National Medical Products Administration announces the fourth batch of typical cases of drug safety special rectification. Since the beginning of 2022, in order to implement the decision-making arrangements of the CPC Central Committee and the State Council on strengthening drug safety, National Medical Products Administration has organized nationwide drug safety special rectification actions with strict investigation of illegal activities and strict control of risks as the main line. Local drug regulatory authorities continued to strengthen supervision and law enforcement, severely cracked down on illegal acts endangering drug safety, investigated and dealt with a number of illegal cases, and earnestly safeguarded people’s health and drug safety. The fourth batch of typical cases of drug safety special rectification is now announced. I. Hao Cheng Oxygen Factory in Tieling Economic Development Zone failed to comply with good manufacturing practice’s case in drug production activities [Brief Introduction to the case] In March 2022, Liaoning Drug Administration found in its daily supervision and inspection that Hao Cheng Oxygen Factory in Tieling Economic Development Zone had a serious violation of the good manufacturing practice. After investigation, the company’s quality management system is not perfect, and there are behaviors such as production, inspection, inspection and recheck that are not in accordance with the regulations, and the person in charge of the enterprise, the person in charge of production management and the quality authorized person fail to perform the corresponding management duties. The above-mentioned behavior of the company violated the first paragraph of Article 43 of the Drug Administration Law and the sixth paragraph of Article 69 of the Measures for the Supervision and Administration of Drug Production. In August 2022, Liaoning Drug Administration ordered the company to suspend production and business for rectification in accordance with Article 126 of the Drug Administration Law and Articles 4, 6 and 9 of the Provisions on the Application of Administrative Punishment Discretion of Liaoning Food and Drug Administration.An administrative penalty of 100,000 yuan will be imposed, and the legal representative, the person in charge of production management and the quality authorized person of the company will be given an administrative penalty of confiscation of income and fines from their own units during the illegal act. [Typical significance] Oxygen is the key substance for human metabolism. Medical oxygen is mainly used for oxygen inhalation in patients with hypoxia in clinic, especially in emergency situations. High-purity oxygen can be used to save patients’ lives. China has strict requirements on the production management, quality control, storage and release of medical oxygen. In this case, the key personnel of the enterprise failed to perform the corresponding management responsibilities, and the enterprise did not comply with the good manufacturing practice to organize production, so the product quality was difficult to guarantee, which brought potential hidden dangers to the public’s safe and effective drug use. The drug regulatory authorities conscientiously implement the requirements of the "double punishment system", and at the same time, impose corresponding administrative penalties on the relevant responsible personnel of the enterprise according to law, which is of great significance to urge enterprises to implement the main responsibility and compact the post responsibilities of relevant employees. II. Case of Wei Motao’s Illegal Acquisition of Drugs [Brief Introduction to the Case] In December 2021, the Fengtai District Market Supervision Administration of Beijing and the Fengtai Branch of the Beijing Municipal Public Security Bureau jointly inspected and found that Wei Motao bought drugs such as Niaoduqing granules and acarbose tablets from individuals around Fengtai District through cash transactions and on-the-spot settlement. Wei Motao’s above behavior violated the provisions of Article 22 of the Measures for the Supervision and Administration of Drug Circulation. In August 2022,According to Article 115 of the Drug Administration Law, Item 1 and Item 4 of Article 17 of the Provisions of Beijing Food and Drug Administration on the Application of Administrative Punishment Discretion (Trial) and Item 3 of Article 152 of Beijing Drug Administration Discretion Benchmark (Trial), Beijing Fengtai Market Supervision Administration imposed an administrative penalty on the party concerned, which included confiscation of the drugs involved and a fine of 1.6 million yuan. [Typical Significance] China implements a strict licensing system for drug business activities, and illegal acquisition of drugs is prohibited. In this case, criminals used the price difference between the purchased medical insurance drugs and the drugs sold normally to obtain high profits, which not only seriously disrupted the order of drug management, but also caused the illegal purchase of drugs to be out of formal management, and the storage conditions of drugs could not be guaranteed, and the related drugs were re-circulated to patients, which brought great hidden dangers to the public’s drug safety. Strict investigation and punishment by drug regulatory authorities in accordance with the law has a positive demonstration role in effectively curbing related illegal activities, which is conducive to standardizing the order of drug circulation and effectively ensuring the safety of people’s medication. Iii. Case of Kangjian Store of Shi ‘antang Pharmaceutical Chain Co., Ltd. in Jining City [Brief Introduction to the Case] In 2021, Jining Municipal Market Supervision Administration of Shandong Province and Qufu Municipal Market Supervision Administration jointly inspected and sampled Kangjian Store of Shi ‘antang Pharmaceutical Chain Co., Ltd. in Jining City within the jurisdiction of Qufu City, and found that the drugs sold in this store, such as "Special Effects on Muscular Pain" and "Pain Eliminating Roots", contained diclofenac sodium and other ingredients and were identified as counterfeit drugs.Qufu Municipal Market Supervision Administration transferred the case to Qufu Municipal Public Security Bureau for investigation. In June 2022, the People’s Court of Qufu City, Shandong Province convicted the person in charge of the store of selling counterfeit drugs, sentenced him to criminal detention and fined him. In October, 2022, according to Articles 116 and 118 of the Drug Administration Law, Jining Municipal Market Supervision Administration imposed an administrative penalty on the store to revoke its Drug Business License, and imposed an administrative penalty on the person in charge of the store to ban drug production and business activities for life. [Typical Significance] As a special commodity for treating diseases and saving lives, the quality and safety of drugs are directly related to the public’s health and life safety. We must strictly guard against and strictly control the drug safety risks, and resolutely prevent and eliminate the damage caused by counterfeit and inferior drugs to people’s lives and health. The parties in this case sell fake drugs, which is extremely harmful to society. The judicial organs sentenced the relevant responsible persons to criminal detention and fined them according to law, and the drug regulatory authorities imposed administrative penalties on the parties concerned and banned the relevant responsible persons according to law, which reflected the determination to resolutely implement the "four strictest" requirements for drug safety. This case is a typical case of execution linkage between the drug regulatory authorities and the public security and judicial departments, which embodies a good working mechanism of information exchange and close cooperation between the administrative departments and the public security and judicial departments, and reflects the efficient law enforcement joint force of execution convergence, which has reference significance for the drug regulatory authorities at all levels and the public security and judicial departments to share information and jointly crack down on illegal acts.IV. Case of Guangzhou Dameikang Medical Device Co., Ltd. Failing to fulfill the obligation of registered agent [Brief Introduction to the case] According to the case clue assigned by National Medical Products Administration, in June 2022, Guangdong Provincial Drug Administration filed an investigation on Guangzhou Dameikang Medical Device Co., Ltd. for allegedly failing to fulfill the obligation of registered agent of overseas medical devices. Upon investigation, the party concerned, as the import registration agent of medical devices, failed to fulfill the obligation to inform the registrant of the need to supplement the notarized letter of ISO certificate, product label and authenticity statement for the change of production address during the process of assisting the registrant to apply for the registration of imported medical devices in National Medical Products Administration, and Yin Moumou, the registration Commissioner of the party concerned, forged a false notarized letter through photo editing software without authorization and submitted it to National Medical Products Administration as registration correction materials. In November 2021, the parties have assisted the registrant to apply for withdrawing the application for registration of medical devices involved. The above-mentioned behavior of the parties violates the provisions of Paragraph 4 of Article 14, Paragraph 5 and Paragraph 2 of Paragraph 1 of Article 20 of the Regulations on the Supervision and Administration of Medical Devices (Order No.739 of the State Council). In August, 2022, Guangdong Drug Administration ordered the parties concerned to correct the above-mentioned illegal acts according to the first paragraph of Article 98 of the Regulations on the Supervision and Administration of Medical Devices (the State Council Order No.739), and imposed an administrative penalty of a fine of 120,000 yuan on the parties concerned, and imposed an administrative penalty of banning the production and operation of medical devices for five years on its responsible person Yin Moumou.[Typical Significance] Applicants for medical device registration should ensure that the submitted materials are legal, true, accurate, complete and traceable. An overseas applicant shall designate an enterprise legal person in China as an agent to handle the relevant medical device registration matters. The agent shall assist the registrant to fulfill the legal obligations according to law, and assist the overseas registrant to fulfill the corresponding legal responsibilities. Since the launch of the special rectification campaign for drug safety, drug regulatory authorities at all levels have severely cracked down on the fraudulent registration of medical devices. This case is the first case of fraudulent registration of medical devices involving medical device agents. Guangdong Provincial Drug Administration has imposed administrative penalties on the parties who are fined and the responsible personnel who are forbidden to engage in the production and business activities of medical devices for five years, investigated the legal responsibilities of the parties according to law, and strictly implemented the punishment for illegal acts to meet the requirements of people, thus forming a powerful deterrent, which is conducive to standardizing the registration behavior of medical devices and ensuring the safety and effectiveness of medical devices. V. Case of Ningbo Jingbo Rehabilitation Aids Co., Ltd. producing Class II medical devices without permission [Brief Introduction to the case] On March 4, 2022, Ningbo Municipal Market Supervision Administration of Zhejiang Province inspected Ningbo Jingbo Rehabilitation Aids Co., Ltd. After investigation, the party involved was suspected of producing scoliosis orthosis without permission, which was not registered according to law. The value of the goods involved was 264,000 yuan, and the illegal income was 264,000 yuan. The parties’ unauthorized production of Class II medical devices that are not registered according to law violates the Regulations on the Supervision and Administration of Medical Devices (the State Council Decree No.739? Number)Paragraph 1 of Article 16 and paragraph 1 of Article 32 stipulate that. On August 3, 2022, Ningbo Municipal Market Supervision Administration issued the Regulations on the Supervision and Administration of Medical Devices (the State Council Decree No.739? No.) Items 1 and 2 of the first paragraph of Article 81 and the Guiding Opinions on Standardizing the Discretion of Administrative Punishment in Market Supervision and Management (Guo Shi Jian Law [2019] No.244) stipulate that it is decided to give the parties a mitigated punishment, and impose an administrative penalty of confiscation of illegal income of 264,000 yuan and a fine of 1.32 million yuan. [Typical Significance] With the development of economy and society, rehabilitation therapy has become a new growth point in the medical field. Adolescent idiopathic scoliosis occurs frequently, and its treatment process and the legality of medical devices used have also become the focus of people’s attention. During the investigation and handling of the case, the supervision department deeply understood the causes, diagnosis points, treatment methods and imaging features of scoliosis, and extracted the electronic data of patients’ radiation images from PACS system by using technical methods, so as to find the breakthrough direction of case handling, thus uncovering the hidden rules of unlicensed production of medical devices in the field of medical rehabilitation and infringing on patients’ rights and interests. The handling of this case highlights the determination of the drug regulatory authorities to make key breakthroughs and overcome difficulties in the light of new illegal acts of medical devices, maintains the order of production and use of medical devices, and effectively guarantees the safety of public equipment. VI. Suzhou Weishijian Medical Instruments and Equipment Import and Export Co., Ltd. operates unregistered Class III medical devices and medical devices without Chinese instructions and labels [Brief Introduction] In June 2022,Law enforcement officers of gusu district Market Supervision Administration in Suzhou, Jiangsu Province inspected Suzhou Weishijian Medical Instruments and Equipment Import and Export Co., Ltd. according to the investigation clues. After investigation, the parties involved were suspected of operating unregistered imported medical devices such as intraocular lighting probes and ultra-emulsion wave cutting machines without Chinese instructions and labels, involving a value of 20,988.73 yuan. The parties’ operation of unregistered Class III medical devices and medical devices without Chinese instructions and labels violates the Regulations on the Supervision and Administration of Medical Devices (the State Council Decree No.739? Number) the provisions of the first paragraph of article thirty-ninth, second paragraph third and fifty-fifth. In September, 2022, the gusu district Municipal Market Supervision Administration of Suzhou City issued the Regulations on the Supervision and Administration of Medical Devices (the State Council Decree No.739? ) Article 88 (2), Article 81 (1) and Article 13 (1) of the Provisions on the Application of Administrative Punishment Discretion in Suzhou Market Supervision and Management (Trial) stipulate that the parties concerned shall be given a lighter punishment, and they shall be given an administrative penalty of confiscation of illegal income, confiscation of 104 unlicensed medical devices and a fine of 358,819.68 yuan. 【 Typical 】 According to the Regulations on the Supervision and Administration of Medical Devices (the State Council Decree No.739th? No.) Article 55 stipulates that medical device trading enterprises and users shall not operate or use medical devices that are not registered or filed according to law, have no certificates, or are expired, invalid or eliminated. At present, ophthalmic surgery technology is developing rapidly, the market competition is fierce, and some medical device business units have a weak sense of main responsibility. In order to gain a competitive advantage,Without authorization, unregistered medical devices (mostly consumable parts) are put into the market, resulting in unlicensed operation and use of medical devices. The investigation and handling of this case made medical device enterprises and users understand the importance of legal operation, which played a positive role in protecting consumers’ rights and purifying the market environment. VII. Case of Guangzhou Henglan Biotechnology Co., Ltd. Using Cosmetic Prohibited Raw Materials to Produce Cosmetics [Brief Introduction to the Case] In March 2022, Guangdong Drug Administration comprehensively analyzed and judged the clues of the case, and jointly conducted a surprise inspection on Guangzhou Henglan Biotechnology Co., Ltd. with the public security organs, and sampled some cosmetics. After investigation, the baby Beixuan baby skin cream and baby Kang Yishengyuan body milk produced by the company from November 2021 to March 2022 were found to contain clobetasol propionate, halobetasol propionate and cyproheptadine, the value of which was 212,667 yuan. Guangdong Drug Administration transferred the case to the public security organ according to law, and the public security organ has filed a case for investigation according to law. At the same time, in view of the fact that the products involved are children’s cosmetics, and the illegal acts are serious, in October 2022, Guangdong Provincial Drug Administration imposed administrative penalties on the company’s use of prohibited raw materials to produce cosmetics, in accordance with Article 59, paragraph 3, of the Regulations on Cosmetics Supervision and Administration, such as revoking its cosmetics production license, canceling its cosmetics product filing, not handling its cosmetics filing within 10 years and accepting its cosmetics administrative license application.Wu Moumou, the legal representative of the company, and Mo Moumou, the person in charge of production, were given an administrative penalty prohibiting them from engaging in cosmetics production and business activities for life. [Typical Significance] Using prohibited raw materials for cosmetics to produce children’s cosmetics or illegally adding substances that may endanger human health in children’s cosmetics is a serious case as stipulated in Article 61 of the Measures for the Supervision and Administration of Cosmetic Production and Operation, and such illegal acts should be severely punished according to law. In this case, the drug supervision and administration department took the initiative to dig deep into the clues of the case source, unblocked the green channel of product inspection involved, deepened the convergence of case execution, and jointly cracked down on the illegal addition of children’s cosmetics with the public security organs. The pharmaceutical supervisory and administrative department shall, in accordance with the law, punish the enterprises involved in the case by revoking their cosmetics production licenses and canceling their product records, and give the legal representative of the enterprises involved a life-long ban on business, and for the first time, give the person in charge of the production of the enterprises involved a life-long ban on business, which has formed a powerful shock to the lawless elements and reflected the firm determination of the supervisory department to resolutely protect the safety of children’s cosmetics. Eight, "5 7" Jiangsu Yangzhou production and sales of counterfeit cosmetics case [Brief Introduction] On September 15, 2022, the Guangling District People’s Court of Yangzhou City, Jiangsu Province sentenced Zhang Moumou and other eight criminals who produced and sold counterfeit cosmetics to fixed-term imprisonment ranging from three years to one year, plus a fine. The discovery of this case originated from the illegal clues found by Yangzhou Inspection Branch of Jiangsu Drug Administration in the cosmetic safety risk monitoring work.After discovering the illegal clues of counterfeit cosmetics mentioned above, Yangzhou Inspection Branch immediately set up a joint task force with Yangzhou Public Security Bureau’s Food and Drug Environmental Investigation Detachment, persisted in tracing the source and digging deep along the line, and finally destroyed a counterfeit cosmetics production den and two hose suppliers, and arrested many suspects such as Zhang Moumou. After investigation, since March, 2020, Zhang Moumou and others have purchased components such as paste, imitation packaging materials, trademarks and anti-counterfeiting labels, processed and assembled counterfeit cosmetics by themselves, and sold them through the Internet. [Typical Significance] In recent years, criminals aim at brand cosmetics to make and sell fakes, and seek illegal benefits by relying on the high-quality brand effect of others. In this case, the drug supervision and administration department attaches great importance to the illegal clues found in the safety risk monitoring of cosmetics in Conghua, gives full play to its professional and technical advantages, and cooperates with the public security organs. Under the framework of the working mechanism of "counterfeiting and protecting famous brands", the administrative law enforcement departments, the public security organs, the judicial organs and the obligee enterprises work together to wipe out the chain of counterfeiting and selling, effectively protect the safety of public cosmetics, maintain fair competition market order and create a good business environment. IX. "6 12" Case of Selling Counterfeit Cosmetics in Zhangzhou, Fujian [Brief Introduction to the Case] In September 2021, Zhangzhou Municipal Market Supervision Administration of Fujian Province received many complaints and reports, reflecting that the registered address was in many Taobao shops in Zhao ‘an County, Zhangzhou City, selling counterfeit brand cosmetics. Zhangzhou Municipal Market Supervision Administration immediately organized an investigation. After comprehensive judgment, Zhao ‘an County Market Supervision Administration transferred the clue to the public security organ.At the same time, Zhangzhou city and county market supervision and public security departments set up a joint task force to jointly investigate the case. In June 2022, the joint task force sent more than 100 law enforcement officers to Shenzhen, Guangdong, Dalian, Liaoning, Handan, Hebei, Zhangzhou, Fujian and other places to carry out the network-closing operation at the same time, destroying 6 dens for selling fake cosmetics in one fell swoop, arresting 73 people involved on the spot and seizing a large number of counterfeit cosmetics. Up to now, Zhao ‘an County People’s Procuratorate has approved the arrest of three major suspects in this case, transferred three people for review and prosecution, and 21 other suspects have been released on bail pending trial. The case is under further investigation. [Typical Significance] In recent years, with the increasing crackdown on cosmetic crimes, cosmetic counterfeiting dens have been further transferred to remote areas such as rural areas and urban-rural junctions. In this case, criminals formed gangs to commit crimes, and they were scattered in remote areas such as rural areas in Fujian and Guangdong, and they had a strong sense of anti-investigation. They opened a number of online stores on multiple e-commerce platforms to produce and sell illegal cosmetics across provinces. Through careful investigation of illegal clues and close cooperation with public security organs, the drug supervision and administration department found out the context of illegal acts in the whole case, and finally successfully destroyed the black dens and safeguarded the safety of public makeup.

　　At the press conference held by the Ministry of Transport today (25th), Wang Tai, deputy director of the Highway Bureau of the Ministry of Transport, said that since the 18th National Congress of the Communist Party of China, the scale of China’s highway infrastructure network has been among the highest in the world, and the transportation service support capacity has been continuously improved, making it easier for people to travel, which has strongly supported economic and social development and the improvement of the country’s comprehensive strength.

　　The National Highway Network Plan released in 2013 proposes that by 2030, the total scale of China’s national highway network will be about 400,000 kilometers, of which the total scale of national highways and ordinary national highways will be 136,000 kilometers and 265,000 kilometers respectively. Through the efforts of all parties, by the end of 2021, 117,000 kilometers of national highways had been built, and the mileage of ordinary national highways was 257,700 kilometers, with the completion ratio reaching 85% and 96.5% respectively.

　　First, the network coverage is more extensive.At present, the expressway network with the national expressway as the main body has covered 98.8% of the cities with a population of more than 200,000 and prefecture-level administrative centers, connecting about 88% of the county-level administrative regions and about 95% of the population; Ordinary national highways basically cover administrative regions at or above the county level and border ports opened all the year round, effectively connecting important towns, industrial parks, transportation hubs and tourist attractions.

　　Second, the level of facilities has been effectively improved.By the end of 2021, the proportion of national highways with two-way six lanes and above will be 20.9%, and a large number of busy sections of national highways such as Beijing-Harbin, Beijing-Shanghai, Beijing-Hong Kong-Macao, Shenhai and Shanghai-Kunming will be expanded and rebuilt, and the service guarantee capacity of national highway backbone channels will be further improved. The proportion of national ordinary national highways of Grade II and above is 79.6%, which is about 10% higher than that in 2013. More than 98% of the roads have been paved with asphalt or cement concrete, which is about 13% higher than that in 2013.

　　Third, major projects continued to advance.The world-famous Hong Kong-Zhuhai-Macao Bridge was opened in October 2018, becoming a super cross-sea project integrating bridges, islands and tunnels. The Beijing-Xinjiang Expressway, which passes through the desert Gobi no man’s land, runs through the whole line, becoming another big passage in and out of Xinjiang after Lianhuo Expressway. Construction of Tianshan Shengli Tunnel on Urumqi-Yuli Expressway, which is more than 22 kilometers, started, constantly setting a new world record for expressway tunnels.

　　The fourth is to achieve breakthroughs in technological innovation.The highway survey and design technology represented by digital map, geological remote sensing, computer-aided design and simulation, and Beidou system application has made continuous progress. The technology of highway construction in soft soil, loess, frozen soil and desert areas is constantly maturing and improving, and the structure and material technology of highway pavement have withstood the double test of time and heavy traffic. Breakthroughs have been made in technologies and equipment related to super-long-span bridges, super-long tunnels in mountainous areas, submarine immersed tunnels and large-diameter shield tunnels, and "China Road, China Bridge and China Tunnel" have become beautiful business cards.

　　(CCTV reporter Tang Ying)

　

While affirming that Guangdong Province attaches great importance to the high-quality development of the pharmaceutical industry, the audit findings also point out that many pharmaceutical consumables distribution enterprises have increased intermediate sales links and raised the price of medical equipment, medical personnel have long accepted the benefits from pharmaceutical companies, and medical institutions have illegally purchased or used medical equipment.

Reporter | Qu Yixian

Source | vision china

On August 8th, an investigation report on special audit of People’s Republic of China (PRC) Audit Office (draft for comments) obtained by Economic Observer Network showed that three pharmaceutical manufacturers in Guangdong Province had used 4.077 billion yuan for public relations and other purposes, pushing up the ex-factory price of drugs.

In addition, while affirming that Guangdong Province attaches great importance to the high-quality development of the pharmaceutical industry, the audit findings also point out that many pharmaceutical consumables distribution enterprises have increased intermediate sales links and raised the price of medical equipment, medical personnel have long accepted the benefits from pharmaceutical companies, and medical institutions have illegally purchased or used medical equipment.

From the end of May to July, 2023, the audit team sent by the National Audit Office conducted a special audit investigation on the production, distribution and use of drugs and high-value medical consumables in Guangdong Province (excluding Shenzhen, the same below), focusing on the relevant administrative departments of drug supervision, medical security and health care in Guangdong Province, public hospitals, primary medical and health service institutions and other medical institutions, and the production and distribution enterprises of drugs and consumables.

People close to the Guangdong Health Care System told Economic Observer that the Guangdong Health Care System was indeed being audited some time ago and just ended. "This audit is very strict."

The above audit investigation report was signed by "Guangdong Provincial Special Audit Investigation Team on the Production, Distribution and Use of Drugs and High-value Medical Consumables", which was forwarded by the Guangdong Provincial Health and Health Commission Office to Guangzhou, Zhuhai, Foshan, Heyuan, Dongguan, Zhongshan Health Bureau (Commission), Provincial People’s Hospital, Provincial Second People’s Hospital, Third Affiliated Hospital of Sun Yat-sen University, Cancer Prevention Center of Sun Yat-sen University, Stomatological Hospital of Sun Yat-sen University, Southern Hospital of Southern Medical University, and Second Affiliated Hospital of Southern Medical University.

The staff of the above-mentioned hospital confirmed to the Economic Observer that the investigation report forwarded by the Guangdong Provincial Health and Health Commission was true. The doctor of another hospital told Economic Observer that the hospital level issued several anti-corruption announcements.

Drug production enterprises collect funds for public relations.

Audit spot checks found that from 2021 to May 2023, three pharmaceutical manufacturers in Guangdong paid fees to 1,936 third-party business promotion companies, and withdrew 4.077 billion yuan in the name of service fees, which increased the comprehensive cost of drugs and pushed up the ex-factory price.

These three enterprises are Guangdong Yifang Pharmaceutical Co., Ltd. (hereinafter referred to as "Guangdong Yifang Company"), Guangzhou Poinsettia Pharmaceutical Co., Ltd. (hereinafter referred to as "Guangzhou Poinsettia Company") and Livzon Group.

Among them, the Guangdong company paid 2.39 billion yuan to 966 business promotion companies in the name of "technical service fee", which was used for the pharmacy construction cost and labor cost of cooperative hospitals.

Guangzhou Poinsettia Company collected 1.675 billion yuan by registering conference service companies in batches, and assigned a third-party company to register and set up 962 conference service companies at the same address in the form of "cluster registration". The third-party company further decomposed the funds according to the requirements of Guangzhou Poinsettia Company and transferred them to specific personnel accounts to pay the public relations expenses of hospitals in various regions.

Livzon Group set up a consulting company through its employees to collect funds of 12.4001 million yuan, and the funds were transferred to the personal accounts of relevant employees for drug public relations.

In addition to pharmaceutical manufacturers, the audit investigation team also found that pharmaceutical consumables distribution enterprises increased intermediate sales links and pushed up the circulation price of medical equipment. The enterprises involved include Kangchao Pharmaceutical Co., Ltd. and Sinopharm Equipment (Dongguan) Co., Ltd., and the products involved include Cao Qinghua Yixin Chushi Zhitong Capsule and other high-value medical consumables such as spinal internal fixators.

It is worth noting that there are also public hospitals that increase procurement intermediate links to make profits to subordinate enterprises. For example, from 2020 to May 2023, the Cancer Hospital affiliated to Sun Yat-sen University appointed Guangdong Guanhua Medical Service Company, a subsidiary of the trade union, to supply medical consumables for it, and Guangdong Guanhua Medical Service Company made a profit of 7,488,200 yuan, with an average price increase rate of 6.6%.

Medical personnel have long accepted the benefits delivered by pharmaceutical companies.

Audit investigation shows that domestic authoritative medical experts have long accepted exclusive service arrangements of foreign-funded pharmaceutical enterprises. Kehui Medical Devices International Trade (Shanghai) Co., Ltd. (hereinafter referred to as "Kehui Company") is a wholly foreign-owned enterprise, which mainly sells Covidien brand medical devices, and has long sponsored academic exchange activities organized by medical and pharmaceutical associations at all levels in China, and requires domestic distributors to pay accommodation, transportation, air tickets and other expenses for participating doctors and experts according to 2% of annual sales.

The audit spot check found that in 2022, Foshan Tailing Trading Co., Ltd., the brand distributor, paid 15.8117 million yuan for transportation, accommodation, catering and other expenses for medical experts and related personnel through nine travel agencies according to the instructions of Kehui Company, of which only one travel agency provided special follow-up, special car transfer and gifts for 272 authoritative experts in the medical field in China (including 63 in Guangdong Province) in seven meetings.

In addition, 4,782 medical staff illegally accepted the benefits delivered by foreign-funded pharmaceutical companies in the name of conference registration fees, involving pharmaceutical companies such as Bayer Healthcare Co., Ltd.

In addition, four medical experts from public hospitals received a targeted donation of 2.37 million yuan from pharmaceutical companies through the foundation of Guangdong Medical Association, involving five pharmaceutical companies including Beihai Kangcheng (Shanghai) Biotechnology Co., Ltd.

Medical institutions illegally purchase or use medical devices.

The audit investigation found that medical institutions illegally purchase or use medical devices, which has hidden hidden dangers of life and health and financial security.

The audit spot check found that three medical institutions, including Zengcheng Branch of Southern Hospital of Southern Medical University (hereinafter referred to as Zengcheng Branch of Southern Hospital), had problems such as determining the winning bidder in advance and purchasing large-scale medical equipment at a high price, involving funds of 73.0828 million yuan (including equipment price increase of 30.209 million yuan).

For example, in 2020, the then president of Zengcheng Branch of Southern Hospital organized the head of the department to conduct a feasibility study on purchasing X-ray computed tomography scanner, and determined the equipment of American GE Company quoted by Guangzhou Tangyun Medical Equipment Co., Ltd. In June 2021, the enterprise actually controlled by the company won the bid with the same brand and model equipment, with the winning bid amount of 29.49 million yuan, the purchase price of which was 14.287 million yuan, and the difference reached 15.2 million yuan.

In addition, the audit survey found that from 2018 to May 2023, a total of 491 medical institutions in Guangdong Province entrusted Guoyi Tendering Co., Ltd. to carry out bidding for more than 10,000 large-scale medical equipment or consumables procurement projects, with a total project amount of 22.386 billion yuan. Among them, only 3 companies participated in the bidding for nearly 9,000 projects.

Zengcheng Branch of Southern Hospital illegally purchased a proton radiotherapy system equipment without the permission of National Health Commission Class A large-scale medical equipment configuration, and paid 50% of the purchase price of 120 million yuan from the special government debt before the main components were shipped.

In terms of illegal use of medical devices, two medical institutions, including Zhongshan People’s Hospital, repeatedly used 2409 disposable ultrasonic blades, involving 15,100 person-times, involving medical insurance fund of 7,730,600 yuan. The Stomatological Hospital of Southern Medical University applied the "ultrasonic osteotome" used in the operation to the charging item of "additional ultrasonic scalpel", and illegally charged 67.2031 million yuan for medical treatment and 5.7011 million yuan for medical insurance fund.

The audit investigation also found that Guangdong Medical Association received 52,056,200 yuan from 329 pharmaceutical companies to designate doctors to promote their products. Guangdong Medical Association fraudulently distributed lecture fees and preparation fees of 169,600 yuan to medical experts in violation of regulations.

It is worth noting that the audit survey results also pointed out that Guangdong Province attaches great importance to the high-quality development of the pharmaceutical industry, actively promotes comprehensive reforms in the pharmaceutical field, and continuously optimizes the business environment of pharmaceutical enterprises, achieving good results. In view of the problems found in the above audit investigation, the audit investigation team also gave a number of suggestions.

On August 8, Economic Observer Network called the investor relations department of Livzon Group several times, but it was not connected. Ask Bayer China for an interview and get no reply; The relevant person in charge of Beihai Kangcheng responded that his company had not received a notice to cooperate with the investigation, and it was not clear about the specific situation.

Original title: Medical Corruption in an Audit Investigation Report

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Full of green’s parks, greenways, clean and tidy farmers’ markets, neatly parked roadside vehicles and colorful volunteer activities … Walking in Longgang, the civilization scene everywhere is refreshing.

The beauty of the city is not limited to the beautiful scenery, but also lies in the profound and heavy background of civilization. In the three years since the town was removed and the city was set up, in the hot spot of reform, the projects of upgrading quality and improving people’s livelihood have been accelerated: more than 30 hectares of green space have been added, and 7.2 kilometers of greenways for people’s livelihood have been completed; Create 4 Wuhua farmers’ markets and 9 provincial assured markets; Get through the microcirculation of regional roads, and traffic congestion has dropped significantly …

Today, Longgang is making great efforts to move towards a provincial demonstration civilized city.

"external beauty"

Dress up the value of the city based on the existing resources

Uniformly decorated interiors, standardized and tidy booth classification, and strict garbage management … The fourth vegetable market in Longgang City is a clean and hygienic modern farmer’s market. "After the management reform in recent years, the environment of the vegetable market has changed too much." Ms. Zhu, a business owner who has been engaged in aquatic products for 20 years, deeply felt: "With the red, yellow and green OEM, we will know where to start improving."

Previously, the Longgang farmers’ market generally had problems such as dirty environment and outdated equipment, and the basic conditions were relatively weak. In order to solve the difficulties, Longgang has transformed the market as a whole in batches based on the original market framework through internal transformation and upgrading. At present, it has created 4 Wuhua farmers’ markets and 9 provincial assured markets.

After the market transformation and upgrading, how to maintain it is a big problem. To this end, Longgang further optimized the management mechanism by means of "green, yellow and red list" scoring mechanism and market professional management. The OEM mentioned by Ms. Zhu is the innovative practice of Longgang City. "We evaluate the farmers’ market and business households separately, and judge the green, yellow and red lists every month according to the scores, reward the winners of the green list, and take punishment measures such as suspending business and rectifying the objects on the’ red list’." Sun Zuogan, deputy director of Longgang State Administration for Market Regulation, said that they have also effectively implemented the main responsibility of the market and improved the market management ability through specialized custody of the farmers’ market.

While dressing up the farmers’ market, the traffic problems closely related to people’s livelihood are also quietly changing. Since July this year, the traffic micro-circulation construction has been implemented in the Xiakou area of Longgang, and 16 two-way paths in the area have been changed to one-way traffic, and on-street parking spaces have been added. As soon as this move comes out, it not only relieves the traffic pressure on main roads, improves the utilization rate of secondary and branch roads, but also relieves the contradiction between parking supply and demand to some extent. "In the case that the urban road reconstruction project is difficult to implement, it is an effective measure with little investment and quick results to carry out traffic microcirculation reconstruction." Lin Hao, deputy squadron leader of Longgang Traffic Police Brigade, said that since the trial, the traffic congestion alarm in Xiabu area has dropped by 80%, and the traffic accident alarm has dropped by 28.1%.

Strolling in the ecological corridor of Yuehu Lake and Cuihu Lake, the beautiful lakeside scenery and the scene of the new district with high-rise buildings are reflected in the curtain. From "beautiful corner" to "dotted", in recent years, Longgang has been deeply involved in the construction of park green space, relying on the renovation of Kugaji to further enhance the urban ecological charm. At present, 15 "Jinjiao Yinbian" park green space projects have been started, with more than 30 hectares of green space added, and 7.2 kilometers of greenway for people’s livelihood has been completed. The first phase of Yuehu Cuihu Ecological Corridor has been completed, and the second phase of the city park (wetland) park is scheduled to open in late September. By then, Longgang citizens will have more good places to rest and entertain.

"inner beauty"

Enriching cultural activities and condensing consensus on writing.

The most beautiful scenery of a city is "people", and the most beautiful scene is that everyone is bathed in the new wind of civilization and everyone is involved in the creation of civilization.

On the occasion of the Mid-Autumn Festival on September 10th, 13 families from Zhixinmingdu Community in Longgang spent an unforgettable full moon night together-tasting moon cakes, learning about Mid-Autumn Festival customs and folklore, and going to the seaside sightseeing belt to watch the tide and enjoy the moon. Under the leadership of volunteers, the scene was full of laughter and laughter, and everyone talked about the beautiful life and felt the romance and warmth of the traditional culture of Mid-Autumn Festival together.

This is a microcosm of Longgang’s rich volunteer service activities and the promotion of the construction of a 10-minute volunteer service circle. In recent years, with the transformation of Longgang from town to city, citizens have put forward new requirements for the content and quality of cultural services.

Based on the construction of a civilized practice center in the new era, Longgang established a voluntary service federation, launched a new form of voluntary service order, and opened up the "last mile" of serving the masses. Through the online platform, communities and citizens can submit the demand for activities, and the system accurately delivers the orders to professional teams in the form of dispatching orders, thus achieving accurate delivery of volunteer activities. As of August this year, Longgang has carried out more than a thousand voluntary service activities. Quietly, the power of civilization imperceptibly infiltrated the hearts of Longgang citizens.

Taking the creation of "Sharing Society Happiness Lane" as the starting point, Longgang actively builds a 15-minute quality cultural life circle and accelerates the construction of cultural activity facilities. A number of key cultural sites with high value and high taste, such as Longgang Art Museum, Yue Long Road City Study Room, and Jiajiao Lacquerware Private Museum, have successively landed.

"The creation of a civilized city is a systematic work, which depends not only on the government’s leadership, but also on the participation of the masses." Huang Changyao, deputy director of the Propaganda and United Front Work Department of Longgang Municipal Committee, said that in order to unite the consensus of creating articles, Longgang focused on the improvement of the exquisite environment in the whole region, promoted the creation of civilized cities, strengthened the construction of the creation mechanism, and established a centralized action plan, a centralized inspection plan, and a civilized "1151" system to create linkage mechanisms. At the same time, it also created Tuesday Civilization Creation Day, monthly volunteer service festival, daily courtesy zebra crossing persuasion and other activity carriers to promote the creation of civilization throughout the world.

Walking in Longgang, wherever you go, the flowers of civilization bloom-every courtesy in front of the zebra crossing, every time you bow your head and pick up the garbage around you, and every smiling face of volunteers is a beautiful interpretation of the broad masses of cadres and people in the city who have devoted themselves to the creation of provincial civilized cities.

If you do not stop, the future can be expected. With the joint efforts of the whole city, the upsurge of creating a civilized city is surging in Longgang, and a picture scroll of butterfly change of civilization showing the characteristics of Longgang is slowly spreading out.(Reporter Jin Ruiya)

New expectations of citizens

Yellow light shuttle

Identity:

Secretary of the Party Branch of Xipai Community in Longgang

Voice:

With the promotion of the establishment of a civilized city, in recent years, the appearance of Longgang farmers’ market has changed completely. In particular, our Xipai Farmers’ Market, as the first five-star standard pilot in our city, has completed the five-star drawing design at present, and will immediately start the budget, bidding and other processes, design and build according to the five-star standard, so as to obtain the acceptance of the four-star civilized and standardized market this year, declare the establishment of the five-star civilized and standardized farmers’ market next year, and strive to create the first five-star civilized and standardized farmers’ market in our city.

　　Cartography: Pan Xutao Caption: Figure 1: The officers and men of the company where "Wang Jieban" is located participated in the actual military exercise. Photo by Wang Lei (Xinhua News Agency)

　　Figure ②: Guangdong Province’s counterpart support to Kashgar, Xinjiang, has brought about profound changes in the local social outlook. The picture shows the employees of Guangdong Cisco Development Industry Co., Ltd. in Jiashi County, Kashgar, Xinjiang, working on the production line. Xinhua News Agency reporter Tian Jianchuan photo

　　Figure ③: In recent years, Shaanxi Province has continued to carry out key comprehensive management of the Hanjiang River Basin, and the ecological protection of the Hanjiang River Basin has achieved initial results. Xinhua News Agency reporter Tao Mingshe

　　Figure ④: Since May, Qingkou Town, Ganyu District, Lianyungang City, Jiangsu Province has organized art teachers of college student village officials to draw civilized wall paintings on the blank walls of various communities with the theme of socialist core values. Photo by Shao Shixin and Li Gang (People’s Vision)

　　On July 26th, General Secretary of the Supreme Leader delivered an important speech at the seminar for leading cadres at the provincial and ministerial levels, pointing out that since the 18th National Congress of the Communist Party of China, on the basis of the great achievements made in China’s development since the founding of New China, especially since the reform and opening up, the cause of the Party and the state has undergone historic changes, China’s development has reached a new historical starting point, and Socialism with Chinese characteristics has entered a new stage of development. Socialism with Chinese characteristics’s continuous great achievements mean that the Chinese nation, which has been suffering for a long time in modern times, has made a historic leap from standing up, becoming rich and becoming strong. It means that socialism in China is full of vitality and constantly opening up a new realm of development. It means that Socialism with Chinese characteristics has expanded the way for developing countries to modernize, contributed China wisdom and provided China’s plan for solving human problems.

　　其中“从站起来、富起来到强起来的历史性飞跃”的论断，既简明扼要地概括了近代以来中国实现飞跃的历史进程，又深刻揭示了中国特色社会主义不断开辟发展新境界的历史意义。其背后，则是中国人民创造幸福生活、一步步实现“中国梦”的生动实践。

　　中国发展的历史方向

　　要深刻领会最高领袖总书记“7·26”重要讲话精神，首先要认识和把握讲话中的历史方位感。对历史经验进行总结与运用，从不断认识和把握历史规律中找到前进的正确方向和正确道路，正是中国共产党长期以来能领导中国革命、建设、改革不断取得胜利的一个重要原因。

　　最高领袖经常在一些重大场合谈及历史。在庆祝中国共产党成立95周年大会上的讲话中，他曾说：“‘明镜所以照形，古事所以知今。’今天，我们回顾历史，不是为了从成功中寻求慰藉，更不是为了躺在功劳簿上、为回避今天面临的困难和问题寻找借口，而是为了总结历史经验、把握历史规律，增强开拓前进的勇气和力量。”

　　而“站起来”“富起来”“强起来”，正是最高领袖在回顾近代中国发展历史的基础上做出的历史判断，是透过“历史规律的望远镜去细心观望”而得出的论断。

　　在几千年的历史发展中，中华民族创造了悠久灿烂的中华文明。但是近代以后，由于西方列强的入侵，由于封建统治的腐败，中国逐渐沦为半殖民地半封建社会，山河破碎，生灵涂炭，中华民族遭受了前所未有的苦难。五四运动后，1921年，在中华民族内忧外患、社会危机空前深重的背景下，中国共产党诞生了。此后，中国共产党带领中国人民打败了日本帝国主义，推翻了国民党反动统治，完成了新民主主义革命，建立了中华人民共和国，实现了中国从几千年封建专制政治向人民民主的伟大飞跃。这是中华民族“站起来”的历史过程。

　　1949年后，中国共产党带领中国人民完成社会主义革命，确立社会主义基本制度。完成了中华民族有史以来最为广泛而深刻的社会变革，为当代中国一切发展进步奠定了根本政治前提和制度基础，为中国发展富强、中国人民生活富裕奠定了坚实基础，实现了中华民族由不断衰落到根本扭转命运、持续走向繁荣富强的伟大飞跃。

　　1978年，改革开放实行，极大激发广大人民群众的创造性，极大解放和发展社会生产力，极大增强社会发展活力。自此，人民生活显著改善，综合国力显著增强，国际地位显著提高。特别是党的十八大以来，中国共产党着眼于实现“两个一百年”奋斗目标和中华民族伟大复兴的历史使命，在一系列治国理政新理念新思想新战略的指导下，砥砺奋进，硕果累累。中国前所未有地接近中华民族伟大复兴目标、前所未有地走近世界舞台中心。中国实现了强起来的伟大飞跃。

　　而今，更多的就业机会，更稳定的收入，更完善的社会保障体系，更健全的社会法制体系，更美好的城市、乡村生活环境，让更多普通的中国人感受到了国家的文明进步，真切体会到了祖国从站起来、富起来到强起来这一历史变革。当今的中国有着前所未有的发展机遇，是“站到了新的历史起点上”。这不是凭空而来的论断，而是对中国的历史和现实最真实、最有力的概括。

　　3个飞跃源于党的领导

　　中华民族能够实现从站起来、富起来到强起来的历史性飞跃，根本原因在于中国共产党的领导。

　　在庆祝中国共产党成立95周年大会上的讲话中，最高领袖指出，“历史和人民选择中国共产党领导中华民族伟大复兴的事业是正确的，必须长期坚持、永不动摇；中国共产党领导中国人民开辟的中国特色社会主义道路是正确的，必须长期坚持、永不动摇；中国共产党和中国人民扎根中国大地、吸纳人类文明优秀成果、独立自主实现国家发展的战略是正确的，必须长期坚持、永不动摇。”

　　在历史的实践中，中国共产党带领中国人民跨过一道又一道沟坎，取得一个又一个胜利。而在勇于和善于推进理论创新、制度创新上，中国共产党更是把中国特色社会主义理论和实践进一步推向前进，开辟了21世纪马克思主义发展新境界，使党的理论和实践始终走在时代前列。

　　有论述指出，“历史性飞跃”其核心要义是：中国共产党在十八大以来推进我国社会发展实现历史性飞跃的同时，推进马克思主义中国化实现新的历史性飞跃。可以说，中华民族“站起来”“富起来”“强起来”的过程，得益于马克思主义中国化的不断推进，同时又促进马克思主义理论的进一步发展。社会主义在中国的活跃和兴旺、成功和胜利，是在中华民族从站起来、富起来到强起来的历史进程中实现的。

　　党的十八大以来，以最高领袖同志为核心的党中央在实践中形成的“五位一体”总体布局、“四个全面”战略布局、新发展理念以及一整套适应和引领经济发展新常态的经济政策框架，以其科学性、指导性、有效性有力推动中国新的发展实践。未来，中国特色社会主义也必定随着时代和实践发展而不断向前发展，必定随着党和人民不懈奋斗而进入新的发展阶段。

　　“强起来”体现在方方面面

　　3个“历史飞跃”把中国带到“强起来”的阶段，那么中国究竟强在何处？过去5年来的成绩，或许可以给出答案。

　　The Supreme Leader pointed out in his important speech on "July 26th" that the five years since the 18th National Congress of the Communist Party of China have been extraordinary in the development process of the Party and the country. We have strengthened the Party’s leadership in an all-round way, greatly enhancing the Party’s cohesion, combat effectiveness, leadership and appeal. We unswervingly implement the new development concept and vigorously promote China’s development in a higher quality, more efficient, fairer and more sustainable direction. We unswervingly deepen the reform in an all-round way and promote the reform to present a brand-new situation of all-round efforts, multi-point breakthroughs and in-depth advancement. We unswervingly and comprehensively promoted the rule of law, which significantly enhanced our party’s ability to lead and govern the country by legal means. We have strengthened the Party’s leadership over ideological work and consolidated the ideological unity of the whole Party and society. We unswervingly pushed forward the construction of ecological civilization and made important strides in promoting the construction of beautiful China. We unswervingly pushed forward the modernization of national defense and the army and made historic breakthroughs in national defense and army reform. We unswervingly pushed forward the diplomacy of a big country with China characteristics and created a peaceful international environment and a good surrounding environment for China’s development. We unswervingly push forward the comprehensive and strict administration of the party, focus on solving the outstanding problems that are most strongly reflected by the people and pose the greatest threat to the party’s ruling foundation, form an overwhelming situation in the anti-corruption struggle, update the atmosphere of political life within the party, strengthen the ideals and beliefs of the whole party, strengthen the party spirit, significantly improve the party’s ability of self-purification, self-improvement, self-innovation and self-improvement, and consolidate the party’s ruling foundation and mass foundation.为党和国家各项事业发展提供了坚强政治保证。

　　例如，党的建设日益加强。治国必先治党，治党务必从严。在过去的5年里，中国共产党把全面从严治党纳入“四个全面”战略布局，破藩篱、去顽疾、立规矩、建制度、正风气，“八项规定”“三严三实”“两学一做”深刻地影响了党内政治生态，“巡视全覆盖”成为党风廉政的监督利器，“老虎苍蝇一起打”的反腐决心令百姓拍手称快。全面从严治党赢得了民心，也令党的领导更加有力。

　　再比如，人民生活愈加富裕。全面建成小康社会是中国共产党向人民作出的庄严承诺。“脱贫攻坚已经到了啃硬骨头、攻坚拔寨的冲刺阶段”，为打赢这场硬仗，最高领袖指示说：“脱贫攻坚任务重的地区党委和政府要把脱贫攻坚作为‘十三五’期间头等大事和第一民生工程来抓，坚持以脱贫攻坚统揽经济社会发展全局。要层层签订脱贫攻坚责任书、立下军令状。”而到2020年中国现行标准下的农村贫困人口将全部脱贫，意味中国将提前10年实现联合国2030年可持续发展议程确定的减贫目标，也为全球减贫治理提供了“中国方案”。

　　The goal of strengthening the army has been gradually realized. Since November 2015, when the Central Military Commission’s reform work conference announced the full implementation of the strategy of strengthening the army through reform, a new round of landmark overall reform of China’s army has been launched in an all-round way. The operational command system, leadership management and supervision system and future development direction of the whole army have all been completely new. Optimize the scale structure, improve the policy system, and promote the in-depth development of integration of defense and civilian technologies. "After five years of hard work, the People’s Army has reshaped its political ecology, organizational form, power system and style image. The People’s Army has regrouped and started again, and has taken solid steps on the road to strengthening the army with China characteristics." The supreme leader said this.

　　In addition, more and more scientific and technological achievements at the forefront of the world, the ever-increasing socialist cultural construction, and the more complete talent construction system all reflect the overall prosperity of China. It can be said that China, who stood up, became rich and became strong, has proved the correctness of his chosen path with eloquent facts.

　　CCTV News:On May 30, the highly concerned HPV nine-valent vaccine (nine-valent cervical cancer vaccine) began to be injected in Boao, Hainan. On the first day of injection, about 1,000 people completed the vaccine appointment.

　　HPV vaccination should be treated rationally

　　A month ago (April 29th), National Medical Products Administration approved the marketing of nine-valent cervical cancer vaccine in the Mainland. Boao Lecheng International Medical Tourism Pioneer Zone enjoys nine supporting policies, such as drug import registration and approval, and it takes only one month to take the lead in completing all the approval of nine-valent cervical cancer vaccine for marketing injection, and injecting it for school-age women in need. According to the regulations,The vaccine in the Mainland is suitable for women aged 16 to 26.

　　It is understood that HPV nine-valent vaccine is the most comprehensive vaccine against HPV virus in the world, and it can prevent 90% of cervical cancer against nine subtypes. It can be injected in Hong Kong earlier, and a shot costs about HK$ 2,250.

　　Experts from National Medical Products Administration, Health and Health Commission and China CDC have recently answered questions related to vaccines.Experts said that HPV vaccination should be treated rationally.(For details, see: the vaccine that can prevent more than 90% of cervical cancer can be listed in China conditionally.)

　　Nine-valent HPV vaccine "conditionally approved for marketing"

　　Experts pointed out that at present, the nine-valent HPV vaccine that has been approved for import registration by priority review is conditionally approved for marketing. Shao Jie, reviewer of the Clinical Department of Biological Products of the National Drug Administration Center, said that conditional approval paid attention to the ethnic differences of clinical trial subjects.

　　Data from overseas clinical trials show that,There are more than 2,000 Asian people in the clinical trial of the nine-valent HPV vaccine.China, Hongkong, China, Taiwan Province, Japan, Korea, etc. The population of China, Hongkong and Taiwan Province, China, which were included in the clinical trial, were analyzed separately, and the results were consistent with those of the global population. This is the basis for the inclusion of imported nine-valent HPV vaccine in conditional approval.

　　Experts said that the overall principle of conditional approval is that the benefits outweigh the risks. After the enterprise is conditionally approved, it needs to improve the follow-up research work as required, and the regulatory agency will continue to follow up and supervise the vaccine throughout its life cycle.

　　The age range of vaccination adaptation is 16 ~26 years old.

　　The nine-valent HPV vaccine approved for marketing in ChinaThe age range of vaccination adaptation is 16 ~26 years old.. The reason why it is designated as this age group comes from three aspects:

　　1. At this age, the overseas clinical research data of the vaccine and its protective effect against persistent infection in East Asian population all suggest that the benefits outweigh the risks.

　　Second, the probability of sexual behavior among girls aged 9-15 in China is very low. However, the 9-to 15-year-old vaccinators only carried out the immune bridging test, and the clinical research data of the East Asian Chinese population in this test were limited.

　　Third, women over the age of 26 may have a history of virus exposure and infection. At present, there is no evidence to prove that this vaccine has a protective effect on the exposed population of this age group.

　　In addition, experts said that,The incidence of adverse reactions of nine-valent HPV vaccine will be higher than that of four-valent vaccine.

　　Wang Huaqing, chief expert of immunization program of China CDC, pointed out that vaccination is primary prevention and screening is secondary prevention, which are equally important at present.Cervical cancer screening measures should not be relaxed because of vaccination.

　　What are the differences between bivalent, tetravalent and ninth-order vaccines used to prevent cervical cancer? A picture makes it clear ↓

　　Rise to the sea, set sail and compete for first class. Since 2012, it has been a decade of passionate progress in Daya Bay, and it has been a decade of pioneering exploration in Daya Bay. Daya Bay bravely undertakes the mission and strives to build a domestic first-class development zone with high quality; Carry forward the great spirit of party building, strengthen historical self-confidence, keep in mind the initial mission, comprehensively promote the overall layout of the "five in one", work hard, focus on solving new development problems, and strive to write a new chapter in sustainable development and improving people’s livelihood and well-being.

　　From 40 billion yuan to 80 billion yuan, Daya Bay has reached four 10 billion yuan steps in ten years. In 2021, the GDP of the whole region reached 80 billion yuan, with a cumulative increase of over 85% in ten years; The added value of industrial enterprises above designated size was 53.33 billion yuan, a cumulative increase of 101.5% in ten years; The total tax revenue of the whole region (including tax collected by customs) was 50.46 billion yuan, with a cumulative increase of 67.4% in ten years; In the past ten years, the total investment in fixed assets in the whole region has reached 310.31 billion yuan, with an average annual investment of 31.03 billion yuan …

　　Groups of data are the imprint of Daya Bay’s solid steps in accurately and comprehensively implementing the new development concept. Nowadays, Daya Bay, which is sailing for the sea, is seizing the great opportunity of "two-zone" construction, building a world-class green petrochemical industry highland with high quality, and striving to become an important supporting area for Huizhou to build a happier domestic first-class city.

Daya Bay firmly adheres to the road of ecological priority and green development.

　　Entering Daya Bay, key national, provincial and municipal projects such as ExxonMobil Huizhou Ethylene Project and Hengli (Huizhou) PTA Project are in full swing. On the other side of Huizhou Port, ships enter and exit, and vehicles shuttle; In the newly planned 100 billion-level Daya Bay Emerging Industrial Park, the production line of Zhouming Technology Daya Bay Science and Technology Park, the world’s largest intelligent LED display base, is running rapidly; Wanda Commercial Circle, Canbang Plaza and Yitian Commercial Circle are three pillars, with towering high-rise buildings, various commercial centers and vigorous consumption … With the rapid economic and social development of Daya Bay in the past 10 years, a new coastal city with integrated development of production, life and ecology has taken shape, and the future can be expected.

　　On November 8, 2021, ExxonMobil announced its investment decision to the world, and increased the first phase of total investment of the project from $5.5 billion to $6.7 billion. With the construction of the project, ExxonMobil Asia-Pacific R&D Center has also settled in Huizhou, which shows the confidence and determination of this oil and gas giant to invest in Daya Bay.

　　In recent years, in the face of the COVID-19 epidemic and the complicated and severe challenges of the domestic and international economic situation, Daya Bay District has continuously optimized its business environment and promoted the construction of major projects at an extraordinary speed. Investing in the development of highland has become a new label of Daya Bay, and leading enterprises in Chinese and foreign industries are coming in droves. According to statistics, in recent years, 129 foreign-invested enterprises (projects) have been newly established in total investment of the project, amounting to 7.16 billion US dollars.

　　Sharpen a sword every ten years. Today, Daya Bay has become one of the seven national petrochemical industrial bases, and Daya Bay Petrochemical Zone has topped the top 30 chemical parks for three consecutive years. Daya Bay has gradually formed the orientation of "attracting large investment, attracting large businesses and developing greatly" in the development of economy, and has drawn a "investment map" of high-quality projects that are helpful to extend, supplement and strengthen the chain.

　　In recent years, Daya Bay District has made precise investment promotion around the industrial chain and further improved the "Investment Promotion Map". A set of investment project evaluation system consisting of 15 rigid quantitative indicators has been translated into English, Korean and Japanese, which has become a "hero post" for investment promotion issued by Daya Bay District to the world.

　　Keeping a close eye on the world’s top 500 enterprises and leading enterprises in the industry, Daya Bay gives full play to the leading role of leading enterprises such as CNOOC, China Shipping Shell, ExxonMobil, Hengli PTA and Guangzhao Lubricant, and conducts business attraction and investment promotion in the industrial chain, focusing on extending, supplementing and strengthening the chain. For example, China Merchants in Daya Bay said that the PC/DPC project of China Shipping Shell will become the only PC project in South China after it is completed and put into operation, forming a highly competitive PC industrial chain and leading the development of the C2 industrial chain. The third phase ABS project of Lejin Chemical will become the largest ABS production base in South China after it is completed and put into operation, and will continue to expand into a long C4 and aromatics industrial chain.

　　The advantages of these large projects are highly consistent with Daya Bay’s concept of building a world-class petrochemical industry highland and adhering to safe and green development, and are also a true portrayal of Daya Bay’s practice of high-quality and green development concepts.

　　The petrochemical industry has made precise efforts, and emerging industrial parks are also a thriving atmosphere. This vibrant park has attracted businessmen from the United States, Japan, Taiwan, China, Hong Kong, China and other countries and regions. At present, more than 100 projects have been settled, with a total investment of over 30 billion yuan. Well-known enterprises include BYD, Dongfeng Honda, Guanghong Technology, Sumitomo Forging, Xinlitai, Zhouming Technology, etc. The electronic information and auto parts industry has begun to take shape. "In the past ten years, with the vigorous development of Daya Bay, Guanghong Technology has made remarkable achievements." The person in charge of Guangdong Guanghong Technology feels that the progress of Guanghong in the past ten years is the best proof of Daya Bay’s development, from the upgrading of processing to intelligent manufacturing, and now it ranks among the high-quality listed companies.

　　"In the past ten years, the changes in the urban appearance of Daya Bay are amazing!" A senior media reporter spoke the voices of many people.

　　In Daya Bay Mangrove City Wetland Park, the plank road is clean and tidy; In the modern office building, energetic engineers are brainstorming; As night falls, the major shopping centers in the city are very busy … In the past ten years, the energy level of Daya Bay city has been continuously improved and the quality of the city has been constantly refreshed.

　　"Urban management should be as delicate as embroidery". Since the beginning of this year, the value of the entrances and exits of toll stations in Daya Bay has been higher, and the greening along the roads at intersections has become more exquisite, especially at night, with bright lights and charming scenery. These changes benefit from the implementation of the pilot project of upgrading urban quality nodes in Daya Bay District. With the issuance and implementation of the Construction Plan for Key Construction Projects in Daya Bay in 2022, Daya Bay District will carry out wall chart operations on 32 key construction projects, involving 6 road traffic projects, 9 industrial supporting projects, 8 human settlements projects, 7 people’s livelihood security projects and 2 flood control and drainage projects.

　　In order to comprehensively improve the urban quality of Daya Bay, Daya Bay has learned from domestic advanced urban management experience and practices, and carried out pilot projects to improve urban quality nodes throughout the region. This project includes the disc quality improvement project of Daya Bay West Area, the quality improvement project of Zhongxing South Road (Zhongxing Middle Road-Zhongxing Fifth Road Section), the elevation renovation project of Songtao Road (Xiaojingwan Toll Station-Shihua Avenue Section), and the quality improvement project of the entrances and exits of five high-speed toll stations such as Xiaojingwan Toll Station. The main facilities include the quality improvement of sidewalks and greening projects, and the lighting project of night scenes. The reporter learned from the Daya Bay Municipal Garden Management Office that the quality improvement project of each node in the project has been basically completed and the finishing work is underway.

　　Daya Bay will carry out the second phase of the urban quality node upgrading project this year, which will upgrade the quality of seven nodes, including Ximenlou of Shihua Avenue, Zhongxing Middle Road (Zhongxing South Road-Shugang Avenue) and Longshan No.1 Road (Longhai No.1 Road-Longhai No.3 Road). The main contents include pavement replacement, green belt combing, tree replacement and relocation, turf laying, micro-topography construction, and lighting engineering renovation and upgrading along the line.

　　It is understood that among the key construction projects in Daya Bay in 2022, there are eight residential environment projects, including Daya Bay Binhai Bidao and Landscape Construction Project (from Baguang to Fisherman’s Wharf), Daya Bay Lion Mountain Park Phase I Construction Project, Daya Bay West Old Community Reconstruction Project, Daya Bay Aotou Old Community Internal Quality Improvement Project, Daya Bay Aotou Old City Intelligent Parking Project and Daya Bay Second Water Purification Plant Phase III Project, etc. These projects are all being accelerated according to the set time nodes.

　　In order to improve the quality of the city, seize the opportunity of the times and practice high-quality development, Daya Bay has compiled the Urban Landscape Planning and Overall Urban Design of Daya Bay. "Overall Urban Design" has built an overall development pattern of "two mountains, one sea, five corridors and one network", cultivated a new platform for urban development at the level of business cards, improved the level of urban public service facilities, and improved public service facilities such as education, medical care, parks, culture and commerce.

　　There are more and more park squares around the people. In recent years, Daya Bay combines natural ecological conditions, with Tieluzhang and Bijiashan as the background mountains, Xiangshui River, Banzhangling, Hutou Mountain, Luoling and Mangrove as the core, Pingshan River and Dan ‘ao River as the main axes, featuring the coastal green spaces of Xiayong and Houzai Bay, and connecting with each other through the urban road greening system, forming a complete, rich, reasonable and urban green space system. At present, a large number of parks and squares, such as Banzhangling Park, Mangrove Urban Wetland Park, Hutoushan Park, Binhai Park, Fisherman’s Wharf, Huimin Square, Haiyun Square and Gold Coast, have met the leisure and recreation needs of residents.

　　In terms of commercial facilities, according to the layout idea of point, line and area, a large number of commercial complexes such as Wal-Mart, wanda plaza, Yitian Holiday Plaza, Canbang City Plaza, Century City Shopping Mall and Longguang Commercial Plaza have been built one after another along the main roads of the city, and citizens’ consumption experience is getting better and better.

　　In recent years, with the promotion of special rectification of municipal facilities, Daya Bay District has effectively improved the green environment of parks such as primary and secondary roads, kerbs, sidewalks, street lamps, Huimin Square, mangrove parks and coastal parks in accordance with the requirements of "purification, beautification and lighting", and the urban landscape has been continuously beautified. At the same time, improve the rapid response mechanism and the maintenance and acceptance mechanism of municipal facilities and landscaping, improve the traffic microcirculation, and make the management and operation of municipal facilities more smooth and effective.

　　Daya Bay District fully implements the responsibility system of "three guarantees in front of the door", implements three-level supervision, and includes "three guarantees in front of the door" in the annual inspection and assessment. At the same time, take the mechanism of creating civilized cities such as "hand-to-hand shooting" as the starting point to carry out rapid supervision and response.

　　A series of refined management has brought citizens and tourists a sense of identity and reputation for Daya Bay.

　　The water is clear and the banks are green, and gulls and herons fly in pieces. After ten years of renovation, the Tam O River has become a good place for citizens to relax.

　　"In the past ten years, the deepest feeling is that Daya Bay’s economy has developed, the city is more beautiful, and the ecological environment is better." In the past ten years, Daya Bay District has adhered to the concept of "Lucid waters and lush mountains are invaluable assets", unswervingly followed the road of ecological priority and green development, and strived to form a spatial pattern, industrial structure, life and production mode of saving resources and protecting the environment. The air quality has been ranked in the forefront of all counties and districts in the city for many years, and "good mountains, good water and good air" is becoming a beautiful business card for Daya Bay District.

　　The policy of paying attention to eco-environmental protection makes the green industry stimulate lasting and abundant development momentum, and the beautiful environment makes the green lifestyle a regional green trend. In Daya Bay Petrochemical Zone, the positive and negative list system is implemented for the EIA approval of projects entering the park, and all those that do not meet the requirements of industrial policies, relevant norms and energy conservation and emission reduction will be rejected by one vote; Take the lead in realizing full coverage of ecological towns and villages in the city.

　　Today, the east, west and north sides of the petrochemical area are wrapped by 2.33 million square meters of green isolation belt. The park is also sky-blue and green. It is difficult to link this environment with the annual output of 22 million tons of oil refining and 2.2 million tons of ethylene, and the scale of refining and chemical integration is the first in China. Here, every production link adheres to the technologies and concepts of recycling, green and low-carbon, safety and environmental protection.

　　The high-end, intelligent and green development of petrochemical industry is a true portrayal of Daya Bay District actively practicing the "five development concepts". "Green water and green mountains" and "Jinshan Yinshan" are mutually integrated and win-win, which lights up the beauty of Daya Bay District.

　　Since 2017, Daya Bay Petrochemical Zone has been recognized by the National Development and Reform Commission as a key support park for recycling transformation of national parks, and by the Ministry of Industry and Information Technology as the first batch of national green manufacturing system construction demonstration parks and national new industrialized industrial demonstration bases; The correlation degree of circular economy industrial chain in the park is as high as 95%, and 100% enterprises in key industries have carried out cleaner production audit, and four centralized sewage treatment plants have been built.

　　Daya Bay District continues to maintain high investment in safety and environmental protection, and has increased investment in environmental protection for many years in a row. In recent years, it has explored the governance strategy of "controlling, reducing and supplementing", that is, controlling source pollution, reducing total emissions, and supplementing ecological shortcomings, so as to comprehensively resolve the impact of development on the environment; In the prevention and control of air pollution, four sets of automatic atmospheric monitoring stations were built to monitor 46 atmospheric characteristic factors for 24 hours, and the air quality in the whole region was monitored and released in real time.

　　From January to June, 2022, the comprehensive index of ambient air quality in the whole region was 2.31, an improvement of 12.8% over the previous year, and the excellent rate was 100%, an improvement of 3.3 percentage points over the same period of last year. The air quality ranked second in seven counties and districts in the city. All the 16 rivers in the whole region meet the requirements of water functional zones, with a compliance rate of 100%, and the water environment quality ranks second among the seven counties in the city. The water quality in the coastal waters remains good; The water quality compliance rate of drinking water sources is 100%; The forest coverage rate is 44.37%, and the per capita park green space is 18.5 square meters, which has achieved the goal of ecological civilization construction with bluer sky, clearer water, more beautiful city and happier people, and presented a beautiful picture in which man and nature live in harmony and the economy, society and ecological environment complement each other.

　　On Tuesday, local time, US stocks finally got rid of the light market trend for more than a week, but unfortunately it was not a big rise but a big drop. The three major indexes closed down across the board, with the Dow down more than 300 points and the Nasdaq down 2%.

　　On the one hand, the power of the earnings season began to show, and giants such as McDonald’s and UPS warned that the macroeconomic prospects were not good in the earnings report. On the other hand, the deposits of Daiwa Bank in the United States dropped by 40%, and UBS’s net profit in the first quarter halved, all of which highlighted that the banking crisis had not completely subsided and the market risk aversion was ignited.

　　On Monday, the First Total Bank disclosed that even though Wall Street giants had jointly deposited 30 billion dollars, they lost over 70 billion dollars in the first quarter of this year alone. At the end of the first quarter, the deposit figure was only $104.5 billion, far below the $136.6 billion expected by analysts.

　　The first total and the bank lost 49.38% of its market value on Tuesday. In the news, the media reported that the bank was going to sell "50 billion to 100 billion dollars" of long-term assets to solve the mismatch problem. It is reported that Biden administration officials have been keeping in touch with Daikyo Bank in recent days, and the White House is increasingly worried that there is not much time left for Daikyo Bank to appease investors and depositors, but American policy makers are not worried that risks may spread further among banks.

　　It is worth noting that due to various indications that there are still many risk factors in the market, traders no longer bet 100% that the Fed will continue to raise interest rates before the middle of this year. According to the observation tool of the Federal Reserve, the probability of raising interest rates by 25 basis points in May fell to 81.5%, compared with 90.5% the previous day.

　　However, for technology stocks, the financial reports of Microsoft and Google have slightly eased some market concerns. AI and cloud services helped Microsoft’s financial report exceed expectations, with revenue of $52.9 billion, higher than analysts’ expectations of $51.03 billion; Earnings per share were $2.45, higher than analysts’ expectations of $2.24. More importantly, a strong profit guidance was released, which rose by 8% after hours.

　　Google’s parent company Alphabet’s revenue in the first quarter was $69.79 billion, higher than analysts’ expectations of $68.99 billion. Earnings per share was $1.17, higher than analysts’ expectations of $1.09. At the same time, it was announced that the board of directors authorized an additional repurchase of up to $70 billion. Google rose more than 4% after hours.

　　In addition, OpenAI plans to launch a new product, ChatGPT Business, which is the enterprise version in the next few months. At the same time, the new function of ChatGPT allows all users to turn off chat records, which will not be used to train and improve the model of OpenAI.

　　In terms of important macro news, according to Xinhua News Agency, US President and Democrat Biden officially announced his re-election as US President on the 25th. Biden released a video on the same day to officially announce his decision to run for re-election as president of the United States, and pointed his finger at the so-called Republican extremist forces, saying that the United States is still in the struggle of "fighting for the soul of the country" and he needs more time to "complete this work."

　　This means that next year, the world may once again witness the "peak confrontation" between Trump and Biden.

　　[overnight U.S. stocks]

　　Among the large Chinese stocks, Alibaba fell by 4.58%, Baidu by 4.63%, Netease by 6.35%, Tencent Music by 4.96% and Pinduoduo by 3.25%.

　　Among the large US technology stocks, Apple fell 0.94%, Amazon fell 3.43%, Google A fell 2.00% and Netflix fell 1.97%.

　　[global index]

　　[global goods]

　　The main contract of WTI crude oil closed at $77.26 per barrel, down 1.90%; The main contract of Brent crude oil closed at $80.76 per barrel, down 2.38%; The main contract of crude oil in the previous period closed at 551.20 yuan per barrel overnight, down 2.58%.

　　Overnight, the Shanghai gold main contract closed up 1.06% to 447.58 yuan per gram; The main contract of Shanghai Bank closed down 0.16% to 5622.00 yuan per kilogram.

　　[overnight news]

　　Biden officially announced his re-election as president of the United States.

　　According to Xinhua News Agency, U.S. President and Democrat Joe Biden officially announced his re-election campaign on the 25th. Biden released a video on the same day to officially announce his decision to run for re-election as president of the United States, and pointed his finger at the so-called Republican extremist forces, saying that the United States is still in the struggle of "fighting for the soul of the country" and he needs more time to "complete this work."

　　Biden is 80 years old. In the 2020 US presidential election, he defeated Trump, the then US president and Republican, and became the US president in January 2021.

　　Banking crisis worries have re-suppressed the market’s interest rate hike pricing for the Fed.

　　The interest rate swap contract of the Federal Reserve in June currently reflects that the benchmark interest rate of the central bank is only 20 basis points higher than the current effective federal funds rate, which implies that the possibility of raising interest rates in one of the next two FOMC meetings is about 80%, while it was almost certain that the Fed would raise interest rates in May.

　　The debt ceiling deadlock is hard to solve. The White House says Biden will veto the Republican bundled spending reduction plan.

　　The Republican proposal put forward by House Speaker McCarthy requires that the debt ceiling of $1.5 trillion be raised and the future total government expenditure be reduced by $4.5 trillion. On Tuesday, the White House said that the debt ceiling must be solved without any conditions. Also on Tuesday, US Treasury Secretary Yellen warned lawmakers that if the debt ceiling is not resolved, the economic achievements made in the past two years will be threatened.

　　New Governor of Bank of Japan: Tightening monetary policy now may lead to serious consequences.

　　Industry insiders predict that Ueda and Kazuo may choose "a cautious start" for their first monetary policy meeting this Friday, but they do not rule out the possibility of changes in June.

　　Argentina’s inflation exceeded 100% for the first time in 30 years.

　　As the inflation rate exceeded 100% for the first time in 30 years, and the record drought dealt a heavy blow to agriculture-related industries, Argentina’s economic activity remained stagnant in February, with GDP increasing by 0% month-on-month and only 0.2% year-on-year. But high inflation does not seem to cool down in a short time. Argentina’s central bank predicts that the country’s inflation rate will reach 110% in 2023.

　　[company news]

　　Prosus, the major shareholder of Tencent, resold 789,600 shares of Tencent, and its shareholding ratio dropped to 25.99%.

　　Prosus, the largest shareholder of Tencent and the Dutch subsidiary of South African Naspers Group, announced in official website on April 25th local time that in order to continue to implement the repurchase plan, Prosus sold 789,600 ordinary shares of Tencent on April 25th, 2023, and its shareholding ratio dropped to 25.99%. In addition, as part of the repurchase plan, during the period from April 17, 2023 to April 21, 2023, Prosus repurchased 2,651,096 shares of Prosus at an average price of 698,795 euros per share, with a total consideration of about 185 million euros.

　　Resist the impact of Microsoft AI, Google search returns to growth in the first quarter, and the cloud business turns losses into profits.

　　In the first quarter, Alphabet’s revenue and profit were better than expected. The year-on-year growth rate of revenue exceeded expectations and accelerated to 3%. EPS profit decreased by 4.9%, less than half of market expectations. Google’s advertising revenue fell by 0.2%, which was much lower than expected, and its search revenue changed from 3.6% in the fourth quarter to nearly 2%. YouTube advertising revenue fell less than expected; Google Cloud changed from an operating loss of more than $700 million a year ago to a profit of 190 million; The expenses related to layoffs and office space reduction in the first quarter were $2.6 billion. Alphabet announced that it plans to buy back up to $70 billion in shares.

　　AI and cloud services help Microsoft’s financial report exceed expectations.

　　After the close of trading on Tuesday, Microsoft announced its financial data for the third quarter. Among them, the revenue was 52.9 billion US dollars, which was higher than the analyst’s expectation of 51.03 billion US dollars; Earnings per share were $2.45, higher than analysts’ expectations of $2.24. In terms of main business, revenue from productivity and business services reached $17.5 billion, up 11% year-on-year; Intelligent cloud’s revenue was US$ 22.1 billion, up 16% year-on-year; Personal computer business revenue was $13.3 billion, a year-on-year decrease of 9%. After the financial report was released, Microsoft’s share price rose more than 8% after hours.

　　Microsoft CEO Nadella said in a statement that the company’s performance indicates the beginning of a "new era of computing", and the world’s most advanced artificial intelligence model is being combined with the world’s most common user interface-natural language.

　　OpenAI will launch a new paid product, ChatGPT Enterprise Edition, and add a new function to "appease" supervision.

　　OpenAI plans to launch a new product ChatGPTBusiness in the next few months, and introduce a new subscription group for ChatGPT to meet the needs of corporate customers. In addition, the new function of ChatGPT allows all users to close the chat record, which will not be used to train and improve the model of OpenAI; ChatGPT data can also be exported to users’ mailboxes.

　　UBS’s quarterly results were bleak, but after the $3.2 billion acquisition, it successfully "retained" $28 billion of Credit Suisse’s client funds.

　　UBS released a quarterly report that after the announcement of the acquisition of Credit Suisse, the wealth management department of UBS obtained a net increase of 28 billion US dollars, of which 7 billion US dollars flowed in in the last ten days of March alone. However, on the whole, UBS’s first-quarter report card is still disappointing: its total revenue decreased by 7% year-on-year to $8.74 billion, its net interest income decreased by 22% year-on-year to $1.39 billion, and its net profit decreased by 52% year-on-year to $1.03 billion, setting a record for the lowest quarterly profit in three years. All three results were lower than market expectations. UBS said that the acquisition of Credit Suisse in the second quarter will actively reduce the risk and resource consumption of Credit Suisse’s investment banking business.

　　After the "escape" of deposits, the first total and the bank brewed self-help and considered selling assets of up to 100 billion US dollars.

　　According to the media, First Total Bank may give warrants or preferred shares to potential buyers, including big American banks, to encourage them to buy assets of the bank above the market value; The bank tried to strengthen its balance sheet, avoid being taken over by the regulator FDIC, and clear the way for possible financing in the future.

　　Apple is developing AI-driven health guidance services and emotional tracking functions.

　　According to informed sources, Apple is developing an AI-driven health guidance service, which will be available as soon as next year. For this year’s WWDC, Apple will release the user emotion tracking function and the first health monitoring application for iPad devices.

　　[financial calendar]

On the afternoon of March 28th, the State Council Joint Prevention and Control Mechanism held a press conference to introduce the vaccination and supply guarantee in COVID-19. As of March 27th, 2021, 102.417 million doses of Covid-19 vaccine have been reported in various places.

About COVID-19 vaccine, the conference also introduced these latest news.

1. What should I do if I am not sure if I am suitable for vaccination?

If it really belongs to the vaccination taboo, it is impossible to provide vaccination services. If it is listed in the vaccination items, it is recommended to tell the vaccination doctor truthfully before vaccination. So that doctors can fully evaluate and determine whether it is suitable for vaccination.

2. How long is the vaccine protection period?

COVID-19 vaccine is a new vaccine. According to the antibody level, it will be monitored for more than six months. But we also know that antibody is not the only protective indicator, and there are other factors in the process of vaccine’s function. Therefore, we should do relevant research on the persistence of the vaccine to confirm how long its protection period is.

3. I have been vaccinated with COVID-19 vaccine. Do I need to be vaccinated again?

According to Zhongsheng of Sinopharm, during the whole clinical research, it is now observed that the persistence of vaccine protection is about half a year, and the persistence of neutralizing antibodies is also about half a year. In the clinical process of the overall design, the booster needle was designed to observe the persistence and protection level of antibodies. At present, the preliminary results show that booster needle can effectively improve the titer of neutralizing antibodies, effectively improve the persistence of antibodies, and also effectively improve the anti-mutation ability of vaccines.

In the future, phase III clinical research will be carried out overseas to continuously observe the persistence of antibodies and protection. Is it necessary to carry out booster vaccination? When will you call? Still have to answer according to the results of the next three clinical studies.

4. What is the preventive effect of COVID-19 vaccine?

The vaccine itself can prevent infection, morbidity, severe illness and death. Now, the effectiveness result we get is the result of our clinical experiment. With the application of the vaccine, we will also carry out related research on its protective effect after marketing.

5. How to ensure the supply of vaccines in COVID-19?

On the one hand, actively and steadily expand the vaccination service capacity, optimize the vaccine distribution process, and improve the efficiency of circulation and operation. To scientifically arrange the turnover quantity of vaccines, the requirement is not to overstock the inventory, and to increase the number of inoculation points and inoculation stations in various ways to meet the vaccination needs of the masses. On the other hand, it is necessary to strengthen the linkage between departments and coordinate the industrial and information departments to strengthen the supply guarantee of vaccines.

6. After the first injection, how long is the best time to inject the second injection?

After the first dose of vaccination, the interval between the second dose of vaccination should be greater than or equal to three weeks, and the second dose of vaccination should be completed as soon as possible within 8 weeks after the first dose of vaccine.

7. If you catch up with a business trip or go out, can you get a second shot in a different place?

According to the guidelines, it is recommended to use the varieties of the same enterprise as much as possible to complete two doses of vaccination. If the same variety is not available in different places, then other vaccine products of the same kind can be replaced to complete two doses of vaccination.

Effective period

8. If I miss the second dose of vaccination for some reason, how can I make it up?

For those who have not completed 2 or 3 doses of COVID-19 vaccine according to the procedure, it is suggested to replant as soon as possible. There is no need to restart the immunization program, just replant and complete the corresponding dose.

9. Some vaccine developers have been vaccinated in February and March last year. What are the antibodies in these people?

Some people, as the vanguard of vaccines, have been vaccinated with inactivated vaccines in COVID-19. We are constantly monitoring the change data of antibodies in their bodies. At present, we have obtained the antibody monitoring data for 9 months. Judging from the current data, the antibodies in 9 months still have a certain level. We will continue to strengthen monitoring in the future.

10. Will foreign virus variation affect the effectiveness of existing vaccines?

Vaccine research and development units and production units pay great attention to dealing with the variation problem. Two inactivated vaccines of Sinopharm Group China Bio, using the serum after the second and third clinical trials at home and abroad, have carried out cross-comprehensive experiments on the strains found in South Africa and Britain, as well as more than 10 strains found in different regions and epidemic areas in China. The results show that neutralizing antibodies produced by the two inactivated vaccines have a good neutralizing effect on these strains. Small variation of the virus will not affect the antigenicity of the vaccine, that is, the vaccine will be effective without variation of protective antigen, especially the whole virus inactivated vaccine.

11. How to advance the national plan for vaccination of the elderly?

At present, Beijing, Shanghai and other regions have been vaccinated with Covid-19 vaccine for some elderly people over 60 years old and patients with chronic diseases who are willing to be vaccinated and in good physical condition under the premise of fully evaluating the health status and infection risk of the vaccinated objects. In the next step, we will actively and steadily promote the vaccination of people over 60 years old and patients with chronic diseases in combination with the use effect of vaccines in large-scale populations.

12. When will people under the age of 18 be vaccinated?

Last year, the phase I/II clinical research conducted by China Bio in Henan covered the systematic, safe and immunogenic clinical research of the young age group of 3-17 years old. At present, the safety data of this age group have been completely obtained, and the expected results have been achieved. The detection of immunogenicity and neutralizing antibodies has also been completed. We will communicate with the Food and Drug Administration in the near future, and I believe that this group of people can be covered in the near future.

(Source: Henan CDC)

Original title: "12 questions about COVID-19 vaccine, look at the answer"

Read the original text

　　Recently, the report that "domestic down jacket sold for 7000 yuan" attracted attention. As a clothing manufacturer and trader, Meng Zhuo is puzzled by this.

　　"Some high-priced situations are marked, and there are often discounts when actually selling." Meng Zhuo opened the e-commerce platform on his mobile phone and said, "You see that some of them have a price tag of 2,000 yuan, and after the discount, it will be 129 yuan."

　　In his long-term experience, the price of conventional down jackets has not risen for many years, and even showed a downward trend in the price war of involution. The prediction of this year’s warm winter also made the down jacket not rebound obviously when the consumption recovery was not as good as expected.

　　To this end, the first financial reporter conducted an investigation and interview, and the suppliers of winter clothes told the truth: the price tag is not the actual price, and the high price is not the price increase.

　　There is no price increase for the regular basic model.

　　Pu Xiaojuan, deputy general manager of Suzhou Fannuo Textile Co., Ltd., has the same feelings as Meng Zhuo. "The cheap down jacket brand, the overall pricing this year is similar to last year." She told CBN that the sales of most brands in various time periods are discounted, and in the end, they must cater to the psychology of the market. The general actual price cannot be ridiculously high.

　　Suzhou Fannuo Textile Co., Ltd. mainly supplies fabrics for high-end down jacket brands. Pu Xiaojuan said that in terms of fabrics, the price of conventional fabrics has not risen, which is basically the same as last year. The affordable e-commerce and lightweight down jackets corresponding to these conventional fabrics sold well in previous years, but this year they only lasted for a week and ended. The total amount is not as good as in previous years, and there is naturally no motivation for price increases.

　　"The price of down jackets sold domestically is basically more than five times the actual price. Some e-commerce platforms are even cheaper. " Meng Zhuo said that in proportion, light down jackets have accounted for the majority of sales in recent years, and they are also one of the most commonly bought winter clothes by ordinary consumers. The price of this kind of clothing has never risen in the context of rising global prices.

　　Wu Dongming, the person in charge of Hengxin Weaving Co., Ltd. told CBN that the price of the basic down jacket fabric has not changed. "It basically can’t go up, even if it has gone up slightly recently, it may only make the enterprise lose a little."

　　The person in charge of Jiangsu Tianwei Textile also admitted that from the overall supply, the market demand this year is lower than expected. In terms of price, "basically, it can’t go up unless new products and old products are reduced in price."

　　Taking into account the shelf life of the market, Meng Zhuo said that for manufacturing factories, the export orders for down jackets have been delivered this winter, and overseas sales are coming to an end in November, as is the case in China. "After New Year’s Day, there are basically few people who buy them … … Needless to say, the factory for domestic sales has basically slowed down at present, mainly supplying small-scale replenishment orders.

　　That is to say, on the one hand, the tag price is not the actual price, on the other hand, the high price on the market today is only some high-end or differentiated products, which does not correspond to the "general increase" of the industry — — A large number of conventional affordable clothing and even raw materials have not seen price increases.

　　Hu Kehua, deputy director of the Social Responsibility Office of China National Textile and Apparel Council, told CBN that the overall global economy was tired, and even though the China market was stable as a whole, there was no obvious improvement in terms of the prices of fabrics and clothing. Recently, the lower-priced down jackets have ushered in some sales due to the approaching cold wave, which has led to certain price increase expectations at the end of down and other materials.

　　Supply chain behind high price

　　"Last year, the same thing sold more expensive this year, but this year’s things are different from many before. (The pricing of different products is different) is not called price increase." Zhou Jianchun, general manager of Wujiang Shengwei Bauhinia Textile Co., Ltd. told CBN. Zhou Jianchun, who is also a fabric supplier of down jackets, thinks that the word "material" can describe their products more accurately than fabric. Because the material of down jacket now goes beyond the scope of traditional fabrics, it emphasizes more and more the sense of science and technology and new functions, and also incorporates materials such as nano-breathable film, volcanic materials and parachutes.

　　Wu Dongming also mentioned that there is no change in the basic model, and the price is increased by the deep-processed materials. "The fabrics used in winter clothes such as down jackets this year are completely different."

　　Pu Xiaojuan said that this year’s hot-selling and high-priced down jackets are mainly those with certain scientific and technological content and partial functionality. This is also the differentiation strategy pursued by brands in recent years in order to seize the mid-to high-end market. Correspondingly, it is the change of consumer demand — — From the original emphasis on warmth and appearance style, it has become more and more functional and scientific, and is willing to pay for it.

　　Zhou Jianchun also said that consumers’ demand for clothing has changed obviously, and the pursuit of technology and functionality of a garment has become a new fashion trend. "This year, the fabrics of the technology series and the corresponding down jackets sell particularly well."

　　"In the past few years, the prices of some conventional down jackets went down, and the involution was seriously playing a price war. However, the prices of down jackets of some brands have been raised all the time, and it is true that things have been done better. " Zhou Jianchun thinks that 70% of the differentiated competition of brands comes from the difference of fabrics, and "more functional and technological fabrics are needed to meet the needs of the consumer market". More functional needs to be realized by science and technology. For example, some down jacket materials can not only prevent wind, store heat and keep warm, but also prevent dirt and oil. When the materials originally used in parachutes are used in clothing, the strength can be improved by more than 1.5 times compared with the traditional ones. A nano-scale film can let water vapor out, but liquid water can’t enter, and at the same time, it has the functions of perspiration, ventilation and waterproof.

　　In addition to functionality and technology, under the global trend of low carbon, high-priced down jackets and fabrics usually need low-carbon environmental protection and renewable elements. These are directly reflected in the product structure, order volume and profit rate of the supply chain.

　　"We started this year, and the conventional lining materials are all renewable materials." Pu Xiaojuan said that today’s materials must have their own characteristics, and they cannot follow the crowd. Those traditional homogeneous materials are highly competitive and have little profit. To this end, since 2019, they have given up their original customers and conventional products, added independent R&D and sample management teams, changed the passive mode of doing development with business, and actively transformed into renewable and technological fabrics. After several years of running-in, they have also gained a doubling of the order amount in these two years. "This year’s orders are expected to increase by 1.75 times, and last year’s increased by 1.2 times." Prior to this, the annual orders were almost flat.

　　Traditional fabrics are declining instead of increasing, but for Pu Xiaojuan, the price of their new materials is more than 30% higher than that of conventional fabrics, which is a rise in volume and price. "Some friends’ enterprises also achieved the performance of last year in August this year."

　　Pu Xiaojuan revealed that they have a vest heating lining jointly developed, and one meter of cloth can be used on several down jackets. The recent orders have been added. "The original order should have ended in October, and now the scale of replenishment has doubled. A domestic brand of this down jacket may have sold more than 1 million pieces. "

　　Zhou Jianchun said that the company’s overall sales this year were the same as last year, but the sales increased by more than 30%. "The price of some (new) fabrics is 2-3 times that of the conventional ones".

　　Jiangnan, head of Romulan Group Outdoor New Materials Co., Ltd., told CBN that since 85% of the company’s orders are mainly for export, this year is inevitably affected by geopolitical and weak market factors. "Originally (this year’s sales) were expected to increase by 20% this year, but the actual forecast is only 8%." However, this growth is in the case of constant quantity, which also means that the price has been significantly improved because of the innovative transformation of outdoor fabrics and the introduction of new products.

　　Not only the high-end functional down jackets, but also the changes in the market and supply chain have made outdoor-related jackets sell better this year. "Many listed textile companies may not meet the overall performance standards, but the related sales of jackets are good". However, Jiangnan believes that, like down jackets with functions such as coping with extreme cold, this kind of clothing is a product with a small customer base in scale, and it is also a high-end subdivision that is less affected by the transfer of traditional textile and clothing production capacity.

　　Whether it is clothing or material manufacturing, another motivation to support high prices lies in branding. As enterprises in China pay more and more attention to brand building, the polarization of the consumer market will become more and more obvious.

　　"Now more and more brands and garment manufacturers are using the design concept of Chinese and foreign integration, and at the same time, they are more and more concerned about the brand effect, which will be expensive." Jiangnan feels that, more accurately, brands have brought about an increase in the added value of products, and there will be two extremes in the future — — Cheaper and more expensive.

　　Zhou Jianchun said that, like clothing brands, the development and transformation of fabric enterprises also need brand building, and in recent years, with the brand transformation of local industrial chain and the introduction of designers, they have also achieved certain brand effects, which is one of the reasons for raising prices. "Some similar fabrics can be sold a little more expensive than their peers."

　　In terms of design and style, Wu Dongming said that Chinese style elements have also become popular recently.

　　Regarding industrial transfer, Jiangnan pointed out that compared with Southeast Asia, China’s manufacturing industry still has certain advantages. First, the demographic dividend is not as good as before, but it still exists. Secondly, the completeness of China’s industrial chain is the most important reason, especially the functional fabric and clothing innovation, which takes time and experience to accumulate. Thirdly, China has a vast domestic market. Even if the export uncertainty increases, it can find a greater balance in the two-legged walk of domestic and foreign trade. Therefore, in addition to adapting to changes in market demand and brand transformation, they will also make a more rational global layout.