminated. At present, ophthalmic surgery technology is developing rapidly, the market competition is fierce, and some medical device business units have a weak sense of main responsibility. In order to gain a competitive advantage,Without authorization, unregistered medical devices (mostly consumable parts) are put into the market, resulting in unlicensed operation and use of medical devices. The investigation and handling of this case made medical device enterprises and users understand the importance of legal operation, which played a positive role in protecting consumers’ rights and purifying the market environment. VII. Case of Guangzhou Henglan Biotechnology Co., Ltd. Using Cosmetic Prohibited Raw Materials to Produce Cosmetics [Brief Introduction to the Case] In March 2022, Guangdong Drug Administration comprehensively analyzed and judged the clues of the case, and jointly conducted a surprise inspection on Guangzhou Henglan Biotechnology Co., Ltd. with the public security organs, and sampled some cosmetics. After investigation, the baby Beixuan baby skin cream and baby Kang Yishengyuan body milk produced by the company from November 2021 to March 2022 were found to contain clobetasol propionate, halobetasol propionate and cyproheptadine, the value of which was 212,667 yuan. Guangdong Drug Administration transferred the case to the public security organ according to law, and the public security organ has filed a case for investigation according to law. At the same time, in view of the fact that the products involved are children’s cosmetics, and the illegal acts are serious, in October 2022, Guangdong Provincial Drug Administration imposed administrative penalties on the company’s use of prohibited raw materials to produce cosmetics, in accordance with Article 59, paragraph 3, of the Regulations on Cosmetics Supervision and Administration, such as revoking its cosmetics production license, canceling its cosmetics product filing, not handling its cosmetics filing within 10 years and accepting its cosmetics administrative license application.Wu Moumou, the legal representative of the company, and Mo Moumou, the person in charge of production, were given an administrative penalty prohibiting them from engaging in cosmetics production and business activities for life. [Typical Significance] Using prohibited raw materials for cosmetics to produce children’s cosmetics or illegally adding substances that may endanger human health in children’s cosmetics is a serious case as stipulated in Article 61 of the Measures for the Supervision and Administration of Cosmetic Production and Operation, and such illegal acts should be severely punished according to law. In this case, the drug supervision and administration department took the initiative to dig deep into the clues of the case source, unblocked the green channel of product inspection involved, deepened the convergence of case execution, and jointly cracked down on the illegal addition of children’s cosmetics with the public security organs. The pharmaceutical supervisory and administrative department shall, in accordance with the law, punish the enterprises involved in the case by revoking their cosmetics production licenses and canceling their product records, and give the legal representative of the enterprises involved a life-long ban on business, and for the first time, give the person in charge of the production of the enterprises involved a life-long ban on business, which has formed a powerful shock to the lawless elements and reflected the firm determination of the supervisory department to resolutely protect the safety of children’s cosmetics. Eight, "5 7" Jiangsu Yangzhou production and sales of counterfeit cosmetics case [Brief Introduction] On September 15, 2022, the Guangling District People’s Court of Yangzhou City, Jiangsu Province sentenced Zhang Moumou and other eight criminals who produced and sold counterfeit cosmetics to fixed-term imprisonment ranging from three years to one year, plus a fine. The discovery of this case originated from the illegal clues found by Yangzhou Inspection Branch of Jiangsu Drug Administration in the cosmetic safety risk monitoring work.After discovering the illegal clues of counterfeit cosmetics mentioned above, Yangzhou Inspection Branch immediately set up a joint task force with Yangzhou Public Security Bureau’s Food and Drug Environmental Investigation Detachment, persisted in tracing the source and digging deep along the line, and finally destroyed a counterfeit cosmetics production den and two hose suppliers, and arrested many suspects such as Zhang Moumou. After investigation, since March, 2020, Zhang Moumou and others have purchased components such as paste, imitation packaging materials, trademarks and anti-counterfeiting labels, processed and assembled counterfeit cosmetics by themselves, and sold them through the Internet. [Typical Significance] In recent years, criminals aim at brand cosmetics to make and sell fakes, and seek illegal benefits by relying on the high-quality brand effect of others. In this case, the drug supervision and administration department attaches great importance to the illegal clues found in the safety risk monitoring of cosmetics in Conghua, gives full play to its professional and technical advantages, and cooperates with the public security organs. Under the framework of the working mechanism of "counterfeiting and protecting famous brands", the administrative law enforcement departments, the public security organs, the judicial organs and the obligee enterprises work together to wipe out the chain of counterfeiting and selling, effectively protect the safety of public cosmetics, maintain fair competition market order and create a good business environment. IX. "6 12" Case of Selling Counterfeit Cosmetics in Zhangzhou, Fujian [Brief Introduction to the Case] In September 2021, Zhangzhou Municipal Market Supervision Administration of Fujian Province received many complaints and reports, reflecting that the registered address was in many Taobao shops in Zhao ‘an County, Zhangzhou City, selling counterfeit brand cosmetics. Zhangzhou Municipal Market Supervision Administration immediately organized an investigation. After comprehensive judgment, Zhao ‘an County Market Supervision Administration transferred the clue to the public security organ.At the same time, Zhangzhou city and county market supervision and public security departments set up a joint task force to jointly investigate the case. In June 2022, the joint task force sent more than 100 law enforcement officers to Shenzhen, Guangdong, Dalian, Liaoning, Handan, Hebei, Zhangzhou, Fujian and other places to carry out the network-closing operation at the same time, destroying 6 dens for selling fake cosmetics in one fell swoop, arresting 73 people involved on the spot and seizing a large number of counterfeit cosmetics. Up to now, Zhao ‘an County People’s Procuratorate has approved the arrest of three major suspects in this case, transferred three people for review and prosecution, and 21 other suspects have been released on bail pending trial. The case is under further investigation. [Typical Significance] In recent years, with the increasing crackdown on cosmetic crimes, cosmetic counterfeiting dens have been further transferred to remote areas such as rural areas and urban-rural junctions. In this case, criminals formed gangs to commit crimes, and they were scattered in remote areas such as rural areas in Fujian and Guangdong, and they had a strong sense of anti-investigation. They opened a number of online stores on multiple e-commerce platforms to produce and sell illegal cosmetics across provinces. Through careful investigation of illegal clues and close cooperation with public security organs, the drug supervision and administration department found out the context of illegal acts in the whole case, and finally successfully destroyed the black dens and safeguarded the safety of public makeup.

　

While affirming that Guangdong Province attaches great importance to the high-quality development of the pharmaceutical industry, the audit findings also point out that many pharmaceutical consumables distribution enterprises have increased intermediate sales links and raised the price of medical equipment, medical personnel have long accepted the benefits from pharmaceutical companies, and medical institutions have illegally purchased or used medical equipment.

Reporter | Qu Yixian

Source | vision china

On August 8th, an investigation report on special audit of People’s Republic of China (PRC) Audit Office (draft for comments) obtained by Economic Observer Network showed that three pharmaceutical manufacturers in Guangdong Province had used 4.077 billion yuan for public relations and other purposes, pushing up the ex-factory price of drugs.

In addition, while affirming that Guangdong Province attaches great importance to the high-quality development of the pharmaceutical industry, the audit findings also point out that many pharmaceutical consumables distribution enterprises have increased intermediate sales links and raised the price of medical equipment, medical personnel have long accepted the benefits from pharmaceutical companies, and medical institutions have illegally purchased or used medical equipment.

From the end of May to July, 2023, the audit team sent by the National Audit Office conducted a special audit investigation on the production, distribution and use of drugs and high-value medical consumables in Guangdong Province (excluding Shenzhen, the same below), focusing on the relevant administrative departments of drug supervision, medical security and health care in Guangdong Province, public hospitals, primary medical and health service institutions and other medical institutions, and the production and distribution enterprises of drugs and consumables.

People close to the Guangdong Health Care System told Economic Observer that the Guangdong Health Care System was indeed being audited some time ago and just ended. "This audit is very strict."

The above audit investigation report was signed by "Guangdong Provincial Special Audit Investigation Team on the Production, Distribution and Use of Drugs and High-value Medical Consumables", which was forwarded by the Guangdong Provincial Health and Health Commission Office to Guangzhou, Zhuhai, Foshan, Heyuan, Dongguan, Zhongshan Health Bureau (Commission), Provincial People’s Hospital, Provincial Second People’s Hospital, Third Affiliated Hospital of Sun Yat-sen University, Cancer Prevention Center of Sun Yat-sen University, Stomatological Hospital of Sun Yat-sen University, Southern Hospital of Southern Medical University, and Second Affiliated Hospital of Southern Medical University.

The staff of the above-mentioned hospital confirmed to the Economic Observer that the investigation report forwarded by the Guangdong Provincial Health and Health Commission was true. The doctor of another hospital told Economic Observer that the hospital level issued several anti-corruption announcements.

Drug production enterprises collect funds for public relations.

Audit spot checks found that from 2021 to May 2023, three pharmaceutical manufacturers in Guangdong paid fees to 1,936 third-party business promotion companies, and withdrew 4.077 billion yuan in the name of service fees, which increased the comprehensive cost of drugs and pushed up the ex-factory price.

These three enterprises are Guangdong Yifang Pharmaceutical Co., Ltd. (hereinafter referred to as "Guangdong Yifang Company"), Guangzhou Poinsettia Pharmaceutical Co., Ltd. (hereinafter referred to as "Guangzhou Poinsettia Company") and Livzon Group.

Among them, the Guangdong company paid 2.39 billion yuan to 966 business promotion companies in the name of "technical service fee", which was used for the pharmacy construction cost and labor cost of cooperative hospitals.

Guangzhou Poinsettia Company collected 1.675 billion yuan by registering conference service companies in batches, and assigned a third-party company to register and set up 962 conference service companies at the same address in the form of "cluster registration". The third-party company further decomposed the funds according to the requirements of Guangzhou Poinsettia Company and transferred them to specific personnel accounts to pay the public relations expenses of hospitals in various regions.

Livzon Group set up a consulting company through its employees to collect funds of 12.4001 million yuan, and the funds were transferred to the personal accounts of relevant employees for drug public relations.

In addition to pharmaceutical manufacturers, the audit investigation team also found that pharmaceutical consumables distribution enterprises increased intermediate sales links and pushed up the circulation price of medical equipment. The enterprises involved include Kangchao Pharmaceutical Co., Ltd. and Sinopharm Equipment (Dongguan) Co., Ltd., and the products involved include Cao Qinghua Yixin Chushi Zhitong Capsule and other high-value medical consumables such as spinal internal fixators.

It is worth noting that there are also public hospitals that increase procurement intermediate links to make profits to subordinate enterprises. For example, from 2020 to May 2023, the Cancer Hospital affiliated to Sun Yat-sen University appointed Guangdong Guanhua Medical Service Company, a subsidiary of the trade union, to supply medical consumables for it, and Guangdong Guanhua Medical Service Company made a profit of 7,488,200 yuan, with an average price increase rate of 6.6%.

Medical personnel have long accepted the benefits delivered by pharmaceutical companies.

Audit investigation shows that domestic authoritative medical experts have long accepted exclusive service arrangements of foreign-funded pharmaceutical enterprises. Kehui Medical Devices International Trade (Shanghai) Co., Ltd. (hereinafter referred to as "Kehui Company") is a wholly foreign-owned enterprise, which mainly sells Covidien brand medical devices, and has long sponsored academic exchange activities organized by medical and pharmaceutical associations at all levels in China, and requires domestic distributors to pay accommodation, transportation, air tickets and other expenses for participating doctors and experts according to 2% of annual sales.

The audit spot check found that in 2022, Foshan Tailing Trading Co., Ltd., the brand distributor, paid 15.8117 million yuan for transportation, accommodation, catering and other expenses for medical experts and related personnel through nine travel agencies according to the instructions of Kehui Company, of which only one travel agency provided special follow-up, special car transfer and gifts for 272 authoritative experts in the medical field in China (including 63 in Guangdong Province) in seven meetings.

In addition, 4,782 medical staff illegally accepted the benefits delivered by foreign-funded pharmaceutical companies in the name of conference registration fees, involving pharmaceutical companies such as Bayer Healthcare Co., Ltd.

In addition, four medical experts from public hospitals received a targeted donation of 2.37 million yuan from pharmaceutical companies through the foundation of Guangdong Medical Association, involving five pharmaceutical companies including Beihai Kangcheng (Shanghai) Biotechnology Co., Ltd.

Medical institutions illegally purchase or use medical devices.

The audit investigation found that medical institutions illegally purchase or use medical devices, which has hidden hidden dangers of life and health and financial security.

The audit spot check found that three medical institutions, including Zengcheng Branch of Southern Hospital of Southern Medical University (hereinafter referred to as Zengcheng Branch of Southern Hospital), had problems such as determining the winning bidder in advance and purchasing large-scale medical equipment at a high price, involving funds of 73.0828 million yuan (including equipment price increase of 30.209 million yuan).

For example, in 2020, the then president of Zengcheng Branch of Southern Hospital organized the head of the department to conduct a feasibility study on purchasing X-ray computed tomography scanner, and determined the equipment of American GE Company quoted by Guangzhou Tangyun Medical Equipment Co., Ltd. In June 2021, the enterprise actually controlled by the company won the bid with the same brand and model equipment, with the winning bid amount of 29.49 million yuan, the purchase price of which was 14.287 million yuan, and the difference reached 15.2 million yuan.

In addition, the audit survey found that from 2018 to May 2023, a total of 491 medical institutions in Guangdong Province entrusted Guoyi Tendering Co., Ltd. to carry out bidding for more than 10,000 large-scale medical equipment or consumables procurement projects, with a total project amount of 22.386 billion yuan. Among them, only 3 companies participated in the bidding for nearly 9,000 projects.

Zengcheng Branch of Southern Hospital illegally purchased a proton radiotherapy system equipment without the permission of National Health Commission Class A large-scale medical equipment configuration, and paid 50% of the purchase price of 120 million yuan from the special government debt before the main components were shipped.

In terms of illegal use of medical devices, two medical institutions, including Zhongshan People’s Hospital, repeatedly used 2409 disposable ultrasonic blades, involving 15,100 person-times, involving medical insurance fund of 7,730,600 yuan. The Stomatological Hospital of Southern Medical University applied the "ultrasonic osteotome" used in the operation to the charging item of "additional ultrasonic scalpel", and illegally charged 67.2031 million yuan for medical treatment and 5.7011 million yuan for medical insurance fund.

The audit investigation also found that Guangdong Medical Association received 52,056,200 yuan from 329 pharmaceutical companies to designate doctors to promote their products. Guangdong Medical Association fraudulently distributed lecture fees and preparation fees of 169,600 yuan to medical experts in violation of regulations.

It is worth noting that the audit survey results also pointed out that Guangdong Province attaches great importance to the high-quality development of the pharmaceutical industry, actively promotes comprehensive reforms in the pharmaceutical field, and continuously optimizes the business environment of pharmaceutical enterprises, achieving good results. In view of the problems found in the above audit investigation, the audit investigation team also gave a number of suggestions.

On August 8, Economic Observer Network called the investor relations department of Livzon Group several times, but it was not connected. Ask Bayer China for an interview and get no reply; The relevant person in charge of Beihai Kangcheng responded that his company had not received a notice to cooperate with the investigation, and it was not clear about the specific situation.

Original title: Medical Corruption in an Audit Investigation Report

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　　At present, the construction of ecological civilization in our country has entered an accelerated period and a critical period, which puts forward higher requirements for the intensive utilization and strict protection of water resources. Studying the scientific issue of water resources carrying capacity and water balance optimization under changing conditions is conducive to deepening the understanding of the factors of regional water cycle in our country and their evolution laws, improving the evaluation method of water resources carrying capacity, clarifying the index significance of water balance status for water resources carrying capacity, clarifying the occurrence mechanism of many water problems and ecological environment problems, and providing important theoretical and technical support for summarizing the economic and social development and ecological protection models that are compatible with water resources carrying capacity, and effectively protecting and restoring the ecological environment.

Question 10: How to establish a theoretical and technical foundation for virtual twins and develop demonstration applications?

　　Virtual twin is a process and method for describing and modeling the characteristics, behavior, formation process and performance of physical entities and intelligent entity objects in the real world using digital technologies such as sensors, Internet of Things, virtual reality, artificial intelligence, etc. on the basis of digital twin, also known as virtual twin technology. It is based on digital twin, but focuses more on modeling and simulation of intelligent entities or living beings. How to realize the interaction and integration of manufacturing the physical world and the information world is one of the core bottlenecks currently faced by the practice of intelligent manufacturing concepts and goals at home and abroad.

Engineering problems

Question 1: How to develop new pathways and technologies for novel immune cells in tumor treatment?

　　Immune cell technology is the hope for human to completely cure tumors, and it is one of the hot areas pursued by cutting-edge medicine and capital around the world. As a key node cell linking cellular immunity and humoral immunity, dendritic cells (DC) can mobilize the entire immune system, resist the invasion of pathogens and promote the clearance of tumor cells, becoming a key research direction of new immune cell therapies. The new DC amplification technology can realize the standardization and mass production of DC vaccines, which can significantly reduce the preparation cost and serve more cancer patients, with obvious economic and social benefits.

Question 2: Why has the integrated design of horizontal take-off and landing combined power vehicles become the new focus of aerospace technology?

　　水平起降组合动力运载器具有快速、廉价、可靠的特点，可成为低成本天地往返运输工具。水平起降组合动力运载器一体化设计技术是支撑未来航天运输系统发展与应用的核心技术之一，是未来先进航天运输系统的重要支撑技术之一。

●问题3：如何实现农业重大入侵生物的前瞻性风险预警和即时控制？

　　农业有害生物入侵不仅仅是简单的植物病虫害或动物疫情问题，入侵生物的发生流行不仅危害食品安全和农业生产，造成巨大的直接经济损失，还可能对人类健康构成越来越大甚至是灾难性的威胁，对外交、经济和社会产生巨大影响。因此，站在国际化、全球化视角，从科学研究和专业技术层面，开展农业入侵生物跨境传播预警及防减技术合作的协同攻关，将有力解决入侵生物疫情的源头治理和联防联控关键技术难题，保障社会稳定与公共安全。

●问题4：信息化条件下国家关键基础设施如何防范重大电磁威胁？

　　强电磁脉冲一旦对金融、能源、电力等领域的关键信息基础设施产生影响，将可能导致交通中断、金融紊乱、电力瘫痪等重大事故。开展此项研究，对确保关键基础设施电磁安全、保护经济建设成果、提升关键基础设施容灾抗毁能力具有重要意义。

●问题5：硅光技术能否促成光电子和微电子的融合？

　　信息光电子芯片已然成为“数字化新基建”的核心和基石，也是全球信息通信价值链的关键领域和网络强国建设的“国之重器”。硅基光电子芯片技术既可应用于芯片级光互连，又适用于长距离光纤通信，可实现全功能光电子集成，具有极高的通用性和兼容性，是微电子和光电子两大产业公认的发展方向。利用国内现有微电子产业资源和互补金属氧化物半导体（CMOS）制造平台，建立健全硅光产业链，可以有效提升我国信息光电子的制造能力，缓解光电子芯片制造工艺的“卡脖子”困境，为我国信息化新基建提供有力支撑。

Question 6: How to solve the problem of on-line defect detection in integrated circuit manufacturing process?

　　The field of integrated circuits is currently the main battlefield of international science and technology competition and the focus of the game between major powers. For integrated circuit defect detection technology and equipment, on the one hand, the most advanced technology and equipment are monopolized by a few developed countries; on the other hand, the defect online detection technology of 7 nanometers and below nodes around the world is still immature, and the equipment gap is still huge. Whoever takes the lead in mastering the corresponding key technologies will have the dominance in the future. This is both an opportunity and a challenge for our country.

Question 7: How can unmanned vehicles achieve high-precision intelligent navigation under conditions where satellites are not available?

　　Special unmanned vehicles represented by unmanned rescue vehicles, unmanned mining vehicles, and unmanned transport vehicles are the core unmanned equipment for completing modern operations, emergency rescue and disaster relief. In order to improve the emergency rescue and joint operation capabilities of unmanned vehicles, its navigation system is required to have functions such as high-precision positioning, autonomous obstacle avoidance, intelligent path planning and guidance. Therefore, it is necessary to study high-precision and fully autonomous navigation methods and to solve the problem of inertia-based intelligent navigation for unmanned vehicles.

● Question 8: How to achieve the unity of "large-scale", "low energy consumption" and "high stability" in the large-scale production of hydrogen by electrolysis of water from renewable energy sources?

　　The development of high-efficiency and low-cost renewable energy and hydrogen energy technologies is a timely response to the country’s major needs, and it is also a high-quality solution for reducing carbon emissions and mitigating climate change globally. However, the current level of development of hydrogen electrolysis technology limits the conversion efficiency and industrialization process of renewable energy into chemical energy. Breakthrough in high-efficiency, low-cost, and large-scale hydrogen electrolysis technology can greatly promote the utilization and development of renewable energy and hydrogen energy.

Question 9: How to break through the intelligent construction and engineering health protection technology of the expressway into Tibet?

　　The lithology of the Qinghai-Tibet Plateau is complex and changeable, the neotectonic movement is intense, the deep and large active faults are widely distributed, the glaciers, permafrost and mountain disaster groups (chains) are developed, and there are "significant terrain height difference", "strong plate activity", "frequent mountain disasters", "sensitive permafrost environment" four geological environmental characteristics, as well as "high frequency freeze-thaw cycle", "severe wet and dry alternation" and "extreme cold and hypoxia" three climatic and environmental characteristics. The series of engineering and technical problems brought about by this are the key technical factors restricting the development of high-speed transportation in Tibet.

　　Cartography: Pan Xutao Caption: Figure 1: The officers and men of the company where "Wang Jieban" is located participated in the actual military exercise. Photo by Wang Lei (Xinhua News Agency)

　　Figure ②: Guangdong Province’s counterpart support to Kashgar, Xinjiang, has brought about profound changes in the local social outlook. The picture shows the employees of Guangdong Cisco Development Industry Co., Ltd. in Jiashi County, Kashgar, Xinjiang, working on the production line. Xinhua News Agency reporter Tian Jianchuan photo

　　Figure ③: In recent years, Shaanxi Province has continued to carry out key comprehensive management of the Hanjiang River Basin, and the ecological protection of the Hanjiang River Basin has achieved initial results. Xinhua News Agency reporter Tao Mingshe

　　Figure ④: Since May, Qingkou Town, Ganyu District, Lianyungang City, Jiangsu Province has organized art teachers of college student village officials to draw civilized wall paintings on the blank walls of various communities with the theme of socialist core values. Photo by Shao Shixin and Li Gang (People’s Vision)

　　On July 26th, General Secretary of the Supreme Leader delivered an important speech at the seminar for leading cadres at the provincial and ministerial levels, pointing out that since the 18th National Congress of the Communist Party of China, on the basis of the great achievements made in China’s development since the founding of New China, especially since the reform and opening up, the cause of the Party and the state has undergone historic changes, China’s development has reached a new historical starting point, and Socialism with Chinese characteristics has entered a new stage of development. Socialism with Chinese characteristics’s continuous great achievements mean that the Chinese nation, which has been suffering for a long time in modern times, has made a historic leap from standing up, becoming rich and becoming strong. It means that socialism in China is full of vitality and constantly opening up a new realm of development. It means that Socialism with Chinese characteristics has expanded the way for developing countries to modernize, contributed China wisdom and provided China’s plan for solving human problems.

　　其中“从站起来、富起来到强起来的历史性飞跃”的论断，既简明扼要地概括了近代以来中国实现飞跃的历史进程，又深刻揭示了中国特色社会主义不断开辟发展新境界的历史意义。其背后，则是中国人民创造幸福生活、一步步实现“中国梦”的生动实践。

　　中国发展的历史方向

　　要深刻领会最高领袖总书记“7·26”重要讲话精神，首先要认识和把握讲话中的历史方位感。对历史经验进行总结与运用，从不断认识和把握历史规律中找到前进的正确方向和正确道路，正是中国共产党长期以来能领导中国革命、建设、改革不断取得胜利的一个重要原因。

　　最高领袖经常在一些重大场合谈及历史。在庆祝中国共产党成立95周年大会上的讲话中，他曾说：“‘明镜所以照形，古事所以知今。’今天，我们回顾历史，不是为了从成功中寻求慰藉，更不是为了躺在功劳簿上、为回避今天面临的困难和问题寻找借口，而是为了总结历史经验、把握历史规律，增强开拓前进的勇气和力量。”

　　而“站起来”“富起来”“强起来”，正是最高领袖在回顾近代中国发展历史的基础上做出的历史判断，是透过“历史规律的望远镜去细心观望”而得出的论断。

　　在几千年的历史发展中，中华民族创造了悠久灿烂的中华文明。但是近代以后，由于西方列强的入侵，由于封建统治的腐败，中国逐渐沦为半殖民地半封建社会，山河破碎，生灵涂炭，中华民族遭受了前所未有的苦难。五四运动后，1921年，在中华民族内忧外患、社会危机空前深重的背景下，中国共产党诞生了。此后，中国共产党带领中国人民打败了日本帝国主义，推翻了国民党反动统治，完成了新民主主义革命，建立了中华人民共和国，实现了中国从几千年封建专制政治向人民民主的伟大飞跃。这是中华民族“站起来”的历史过程。

　　1949年后，中国共产党带领中国人民完成社会主义革命，确立社会主义基本制度。完成了中华民族有史以来最为广泛而深刻的社会变革，为当代中国一切发展进步奠定了根本政治前提和制度基础，为中国发展富强、中国人民生活富裕奠定了坚实基础，实现了中华民族由不断衰落到根本扭转命运、持续走向繁荣富强的伟大飞跃。

　　1978年，改革开放实行，极大激发广大人民群众的创造性，极大解放和发展社会生产力，极大增强社会发展活力。自此，人民生活显著改善，综合国力显著增强，国际地位显著提高。特别是党的十八大以来，中国共产党着眼于实现“两个一百年”奋斗目标和中华民族伟大复兴的历史使命，在一系列治国理政新理念新思想新战略的指导下，砥砺奋进，硕果累累。中国前所未有地接近中华民族伟大复兴目标、前所未有地走近世界舞台中心。中国实现了强起来的伟大飞跃。

　　而今，更多的就业机会，更稳定的收入，更完善的社会保障体系，更健全的社会法制体系，更美好的城市、乡村生活环境，让更多普通的中国人感受到了国家的文明进步，真切体会到了祖国从站起来、富起来到强起来这一历史变革。当今的中国有着前所未有的发展机遇，是“站到了新的历史起点上”。这不是凭空而来的论断，而是对中国的历史和现实最真实、最有力的概括。

　　3个飞跃源于党的领导

　　中华民族能够实现从站起来、富起来到强起来的历史性飞跃，根本原因在于中国共产党的领导。

　　在庆祝中国共产党成立95周年大会上的讲话中，最高领袖指出，“历史和人民选择中国共产党领导中华民族伟大复兴的事业是正确的，必须长期坚持、永不动摇；中国共产党领导中国人民开辟的中国特色社会主义道路是正确的，必须长期坚持、永不动摇；中国共产党和中国人民扎根中国大地、吸纳人类文明优秀成果、独立自主实现国家发展的战略是正确的，必须长期坚持、永不动摇。”

　　在历史的实践中，中国共产党带领中国人民跨过一道又一道沟坎，取得一个又一个胜利。而在勇于和善于推进理论创新、制度创新上，中国共产党更是把中国特色社会主义理论和实践进一步推向前进，开辟了21世纪马克思主义发展新境界，使党的理论和实践始终走在时代前列。

　　有论述指出，“历史性飞跃”其核心要义是：中国共产党在十八大以来推进我国社会发展实现历史性飞跃的同时，推进马克思主义中国化实现新的历史性飞跃。可以说，中华民族“站起来”“富起来”“强起来”的过程，得益于马克思主义中国化的不断推进，同时又促进马克思主义理论的进一步发展。社会主义在中国的活跃和兴旺、成功和胜利，是在中华民族从站起来、富起来到强起来的历史进程中实现的。

　　党的十八大以来，以最高领袖同志为核心的党中央在实践中形成的“五位一体”总体布局、“四个全面”战略布局、新发展理念以及一整套适应和引领经济发展新常态的经济政策框架，以其科学性、指导性、有效性有力推动中国新的发展实践。未来，中国特色社会主义也必定随着时代和实践发展而不断向前发展，必定随着党和人民不懈奋斗而进入新的发展阶段。

　　“强起来”体现在方方面面

　　3个“历史飞跃”把中国带到“强起来”的阶段，那么中国究竟强在何处？过去5年来的成绩，或许可以给出答案。

　　The Supreme Leader pointed out in his important speech on "July 26th" that the five years since the 18th National Congress of the Communist Party of China have been extraordinary in the development process of the Party and the country. We have strengthened the Party’s leadership in an all-round way, greatly enhancing the Party’s cohesion, combat effectiveness, leadership and appeal. We unswervingly implement the new development concept and vigorously promote China’s development in a higher quality, more efficient, fairer and more sustainable direction. We unswervingly deepen the reform in an all-round way and promote the reform to present a brand-new situation of all-round efforts, multi-point breakthroughs and in-depth advancement. We unswervingly and comprehensively promoted the rule of law, which significantly enhanced our party’s ability to lead and govern the country by legal means. We have strengthened the Party’s leadership over ideological work and consolidated the ideological unity of the whole Party and society. We unswervingly pushed forward the construction of ecological civilization and made important strides in promoting the construction of beautiful China. We unswervingly pushed forward the modernization of national defense and the army and made historic breakthroughs in national defense and army reform. We unswervingly pushed forward the diplomacy of a big country with China characteristics and created a peaceful international environment and a good surrounding environment for China’s development. We unswervingly push forward the comprehensive and strict administration of the party, focus on solving the outstanding problems that are most strongly reflected by the people and pose the greatest threat to the party’s ruling foundation, form an overwhelming situation in the anti-corruption struggle, update the atmosphere of political life within the party, strengthen the ideals and beliefs of the whole party, strengthen the party spirit, significantly improve the party’s ability of self-purification, self-improvement, self-innovation and self-improvement, and consolidate the party’s ruling foundation and mass foundation.为党和国家各项事业发展提供了坚强政治保证。

　　例如，党的建设日益加强。治国必先治党，治党务必从严。在过去的5年里，中国共产党把全面从严治党纳入“四个全面”战略布局，破藩篱、去顽疾、立规矩、建制度、正风气，“八项规定”“三严三实”“两学一做”深刻地影响了党内政治生态，“巡视全覆盖”成为党风廉政的监督利器，“老虎苍蝇一起打”的反腐决心令百姓拍手称快。全面从严治党赢得了民心，也令党的领导更加有力。

　　再比如，人民生活愈加富裕。全面建成小康社会是中国共产党向人民作出的庄严承诺。“脱贫攻坚已经到了啃硬骨头、攻坚拔寨的冲刺阶段”，为打赢这场硬仗，最高领袖指示说：“脱贫攻坚任务重的地区党委和政府要把脱贫攻坚作为‘十三五’期间头等大事和第一民生工程来抓，坚持以脱贫攻坚统揽经济社会发展全局。要层层签订脱贫攻坚责任书、立下军令状。”而到2020年中国现行标准下的农村贫困人口将全部脱贫，意味中国将提前10年实现联合国2030年可持续发展议程确定的减贫目标，也为全球减贫治理提供了“中国方案”。

　　The goal of strengthening the army has been gradually realized. Since November 2015, when the Central Military Commission’s reform work conference announced the full implementation of the strategy of strengthening the army through reform, a new round of landmark overall reform of China’s army has been launched in an all-round way. The operational command system, leadership management and supervision system and future development direction of the whole army have all been completely new. Optimize the scale structure, improve the policy system, and promote the in-depth development of integration of defense and civilian technologies. "After five years of hard work, the People’s Army has reshaped its political ecology, organizational form, power system and style image. The People’s Army has regrouped and started again, and has taken solid steps on the road to strengthening the army with China characteristics." The supreme leader said this.

　　In addition, more and more scientific and technological achievements at the forefront of the world, the ever-increasing socialist cultural construction, and the more complete talent construction system all reflect the overall prosperity of China. It can be said that China, who stood up, became rich and became strong, has proved the correctness of his chosen path with eloquent facts.

　　Rise to the sea, set sail and compete for first class. Since 2012, it has been a decade of passionate progress in Daya Bay, and it has been a decade of pioneering exploration in Daya Bay. Daya Bay bravely undertakes the mission and strives to build a domestic first-class development zone with high quality; Carry forward the great spirit of party building, strengthen historical self-confidence, keep in mind the initial mission, comprehensively promote the overall layout of the "five in one", work hard, focus on solving new development problems, and strive to write a new chapter in sustainable development and improving people’s livelihood and well-being.

　　From 40 billion yuan to 80 billion yuan, Daya Bay has reached four 10 billion yuan steps in ten years. In 2021, the GDP of the whole region reached 80 billion yuan, with a cumulative increase of over 85% in ten years; The added value of industrial enterprises above designated size was 53.33 billion yuan, a cumulative increase of 101.5% in ten years; The total tax revenue of the whole region (including tax collected by customs) was 50.46 billion yuan, with a cumulative increase of 67.4% in ten years; In the past ten years, the total investment in fixed assets in the whole region has reached 310.31 billion yuan, with an average annual investment of 31.03 billion yuan …

　　Groups of data are the imprint of Daya Bay’s solid steps in accurately and comprehensively implementing the new development concept. Nowadays, Daya Bay, which is sailing for the sea, is seizing the great opportunity of "two-zone" construction, building a world-class green petrochemical industry highland with high quality, and striving to become an important supporting area for Huizhou to build a happier domestic first-class city.

Daya Bay firmly adheres to the road of ecological priority and green development.

　　Entering Daya Bay, key national, provincial and municipal projects such as ExxonMobil Huizhou Ethylene Project and Hengli (Huizhou) PTA Project are in full swing. On the other side of Huizhou Port, ships enter and exit, and vehicles shuttle; In the newly planned 100 billion-level Daya Bay Emerging Industrial Park, the production line of Zhouming Technology Daya Bay Science and Technology Park, the world’s largest intelligent LED display base, is running rapidly; Wanda Commercial Circle, Canbang Plaza and Yitian Commercial Circle are three pillars, with towering high-rise buildings, various commercial centers and vigorous consumption … With the rapid economic and social development of Daya Bay in the past 10 years, a new coastal city with integrated development of production, life and ecology has taken shape, and the future can be expected.

　　On November 8, 2021, ExxonMobil announced its investment decision to the world, and increased the first phase of total investment of the project from $5.5 billion to $6.7 billion. With the construction of the project, ExxonMobil Asia-Pacific R&D Center has also settled in Huizhou, which shows the confidence and determination of this oil and gas giant to invest in Daya Bay.

　　In recent years, in the face of the COVID-19 epidemic and the complicated and severe challenges of the domestic and international economic situation, Daya Bay District has continuously optimized its business environment and promoted the construction of major projects at an extraordinary speed. Investing in the development of highland has become a new label of Daya Bay, and leading enterprises in Chinese and foreign industries are coming in droves. According to statistics, in recent years, 129 foreign-invested enterprises (projects) have been newly established in total investment of the project, amounting to 7.16 billion US dollars.

　　Sharpen a sword every ten years. Today, Daya Bay has become one of the seven national petrochemical industrial bases, and Daya Bay Petrochemical Zone has topped the top 30 chemical parks for three consecutive years. Daya Bay has gradually formed the orientation of "attracting large investment, attracting large businesses and developing greatly" in the development of economy, and has drawn a "investment map" of high-quality projects that are helpful to extend, supplement and strengthen the chain.

　　In recent years, Daya Bay District has made precise investment promotion around the industrial chain and further improved the "Investment Promotion Map". A set of investment project evaluation system consisting of 15 rigid quantitative indicators has been translated into English, Korean and Japanese, which has become a "hero post" for investment promotion issued by Daya Bay District to the world.

　　Keeping a close eye on the world’s top 500 enterprises and leading enterprises in the industry, Daya Bay gives full play to the leading role of leading enterprises such as CNOOC, China Shipping Shell, ExxonMobil, Hengli PTA and Guangzhao Lubricant, and conducts business attraction and investment promotion in the industrial chain, focusing on extending, supplementing and strengthening the chain. For example, China Merchants in Daya Bay said that the PC/DPC project of China Shipping Shell will become the only PC project in South China after it is completed and put into operation, forming a highly competitive PC industrial chain and leading the development of the C2 industrial chain. The third phase ABS project of Lejin Chemical will become the largest ABS production base in South China after it is completed and put into operation, and will continue to expand into a long C4 and aromatics industrial chain.

　　The advantages of these large projects are highly consistent with Daya Bay’s concept of building a world-class petrochemical industry highland and adhering to safe and green development, and are also a true portrayal of Daya Bay’s practice of high-quality and green development concepts.

　　The petrochemical industry has made precise efforts, and emerging industrial parks are also a thriving atmosphere. This vibrant park has attracted businessmen from the United States, Japan, Taiwan, China, Hong Kong, China and other countries and regions. At present, more than 100 projects have been settled, with a total investment of over 30 billion yuan. Well-known enterprises include BYD, Dongfeng Honda, Guanghong Technology, Sumitomo Forging, Xinlitai, Zhouming Technology, etc. The electronic information and auto parts industry has begun to take shape. "In the past ten years, with the vigorous development of Daya Bay, Guanghong Technology has made remarkable achievements." The person in charge of Guangdong Guanghong Technology feels that the progress of Guanghong in the past ten years is the best proof of Daya Bay’s development, from the upgrading of processing to intelligent manufacturing, and now it ranks among the high-quality listed companies.

　　"In the past ten years, the changes in the urban appearance of Daya Bay are amazing!" A senior media reporter spoke the voices of many people.

　　In Daya Bay Mangrove City Wetland Park, the plank road is clean and tidy; In the modern office building, energetic engineers are brainstorming; As night falls, the major shopping centers in the city are very busy … In the past ten years, the energy level of Daya Bay city has been continuously improved and the quality of the city has been constantly refreshed.

　　"Urban management should be as delicate as embroidery". Since the beginning of this year, the value of the entrances and exits of toll stations in Daya Bay has been higher, and the greening along the roads at intersections has become more exquisite, especially at night, with bright lights and charming scenery. These changes benefit from the implementation of the pilot project of upgrading urban quality nodes in Daya Bay District. With the issuance and implementation of the Construction Plan for Key Construction Projects in Daya Bay in 2022, Daya Bay District will carry out wall chart operations on 32 key construction projects, involving 6 road traffic projects, 9 industrial supporting projects, 8 human settlements projects, 7 people’s livelihood security projects and 2 flood control and drainage projects.

　　In order to comprehensively improve the urban quality of Daya Bay, Daya Bay has learned from domestic advanced urban management experience and practices, and carried out pilot projects to improve urban quality nodes throughout the region. This project includes the disc quality improvement project of Daya Bay West Area, the quality improvement project of Zhongxing South Road (Zhongxing Middle Road-Zhongxing Fifth Road Section), the elevation renovation project of Songtao Road (Xiaojingwan Toll Station-Shihua Avenue Section), and the quality improvement project of the entrances and exits of five high-speed toll stations such as Xiaojingwan Toll Station. The main facilities include the quality improvement of sidewalks and greening projects, and the lighting project of night scenes. The reporter learned from the Daya Bay Municipal Garden Management Office that the quality improvement project of each node in the project has been basically completed and the finishing work is underway.

　　Daya Bay will carry out the second phase of the urban quality node upgrading project this year, which will upgrade the quality of seven nodes, including Ximenlou of Shihua Avenue, Zhongxing Middle Road (Zhongxing South Road-Shugang Avenue) and Longshan No.1 Road (Longhai No.1 Road-Longhai No.3 Road). The main contents include pavement replacement, green belt combing, tree replacement and relocation, turf laying, micro-topography construction, and lighting engineering renovation and upgrading along the line.

　　It is understood that among the key construction projects in Daya Bay in 2022, there are eight residential environment projects, including Daya Bay Binhai Bidao and Landscape Construction Project (from Baguang to Fisherman’s Wharf), Daya Bay Lion Mountain Park Phase I Construction Project, Daya Bay West Old Community Reconstruction Project, Daya Bay Aotou Old Community Internal Quality Improvement Project, Daya Bay Aotou Old City Intelligent Parking Project and Daya Bay Second Water Purification Plant Phase III Project, etc. These projects are all being accelerated according to the set time nodes.

　　In order to improve the quality of the city, seize the opportunity of the times and practice high-quality development, Daya Bay has compiled the Urban Landscape Planning and Overall Urban Design of Daya Bay. "Overall Urban Design" has built an overall development pattern of "two mountains, one sea, five corridors and one network", cultivated a new platform for urban development at the level of business cards, improved the level of urban public service facilities, and improved public service facilities such as education, medical care, parks, culture and commerce.

　　There are more and more park squares around the people. In recent years, Daya Bay combines natural ecological conditions, with Tieluzhang and Bijiashan as the background mountains, Xiangshui River, Banzhangling, Hutou Mountain, Luoling and Mangrove as the core, Pingshan River and Dan ‘ao River as the main axes, featuring the coastal green spaces of Xiayong and Houzai Bay, and connecting with each other through the urban road greening system, forming a complete, rich, reasonable and urban green space system. At present, a large number of parks and squares, such as Banzhangling Park, Mangrove Urban Wetland Park, Hutoushan Park, Binhai Park, Fisherman’s Wharf, Huimin Square, Haiyun Square and Gold Coast, have met the leisure and recreation needs of residents.

　　In terms of commercial facilities, according to the layout idea of point, line and area, a large number of commercial complexes such as Wal-Mart, wanda plaza, Yitian Holiday Plaza, Canbang City Plaza, Century City Shopping Mall and Longguang Commercial Plaza have been built one after another along the main roads of the city, and citizens’ consumption experience is getting better and better.

　　In recent years, with the promotion of special rectification of municipal facilities, Daya Bay District has effectively improved the green environment of parks such as primary and secondary roads, kerbs, sidewalks, street lamps, Huimin Square, mangrove parks and coastal parks in accordance with the requirements of "purification, beautification and lighting", and the urban landscape has been continuously beautified. At the same time, improve the rapid response mechanism and the maintenance and acceptance mechanism of municipal facilities and landscaping, improve the traffic microcirculation, and make the management and operation of municipal facilities more smooth and effective.

　　Daya Bay District fully implements the responsibility system of "three guarantees in front of the door", implements three-level supervision, and includes "three guarantees in front of the door" in the annual inspection and assessment. At the same time, take the mechanism of creating civilized cities such as "hand-to-hand shooting" as the starting point to carry out rapid supervision and response.

　　A series of refined management has brought citizens and tourists a sense of identity and reputation for Daya Bay.

　　The water is clear and the banks are green, and gulls and herons fly in pieces. After ten years of renovation, the Tam O River has become a good place for citizens to relax.

　　"In the past ten years, the deepest feeling is that Daya Bay’s economy has developed, the city is more beautiful, and the ecological environment is better." In the past ten years, Daya Bay District has adhered to the concept of "Lucid waters and lush mountains are invaluable assets", unswervingly followed the road of ecological priority and green development, and strived to form a spatial pattern, industrial structure, life and production mode of saving resources and protecting the environment. The air quality has been ranked in the forefront of all counties and districts in the city for many years, and "good mountains, good water and good air" is becoming a beautiful business card for Daya Bay District.

　　The policy of paying attention to eco-environmental protection makes the green industry stimulate lasting and abundant development momentum, and the beautiful environment makes the green lifestyle a regional green trend. In Daya Bay Petrochemical Zone, the positive and negative list system is implemented for the EIA approval of projects entering the park, and all those that do not meet the requirements of industrial policies, relevant norms and energy conservation and emission reduction will be rejected by one vote; Take the lead in realizing full coverage of ecological towns and villages in the city.

　　Today, the east, west and north sides of the petrochemical area are wrapped by 2.33 million square meters of green isolation belt. The park is also sky-blue and green. It is difficult to link this environment with the annual output of 22 million tons of oil refining and 2.2 million tons of ethylene, and the scale of refining and chemical integration is the first in China. Here, every production link adheres to the technologies and concepts of recycling, green and low-carbon, safety and environmental protection.

　　The high-end, intelligent and green development of petrochemical industry is a true portrayal of Daya Bay District actively practicing the "five development concepts". "Green water and green mountains" and "Jinshan Yinshan" are mutually integrated and win-win, which lights up the beauty of Daya Bay District.

　　Since 2017, Daya Bay Petrochemical Zone has been recognized by the National Development and Reform Commission as a key support park for recycling transformation of national parks, and by the Ministry of Industry and Information Technology as the first batch of national green manufacturing system construction demonstration parks and national new industrialized industrial demonstration bases; The correlation degree of circular economy industrial chain in the park is as high as 95%, and 100% enterprises in key industries have carried out cleaner production audit, and four centralized sewage treatment plants have been built.

　　Daya Bay District continues to maintain high investment in safety and environmental protection, and has increased investment in environmental protection for many years in a row. In recent years, it has explored the governance strategy of "controlling, reducing and supplementing", that is, controlling source pollution, reducing total emissions, and supplementing ecological shortcomings, so as to comprehensively resolve the impact of development on the environment; In the prevention and control of air pollution, four sets of automatic atmospheric monitoring stations were built to monitor 46 atmospheric characteristic factors for 24 hours, and the air quality in the whole region was monitored and released in real time.

　　From January to June, 2022, the comprehensive index of ambient air quality in the whole region was 2.31, an improvement of 12.8% over the previous year, and the excellent rate was 100%, an improvement of 3.3 percentage points over the same period of last year. The air quality ranked second in seven counties and districts in the city. All the 16 rivers in the whole region meet the requirements of water functional zones, with a compliance rate of 100%, and the water environment quality ranks second among the seven counties in the city. The water quality in the coastal waters remains good; The water quality compliance rate of drinking water sources is 100%; The forest coverage rate is 44.37%, and the per capita park green space is 18.5 square meters, which has achieved the goal of ecological civilization construction with bluer sky, clearer water, more beautiful city and happier people, and presented a beautiful picture in which man and nature live in harmony and the economy, society and ecological environment complement each other.

天安门广场上，人民英雄纪念碑巍然矗立。错落有致的观众席拼成一幅“巨轮启航”的壮阔画面。在“巨轮”船首，中国共产党党徽熠熠生辉，党徽两侧，是醒目的“1921”“2021”金色字标。全国各族各界人士7万余人相聚于此，共祝中国共产党百年华诞！

庆祝中国共产党成立100周年大会上，最高领袖总书记发表重要讲话，铿锵有力的话语声中，一幅壮阔恢宏的“百年答卷”徐徐展开。

△2021年7月1日上午，庆祝中国共产党成立100周年大会在北京天安门广场隆重举行。这是国旗护卫队准备升旗。

“百年答卷”主题深刻鲜明。

“一百年来，中国共产党团结带领中国人民进行的一切奋斗、一切牺牲、一切创造，归结起来就是一个主题：实现中华民族伟大复兴。”最高领袖总书记的精辟论述，高度概括了中国共产党百年历史。

△独家V观丨最高领袖总书记：为中国人民谋幸福、为中华民族谋复兴是中国共产党的初心使命

犹记得2012年11月29日，当选中共中央总书记仅15天的最高领袖同志，与十八届中央政治局常委一起参观《复兴之路》展览时明确提出，实现中华民族伟大复兴，就是中华民族近代以来最伟大的梦想。

Since the 18th National Congress of the Communist Party of China, General Secretary of the Supreme Leader has put the distinct theme of "realizing the great rejuvenation of the Chinese nation" into all aspects of governing the country. Today, China’s GDP exceeds 100 trillion yuan, making it the second largest economy in the world. 98.99 million poor people in rural areas have all been lifted out of poverty and completely got rid of absolute poverty; Maintaining social harmony and stability for a long time and people living and working in peace and contentment have been praised by the international community as one of the most secure countries … …

Give an outline and read it, solve a volume and make it clear to all. The little "red boat" became a mighty "great ship", and after realizing the first century-long struggle goal, it continued to ride the wind and waves and sailed steadily to the second century-long struggle goal.

Great achievements in writing "Centennial Answers".

Focusing on the theme of realizing the great rejuvenation of the Chinese nation, General Secretary of the Supreme Leader comprehensively concluded that the Communist Party of China (CPC) United and led the people of China to create the great achievements of the new-democratic revolution, socialist revolution and construction, reform and opening up and socialist modernization, and Socialism with Chinese characteristics in the new era.

These great achievements have made China grow from a "sick man of East Asia" who is bullied by others to an oriental power that makes the world sit up and take notice, and from a bystander of the international system to a builder of world peace, a contributor to global development and a defender of the international order … … It was under the strong leadership of the Communist Party of China (CPC) that China approached the center of the world stage step by step.

After a hundred years’ history, looking back has changed a lot. As General Secretary of the Supreme Leader said, "China has been able to look down on the world", and Chinese has more ambition, backbone and confidence to make a solemn declaration to the world!

"Centennial answer sheet" contains great spirit.

People can’t stand without spirit, and countries can’t stand without spirit. A hundred years after the founding of the Party, a large number of revolutionary martyrs, a large number of heroic figures with tenacious struggle and a large number of advanced models with selfless dedication have emerged.

There is Li Dazhao who firmly believes that "if you look at the world in the future, it will be a world with red flags"; Yang Jingyu, who was in a world of ice and snow, ran out of ammunition and was alone in a bloody battle with the Japanese aggressors; There are Wang Ganchang, Deng Jiaxian and other anonymous "two bombs and one satellite" fathers; There is Jiao Yulu, who is in the late stage of liver cancer and sticks to his liver to keep working; There are Wang Jicai, Gu Wenchang, Nan Rendong, Huang Wenxiu … …

General Secretary of Supreme Leader once solemnly stated that the great spirits such as Jinggangshan spirit, Long March spirit, Zunyi Conference spirit, Yan ‘an spirit, Xibaipo spirit, Hongyan spirit, the spirit of resisting US aggression and aiding Korea, the spirit of "two bombs and one satellite", the spirit of the special zone, the spirit of fighting floods, the spirit of earthquake relief and the spirit of fighting epidemics have built up the spiritual pedigree of the Communist Party of China (CPC) people.

Nowadays, the Communist Party of China (CPC) people’s spiritual pedigree is further enriched, and the General Secretary clearly put forward the 32-word great party-building spirit at the celebration of the centenary of the founding of the Communist Party of China (CPC).

The great party-building spirit, generated with the great practice of communist party people from generation to generation, is the source of the Communist Party of China (CPC)’s spirit, leading countless communist party people to wave upon wave and China people to write the most magnificent epic in China.

Feeling the great spirit of party building is like touching the historical pulse of the Communist Party of China (CPC)’s century-long development.

On the eve of "July 1st", the Political Bureau of the Communist Party of China (CPC) Central Committee conducted a special collective study around making good use of red resources and continuing the red vein. General Secretary of the Supreme Leader said earnestly: "The great spirit and glorious tradition of the Party are our precious spiritual wealth and a powerful spiritual driving force that inspires us to forge ahead bravely."

"Centennial Answer Sheet" continues to write a new journey.

The history of the Party is the most vivid and convincing textbook. The General Secretary of the Supreme Leader has repeatedly asked all party member to repair the compulsory course of Party history, and he himself has taken the lead in learning Party history.

In October 2017, shortly after the closing of the 19th National Congress of the Communist Party of China, General Secretary of the Supreme Leader made a special trip to Shanghai and Zhejiang to pay tribute to the site of the First Congress of the Communist Party of China and the Nanhu Red Boat, and led Comrade The Politburo Standing Committee (PSC) to review the pledge of joining the Party.

今年6月18日，总书记专程来到新落成的中国共产党历史展览馆，察看一件件文物实物，倾听一个个党史故事，又一次带领中央领导同志重温入党誓词。

回望奋斗之路，眺望新的征程。如何以史为鉴、开创未来？最高领袖总书记在庆祝中国共产党成立一百周年大会上提出“九个必须”，为新的伟大征程指明前进方向。

“中国人民也绝不允许任何外来势力欺负、压迫、奴役我们，谁妄想这样干，必将在14亿多中国人民用血肉筑成的钢铁长城面前碰得头破血流！”

“任何人都不要低估中国人民捍卫国家主权和领土完整的坚强决心、坚定意志、强大能力！”

…………

最高领袖总书记的铿锵话语，赢得了天安门广场上潮水般的掌声和热烈的欢呼声！

“时代是出卷人，我们是答卷人，人民是阅卷人。”建党百年，中国共产党向人民、向历史交出了一份优异答卷。

今天，向着实现第二个百年奋斗目标，中国共产党踏上了新的赶考之路，开始书写新时代的历史答卷。

（中央广播电视总台央视网）

The commendation meeting of the 2016 Shanghai Key Project Practical Meritorious Competition was held this morning (January 12). Before the meeting, Han Zheng, secretary of the Shanghai Municipal Party Committee, met with representatives of advanced collectives and individuals. Han Zheng said,2017 is the year of deepening the "Thirteenth Five-Year Plan". It is hoped that advanced collectives and individuals will play a leading and exemplary role, always adhere to safety first, quality first, management first, science and technology leading, and make greater contributions to building Shanghai into a more beautiful city and making people’s lives happier.

On the morning of January 12th, Han Zheng, secretary of the Shanghai Municipal Party Committee, met with representatives of advanced collectives and individuals. The pictures in this article are all Chen Zhengbao’s pictures.

Shanghai leaders Yang Xiong, Wu Zhiming, Ying Yong, Yin Hong, Xue Chao and Li Yiping, and Shanghai Garrison Political Commissar Ma Jiali attended the meeting.

On behalf of the Shanghai Municipal Party Committee, the Municipal People’s Congress, the Municipal Government and the CPPCC, Han Zheng congratulated the advanced collectives and individuals who were commended for their meritorious deeds in key projects, paid tribute to the vast number of urban builders and managers who fought in the front line all the year round, and expressed gratitude to the general public who understood, cared for and supported urban construction and major projects. He said that at this time of the year, we review the course of Shanghai’s key projects’ practical meritorious deeds competition, feel the hardships and share the joy of success. Since China’s reform and opening-up, especially since Pudong’s development and opening-up, Shanghai’s key projects have been closely focused on making up the shortcomings and facing the future development, constantly pushing forward, laying a solid foundation for the city’s economic and social development. This year is the year of deepening the 13th Five-Year Plan. According to the requirements of the central authorities, Shanghai is striving to be the vanguard of national reform and opening up and the pioneer of innovation and development, and is striving to basically build the "four centers" and a socialist modern international metropolis by 2020. The field of urban construction shoulders heavy responsibilities. Hope that advanced collectives and individualsAlways adhere to safety first, quality first, safety is the bottom line, and quality is life. We must always tighten the string of safety and continue to play a benchmark and leading role in key projects and practical projects with the world’s advanced level as the standard. Always adhere to management as the priority and science and technology as the guide, put management in a more important position to ensure safety and quality, highlight scientific and technological innovation, and improve the quality of the city. Always adhere to the people-friendly and civilized construction, and try to minimize the impact on the orderly operation of the city and the normal life of the citizens during the construction process.

At the commendation meeting, Yang Xiong said that last year, the achievements of major projects and practical projects in this city were gratifying, the shortcomings of urban management were remarkable, and the task of aiding Xinjiang was successfully completed, achieving the "Thirteenth Five-Year Plan" and "a good start". This year is an important year for implementing the 13th Five-Year Plan and deepening the structural reform on the supply side. Facing the new situation, we should conscientiously implement the general tone of striving for progress while maintaining stability, sum up experience, blaze new trails, roll up our sleeves and go all out to complete various construction tasks.

"Safety and quality are the lifeline of major engineering construction and must always be put in the first place." Yang Xiong pointed out that it is necessary to pay strict attention to construction safety, take effective measures, consolidate the main safety responsibilities of construction, survey, design, construction and supervision, pay close attention to key construction links, and strengthen the safety control of major risk sources. It is necessary to continuously improve the quality of the project, adhere to the international first-class benchmarking, comprehensively consider the design, construction and operation, adopt more advanced international quality standards, vigorously carry forward the craftsman spirit, and strive to create more excellent projects. To improve the level of civilized construction, the construction unit should further strengthen the overall awareness, focus on improving internal management, reduce related social costs, and minimize the impact of engineering construction on the city. The construction of rail transit stations should strive to occupy less roads and return them early. It is necessary to strengthen dust control on construction sites and roads, and urge transportation enterprises to reduce "leakage" in muck transportation. We should persist in scientific and technological innovation and promote the transformation and upgrading of the construction industry. To become an important carrier of scientific and technological innovation, major projects should promote prefabricated buildings in major projects throughout the city, and constantly increase the proportion of prefabricated components used in each project. It is necessary to speed up the popularization of building information model technology (BIM), and establish and improve the matching project approval mode and standard system. It is necessary to make more use of new technologies such as the Internet of Things and big data to explore intelligent life cycle management of buildings.

Shanghai leaders Ying Yong and Xue Chao, and Yi Li Pinghe Garrison leader Ma Jiali attended the meeting. A number of advanced collectives and individuals who made outstanding contributions to the construction of major projects and practical projects in this city in 2016 were commended.

It is reported that in 2016, 122 major engineering projects in the city were comprehensively promoted. By the end of December of that year, a total investment of 128.01 billion yuan had been completed, and 123.6% of the plan was completed at the beginning of the year.

　　On Tuesday, local time, US stocks finally got rid of the light market trend for more than a week, but unfortunately it was not a big rise but a big drop. The three major indexes closed down across the board, with the Dow down more than 300 points and the Nasdaq down 2%.

　　On the one hand, the power of the earnings season began to show, and giants such as McDonald’s and UPS warned that the macroeconomic prospects were not good in the earnings report. On the other hand, the deposits of Daiwa Bank in the United States dropped by 40%, and UBS’s net profit in the first quarter halved, all of which highlighted that the banking crisis had not completely subsided and the market risk aversion was ignited.

　　On Monday, the First Total Bank disclosed that even though Wall Street giants had jointly deposited 30 billion dollars, they lost over 70 billion dollars in the first quarter of this year alone. At the end of the first quarter, the deposit figure was only $104.5 billion, far below the $136.6 billion expected by analysts.

　　The first total and the bank lost 49.38% of its market value on Tuesday. In the news, the media reported that the bank was going to sell "50 billion to 100 billion dollars" of long-term assets to solve the mismatch problem. It is reported that Biden administration officials have been keeping in touch with Daikyo Bank in recent days, and the White House is increasingly worried that there is not much time left for Daikyo Bank to appease investors and depositors, but American policy makers are not worried that risks may spread further among banks.

　　It is worth noting that due to various indications that there are still many risk factors in the market, traders no longer bet 100% that the Fed will continue to raise interest rates before the middle of this year. According to the observation tool of the Federal Reserve, the probability of raising interest rates by 25 basis points in May fell to 81.5%, compared with 90.5% the previous day.

　　However, for technology stocks, the financial reports of Microsoft and Google have slightly eased some market concerns. AI and cloud services helped Microsoft’s financial report exceed expectations, with revenue of $52.9 billion, higher than analysts’ expectations of $51.03 billion; Earnings per share were $2.45, higher than analysts’ expectations of $2.24. More importantly, a strong profit guidance was released, which rose by 8% after hours.

　　Google’s parent company Alphabet’s revenue in the first quarter was $69.79 billion, higher than analysts’ expectations of $68.99 billion. Earnings per share was $1.17, higher than analysts’ expectations of $1.09. At the same time, it was announced that the board of directors authorized an additional repurchase of up to $70 billion. Google rose more than 4% after hours.

　　In addition, OpenAI plans to launch a new product, ChatGPT Business, which is the enterprise version in the next few months. At the same time, the new function of ChatGPT allows all users to turn off chat records, which will not be used to train and improve the model of OpenAI.

　　In terms of important macro news, according to Xinhua News Agency, US President and Democrat Biden officially announced his re-election as US President on the 25th. Biden released a video on the same day to officially announce his decision to run for re-election as president of the United States, and pointed his finger at the so-called Republican extremist forces, saying that the United States is still in the struggle of "fighting for the soul of the country" and he needs more time to "complete this work."

　　This means that next year, the world may once again witness the "peak confrontation" between Trump and Biden.

　　[overnight U.S. stocks]

　　Among the large Chinese stocks, Alibaba fell by 4.58%, Baidu by 4.63%, Netease by 6.35%, Tencent Music by 4.96% and Pinduoduo by 3.25%.

　　Among the large US technology stocks, Apple fell 0.94%, Amazon fell 3.43%, Google A fell 2.00% and Netflix fell 1.97%.

　　[global index]

　　[global goods]

　　The main contract of WTI crude oil closed at $77.26 per barrel, down 1.90%; The main contract of Brent crude oil closed at $80.76 per barrel, down 2.38%; The main contract of crude oil in the previous period closed at 551.20 yuan per barrel overnight, down 2.58%.

　　Overnight, the Shanghai gold main contract closed up 1.06% to 447.58 yuan per gram; The main contract of Shanghai Bank closed down 0.16% to 5622.00 yuan per kilogram.

　　[overnight news]

　　Biden officially announced his re-election as president of the United States.

　　According to Xinhua News Agency, U.S. President and Democrat Joe Biden officially announced his re-election campaign on the 25th. Biden released a video on the same day to officially announce his decision to run for re-election as president of the United States, and pointed his finger at the so-called Republican extremist forces, saying that the United States is still in the struggle of "fighting for the soul of the country" and he needs more time to "complete this work."

　　Biden is 80 years old. In the 2020 US presidential election, he defeated Trump, the then US president and Republican, and became the US president in January 2021.

　　Banking crisis worries have re-suppressed the market’s interest rate hike pricing for the Fed.

　　The interest rate swap contract of the Federal Reserve in June currently reflects that the benchmark interest rate of the central bank is only 20 basis points higher than the current effective federal funds rate, which implies that the possibility of raising interest rates in one of the next two FOMC meetings is about 80%, while it was almost certain that the Fed would raise interest rates in May.

　　The debt ceiling deadlock is hard to solve. The White House says Biden will veto the Republican bundled spending reduction plan.

　　The Republican proposal put forward by House Speaker McCarthy requires that the debt ceiling of $1.5 trillion be raised and the future total government expenditure be reduced by $4.5 trillion. On Tuesday, the White House said that the debt ceiling must be solved without any conditions. Also on Tuesday, US Treasury Secretary Yellen warned lawmakers that if the debt ceiling is not resolved, the economic achievements made in the past two years will be threatened.

　　New Governor of Bank of Japan: Tightening monetary policy now may lead to serious consequences.

　　Industry insiders predict that Ueda and Kazuo may choose "a cautious start" for their first monetary policy meeting this Friday, but they do not rule out the possibility of changes in June.

　　Argentina’s inflation exceeded 100% for the first time in 30 years.

　　As the inflation rate exceeded 100% for the first time in 30 years, and the record drought dealt a heavy blow to agriculture-related industries, Argentina’s economic activity remained stagnant in February, with GDP increasing by 0% month-on-month and only 0.2% year-on-year. But high inflation does not seem to cool down in a short time. Argentina’s central bank predicts that the country’s inflation rate will reach 110% in 2023.

　　[company news]

　　Prosus, the major shareholder of Tencent, resold 789,600 shares of Tencent, and its shareholding ratio dropped to 25.99%.

　　Prosus, the largest shareholder of Tencent and the Dutch subsidiary of South African Naspers Group, announced in official website on April 25th local time that in order to continue to implement the repurchase plan, Prosus sold 789,600 ordinary shares of Tencent on April 25th, 2023, and its shareholding ratio dropped to 25.99%. In addition, as part of the repurchase plan, during the period from April 17, 2023 to April 21, 2023, Prosus repurchased 2,651,096 shares of Prosus at an average price of 698,795 euros per share, with a total consideration of about 185 million euros.

　　Resist the impact of Microsoft AI, Google search returns to growth in the first quarter, and the cloud business turns losses into profits.

　　In the first quarter, Alphabet’s revenue and profit were better than expected. The year-on-year growth rate of revenue exceeded expectations and accelerated to 3%. EPS profit decreased by 4.9%, less than half of market expectations. Google’s advertising revenue fell by 0.2%, which was much lower than expected, and its search revenue changed from 3.6% in the fourth quarter to nearly 2%. YouTube advertising revenue fell less than expected; Google Cloud changed from an operating loss of more than $700 million a year ago to a profit of 190 million; The expenses related to layoffs and office space reduction in the first quarter were $2.6 billion. Alphabet announced that it plans to buy back up to $70 billion in shares.

　　AI and cloud services help Microsoft’s financial report exceed expectations.

　　After the close of trading on Tuesday, Microsoft announced its financial data for the third quarter. Among them, the revenue was 52.9 billion US dollars, which was higher than the analyst’s expectation of 51.03 billion US dollars; Earnings per share were $2.45, higher than analysts’ expectations of $2.24. In terms of main business, revenue from productivity and business services reached $17.5 billion, up 11% year-on-year; Intelligent cloud’s revenue was US$ 22.1 billion, up 16% year-on-year; Personal computer business revenue was $13.3 billion, a year-on-year decrease of 9%. After the financial report was released, Microsoft’s share price rose more than 8% after hours.

　　Microsoft CEO Nadella said in a statement that the company’s performance indicates the beginning of a "new era of computing", and the world’s most advanced artificial intelligence model is being combined with the world’s most common user interface-natural language.

　　OpenAI will launch a new paid product, ChatGPT Enterprise Edition, and add a new function to "appease" supervision.

　　OpenAI plans to launch a new product ChatGPTBusiness in the next few months, and introduce a new subscription group for ChatGPT to meet the needs of corporate customers. In addition, the new function of ChatGPT allows all users to close the chat record, which will not be used to train and improve the model of OpenAI; ChatGPT data can also be exported to users’ mailboxes.

　　UBS’s quarterly results were bleak, but after the $3.2 billion acquisition, it successfully "retained" $28 billion of Credit Suisse’s client funds.

　　UBS released a quarterly report that after the announcement of the acquisition of Credit Suisse, the wealth management department of UBS obtained a net increase of 28 billion US dollars, of which 7 billion US dollars flowed in in the last ten days of March alone. However, on the whole, UBS’s first-quarter report card is still disappointing: its total revenue decreased by 7% year-on-year to $8.74 billion, its net interest income decreased by 22% year-on-year to $1.39 billion, and its net profit decreased by 52% year-on-year to $1.03 billion, setting a record for the lowest quarterly profit in three years. All three results were lower than market expectations. UBS said that the acquisition of Credit Suisse in the second quarter will actively reduce the risk and resource consumption of Credit Suisse’s investment banking business.

　　After the "escape" of deposits, the first total and the bank brewed self-help and considered selling assets of up to 100 billion US dollars.

　　According to the media, First Total Bank may give warrants or preferred shares to potential buyers, including big American banks, to encourage them to buy assets of the bank above the market value; The bank tried to strengthen its balance sheet, avoid being taken over by the regulator FDIC, and clear the way for possible financing in the future.

　　Apple is developing AI-driven health guidance services and emotional tracking functions.

　　According to informed sources, Apple is developing an AI-driven health guidance service, which will be available as soon as next year. For this year’s WWDC, Apple will release the user emotion tracking function and the first health monitoring application for iPad devices.

　　[financial calendar]

Special feature of 1905 film network On April 8, 2022, a fantasy adventure film directed by, mads mikkelsen, and starring was released in national cinemas. As the third part of the Fantastic Animals series, the film’s reputation was low and its performance was not satisfactory.

In the quick question-and-answer session, Liu Yanyan, a visiting professor, director and screenwriter of Beijing Film Academy, gave humorous answers to the host’s questions.

The Fantastic Animals series is very interesting. As a series of movies, each one has a different style. In the first part, the relaxed and interesting magical animals attracted many audiences, while in the second part, it began to become deep and difficult to understand. In the third part, The Mystery of Dumbledore began to take the popcorn route again and played the emotional card. What is the problem with such a series of films with inconsistent tonality?

The tonality of the first Fantastic Beasts and Where to Find Them is the closest to that of the Harry Potter series, and it does not show a complete adult magic world. Although the protagonist Newt is an adult, he maintains his innocence. "Fantastic Animals: The Crime of Grindelwald" began to want to turn the series to more mature and adult topics, and to change the works of children to a wider age, so as to be more convenient for the audience to substitute. For example, Newt’s brother works in the Ministry of Magic and thinks that he should find a decent job within the system, which is a copy of real history and a re-expression of discourse expression. It can be said that the fact that the tonality of each series is different is the business plan of the creative team, but there are problems in its implementation. For example, the role of Grindelwald has changed corners, and what happened in the objective world has affected the presentation of the magical world in the film.

Originally, Grindelwald was played by, and Fantastic Animals: The Mystery of Dumbledore was changed to mads mikkelsen. Liu Yanyan said: "These two are very good, but they are not the same type of actors. Depp, an actor, belongs to him sitting on the side of the road. When you pass by, you will take a look, because you will feel that this person’s temperament is very strange and always carries an unstable factor; At first glance, Micol Sen is the kind of person who has experienced everything. He is particularly calm in his heart. He has seen everything and won’t panic. No matter what kind of business leader he is, he must be the backbone of his business. Choosing two completely different types of actors in tandem will have problems with the coherence of tonality. "

"Fantastic Animals: The Mystery of Dumbledore" encountered a storm of temporary angle change, but the temporary angle change was not the key reason for the low reputation. Many bad reviews mentioned that the film’s plot was dull and lengthy, and its logic was weak. It put too much pen and ink on Dumbledore and Grindelwald, two close friends and enemies, and gave up the control of the main plot and the much-anticipated magical animals. What "hidden rules" does this reflect in the operation of Hollywood film projects? First of all, the most fatal problem is that they don’t stick to their original intention, bow to the flow excessively, are keen on speculating the so-called CP, encroach on the normal narrative atmosphere, do nothing in the drama, and damage the quality of the product itself for marketing. The characters in the film are quietly laid very deep in the first two films, and as a result, in the third film, they suddenly become just characters from villains, which is very unconvincing because they lose the support of the dramatic structure. The film’s handling of the transition from rhythm to combination is also lacking, which does not give the audience a refreshing feeling of climax scenes, and does not have the basic ethics of transition from combination as a commercial film.

Liu Yanyan mentioned: "Like playing house, everyone took the characters to the place where the incident happened, put them there, pressed a button to do it, and there was nothing beyond expectations. This is actually the amusement park mentioned by some excellent American directors when they criticized superhero movies in recent years, saying that this is not a movie, but an entertainment project in an amusement park. When you sit in it, you know exactly how to upset you and turn you, and the next movie is still the same.

To build a brand, the core logic needs long-term development, which is just contradictory to traffic thinking. One of the important reasons for the success of the Harry Potter series is that it has not completely bowed to the flow, but has its own persistence, winning by narrative and completely portraying the characters and the world, and at the same time, telling the story with great restraint, which will not change the plot because of the audience’s hope. Many British national treasure actors appeared in Harry Potter, but they often left after a guest appearance. At the same time, the United States produced a number of classic original remakes of movies, such as percy jackson series and very famous series, and their embrace of traffic was much higher than that of Harry Potter series. From this point of view, the interesting thing about Fantastic Animals series is that it came from the early days before the flood of Hollywood superheroes, and its transformation is epochal, and it can be seen that it struggled when the traffic was rampant. Liu Yanyan thinks: "Fantastic Animals is a good research specimen for the film industry." It can be said that the birth of "Fantastic Animals" series has two eras.

At present, the planning of the series is to shoot five films, and some viewers have begun to call for a new director for the latter two films. Can a new director solve the current problem? In this regard, Liu Yanyan held a negative attitude: "I don’t think so. If the director of the next film changes and there is no change, then you will know that the problem of the film is not the director, but the producer. The producers in Hollywood are very strong. Commercial films like this series are stable in business, and the directors don’t have much right to speak. The damage to a film industry is obvious. If you really get a son of destiny and turn decadence into magic, you need a very strong game ability with the producers, and the producers must be determined to decentralize before they can turn the tide and return the film to a more comfortable direction. "

"Fantastic Animals" series films bear the romantic feelings of countless magic fans. In other words, it is a series of magical films. I hope the producers can learn this lesson and stick to themselves instead of catering to the market, which will eventually damage the film and make people who love it sad and lost. Looking forward to the series rekindling the magic of magic, so that fans can continue to unite and believe in magic together!

　　Source: Ministry of Agriculture and Rural Affairs, etc.

　　In April 2022, General Secretary of the Supreme Leader visited Hainan and came to the "brain" of Nanfan Scientific and Research Breeding Base — — Sanya yazhouwan seed laboratory. The general secretary said: "Only by grasping the seeds of China with your own hands can you stabilize China’s rice bowl and achieve food security."

　　Nanfan, a large number of agricultural workers’ repeated migration journey. From September every year to May the following year, they come to Hainan from all over the world to take advantage of the unique tropical climate conditions here to carry out a series of scientific research activities such as crop seed breeding, hence the name "Southern Breeding".

　　At the moment, it is the season of the south. Let’s follow a rice seed to observe how it will grow from creating materials to breeding and seed production.

　　Sampling — — Sanya, Hainan

　　It took 10 years to produce a good variety.

　　Some have just been sown or seedlings, some are heading green, and some are golden to be harvested — — Walking into the Nanfan Base in Sanya, Zhongzhong Group, you can get a glimpse of rice at all growth stages.

　　"The advantage of Hainan is that there are abundant light and temperature resources, and we will sow here every one or two months." Shi Yitao, assistant of rice breeding in Zhongzhong Group, is a good way in the crop field. "Farmers will, we will;" Farmers won’t, and we understand. "

　　For a year, he guarded the experimental field like a child, and his broad face was tanned. "Water carefully every day to observe, prevent snails, birds and mice. I want every seedling to sprout and thrive. " Shi Yitao said.

　　It’s windy, rainy and sunny, which is a summary of the local climate by Nanfan people.

　　Sowing in the hot sun, sometimes, you have to hide from the rain four or five times for half a day. Whenever it rains, Shi Yitao is on tenterhooks: when the seedlings were young, he was afraid of the heavy rain and washed up the nutrient soil and washed away the seedlings; The rice is a little longer, catching up with the typhoon. The water in the field is more than 60 centimeters, leaving an ear on the water surface. It is raining against the wind and drowning again and again. "Danger is not afraid, and nothing is important to keep the seedlings."

　　In the corner of the experimental field, the iron fence was deeply embedded in the soil, and a small rice field was specially taken care of. "Specially rat-proof, afraid of gnawing materials." Shi Yitao gently pulled open the iron door and walked through a ridge, and the green and tall seedlings came into view.

　　"these are breeding materials R1607 with low cadmium gene introduced, which is already in tillering stage." Shi Yitao bowed down and took off a piece of leaf with tweezers, about 1 cm long, and carefully put it in a deep hole plate. "I hope it will be successful in one sampling."

　　From the summer of 2021 to now, this batch of materials has been planted in Hainan for three consecutive seasons, plus one season in Hainan in winter of 2020 and one season in Hubei in early 2021. It has been crossing, backcrossing and selfing for more than two years, and it has been five generations. Preliminary laboratory data show that the genetic traits of low cadmium gene have already appeared in future generations.

　　"If there is no problem with the re-inspection data, after maturity, you can select a trial plant with the best growth and the best laboratory genetic data from these 2000 strains." Shi Yitao said.

　　Just pick one plant, will it be too few?

　　"You don’t look down upon it, the seed setting rate is very high, one plant also has one or two thousand grains, and the ear of rice is half an arm long. This is also the reason why the rice variety Youyou 607 is favored by the market. "

　　"If you compare Quanyou 607 to an excellent ‘ Baby ’ Then R1607 is like an excellent ‘ Father ’ 。” Zhou Hua, director of rice testing of Zhongzhong Group, said that R1607 not only aggregated 8 rice blast resistance genes and 3 lodging resistance genes, but also aggregated 17 genes of sheath blight resistance, cold tolerance, flood tolerance, nitrogen efficiency and yield. Now, after introducing the low cadmium gene, even if rice is planted in fields with excessive cadmium content, it is low in adsorption or insensitive to cadmium.

　　How long does it take to breed a fine variety like Quanyou 607?

　　"It took 10 years from breeding to variety approval!" Zheng Ruifeng, the head of the R&D team of Quanyou 607 and the director of rice breeding of Zhongzhong Group, said that the creation of new materials is very uncertain. "There have been 52 cross combinations, and finally only R1607 was bred."

　　The R&D team will then introduce genes against bacterial blight, rice planthopper and fragrance, etc., and constantly upgrade and transform R1607 to become an all-around champion, so that the "baby" born will be better.

　　What is the most difficult thing in breeding?

　　Zheng Ruifeng replied in this way: if the varieties that show "leverage" are planted in other places for trial planting, some unexpected situations may occur, such as not resisting high temperature, low temperature, lodging, a certain disease, or a certain climate. Sensitive, "this will make all previous efforts and investments zero."

　　The early research and development is difficult, but the heart is still not hanging. Once it enters large-scale production, the strings in the heart will be tightly stretched. The bigger the promotion area, the more worried it is. "If farmers fail to harvest food, we will have trouble sleeping, and we will be relieved when we harvest it." Zheng Ruifeng said.

　　Detection — — Wuhan, Hubei

　　Breeding experts wear "gene glasses"

　　In Wuhan, Hubei Province, the genotyping laboratory of the Life Science and Technology Center of China Seed Group, the low cadmium sample sent from Sanya base, finally ushered in the key experimental link — — DNA genetic material was extracted and analyzed.

　　Zhang Xiaobo, the head of the laboratory, tapped the button, and the shaker, centrifuge and PCR instrument ran one after another. The data showed that the recovery rate of differential loci was 88.7%, and the recovery rate of whole genome reached 97.5%.

　　What do these data mean? "This shows that the low cadmium gene has indeed been stably passed on to the offspring of R1607. After the upgraded version of R1607 matures, a new trial production process can be started." Zhang Xiaobo explained.

　　"In the breeding process, the laboratory and the experimental field are closely linked." Ye Rongjian, deputy director of the Technology Platform Department of the Science and Technology Center of Zhongzhong Group, said that the genetic performance after the introduction of low cadmium gene is difficult to observe by experience. "Is cadmium adsorbed into rice seeds? The naked eye can’t see it at all."

　　"When R1607 was first created, molecular biological breeding technology was just beginning, and we took the path of traditional cross breeding combined with molecular breeding assisted selection. Nowadays, molecular marker detection and genome breeding technology have become very common, which is like wearing a pair of glasses that can see through the function of genes for breeding experts. " Zheng Ruifeng said that intelligent breeding in the future, relying on artificial intelligence, big data and biotechnology, will be more efficient and accurate.

　　Of course, the powerful function of this pair of glasses depends on the breakthrough of basic research. "The reason why the introduction of low cadmium gene has achieved results for more than two years is because the functional sequence of low cadmium gene is very clear." According to Ye Rongjian, there are about 50,000 genes predicted in rice. At present, about 4,000 genes are cloned and their functions are clear. It may take many years for a gene to know its functions, and the road ahead is still very long.

　　"The laboratory not only undertakes the task of detection and analysis, but also explores the mystery of genes." Nie Dongming, the seed administrator, pushed open the heavy security door, and a germplasm resource bank with more than 100,000 rice materials was presented. Here, at the temperature of 4 degrees Celsius, the seeds enter a dormant state and can be safely stored for 5-mdash; Ten years.

　　Zhou Hua said that the germplasm resource bank is a treasure house for creating breeding materials. At that time, Academician Yuan Longping discovered the special material of wild rice sterile plant "Wild Abortion" in Sanya, and achieved the breakthrough of hybrid rice breeding.

　　R1607′ s breakthrough in rice blast resistance is also due to the germplasm resource bank. "At that time, we were making a breakthrough in the technology against rice blast. I heard that the Chinese Academy of Sciences discovered a gene with strong resistance, but breeding experts did not have this material at hand. We went to the germplasm resource library to search and found the original material. " Zheng Ruifeng introduced that this peasant variety was used to cross and backcross with indica rice varieties, and a series of materials containing rice blast resistance genes were bred.

　　"If things in nature are lost, you may not find them when you want to use them in the future. The importance of the germplasm resource bank is now more and more deeply understood. " Zheng Ruifeng said that it is a source protection when its value is not clear and the advantages of germplasm resources are not tapped.

　　Zhou Hua introduced that China Seed Group and Yazhouwan Seed Laboratory jointly issued a list for the first-class scientific research institutes and universities in China, and Industry-University-Research jointly integrated gene resources, and there were more than 10 topics in the field of rice alone. In addition to further cooperative research on low cadmium genes, there are also cooperation in herbicide resistance and rice false smut resistance. "The goal is to make excellent rice varieties full of treasures."

　　Seed production — — Hainan dongfang

　　One mu of seed production can be used for more than 100 mu of fields.

　　"Yanmei, throw me the seedling!" "Good, then!" Fu Yanmei didn’t lift her head. A bunch of tender rice seedlings came out and flew over eight or nine women who worked hard, drawing an arc over the paddy field and accurately "delivering" it to Zeng Yabei.

　　On February 3rd, gancheng town, Dongfang City, Hainan Province, after the Spring Festival, seed production and rice transplanting have been busy for more than a week. The villagers cooperated skillfully, transplanting rice in the field, and there were bursts of laughter from time to time.

　　Such busy and cheerful scenes often appear in the process of seed production. In the whole seed production process, the most attractive thing is heading and flowering, which is also called catching powder.

　　At the end of October last year, in this field, the reporter witnessed a scene of catching powder. The sky clears up, the temperature rises, the male parent and female parent materials in the rice field bloom and spit, and pale yellow flowers are dotted with light green ears of rice swaying gently in the breeze. A 40-meter-long rope hangs in an arc on the ear of rice. The two workers each held one end and walked quickly forward in parallel. Where the rope passed, the ears of rice touched, the stamens trembled, the pollen floated to the pistil of the female parent, and suddenly a pale yellow powder fog was stirred in the field.

　　Wang Shiming, general manager of Hainan Nongle Nanfan Technology Co., Ltd. said: "Breeding is to bring a bag of seeds and carry a bag of seeds back. Seed production is different. One acre of seed production can be used for more than 100 acres of fields. "

　　There are many seed production processes, so it is necessary to plant seeds in reverse order to let parents meet this flowering period. For example, it takes 100 days for the male parent of Quanyou 607 to plant and 80 days for the female parent, so the male parent should plant 20 days in advance; After that, we constantly observe the leaf period, analyze the flowering period, and sometimes adjust it through water and fertilizer to ensure that the flowering period meets.

　　"Artificial powder driving can improve the seed setting rate of hybrid rice." Wang Shiming introduced that many years ago, there were as many as 100,000 people in Hainan from Pingxiang City, Jiangxi Province. In recent years, the country has revitalized the seed industry, and Pingxiang has also introduced measures such as subsidies for large seed producers and subsidies for grain production. Encouraged by this, many Jiangxi farmers who have produced seeds in Hainan have returned to their hometowns for development.

　　"Raising seedlings, transplanting seedlings, heading and pollination, harvesting and drying seeds, selecting seeds and packaging, I can play when I am young." Wang Shiming has been following his parents to Hainan for more than 20 years. His skin is tanned and he speaks slowly. In 2022, Dongfang City, where he lives, was recognized as a national seed production county, with a million mu of fertile land in Thanksgiving Plain. "Winter seed production starts at the end of December every year, and the seeds are harvested in April and May of the following year, which is just the time for the middle and lower reaches of the Yangtze River."

　　Affected by rising land rent and labor costs, Hainan rice seed production has been moving westward, from Sanya to Ledong Li Autonomous County, and then to Dongfang City. "The average annual land circulation per mu in the East is 1,300 yuan, but it has already exceeded 3,500 yuan in Sanya." Wang Shiming said.

　　In the middle and late September of 2022, Wen Mincao, deputy manager of the production department of Zhongzhong Agricultural Science and Technology Company, received an urgent task. When the seed production area of Quanyou 607 Hainan suddenly increased from the original six or seven thousand mu to more than 20,000 mu, his head was buzzing. Where can he find the producer and production base?

　　The Chinese company implements the order system and gives plans to manufacturers and professional teams all over the country every year. However, the farming season in the mainland has passed in winter and it is difficult to produce seeds; Although Hainan can produce seeds, it is also the winter melon and vegetable season, with less open space, high land rent and early seed delivery time. At one time, it is a bit intense to "grab the base".

　　Thanks to Wang Shiming’s contacts in many ways, Wenmin Cao took only one week to reach an intention on 6,000 mu of land and finally breathed a sigh of relief. "Seed production counties support the integration of production, processing, warehousing, packaging and logistics. With favorable policies, we have signed a cooperation framework for the integration of production and supply chain with local manufacturers, which can be produced locally, packaged locally and sent to the market, and can be stored locally if they are not sold out."

　　All the efforts are worthwhile.

　　In the middle and lower reaches of the Yangtze River, farmers who have tasted the sweetness have long been thinking about good seeds. In Shilou Village, Wudian Town, Zaoyang City, Hubei Province, Chen Bangguo, a large grain grower, called Qiu Yunze, a seed dealer in Wudian Town, after planting winter wheat.

　　"Good seeds are in demand! When we tried to plant Quanyou 607, it was Laoqiu who came to sell it, and he guaranteed it, saying that it was not good to compensate my output. As a result, two or three hundred kilograms of rice were added to an acre of land. I am happy to invite Laoqiu to eat! " Chen Bangguo said.

　　"In the early stage, we will build a model field display, and invite large households to go to the scene to observe the harvest and yield measurement, so that more farmers can see the comparative advantages of varieties. In the later stage, collect information about high-yield farmers, make posters, and organize seedling meetings from seedling stage to heading stage to expand influence. " Speaking of the promotion experience of good seeds, Wang Hanyong, deputy sales manager of Hubei Branch of China National Seed Group, talked endlessly.

　　The field of hope, season after season, the story of a fine variety will be told constantly.

　　Planning for this issue: Yin Xinyu, Wu Yan and Cheng Juxin