(A) the original achievements made in the frontier field of science
　　　　1. NanoSCIENCE, life science, information science, earth science, mathematics, physics and chemistry have published a series of important papers in first-class magazines of science, NATURE and related disciplines, occupying an important place in the world.

　　　　Nonlinear optical crystals, quantum information and communication, and ultra-strong and ultra-short lasers are among the top in the world. A series of innovative achievements have been made in the fields of nanomaterials and nanostructures, protein’s structure and function, brain and cognition, animal cloning, molecular engineering for creating new substances, paleontology, marine science, etc., and the overall research level has been significantly improved, which has had an important impact in the world; Mathematical mechanization, symplectic geometry algorithm and other aspects to maintain China’s characteristics and advantages.

　　　　2. The research of nonlinear optical crystals keeps the leading position in the world.

　　　　Innovative achievements have been made in the design and growth of ultraviolet and deep ultraviolet nonlinear optical crystals and the development of prototype lasers. The fully transparent KBBF single crystal of 20×10×1.8mm3 was successfully grown, which broke through the limit that the thickness of the crystal never exceeded 1mm in the past. KBBF prism coupling technology is put forward for the first time in the world, which realizes the effective output of deep ultraviolet laser from 200 nm to 193 nm, thus jumping over the technical threshold of realizing deep ultraviolet frequency doubling light output and taking an important step towards the realization of the fourth generation light source, which will have a far-reaching impact on the competition of optoelectronic industry in the future.

　　　　3. Quantum information and communication research has achieved a number of important innovations with international influence.

　　　　In the research of preparation and manipulation of multi-particle entangled states, the preparation and manipulation of five-particle entangled states were realized for the first time in the world, and the teleportation of quantum states with "open terminal" was demonstrated experimentally by using a five-photon entangled source, which was rated as one of the top ten advances in international physics in 2004 by american physical society and European physics at the same time. In the aspect of quantum key distribution, an experimental scheme of quantum key distribution with good one-way transmission stability is designed, and a 150 km indoor quantum key distribution experiment is realized. Using the actual communication optical cable, the quantum key distribution with a length of 125 kilometers from Beijing to Tianjin via Xianghe, Hebei Province is realized.

　　　　4. The research of ultra-intense and ultra-short laser is in the forefront of the world.

　　　　Great progress has been made in the development of new principles and methods of CPA’s new generation ultra-short laser and the integration and innovation of miniaturized OPCPA ultra-short laser system, and the output power of 3.67TW has been achieved, and the CPA ultra-short laser device with high beam quality and world-class overall performance has been successfully developed. On this basis, a new phenomenon of double-peak splitting of high-order harmonic spectrum is observed experimentally for the first time, and a new mechanism of generating high-intensity correlated atomic beams by quantum coherent control of atomic system is proposed. The theoretical model and calculation method of non-perturbation quantum electrodynamics of strong-field interaction are established and applied to explain and predict the experimental phenomena of strong-field laser physics.

　　　　5. The research on nano-materials and nano-structures has made a series of innovative achievements, which is at the forefront of the world.

　　　　In the research of carbon nanotubes, the technology of preparing single-walled carbon nanotubes by combining template with organic catalytic pyrolysis is considered by foreign counterparts as one of the four main preparation methods of carbon nanotubes at present. The growth process of carbon nanotubes was proved by isotope labeling method, ultrafine carbon nanotubes were prepared by secondary discharge method, carbon nanotube wires were drawn by superparamagnetic carbon nanotube array, and preparation methods of double-walled nanotubes by floating catalysis method and large-scale preparation of carbon nanotubes by alcohol thermal reduction method were developed. In the preparation of ordered array of one-dimensional nanowires of GaN single crystal, coaxial nano-cables with the core of GaN and the outer layer of BN and the diameter of 50nm have been successfully developed, and the world’s thinnest probe with good performance has been assembled by using single-walled carbon nanotubes, which has had an important impact in the world. The work of polarized incandescent spectrum of carbon nanotube filament opens up a new way for the application of carbon nanotube in lighting field. It is found that the deformation process of bulk nano-copper is mainly controlled by grain boundary behavior rather than traditional lattice dislocation behavior. It is found that the twin interface induces the high strength and high conductivity of nano-copper, which shows that the material properties can be optimized through the structural design on the nano-scale. A new principle of binary synergism to produce superhydrophobicity is put forward, and interface structural materials with bionic superhydrophobicity function are designed and synthesized, and the "switching effect" of superhydrophobicity/superhydrophilicity reversible transformation controlled by temperature field and light field is found. Lead thin films with atomic flatness were successfully prepared on silicon single crystal substrate by low temperature growth method.It is also observed that the superconducting transition temperature and thermal expansion coefficient of lead thin films oscillate with the thickness of the films and other strange material properties.

　　　　6. A breakthrough was made in the study of protein’s structure and function.

　　　　The 3-D structure analysis of spinach light-harvesting complex (LHCII) with resolution of 2.72 was obtained for the first time. This is the first 3-D structure analysis of LHC II at atomic level so far, which is considered as a breakthrough in photosynthesis research in recent years. The research results were published in the journal NATURE in the form of an article. The crystal structure of mitochondrial respiratory chain membrane protein complex II and its inhibitor complex was successfully analyzed, which filled a blank in the study of mitochondrial respiratory chain and provided a real and available model for studying the electron transfer system of mitochondrial respiratory chain and human mitochondrial diseases related to this complex. The research results were published in CELL magazine.

　　　　7. Breakthrough in brain science research

　　　　A number of innovative achievements have been made in brain cognition, nerve signal transmission and nerve growth, and a number of important papers have been published in internationally renowned journals such as SCIENCE, NATURE and NEURON. The research on the choice of Drosophila in the face of dilemma clues has been initiated internationally. It is found that Drosophila can learn multiple clues of visual mode to guide flight orientation behavior, and it is proved that the mushroom body of Drosophila brain participates in the choice process, which provides a simpler model organism and a new choice paradigm for understanding this intelligent behavior of brain. In the study of the regulation mechanism of some basic processes of nerve development, it is found that a protein kinase called CSK has polarity in the development of nerve cells, and its activity in axons is lower than that in dendrites, which controls the polarity of nerve cells. In the research of cognitive science, the initial perception theory of topological properties is put forward, which challenges the dominant feature analysis theory for half a century. Further research has found the biological evidence of magnetic resonance imaging to support this theory.

　　　　8. Successful birth of transgenic intergeneric cloned fish.

　　　　It marks a new breakthrough in the basic research field of animal cloning in China. Intergeneric nuclear transfer was carried out with the blastocyst cells of the transgenic red carp (Cyprinus carpio var. rubra) with MThGH F4 as the donor and the enucleated eggs of goldfish as the recipient, and the transgenic inter-generic cloned fish was successfully obtained, and the new evidence that cytoplasm affected the development of cloned fish was found at the molecular level for the first time.

　　　　9. Important new breakthroughs have been made in immunology research.

　　　　A new DC subgroup with special negative immune regulation function was found, which challenged the traditional theory that mature DC no longer proliferated in traditional immunology, and was helpful to deeply understand the mechanism of immune response and the pathogenesis of many diseases.

　　　　10. Molecular engineering to create new substances

　　　　It has gathered 5 academicians in this field, 14 winners of the National Outstanding Youth Fund and 3 "innovative research groups" to carry out innovative research, made high-level research results, and published more than 40 papers in international authoritative magazines in the chemical field such as SCIENCE, NATURE, ACCOUNT OF CHEMICAL RESEARCH and JACS, which has had an important impact internationally.

　　　　11. Paleontological research

　　　　Based on the abundant paleontological data in China, a series of important discoveries and innovative achievements have been made in the origin of important biological groups such as metazoa, vertebrates and birds, the Cambrian biological explosion, the biological radiation in Paleozoic, Mesozoic and Cenozoic, the three biological extinctions in Paleozoic and their subsequent recovery, and the exploration of the basic laws of the co-evolution of biology and environment. The first author published 32 papers in SCIENCE and NATURE, which attracted great attention from international academic circles. Among them, the research on "Chengjiang Fauna and Cambrian Outbreak" won the first prize of National Natural Science Award in 2003; The Paibi section of Huayuan, Hunan Province was established as the first global boundary stratotype section ("Golden Nail") in Cambrian.

　　　　12. Qinghai-Tibet Plateau evolution and environmental effects

　　　　New views are put forward on the collision time limit, process and collision mode of the northern and southern edges of the plateau in India. High-resolution environmental records in different areas of the plateau have been established, revealing the characteristics of climate and environment changes in the past 20 thousand years, especially in the last 2000 years. The relationship between the uplift of Himalayas and Qinghai-Tibet Plateau and Asian monsoon climate is studied comprehensively and systematically for the first time. The results show that the uplift of the Qinghai-Tibet Plateau 10-8 million years ago led to the emergence of the Asian monsoon, and the accelerated uplift of the Qinghai-Tibet Plateau 3.6-2.6 million years ago laid the basic framework of the Asian monsoon climate. It shows that the evolution of Asian monsoon is closely related to the periodic uplift of plateau.

　　　　13. Many breakthroughs have been made in the deep subduction of the mainland.

　　　　The continuous material composition, three-dimensional structure, material exchange between crust and mantle and geophysical state in the deep part of plate convergence boundary are revealed. It is proved that there was an important geological event in geological history when the plate carried a huge amount of material and dived deep into the mantle below 100 kilometers. It is found that the instability caused by dehydration of structural water (OH) in eclogite minerals can induce fractures and cause high-temperature earthquakes, which explains the cause of deep earthquakes in mantle transition zone. This achievement was published in NATURE magazine in 2004.

　　　　14. Marine scientific research

　　　　The theoretical framework of China’s offshore ecosystem dynamics is established, and it is the first time to establish a theoretical framework based on the ecosystem level. The quota fishing assessment and management model, taking fish as an example, found that the strategy of Daphnia sinensis to spend the summer in the shallow sea of temperate continental shelf is considered as one of the representative research achievements since the implementation of the international Global Marine Ecosystem Dynamics (GLOBEC) plan. At the invitation of members of the GLOBEC Scientific Steering Committee and the North Pacific Scientific Organization (PICES), it was reported at international scientific conferences many times, which had a great impact. In terms of the formation mechanism and variation of offshore circulation, the formation mechanism of Kuroshio "multi-core structure" in the East China Sea is revealed. It is found that the circulation exists in the outer shelf of the southern East China Sea, and the distribution and variation of "flow-vortex structure" are simulated. The evolution law of "multi-vortex structure" of South China Sea circulation is expounded. A wind-wave-tide-current coupled numerical model is developed.

　　　　15. Research on Mathematical Mechanization Method

　　　　This paper proves the "finite kernel" theorem of global optimization of a certain algebraic system, gives a complete global optimization method for this kind of system, provides a new method for global optimization in many scientific fields, and completes the automatic reasoning platform of mathematical mechanization. It is proved theoretically that any reversible linear transformation can be realized by integer, and a necessary and sufficient condition and a fast algorithm for integer realization are given. The "multi-component transformation" technology based on this theory has been adopted by the international standard of JPEG2000 image compression.

　　　　16. Large-scale scientific computing research

　　　　The adaptive algorithm, symplectic algorithm and multi-scale algorithm suitable for solving large partial differential equations are developed. Symplectic algorithm is used to assimilate atmospheric and ocean GPS data for the first time, and a new generation atmospheric circulation model GAMIL1.0 is established.

　　　　17. Research on high performance optimization algorithm

　　　　An innovative method that can quickly find the effective solution space and algorithm is developed, which improves the quality of stable solution and the calculation speed of solving very large-scale examples of the same scale traveling salesman problem by one order of magnitude respectively. Large-scale optimization algorithms such as multi-space search are developed and applied to Internet search, mobile communication and multimedia communication systems, VLSI design, intelligent power information management systems and other technical fields.

　　　　(B) the source of innovation in basic theory
　　　　1. Basic theoretical research on solidification and crystallization control of steel.

　　　　It is found that the regulation of grain refinement in metallurgical process can greatly improve the strength of steel. A new generation of steel materials developed by systematically integrating high clean steel production technology, high homogeneous solidification structure technology and deformation-induced transformation structure refinement technology is characterized by high cleanliness, high homogeneity and ultra-fine structure, and its strength is about twice that of ordinary materials at present. The achievements have been partially applied to automobile, construction and other industries, and are regarded by domestic metallurgical circles as a "revolution" to promote the structural adjustment, product upgrading and improve the technical level of the steel industry.

　　　　2. Key problems in industrial production of high performance polyolefin materials.

　　　　Based on the relationship between polymer chain structure and processability, this paper puts forward the theory of analyzing the flow stability of biaxial stretching, introduces rheological research into the improvement of polyolefin processability, designs the chain structure of BOPP film special material suitable for high-speed stretching, and develops an ultra-high-speed BOPP special material with a capacity of 400 m/min without basically changing the existing production equipment conditions, and the product quality exceeds that of imported products.

　　　　3. The theory and technology of diaspore bauxite reverse flotation are established for the first time in the world.

　　　　The principle of changing the interfacial interaction force between aluminum and silicon minerals to control dispersion is put forward, the structural model of high-efficiency collector for aluminosilicate minerals and the new idea of activated flotation are put forward, and the desilication technology prototype of "controlling dispersion-selective inhibition-enhanced collection" and the desilication technology of selective grinding-agglomeration positive flotation are formed. The original flotation desilication method and the improved Bayer process may expand the available bauxite resources in China by 2-5 times.

　　　　4. Some breakthroughs have been made in the research of optoelectronic devices, optical storage and information functional materials, and a series of achievements with independent intellectual property rights have been made.

　　　　In the research of quantum cascade lasers and detectors, gallium arsenic/aluminum gallium arsenic quantum cascade lasers and the world’s first short cavity single-mode strain compensation indium gallium arsenic/indium aluminum arsenic quantum cascade laser have been successfully developed, and the world’s first gallium indium nitrogen arsenic/gallium arsenic multi-quantum well resonant cavity enhancement detector has been developed. These achievements indicate that the research level of GaAs-based near-infrared optoelectronic materials and devices in China has entered the world’s advanced ranks. In the aspect of optical storage, a new generation of optical storage technology is developed by using multi-wavelength and multi-order optical storage method, which can greatly improve the storage density and capacity of optical disks without changing the numerical aperture of optical systems, thus doubling the capacity of optical disks and opening up a new way for establishing the optical disk industry with independent intellectual property rights in China. In the research of semiconductor optical amplifier, the polarization insensitive semiconductor optical amplifier with graded strain active region is proposed and fabricated for the first time in the world, and the semiconductor optical amplifier is fabricated by alternately growing tensile strain quantum wells and compressive strain quasi-materials for the first time. In the aspect of organic small molecule fluorescent materials, a series of phenol pyridine complexes with independent intellectual property rights were designed and synthesized. Breaking through the framework of studying microwave dielectric ceramics in traditional perovskite compounds, a new system of K2NiF4 MRAlO4 microwave dielectric ceramics with independent intellectual property rights was developed.

　　　　5. A series of outstanding progress has been made in the research of micro-nano electronic materials and devices and micro-electromechanical systems.

　　　　In the research of miniaturization of silicon-based integrated devices, a new CMOS device with a gate length of 27nm and a CMOS32 frequency division circuit with a gate length of 36nm have been successfully developed, which marks a new step in the research of chip miniaturization in China. In the research of compound semiconductor electronic devices, a PHEMT transistor with cutoff frequency exceeding 100GHz was successfully obtained, which laid the foundation for the development of InP-based devices in China. In the research of field emission flat panel display, silicon nanowire cold cathode with grid structure and WO3 nanowire cold cathode array have been developed, and the research results are first reported at home and abroad. The energy transfer model of thin air damping is proposed by integrating the research of MEMS. DBao model and air damping model of MEMS orifice plate structure? D modified Reynolds equation; According to the characteristics of MEMS structure, a new dynamic equation is established, and a micro inertial sensor with independent intellectual property rights is developed and applied.

　　　　(3) A number of key scientific problems have been solved in energy, resources and environment.
　　　　1. Many innovations have been made in efficient and clean utilization of fossil energy.

　　　　On the basis of revealing the mechanism of calcium-based desulfurization promoted by water, the medium temperature flue gas desulfurization technology was developed, and the desulfurization efficiency could reach 85-95% with only 4% water equivalent to wet desulfurization technology. The mechanism of plasma NOx reduction reaction is put forward and proved, and the new technology of NOx removal developed on this basis has been preliminarily popularized and applied. The basic research on catalysis for the optimal utilization of natural gas and coalbed methane pioneered the application theory and technology of ultraviolet Raman spectroscopy in in-situ and dynamic characterization of catalysis in the world, which was widely recognized by peers at home and abroad. The technology of preparing low-carbon olefins from synthetic gas made from natural gas and coal gasification by methanol and dimethyl ether was successful. A theory of anaerobic activation of methane is put forward, which opens up a new way to prepare chemical raw materials and hydrogen from natural gas.

　　　　2. Petroleum exploration and development and enhanced oil recovery

　　　　The grading evaluation method and index system of carbonate oil and gas source rocks are established, and four distribution prediction models and two development models of marine source rocks in China superimposed basin are put forward. It is put forward that the lower limit of organic matter abundance of carbonate rocks as source rocks is TOC=0.5%, which has played an important role in the new round of oil and gas resources evaluation as a new standard of China Petroleum and China Petrochemical Company. The relationship between the structure and performance of surfactant for oil displacement is mastered from the molecular scale, and the molecular design criteria of surfactant for oil displacement are put forward for the first time. The cheap, efficient and pollution-free alkylbenzene sulfonate surfactant products for oil displacement with independent intellectual property rights are designed and produced. The field test in Daqing Oilfield shows that the recovery ratio is 15-20% higher than that of water flooding, and the cost is significantly reduced. In the exploration and development of natural gas reservoirs, wavelet analysis and multi-attribute quantitative prediction methods are used for the first time to effectively predict the gas-bearing characteristics of reservoirs and improve the success rate of drilling. The research results are initially applied to the study of gas reservoir identification in Sulige gas field.

　　　　3. Research on strategic mineral resources

　　　　Around the eastern Pacific Rim metallogenic domain, the Mesozoic-Cenozoic and Late Paleozoic continental metallogenic theories were initially established, a number of new technologies and methods for prospecting and prediction were developed, and a series of target areas of large mines and large ore concentration areas were put forward, which were successively included in the preliminary risk exploration by China Geological Survey. In the area of Paleo-Tethys metallogenic domain, the geological map and structural outline map of the main collision zone of Qinghai-Tibet Plateau have been compiled, a new model of tectonic evolution in collision orogeny process has been preliminarily put forward, and a new theoretical framework of continental collision orogeny has been established.

　　　　4. Ecological environment

　　　　Aiming at the arid and semi-arid areas in the north, the relationship between the long-term evolution of Asian monsoon and the drought in the north and related evidence are systematically analyzed, and the integrated model of regional environmental system is established, which provides an effective tool for drought prediction and virtual experiment of "orderly human activities", and the forecast report of drought development trend has been paid attention to by relevant government departments. In the aspect of the evolution and regulation of ecological environment in the western arid area, the ecological construction and sustainable agriculture paradigm of the mountain-oasis-desert system in the northern Tianshan Mountains and the ecological division in the northwest arid area are put forward, and the technical integration of major engineering protection system construction in the desert area is established, which provides support for the protection of the Tarim desert highway and the desert section of the Xinjiang North-South Water Transfer Project. The relationship between soil quality and erosion, acidification and acid deposition, and gas exchange at soil-air interface was deeply studied, and the viewpoint that paddy field ecosystem is an environmentally friendly and sustainable agricultural ecosystem in Taihu Lake area was put forward. Based on this viewpoint, the proposal of "protecting artificial wetland-paddy field in Taihu Lake basin" was adopted by Suzhou Municipal Government.

　　　　5. Prevention and control of environmental pollution

　　　　A comprehensive monitoring of air pollution in Beijing and its surrounding areas was carried out, especially the observation of air-water-soil interaction, urban building development, and the influence of U-shaped topography on the strengthening of heat island. A number of accurate quantitative results were obtained, which provided scientific basis for improving forecasting ability, pollution control decision-making, early warning of pollution and monitoring system design. It was highly evaluated by the World Meteorological Organization and was rated as one of only two pilot demonstration projects in the world.

　　　　6. Formation mechanism and prediction of harmful red tide in China’s offshore waters.

　　　　The discovery of a large-scale harmful red tide of Alexandrium in the East China Sea for the first time confirmed the important role of key physical ocean processes in the formation of red tide in the East China Sea, and initially revealed the potential harm and harm mechanism of large-scale red tide in the East China Sea. In 2005, a large-scale red tide was found in the waters with high incidence of red tide in the East China Sea, and some suggestions on red tide prevention and control were put forward for reference by relevant departments.

　　　　7. Formation mechanism and prediction of major disasters

　　　　This paper reveals the basic fact that strong earthquakes in Chinese mainland are controlled by the movement of active blocks and concentrated on the boundaries of active blocks, obtains a preliminary understanding of the process of strong earthquakes in mainland China, develops the method of medium and long-term strong earthquake prediction, and gives the prediction of strong earthquake risk areas in Chinese mainland in the next 10 years. A large-scale scientific experiment of intensive observation of rainstorm in the field was carried out, and a multi-scale physical model and a synoptic model of Meiyu front rainstorm were put forward, and a mesoscale numerical forecast model system with three-dimensional variational assimilation scheme suitable for China was developed. Based on some important climate theories, such as "Monsoon-Warm Pool -ENSO Cycle Interaction Theory" and "Atmospheric Thermal Adaptation Theory", the inter-seasonal and annual prediction experiments of climate anomalies in East Asia were carried out, and the evolution of La Nina event and the severe drought climate in North China were successfully predicted. A cross-seasonal climate numerical prediction system is proposed, and an 18-layer new atmospheric circulation numerical model framework is designed, which provides a basis for the updating of China’s climate numerical model.

　　　　(4) The level of basic research in the fields of agriculture, population and health has been significantly improved.
　　　　1. Basic research on functional genomics and molecular improvement of agricultural animals and plants.

　　　　The important gene MOC1 related to rice tillering formation was cloned for the first time. This achievement is one of the most important discoveries in the field of plant morphogenesis, especially lateral branch formation in recent years, and its application in agricultural production is of great significance to improve the yield of Gramineae crops such as rice. The BC1 gene directly involved in rice cellulose synthesis and regulation was cloned. The study showed that it was of great significance to regulate the stem and leaf strength of Gramineae plants, make efficient and rational use of plant stems and improve the utilization rate of crop resources. Successfully cloned pig FSH-β gene, which was the first in the world to be found as a major gene or genetic marker affecting the litter size of pigs. The application of this achievement greatly accelerated the breeding speed of excellent pig breeds.

　　　　2. Efficient utilization of agricultural resources

　　　　The core germplasm of rice, wheat and soybean with 5% samples representing more than 85% genetic diversity was constructed for the first time in the world, which laid an important foundation for deepening the research of germplasm resources and crop breeding in China. In the study on the interaction of gene regulation level of photosynthesis and nitrogen fixation, it was found that HetR, the key protein in charge of heterotopic cell development in cyanobacteria, could form dimer, which could regulate the gene expression level by combining the DNA of the target gene, and put forward a gene regulation model affecting the new nitrogen fixation efficiency, which laid a theoretical foundation for improving the nitrogen utilization efficiency of crops. In the research of plant drought resistance mechanism, it is found that the stomatal oscillation can be caused by regulating the atmospheric water deficit. According to this principle, a stomatal oscillation drought-resistant agent was developed. Field experiments show that the crop yield in semi-arid areas with annual rainfall of about 300 mm can be 1 to 2 times higher than that in the control in large and medium drought years, which is of great significance to agricultural production in arid and semi-arid areas of China.

　　　　3. Agricultural ecological security

　　　　The biotype of Bemisia tabaci in China was identified at the molecular level, the rapid molecular detection technology of Phytophthora sojae was successfully developed, and the risk of wheat dwarf smut (TCK) invading China was systematically studied, which provided scientific basis and technical support for the negotiation of wheat import and quality inspection and quarantine in China. It is found for the first time that the change of insect resistance is related to the mutation of functional sites related to acetylcholine receptor. This achievement can not only guide the development of new molecular detection technology for drug resistance, but also provide theoretical basis for drug resistance management, and at the same time provide new ideas and new ways for molecular design of efficient and safe pesticides. A class of highly active nicotine compound IPP-44 with novel structure and independent intellectual property rights was successfully developed, and the adaptive defect mechanism of point mutation D421 and AChE resistance allele related to organophosphorus and carbamate resistance was found. It is found that highly pathogenic avian influenza virus has gradually acquired the ability to infect mammals, and it is proved that its pathogenicity to mice is closely related to the 701st amino acid of PB2 protein, which lays a foundation for further understanding the molecular mechanism of cross-species transmission of highly pathogenic avian influenza virus.

　　　　4. Major breakthroughs have been made in the localization, cloning and functional research of disease-causing genes.

　　　　In the aspect of monogenic diseases, the essential pathogenic gene of hereditary milk Koga was cloned, and the essence of hereditary milk Koga caused by mutation of DSPP gene was clarified. The pathogenic gene of type A-1 short finger disease was cloned, and the role of IHH gene in causing human genetic diseases was clarified. The pathogenic gene of atrial fibrillation was cloned, which explained the pathogenesis of atrial fibrillation caused by multiple pathway reentry. In the aspect of polygenic diseases, it was found that the susceptibility gene of nasopharyngeal carcinoma exists in the region of 4p15.1 -4q12 on human chromosome 4, which proved the genetic susceptibility of nasopharyngeal carcinoma for the first time. It was found that the gene expression of primary tumor and metastatic tumor was highly consistent between liver cancer and gastric cancer, which showed that tumor metastasis had no obvious relationship with tumor size and capsule integrity, but was related to gene expression of tumor itself. The preliminary evidence that PRKCZ is a susceptibility gene for type 2 diabetes mellitus is provided.

　　　　5. Significant progress has been made in the treatment and research of major diseases.

　　　　Studies on the pathogenesis of acute promyelocytic leukemia (APL) show that the disease has a specific chromosome heterotopic t(15; 17) PML caused? DRARα fusion protein and all-trans retinoic acid can induce APL cell differentiation, while arsenic trioxide can selectively induce apoptosis, and their targets are PML? DRARα fusion protein, clinical research shows that the application of two drugs combined with targeted therapy makes the initial APL the first curable adult leukemia, which has been widely used. Active immunotherapy for anti-tumor angiogenesis can induce autoimmune reaction against tumor angiogenesis in mice, showing anti-tumor activity, which provides a new idea for tumor vaccine development and tumor treatment.

　　　　6. Basic research on important infectious diseases

　　　　Complete the whole genome sequencing of four representative strains of Shigella dysenteriae; Determine the transmission route of HIV epidemic in China from the molecular level; The three-dimensional structure of the main protease (3CLpro) of SARS coronavirus was firstly analyzed in the world, and the precise mode of binding 3CLpro to substrate was revealed, which opened up a new way for developing drugs for preventing and treating SARS coronavirus.

　　　　7. Reproductive health

　　　　Bin1b, the first natural antimicrobial peptide gene in reproductive system, was cloned for the first time. It was found that this gene can start the movement of sperm in epididymis head, thus revealing the important cause of sperm from inactive state to active state, and providing clues for the design of male contraceptives and the diagnosis and treatment of male infertility. It was found that the mutation of cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene hindered the secretion of HCO3- in uterine epithelium, which affected sperm capacitation and fertilization, and revealed the infertility mechanism of this kind of patients.

　　　　8. Innovative drug research

　　　　A series of research platforms and new methods for new drug creation have been established and improved, and many candidate drug targets have been found. It is the first time in the world that CD146 molecule is selectively expressed in tumor vascular endothelial cells, which provides a new target molecule for the screening of new anti-tumor drugs. More than 80 novel enzyme, receptor and cell-level screening models, including matrix metalloproteinase Qualcomm screening and tumor angiogenesis inhibitor screening, have been established, and a number of lead compounds and candidate new drugs with new structures or novel pharmacological effects for major diseases have been found. Three new drugs, Shipulin (ZT-1) for the treatment of Alzheimer’s disease, Salvicine (Salvicine) and Lidamycin (Lidamycin), have entered clinical research. Among them, Shipulin has completed Phase II clinical trials in more than 30 hospitals in Europe, which may become a new drug for China to go global and produce remarkable economic and social benefits. Some achievements in innovative drug research have been supported by the 863 Program and major scientific and technological projects, or cooperative development relations have been established with enterprises.

　　　　9. Bone induction theory of biomedical materials

　　　 This theory has gained international recognition, clarified that biomaterials can induce bone formation, confirmed the important conditions of inducing bone formation from two aspects of materials science and biology, and established a relatively complete original bone induction theory. A new generation of osteoinductive bone developed based on this theory has obtained the production registration certificate of the State Food and Drug Administration, and more than 400 clinical trials have achieved good results.

　　At the China committee of 100 Forum on Electric Vehicles held yesterday, Finance Minister Lou Jiwei said that the subsidy standard for new energy vehicles will be gradually lowered from 2017, and the subsidy policy will be withdrawn after 2020. Xin Guobin, vice minister of the Ministry of Industry and Information Technology, said that the state subsidy policy for new energy vehicles will be gradually withdrawn in the future, and the Ministry of Industry and Information Technology is prepared to adopt the method of linking the points of new energy vehicles with the fuel consumption limit of traditional energy vehicles to encourage industrial development.

　　Last year, the production and sales of new energy vehicles exceeded 300,000.

　　Xin Guobin said that the rapid development of China’s new energy automobile industry is changing from a market introduction period to a rapid growth period and entering a new stage of large-scale development. In the past 2015, the production and sales of new energy vehicles in China exceeded 300,000. By the end of 2015, the cumulative production and sales of new energy vehicles in China was nearly 500,000, making it the largest new energy vehicle market in the world.

　　Xin Guobin said that compared with the world’s advanced level, there is still a big gap in the quality of new energy vehicles in China, and the development of new energy vehicles in China still faces some prominent contradictions and problems. These problems include the lack of general technology development ability of the whole vehicle, insufficient technical reserves such as intelligent networked vehicles, the incompatibility between the construction of charging facilities and the development of new energy vehicles, and the imperfect follow-up maintenance system.

　　Prepare to adopt the new energy vehicle integral method.

　　Lou Jiwei said that the original intention of the consumer subsidy policy is to cultivate the initial market. However, if the consumer subsidy is implemented for a long time, enterprises are prone to policy dependence, keeping a close eye on policies to set products and forming new industrial surpluses. From 2017 to 2018, the subsidy standard for new energy vehicles will be lowered by 20% on the basis of 2016 and 40% from 2019 to 2020. After 2020, the subsidy policy will be withdrawn.

　　Xin Guobin revealed that the Ministry of Industry and Information Technology is going to adopt the method of linking the points of new energy vehicles with the fuel consumption limit of traditional energy vehicles to encourage industrial development.

　　Resolutely crack down on fraudulent compensation of new energy vehicles

　　In response to recent media reports that some enterprises have falsified data and defrauded financial subsidies for new energy vehicles, Minister of Finance Lou Jiwei said that special inspections will be organized in conjunction with relevant ministries and commissions, and the problem of fraudulent compensation will be dealt with seriously according to laws and regulations, and all kinds of fraudulent compensation and rent-seeking behaviors will be severely cracked down, and they will never be soft. "Several electric vehicle safety accidents that occurred last year and the recent online exposure of electric vehicles have fully demonstrated that the new energy vehicle management system needs to be improved." Xin Guobin said that these problems require relevant departments to take effective measures and make great efforts to solve them.

　　Science and Technology Daily, Beijing, March 16 (Reporter Liu Xia) New Zealand scientists published a paper in the latest issue of PLoS One, saying that a new study they conducted found that since 2005, plastic pollution in the global ocean has reached an "unprecedented level". At present, about 170 trillion pieces of plastic are floating in the ocean, with an estimated total weight of 2.3 million tons. If it is not controlled, the speed of plastics entering the ocean may be several times faster in the next few decades.

　　Researchers collected plastic samples from more than 11,000 sites around the world, focusing on the situation during the 40 years from 1979 to 2019. The results show that the trend of plastics entering the ocean before 1990 was not obvious, and it fluctuated between 1990 and 2005, and then it increased sharply.

　　Lisa Edeler of the University of Auckland, who is in charge of the latest research, pointed out that there are many sources of plastic pollution in the ocean: fishing nets, buoys, discarded clothes, car tires and disposable plastics, which will eventually decompose into microplastics. In addition, at present, only a small part of plastic is properly recycled, and many plastics will eventually be landfilled. If the landfill is not properly managed, plastic waste will enter the environment and eventually flow to the ocean.

　　Edeler explained that from 1990 to 2005, the amount of plastic waste in the ocean declined in some cases, partly because there were some effective policies to control pollution, including the International Convention for the Prevention of Pollution from Ships, which came into effect in 1988, which was a legally binding agreement among 154 countries, aiming at stopping the discharge of plastic by the navy, fishing and shipping fleets.

　　She appealed that with the increasing production of plastics, countries need to formulate a new treaty, not only to reduce the production and use of plastics, but also to better manage how to dispose of plastics.

　　Eleven, sail boat (1 staff, 2 coaches, 6 athletes)

　　Team leader: Yu Huawu (Shandong)

　　Coaches: Suri (Shandong) and Wang Jianbin (Shandong)

　　Male athletes: Qi Mingxue (Shandong), Jia Hailiang (Shandong), Wang Tao (Shandong), Xu Jingkun (Shandong) and Li Ke (Shandong).

　　Female athlete: Xiujuan Yang (Shandong)

　　Twelve, rowing (2 staff, 2 coaches, 8 athletes)

　　Leader: Song Biwen (Guangdong)

　　Deputy Team Leader: Gu Yangchun (Guangdong)

　　Coaches: Liu Xiaochun (Guangdong) and Li Kunyun (Guangdong)

　　Male athletes: Tan Yeteng (Guangdong), Dan Zilong (Guangdong), Liming (Guangdong) and Dong Hongyan (Liaoning).

　　Female athletes: Zhang Jinhong (Guangdong), Zhou Yangjing (Guangdong), Lin Cuizhi (Guangdong) and Gao Wenwen (Liaoning).

　　Helmsman: Hao Tongtu (Beijing, male)

　　Thirteen, hard ball (3 staff, 5 coaches, 9 athletes)

　　Team leader: Xie Xile (Guangdong)

　　Deputy Team Leader: Li Xiaohua (Guangdong)

　　Liaison: Lu Juan (Paralympic Center)

　　Coaches: Tian Jianan (Beijing), Ran Jun (Chongqing), Wen Dinghua (Guangdong), Tan Weilin (Guangdong) and Yang Sen (Guangdong).

　　Male athletes: Zhu Jianhui (Guangdong), Shen Cong (Guangdong), Wang Yi (Beijing), Yan Zhiqiang (Chongqing) and Cao Fei (Liaoning).

　　Female athletes: Zhang Qi (Beijing), Zhu Heqiao (Guangdong), Ni Suili (Guangdong) and Qi Cuifang (Guangdong)

　　Fourteen, horse skills (2 staff, 1 coach, 1 athlete)

　　Team leader: Tan Zhiqin (Guangdong)

　　Coach: Bai Jieyong (Guangdong)

　　Stable boy: Huang Yumei (Guangdong)

　　Athlete: Peng Yulian (Guangdong)

　　Fifteen, sitting volleyball (2 staff, 3 coaches, 24 athletes)

　　Team leader: Lv Zhixin (Shanghai)

　　Liaison: Zhang Guiying (Paralympic Center)

　　Men’s team

　　Coaches: Liu Fangqing (Yunnan) and Zhang Guiying (Paralympic Center, concurrently)

　　Athletes: Tong Ba (Shanghai), Huang Chunji (Shanghai), Wang Haidong (Shanghai), Wang Xiaoliang (Shanghai), Ding Xiaochao (Shanghai), Li Lei (Shanghai), Gao Hui (Yunnan), Li Mingfa (Yunnan), Li Ji (Yunnan) and Zhou Canming (Zhejiang) Dou.

　　Women’s team

　　Coaches: Zhang Jun (Shanghai) and Ma Dongmei (Gan Su)

　　Athletes: Lu Hongqin (Shanghai), Li Liping (Shanghai), Lu Chunli (Shanghai), Zhang Xufei (Shanghai), Zhong Haihong (Shanghai), Sheng Yuhong (Jiangsu), Tan Yanhua (Jiangsu), Yang Yanling (Gansu), Liu Lijuan (Gansu), Zheng Xiongying (Zhejiang) and Liang Fen (Yunnan).

　　Sixteen, goalball (3 staff, 4 coaches, 12 athletes)

　　Team Leader: Chen Yuguo (Zhejiang)

　　Deputy Team Leader: Lu Cailiang (Zhejiang)

　　Liaison: Fu Juan (Paralympic Center)

　　Men’s team:

　　Coaches: Zhang Yong (Yunnan) and Xia Xiang (Zhejiang)

　　Athletes: Du Jinran (Beijing), Yao Yongquan (Beijing), Chen Liangliang (Zhejiang), Cai Changgui (Zhejiang), Yang Chunhong (Yunnan) and Bao Daolei (Shanghai).

　　Women’s team

　　Coaches: Shao Baolin (Beijing) and Wang Jinqin (Shandong)

　　Athletes: Wang Ruixue (Shandong), Fan Feifei (Shandong), Xu Juan (Jiangsu), Wang Shasha (Jiangsu), Lin Shan (Beijing) and Chen Fengqing (Yunnan).

　　17. Wheelchair Basketball (2 staff members, 4 coaches and 24 athletes)

　　Leader: Qiao Jingchun (Beijing)

　　Liaison: Xue Liang (Paralympic Center)

　　Men’s team

　　Coaches: Xu Yuansheng (Paralympic Center) and Zhai Yongjun (Beijing)

　　Athletes: Chen Haijiang (Beijing), Guo Zhendong (Beijing), Yang Lei (Beijing), Li Pengcheng (Beijing), Zhang Lei (Beijing), Huang Xunan (Liaoning), Qu Huanjian (Liaoning), Ding Hai (Liaoning), Xu Hang (Jiangsu), Chen Guojun (Jiangsu), Chen Qi (Guangdong), Chen Qi.

　　Women’s team

　　Coaches: Liu Tiehua (Yunnan) and Zhang Chunling (Shaanxi)

　　Female athletes: Peng Fengling (Beijing), Cao Qiuping (Beijing), Li Yanhua (Yunnan), Zheng Donghuai (Yunnan), Chen Damei (Yunnan), Yang Chao (Yunnan), Fu Yongqing (Yunnan), Chen Qiurong (Yunnan), Liu Mihuan (Yunnan), Gu Li (Liaoning) and Hao Wenhua (Hebei).

　　Eighteen, cerebral palsy football (2 staff, 2 coaches, 12 athletes)

　　Team leader: Geng Lin (Chongqing)

　　Liaison: Fan Ko (Paralympic Center)

　　Coaches: Li Yi (Chongqing) and Jia Hongwen (Jiangxi)

　　Male athletes: Fan Zhichao (Yunnan), Dong Xinliang (Yunnan), Yang Wenshun (Yunnan), He Jinghua (Liaoning), Zhu Xu (Liaoning), Li Chuan (Chongqing), WU GANG (Chongqing), Zhu Gebin (Beijing), Liu Bo (Heilongjiang), Xu Guojun (Jiangsu), Yang Ye (Shanghai), and so on.

　　Nineteen, blind football (2 staff, 2 coaches, 1 guide, 10 athletes)

　　Leader: Lu Shangji (Fujian)

　　Liaison Officer: Cheng Xuyang (Paralympic Center)

　　Coaches: Dong Junjie (Liaoning) and Zou Hongmou (Fujian)

　　Guide: Li Jianwei (Shandong)

　　Male athletes: Zhang Qiang (Heilongjiang), Yang Xinqiang (Heilongjiang), Zheng Wenfa (Liaoning), Wei Zhi (Liaoning), Wang Yafeng (Fujian), Wang Zhoubin (Fujian), Yu Yuchun (Fujian), Chen Shanyong (Jiangsu), Xia Zheng (Jiangsu) and Li Xiaoqiang (Yunnan).

　　Twenty, wheelchair football (5 staff, 2 coaches, 12 athletes)

　　Team leader: Wang Rongguang (Liaoning)

　　Deputy Team Leader: Xu Shuguo (Liaoning)

　　Liaison: Yue Xin (Paralympic Center)

　　Coaches: Wen Yan (Beijing) and Wu Zhiming (Liaoning)

　　Male athletes: Cheng Shuangmiao (Beijing), Han Guifei (Beijing), Chen Jun (Beijing), Tian Shilin (Beijing), Shao Dequan (Beijing), Xia Junfeng (Beijing), Sheng Wang (Shandong), Tao Zhenfeng (Shandong), Cui Maosheng (Yunnan), Pan Zilin (Guangdong) and Yu Zhongtao (Liaoning

　　Female athlete: Zhang Wenli (Shandong)

　　Carers: Feng Yining (Beijing) and Yu Zhiwei (Liaoning)

Editor: Feng Ye

According to foreign media reports, on January 23, US time, the 20-year-old "Little King of Pop Music" and Canadian pop singer Justin • Justin Bieber was arrested in the coastal city of Miami for "holding an invalid driving license", "drunk driving" and "resisting arrest". Before his arrest this week, Bieber was exposed to spending $75,000 in a strip club.

Miami police’s inspection report confirmed that Justin Bieber was charged with drunk driving, drug abuse and speeding, and faced six months in prison.Then Bieber’s video appeared at the bail hearing and was finally released on bail for $2,500. Bieber admitted to the police that he was drinking and taking drugs that night. When asked about the source of the prescription drug, he said it was given by his mother. According to TMZ, a well-known gossip media, Bieber refused to obey the police inspection after his arrest and swore at the police.His friend Ryan Butler Twitter: Bieber called and cried and told him that he was going to disappoint his fans this time.

Bieber’s prison photo is exposed

Bieber drunk driving test report　

Bieber was arrested by Miami police for drunk driving and drug abuse.

Raymond &bull, an official of Miami Beach Police Department; Martinez told reporters on the 23rd that at about 4 am on the 23rd, a Miami beach official saw Bieber driving a yellow Lamborghini and a red Ferrari racing car in a residential area near Miami beach. These cars were seriously speeding, driving at a speed of 55 to 60 miles per hour, while the speed limit in this area was 30 miles per hour.

A person familiar with the matter told foreign media that Bieber had drunk in a local bar and drove away, and he was racing with a friend. In order to satisfy Bieber’s desire for racing, Bieber’s team even blocked some streets. It is reported that Bieber was driving a yellow Lamborghini and his friend was driving a red Lamborghini. At present, the police have also arrested Bieber’s friend. At that time, Bieber was not only alone in the car, but also a female model as a car companion.

Female model in the car (video screenshot)

On the same day, 20-year-old Bieber was sent to prison for failing an alcohol test. After arriving at Miami-Dade County Prison, Justin was taken head photos and fingerprints there. Justin’s video later appeared at the bail hearing, and the bail was $2,500. Martinez said that in the inquiry record, Justin • Bieber admitted drinking, smoking marijuana and taking some prescription drugs.

It is said that Justin, who was stopped by the police, did not cooperate at first, and repeatedly asked the police why they stopped him. The arrest report described Bieber as "red in the face, bloodshot in the eyes and full of alcohol."

Bieber appeared in court to accept the charges and hired Roy Black as his representative. In the end, Bieber was released on bail for $2,500, including $1,000 for drunk driving, $1,000 for resisting arrest and $500 for expired driver’s license. Bieber admitted to the police that he had been drinking and taking drugs that night. After getting bail, Bieber sat on the roof and waved to the fans who had been waiting for him.

After Bieber was released on bail,

Spent $75,000 to watch a strip show before the incident.

Justin • Bieber became famous when he was young. Since he became popular, he has been in constant trouble, from climbing stairs at midnight to smoking marijuana and drinking alcohol, and he has made headlines in foreign media gossip every once in a while.

Justin • Bieber came to Miami to have fun this week. Earlier this week, Bieber was caught spending money at the "King of Diamonds Strip Club" in Miami, throwing $75,000 into the highest-level box and invited four favorite strippers to perform for himself.

Bieber is in constant trouble (video screenshot)

20-year-old pop music king is in constant trouble

In addition to the suspicion of drunk driving, Bieber’s plane was escorted by the police without permission after landing at O ‘Pallocca Airport in Florida this week, and the O ‘Pallocca local police station has also begun to investigate this.

In 2013, Justin • Bieber was accused of doodling on the wall of his hotel in Brazil and Australia.

In February 2013, Justin • Bieber joked with former US Secretary of State Hillary Clinton. He took a selfie and passed it on to Hillary Clinton. The "amazing move" was bombarded.

In July 2013, a video of Bieber insulting former US President Bill Clinton was exposed by the US website TMZ10. In the picture, Bieber urinates in the mop pool of a restaurant kitchen, then sprays water on a photo of Clinton and shouts "Fuck Bill Clinton". In this regard, Bieber has apologized.

On the evening of January 10, 2014, Justin threw 20 eggs at his neighbor’s apartment in Los Angeles. The neighbor was unbearable to harass the police and reported to the police that the estimated maintenance cost was $20,000, which was a felony in the local area.

Last week, the police searched Justin’s residence in Los Angeles, and a friend in his residence was arrested on suspicion of possessing drugs.

Justin • Bieber was born in Canada on March 1, 1994. He has shown great musical talent since he was a child and is regarded as the little prince of music in the world pop music scene. In 2011, Bieber was named the richest young man in Hollywood by People magazine, and was also the best-selling male artist in 2011.

　　In the past few days, many places across the country have further optimized and adjusted epidemic prevention and control measures, involving travel, medical treatment, drug purchase, nucleic acid testing and many other aspects.

　　Beijing

　　Beijing Municipal Transportation Commission released on December 2: Since the first bus on December 5, when bus and subway operators verify health information,Passengers who have no 48-hour nucleic acid negative certificate shall not be refused to ride.

　　The Beijing Municipal Health and Health Commission said on December 1 that when medical and health institutions at all levels in Beijing check health codes,Patients without 48-hour negative nucleic acid results shall not be denied entry;Infants under 3 years old can be exempted from nucleic acid testing, and only the nucleic acid of the accompanying doctors can be tested; For critically ill patients, medical institutions shall not refuse to consult or delay treatment because there is no nucleic acid result.

　　From November 30, Beijing’s long-term home-based elderly, home-based office and learning personnel, infants and other people without social activities,If there is no need to go out, you can not participate in community nucleic acid screening.

　　Guangdong

　　On December 3, Guangdong Shenzhen Municipal Transportation Bureau issued a notice: From now on, take public transportation, subway, taxi, internet car and other local means of transportation to scan the place code and check the green code of health code.No longer check the nucleic acid test certificate.

　　On December 2nd, a press conference on epidemic prevention and control was held in Guangzhou, Guangdong. The relevant person in charge introduced:From now on, all kinds of medical institutions at all levels in the city and district, ordinary outpatient and emergency personnel will pass by health code green code;Newly admitted inpatients and their accompanying staff shall be admitted with 24-hour negative nucleic acid certificate. In addition, from December 1st, Guangzhou citizens went to pharmacies to buy drugs, including 37 kinds of drugs in the Catalogue of Drugs to be Registered and Reported during Epidemic Period, and no longer checked the 48-hour negative nucleic acid certificate.

　　The Health and Health Commission of Guangzhou City, Guangdong Province said on December 1 that at present, Guangzhou implements classified nucleic acid testing, adopts different nucleic acid testing strategies for different groups of people, carries out nucleic acid testing with specified frequency for risk positions and key personnel, and conducts "landing inspection" for migrant workers across provinces.Encourage families to bring their own antigen kits.

△ On December 1 ST, Guangzhou, the tip of "Employees in key industries should be thoroughly inspected, and residents do not need to be tested" was posted at the nucleic acid testing point.

　　Chongqing

　　The Chongqing Municipal Health and Health Commission introduced on December 2 that Chongqing’s public transportation has resumed one after another.Citizens only need to check the Chongqing-Kangma code when they take the means of transportation.However, it takes 72 hours to prove that nucleic acid is negative when entering public places.

　　The Chongqing Municipal Health and Health Commission introduced on December 1 that Chongqing has carried out corresponding frequency nucleic acid testing for centralized isolation personnel, home isolation personnel, high-risk areas and key populations in accordance with corresponding regulations.No longer carry out all-staff nucleic acid testing by administrative region.

　　Sichuan(Province)

　　From December 2nd, citizens of Chengdu, Sichuan Province will be able to enter public places and take public transport by showing their health codes in green, taking their temperature and scanning their place codes.No longer check the nucleic acid test certificate.

　　Sichuan Chengdu Health and Health Commission news on November 30,Chengdu citizens no longer need to show their negative nucleic acid certificates when they enter and leave communities and courtyards, but only need to show their own health codes.

　　Tianjin

　　From December 2nd, TianjinRail transit and buses cancel the inspection of 72-hour nucleic acid certificates.Passengers can take the bus with the cooperation of checking health code, scanning place code and measuring body temperature.

△ On December 2, Tianjin citizens took the subway.

　　Xinjiang

　　Since December 2, XinjiangCitizens in low-risk areas of Urumqi can move across regions.It is forbidden to go to high-risk areas.

　　Ningxia

　　From December 1 ST,Ningxia cancels the restrictions on personnel flow in low-risk areas.Residents in low-risk areas can travel normally. During the regional nucleic acid screening, in principle, they should stay in the community to complete the nucleic acid sampling. If they really need to leave the community before the nucleic acid sampling, they should complete the nucleic acid sampling on the same day.

　　Xizang

　　On December 2nd, Lhasa, Tibet issued an announcement on matters related to the application for registration in Tibet: the application targets are all foreign (returning) migrants outside the region and the city, and the floating population across counties (districts) in the city.Chengguan District flows with Liuwu New District, Economic Development Zone and Wenchuang Park, while Duilong Deqing District flows with Economic Development Zone and Liuwu New District without reporting.

　　Shanxi

　　Shanxi Taiyuan Education Bureau news on November 30,Students who take online classes every day can skip the daily nucleic acid test if they have no need to go out.

　　Liaoning (Province)

　　On November 30th, the epidemic prevention and control headquarters of COVID-19, Shenyang, Liaoning Province issued a notice: Except in high-risk areas, people who have no social activities, such as long-term stay-at-home elderly people, daily online students and home office workers,If there is no need to travel, you don’t need to do nucleic acid testing.

　　Producer Zhang Tianyu?

　　Editor-in-Chief Ma Weilu

　　CCTV reporter Zhang Jing Wu Liming Zheng Shu Huiting Chen Liu Runze Huang Weizhe Chen Qin Deqing Bai Zhenjiang Bai Xu Bo Niu Qiaogang Li Haonan Zheng Yi Tian Tong Bu Peng Sharla Cheung Li Hang Guo Peiyu Suonan Zhang Weize Deng Yuzhou Sun Mengzhu Chen Xuting Li Chengze Li Hongmiao Liu Chunhong Song Yunyi Zhou Yu

From AlphaGo’s battle with Ke Jie to OpenAI’s bloody abuse of Dota2 semi-professional players, AI once again stepped onto the stage of history. Since 2012, thanks to the increase in data volume and the substantial increase in computing power due to the emergence of deep learning, artificial intelligence has begun to explode.

However, there are reports that IBM’s medical department has laid off a large number of employees, with a scale of 50%-70%; Then there was news from STAT, an American medical media. STAT got a document from Andrew Norden, then the deputy chief health officer of IBM Watson Health. The report showed that doctors who were using Watson for Oncology(Watson strong criticisms, pointing out that Watson often made inaccurate medical advice, which made IBM Watson fall into the biggest crisis of trust in history. Recently, some media surveys have pointed out that many medical imaging AI products are lying in the hospital "eating ash".

Behind the medical AI carnival is the embarrassment that new technologies frequently encounter the application of landing scenes. Is medical AI a conceptual obscenity or just a capital game? If the technical scene can be realized, then what characteristics of products can be truly accepted by hospitals and avoid the fate of "eating ash"?

At present, the development trend of artificial intelligence is unstoppable. From abroad to China, from capital giants to technology giants, the smart medical industry has been actively deployed. Medical imaging AI is highly favored by capital and is considered to be the first to be commercialized, which is expected to achieve overtaking in corners.

At present, many companies have developed products to assist doctors in different departments, which are accelerating the commercial layout. However, after the carnival from 2017 to the first half of 2018, medical AI companies did not seem to hand over a beautiful answer sheet. It is reported that there are as many as 10 medical AI companies cooperating with the Imaging Department of Run Run Run Shaw Hospital in Zhejiang.

Chai Xiangfei, CEO of Huiyi Huiying, believes that AI medical entrepreneurship is still in its infancy as a whole, and there is still much room for improvement in terms of underlying technology, product creativity and product experience. At present, there are several reasons why medical AI products lie in the hospital and "eat ash":

First, everyone has relatively high expectations for medical AI. At present, the speed requirement of AI medical care and the slow change of the medical industry are the biggest contradictions, and the overall research and development cycle is long. Medical care is a traditional industry, which has many characteristics of the original industry. For example, it may take 10 to 15 years for new drugs to be developed and commercialized, and 5 to 10 years for devices to be developed.

Second, at present, most of the products are actually tried in hospitals, and the usability and friendliness remain to be investigated, and at present, AI’s participation in clinical practice is too shallow and too little. AI company should not only design products with doctors as the center, but also integrate products into doctors’ work scenes, and also conform to doctors’ usage habits to help doctors improve diagnosis efficiency and accuracy; In addition, it is necessary to design products with patients as the center, and truly serving patients and improving their medical experience are the end points of product design, and creating easy-to-use and friendly medical AI products is the key to success. Huiyi Huiying cooperates with well-known medical equipment suppliers at home and abroad, such as GE, Philips, Qixi Medical and Medtronic, and develops customized applications for the application of medical equipment such as imaging equipment and high-value consumables, so that artificial intelligence can empower traditional medical care. For example, Huiyi Huiying provides intelligent report interpretation services to patients on the basis of existing business digital films, which has been welcomed by hospitals and patients in many aspects.

AI technology can master different professional knowledge through data training, and many business fields can benefit. The artificial intelligence medical image is to use the method of image recognition to judge the picture. There may be several kinds of data in medicine, mainly image data and pathological data, and many of them can be solved by image recognition.

Lung nodule screening is an area that most AI imaging companies focus on at present. Although AI can help to find out nodules, AI can’t give a conclusion on further benign and malignant judgment and report opinions. Moreover, the products on the market at present are mostly concentrated on pulmonary nodules, and the homogenization is serious. A top-three hospital may install more than 10 AI companies’ products at the same time, but only one or two are often used. Because there is no feedback from doctors to optimize the products of other companies, the product iteration is slow, and there is a situation of lying in the hospital "eating ash".

There are many public data of pulmonary nodules, and many data sets can be downloaded directly, so a large number of companies have developed pulmonary nodule screening products in the past two years. However, for a wider range of diseases, the research and development of AI products is difficult. It is difficult to obtain data of new diseases, and high-quality data needs experts to cooperate and label, so the research and development cycle of the whole disease AI product is long. In addition, it is not enough to identify images in medical scenes alone, and the clinical value of disease screening and auxiliary diagnosis is limited. To become an indispensable tool for doctors’ daily use, they must be involved in clinical decision-making, and doctors need AI products that can cover all medical processes.

Therefore, products that go deep into more diseases and participate in more medical processes may be supported and affirmed by more hospitals and doctors, which may be the most important competitive advantage of AI imaging companies in the future. At this point, Huiyi Huiying found a new way, reached cooperation with Tsinghua University, Peking University, Stanford University and intel, and set up a joint laboratory of artificial intelligence, hoping to cut in with image data, let AI run through the whole process of imaging department, and realize a closed-loop service from screening to diagnosis to treatment and prognosis.

In 2018, Huiyi Huiying released three commonly used mapping products for screening scenes, such as CT lung nodule detection, chest DR detection and fracture detection. Its training model not only has image information, but also adds many patients’ clinical information, test information and follow-up information. Its AI products can not only locate and label lesions, but also participate in tumor staging and classification, and can provide support for doctors’ treatment decisions.

In April 2019, Huiyi Huiying and 301 Hospital released AORTIST3.0, an artificial intelligence platform for aortic dissection, which well combined the development of new disease models with the whole process coverage of single disease. Through verification, the accuracy of AORTIST3.0 far exceeds that of conventional manual measurement, and it also provides the prognosis prediction results of aortic dilatation and composite endpoint events. The performance of AORTIST3.0 can basically reach the level of accurate judgment and prediction like 301 Hospital, which can reduce the five-year recovery of 40% to 15%, and can go deeper into the medical scene and decision-making process.

Chai Xiangfei said that medical AI has entered the second half, and AI has moved from the 1.0 era to the 2.0 era. The reason for this change is. "In the past 1-2 years, we have focused on improving the diagnostic efficiency for doctors. Today, we find that the real core of medical services is patients. It is very important to take patients as the center and open up the service chain from patients to doctors to hospitals."

At present, Huiyi Huiying is committed to building an online image center, connecting patients, hospitals and doctors, providing a digital, mobile and intelligent image closed-loop service system for the three, and trying to build a platform that can continuously incubate innovative medical services and develop in depth, trying to participate in medical treatment and prognosis follow-up links. At the same time, the most troublesome profit dilemma in the industry was broken by Huiyi Huiying’s full-chain service business model. deus ex jumped out of the curse of burning money. It is reported that Huiyi Huiying has a beautiful income report card and has been regarded as a quasi-unicorn and unicorn by the industry.

The medical field in China faces two difficult problems, one is the lack of medical resources, and the other is the unbalanced distribution of medical resources. According to the data of China Health and Family Planning Statistical Yearbook, among all medical institutions in China, there are 28,261 urban hospitals, and the number of primary medical institutions reaches 927,147, which is 32 times that of urban hospitals.

Statistics on the number of various medical institutions in China in 2016

According to a misdiagnosis data of China Medical Association, the total misdiagnosis rate of clinical medicine in China is 27.8%, among which the average misdiagnosis rate of malignant tumor is 40%, and these misdiagnosis mainly occur in primary medical institutions. The total number of misdiagnosed patients in China exceeds 5,700 every year, which is four times that of the United States.

Guo Na, co-founder and COO of Huiyi Huiying, said: The scarcity and scarcity of high-quality medical resources is a fundamental contradiction. What primary hospitals really lack is diagnostic ability, which is a scarce resource. As an inevitable starting point for graded diagnosis and treatment, artificial intelligence can enable grassroots people to enjoy homogeneous resources and services.

In this regard, Huiyi Huiying has cooperated strategically with China Telecom, China Unicom, Alibaba Cloud, Jiuzhoutong, excellent companies and teams in medical care, IT, cloud computing, big data, artificial intelligence and other dimensions, integrating various resources and its own solid technical foundation, hoping to provide a whole set of services for primary hospitals by taking the medical association as the carrier. Taking the Third Affiliated Hospital of Zhengzhou University as an example, Huiyi Huiying, based on cloud computing, big data and artificial intelligence technology, built a set of intelligent imaging center for the Women and Children’s Union Medical Association, which realized the sharing of medical imaging information and diagnostic information in the medical association, promoted the integration and sharing of medical imaging resources and imaging medical resources, and all women and children’s medical institutions in the medical association could realize the uploading and centralized management of image data, as well as the sharing and reading of image information and diagnostic reports, and finally realized the sinking of high-quality medical resources.

The Third Affiliated Hospital of Zhengzhou University is not a case. It is reported that there are dozens of cases of such medical association imaging center. Guo Na said that in order to further promote the application and popularization of medical AI in primary medical institutions and greatly improve their diagnosis and treatment capabilities, Huiyi Huiying will launch the AI-empowered graded diagnosis and treatment public welfare 100 projects recently, and first provide 100 primary hospitals with free screening services for pulmonary nodules for one year. At present, Huiyi Huiying’s lung nodule screening products can quickly locate and label the lesions, and the automatic recognition accuracy of CT lung nodules exceeds 90%, which helps doctors improve the diagnostic efficiency and reduce the rate of missed diagnosis and misdiagnosis.

Talking about starting from lung nodule screening, Guo Na said that this is based on the current national conditions and future strategic goals. On the one hand, lung cancer can be said to be the first killer of cancer in China. According to the 2013 Annual Report on Cancer Registration in China issued by the National Cancer Registry, there are about 600,000 new cases of lung cancer every year. Lung cancer accounts for 20.48% of all malignant tumors in the city and 27.05% of the mortality. It accounts for 18.05% of the incidence and 22.42% of the mortality of rural malignant tumors, and the incidence and mortality are on the rise. Pulmonary nodule screening can help primary hospitals to provide primary screening services.

On the other hand, the country is vigorously promoting the policy of graded diagnosis and treatment. The medical image cloud platform provided by Huiyi Huiying can provide a good cloud platform support for medical associations and graded diagnosis and treatment, help primary medical institutions and urban hospitals to share data and doctors’ resources, and truly realize "primary examination and superior diagnosis", which can be said to be in response to the call of national graded diagnosis and treatment.

As Chai Xiangfei said, "In the context of insufficient overall medical production capacity, the application of medical artificial intelligence to the grassroots is not only just needed at present, but also the environment is relatively mature. First, using artificial intelligence to help doctors improve the efficiency of diagnosis and liberate doctors from inefficient repetitive work; The second is to help grassroots doctors improve their diagnostic level and reduce the misdiagnosis rate at the grassroots level. Although this road is difficult to walk, we can’t quit because it is difficult. Someone has to do it, and it is valuable to do it. It is worthless not to do it. "

At present, Huiyi Huiying intelligent imaging products have entered more than 1000 hospitals and are widely used in hundreds of medical institutions. It can be said that AI+ primary medical institutions are an excellent pair of "CP", which has achieved a win-win situation for AI medical enterprises, primary medical institutions and primary patients, and has also greatly promoted the development of China’s AI medical industry.

Since the outbreak of COVID-19, Huiyi Huiying has devoted herself to product development, upgrading and implementation. Based on the overall framework of Huiyi Huiying intelligent imaging solution, the algorithm and platform were upgraded for COVID-19 epidemic, and the "Trinity" COVID-19 AI solution was launched, which was helpful for clinical work by effectively combining intelligent auxiliary screening, intelligent remote consultation and digital intelligent film to empower COVID-19 epidemic prevention and control. It has provided scientific and technological assistance to many designated hospitals and shelter hospitals in Beijing, Shanxi, Henan and other places, as well as in the center of Hubei epidemic area. The solution has achieved good feedback in clinical application. The landing application results of Huiyi Huiying COVID-19 AI solution have been reported and affirmed by the top domestic and international media, and also highly praised by the three users in the hospital.

Recently, in the face of the global COVID-19 epidemic, Huiyi Huiying developed and upgraded the artificial intelligence aided diagnosis system in COVID-19 for the rapid COVID-19 epidemic. At present, Huawei has been promoted in Germany, Russia, Thailand, South Africa, Malaysia and other 40+ countries, and has cooperated with 200+ hospitals to provide support for global epidemic prevention and control.

　　Dog days are the hottest and most yang-filled stage in a year, and it is also an important time for health preservation. Various health preservation methods circulating on the Internet, such as drinking hot water in the dog days to force out the cold in the body, eating more mutton and ginger to "heat up" and so on, have also made many people follow suit for many years. So, are these health care methods reliable? Recently, shenyang evening news and Shenbao all-media reporters interviewed a number of health experts on related issues. They said that the principle of TCM health care is to conform to nature and pay attention to people, time and local conditions. Many widely spread health care methods are not necessarily scientific and not necessarily suitable for everyone. People should not fall into misunderstanding and blindly follow.

　　A

　　Myth 1: You can’t eat cold drinks and insist on drinking hot water in the dog days.

　　Some people think that drinking hot water in the dog days can force out the cold that has penetrated into the bone marrow for many years, and you can’t touch a cold drink, otherwise it will damage the yang, destroy human immunity and increase the probability of illness. Is this really the case?

　　Expert analysis: Yuan Renjie, director of the Center for Prevention and Treatment of Diseases of the Fourth People’s Hospital of Shenyang, said that cold and heat are a pair of natural attributes, and they also represent yin and yang, such as "cold and heat are signs of yin and yang" in Huangdi Neijing. A healthy body is "yin and yang are secret, and the spirit is the rule." The most controversial thing about health care in the dog days is that the yang is strong in the dog days, and drinking ice drinks, with the attribute of yin, will hurt the yang, causing the imbalance between yin and yang to be a disease, but this statement is too absolute. Some people do have diarrhea and other symptoms when drinking ice drinks. This is because of the different constitutions. People with yang deficiency are inherently yang-deficient, and drinking yin-cold products makes the deficiency of yang more deficient, so they can’t drink it. So for people with peaceful constitutions, it is not bad to drink a small amount of ice drinks to relieve summer heat. In that case, drinking hot water can force out the cold in the body, in fact, this effect is very small. Hot water can ensure the normal operation of yang on people’s body surface, but the cold in the body is accumulated over time, and there are many reasons for its formation. Drinking hot water alone cannot solve the fundamental problem.

　　B

　　Myth 2: Eat more mutton and ginger in "heating with heat"

　　A health post was circulated in a circle of friends: "A bowl of mutton soup in dog days does not require a doctor to prescribe a prescription", saying that eating mutton and drinking mutton soup in dog days can "heat up, sweat and detoxify". In addition, the same is true of "eating radish in winter and ginger in summer, without a doctor prescribing". So, is it really better to eat these hot foods in the dog days?

　　Expert analysis: this statement is not completely correct. If you understand it incorrectly, you will not achieve the purpose of health preservation, but it will be counterproductive. Ginger and mutton are spicy and hot foods, so people with yin deficiency constitution, damp heat constitution constitution and partial qi stagnation constitution should not eat more. However, for some special people, this way of keeping in good health is very suitable. For example, people who eat too much cold and cold food to relieve summer heat are prone to damage the spleen and stomach and consume yang. Proper eating of some foods that are pungent and cold can eliminate these side effects, which is the meaning of "heating with heat". If you don’t have the habit of eating cold food, or have been eating warm food, or are hot people, the "heating with heat" regimen will only "add fuel to the fire" and cause people to get angry.

　　C

　　Myth # 3: Practice in summer, exercise after three days of rain, and keep cool.

　　Many people think that summer is very cool after rain and suitable for exercise, so they will take a walk after rain, or go out for running and fitness, breathe the air after rain and feel comfortable. In fact, going to exercise after the rain in summer will aggravate the moisture in the body.

　　Expert analysis: "Practicing 39 in winter and three volts in summer" is the experience summarized by predecessors in the long-term exercise process, which makes sense. However, for the elderly, "training for three days in summer" is not suitable. The climate in dog days is characterized by high temperature, low air pressure and high humidity. In this weather, summer is the main way to maintain health, and quietness is to nourish the heart, with more quietness and less movement. Middle-aged and elderly people must not exercise excessively in midsummer, because sweating will lead to blood viscosity, blood volume reduction and other cardiovascular and cerebrovascular diseases. Exercise in the dog days must avoid high temperature and be carried out in a cool place and at a cool time. It is advisable to do gymnastics, walking, Tai Chi and other light exercises, as long as you sweat slightly. It is very fresh to exercise the air after rain, but the relative humidity is relatively high, and dampness is also easy to invade the human body, especially when sweating after exercise and the hair is wide open, it is necessary to prevent dampness from invading.

　　D

　　Myth 4: Prevent heatstroke and catch a cold, and always drink Huoxiang Zhengqi water.

　　Many people carry Huoxiang Zhengqi water with them to prevent heatstroke in summer. However, Huoxiang Zhengqi Water is not suitable for everyone. If the physique is not suitable, taking it blindly will only hurt the body.

　　Expert analysis: The main component of Huoxiang Zhengqi Water is Huoxiang, with Atractylodes lancea, Pericarpium Citri Tangerinae, Magnolia Officinalis, Radix Angelicae Dahuricae, Poria, Pericarpium Arecae, Pinellia ternata, etc., which has the functions of relieving exterior dampness, regulating qi and harmonizing middle energizer. It can be used for treating common cold caused by exogenous wind-cold, internal injury and dampness stagnation or summer injury and summer dampness, with symptoms such as headache, heaviness in chest and diaphragm, abdominal distension and pain, vomiting and diarrhea, etc. When taking it, it needs to be accurate in syndrome differentiation, and it is best to take it under the guidance of pharmacists and doctors. Because the medicine is Xinwenfa powder, it is suitable for patients whose dampness is heavier than heat or cold-dampness. If people with heat-toxic reaction eat Huoxiang Zhengqi, it is equivalent to eating backwards, and the medicine will not only be ineffective but also delay the illness.

　　In addition, Zhao Liren, a health expert at Ministry of Human Resources and Social Security Education and Training Center in China, reminded that Huoxiang Zhengqi Water contains a certain amount of ethanol. If you drink a drink containing ethanol after applying cephalosporins, it will lead to "ethanol accumulation" in the body and a disulfiram-like reaction (also known as sulfur-like reaction of abstinence, which is manifested by symptoms such as facial flushing, headache, abdominal pain, sweating, palpitation and dyspnea). Therefore, be careful not to use cephalosporins when taking Huoxiang Zhengqi Water.

　　E

　　Expert advice: mung bean soup after "transformation" has better health care effect.

　　In hot weather, the cool mung bean soup must be the favorite of many people. Then, do you know why mung bean soup can relieve summer heat? How to decoct and match, and the effect of relieving summer heat is better? Let’s listen to the introduction of health expert Zhao Liren.

　　Drinking mung bean water in summer can effectively stimulate appetite and have the effects of clearing away heat, promoting diuresis, relieving summer heat, cooling blood and detoxifying. It has a good auxiliary treatment effect on sore throat, sore mouth, dry stool, dry mouth and bad breath. The heat-clearing power of mung beans lies in the skin, and the detoxification power is included. Therefore, if you just want to cool off the heat, wash the mung beans when cooking the soup, and boil them with strong fire for about 10 minutes. The soup cooked in this way is green and clear, and has the best effect of cooling off the heat.

　　In addition, cooking mung bean soup with other ingredients will also produce good health effects. For example, mung bean double flower soup: choose 100 grams of mung bean and 10 grams of honeysuckle, and decoct them with water. You can also add Coicis Semen for invigorating spleen and eliminating dampness to make Coicis Semen and mung bean soup, and add Lily for nourishing yin and moistening lung to make Lily and mung bean soup. It should be noted that mung beans are cool, and people with weak constitution and cold are not suitable for drinking. In addition, mung bean also has detoxification function. Therefore, if the drugs taken by patients, whether traditional Chinese medicine or western medicine, contain organic phosphorus, calcium, potassium and other components, mung bean will combine with these components to form a precipitate, thus decomposing the efficacy and affecting the treatment. (Reporter Wang Yuzhe)

　　

　　Cctv newsAccording to "Tianjin Hexi" WeChat WeChat official account news, the epidemic prevention and control headquarters of Hexi District reported on September 12 that at present, the situation of epidemic prevention and control in the whole country is still severe and complicated. Hexi District is located in the bustling area of this city, and people are highly mobile. In order to effectively reduce the risk of epidemic spread, safeguard the life safety and health of the broad masses of people, and ensure that there is no local large-scale epidemic around the "National Day", from September 13, 2022, the nucleic acid test will be negative for 72 hours in the whole region. The relevant information is hereby notified as follows:

　　I. Scope of inspection

　　Personnel entering all organs, enterprises and institutions in the district, tourist attractions, commercial buildings, supermarkets, vegetable markets and other crowded places; Migrant workers staying in hotels, hotels and other places and all residential areas.

　　Second, the inspection method

　　It is recommended to use the "Tianjin Digital Epidemic Prevention" APP to produce a 72-hour negative nucleic acid test certificate. Old people and children without smart phones can be assisted to inquire about the test results after their families are bound by the "Tianjin Digital Epidemic Prevention" APP. If there is no escort, they can download and print the test results in advance or register their identity information on site before entering.

　　Iii. Inspection requirements　

　　All kinds of public places should strictly implement the main responsibility of epidemic prevention and control, urge the employees of this unit to take the initiative to participate in nucleic acid testing, and set up special personnel to check the negative certificate of nucleic acid testing within 72 hours. Residents of this community enter and leave the community with their "pass" (the health code of those who have not participated in nucleic acid screening within 72 hours is given "yellow code"). When migrant workers enter the community, please actively cooperate with the personnel on duty for inspection. All kinds of personnel entering residential areas and various public places must strictly implement epidemic prevention and control measures such as scanning codes, wearing masks and preventing gathering.

Intellectual property offices of all provinces, autonomous regions, municipalities directly under the Central Government and Xinjiang Production and Construction Corps, Sichuan Intellectual Property Service Promotion Center and relevant local centers; Local trade promotion agencies and industry trade promotion agencies:

In order to thoroughly implement the Guiding Opinions on Promoting the High-quality Development of Trade, the Outline for Building a Powerful Intellectual Property Country (2021-2035) and the Opinions on Strengthening Intellectual Property Protection, and comprehensively strengthen overseas intellectual property protection, we hereby put forward the following guiding opinions on further strengthening the construction of overseas intellectual property dispute settlement mechanism.

I. General requirements

(1) Guiding ideology and principles. Guided by Socialism with Chinese characteristics Thought of the Supreme Leader in the New Era, we will fully implement the spirit of the 19th National Congress of the Communist Party of China and the Second, Third, Fourth, Fifth and Sixth Plenary Sessions of the 19th Congress, thoroughly implement the spirit of the important speech delivered by the General Secretary of the Supreme Leader at the 25th collective study in the Political Bureau of the Central Committee, adhere to overall coordination and multi-party linkage, base ourselves on the new development stage, grasp the new development concept, build a new development pattern, and strive to improve the guidance system for overseas intellectual property disputes. Strengthen information services, capacity building and support, promote international cooperation and competition in the field of intellectual property as a whole, earnestly safeguard national security in the field of intellectual property, effectively promote high-level opening up and promote high-quality economic development.

Adhere to government guidance, multi-party linkage, problem-oriented and key breakthroughs. Government departments take the lead in integrating the superior resources of trade associations, service organizations, enterprises and other parties, focusing on the pain points and difficulties of overseas rights protection of enterprises, focusing on key areas and key links, continuously improving the guidance system for overseas intellectual property disputes, and effectively increasing the assistance for overseas intellectual property rights protection.

(2) Work objectives. By 2025, an overseas intellectual property dispute response mechanism with horizontal interconnection, vertical intercommunication, cooperation and sharing between central and local governments will be basically established, a convenient and efficient international intellectual property risk early warning and emergency response mechanism will be initially formed, the foreign-related risk prevention and control system of intellectual property rights will be more perfect, the overseas intellectual property dispute response guidance service network will be more perfect, the awareness of overseas intellectual property protection of Chinese enterprises will be significantly enhanced, the ability to deal with overseas intellectual property disputes will be significantly improved, and the social satisfaction of overseas intellectual property dispute response guidance will reach and maintain a high level.

Two, improve the work system, enrich the overseas intellectual property dispute response network.

(3) Improve the guidance system for dealing with disputes. Optimize the layout of work outlets, lay out and build local sub-centers of the National Overseas Intellectual Property Dispute Response Guidance Center in places with high demand, good foundation and mature conditions, and explore the construction of overseas sub-centers of the National Overseas Intellectual Property Dispute Response Guidance Center in key trading countries (regions) to form an overseas dispute response service network. Establish and improve the work rules for dealing with disputes, realize standard management, standardize operation, and comprehensively improve the ability of dealing with overseas intellectual property disputes.

(4) Optimize the information service platform. Relying on the national overseas intellectual property information service platform "Zhinan Needle Network", we will strengthen the integration of information resources and gradually realize the efficient circulation and sharing of overseas intellectual property information throughout the country. Optimize the website of the National Overseas Intellectual Property Dispute Response Guidance Center, and promote the smooth interconnection between the National Guidance Center and the websites of local sub-centers and overseas sub-centers. Promote the upgrade of business modules, and constantly improve the "four-in-one" information service network of websites, service numbers, small programs and offline salons.

(5) Strengthen the support system for dispute handling guidance talents. Improve the overseas intellectual property expert consultation system, strengthen the construction of overseas intellectual property dispute response guidance expert database, encourage and support the docking of expert databases around the country, and fully share expert resources. Select and cultivate overseas intellectual property research think tanks and conduct research on major overseas intellectual property disputes. Guide export-oriented enterprises, intellectual property and legal service institutions to strengthen the training of overseas intellectual property practitioners and strengthen the overseas intellectual property talent reserve. Establish an overseas intellectual property Commissioner system to help enterprises expand overseas intellectual property protection talent resources.

Third, strengthen guidance services and improve the level of overseas intellectual property disputes.

(6) Strengthen overseas risk prevention and control and dispute response guidance services. Establish and improve the tracking and publishing mechanism of overseas intellectual property litigation, trade investigation and other information, provide early warning services for enterprises in a timely manner, and strengthen the guidance of coping strategies. Strengthen intellectual property rights protection assistance services for overseas key exhibitions, strengthen exchanges, cooperation and coordination and consultation with exhibition organizers and law enforcement agencies in the host places, and realize the full chain service of pre-exhibition training and risk investigation, exhibition resident service and rights protection guidance, post-exhibition case tracking and summary feedback. Establish and improve the early warning and response mechanism for overseas registered trademarks of enterprises in China, continuously update the guidelines for trademark rights protection in key overseas countries, and guide China enterprises to reasonably deal with overseas trademark disputes. Carry out the construction of overseas intellectual property risk prevention and control system in key industries, monitor key overseas intellectual property information in real time, strengthen the research on overseas intellectual property protection mode of key industries, and provide timely guidance services for overseas intellectual property risk prevention and control and dispute response.

(seven) to promote the development of diversified dispute resolution mechanism. Promote the establishment of intellectual property arbitration institutions and mediation organizations, explore the establishment of intellectual property professional committees in overseas civil and commercial dispute mediation institutions, give full play to the advantages of diversified dispute resolution mechanisms such as arbitration and mediation, provide efficient and convenient overseas intellectual property dispute resolution platforms for Chinese enterprises, and guide enterprises to quickly resolve overseas intellectual property disputes through reconciliation, mediation and arbitration.

(eight) encourage the use of various means to reduce the cost of overseas rights protection of enterprises. Encourage insurance institutions to carry out overseas intellectual property infringement liability insurance, patent enforcement insurance, patent infringement loss insurance and overseas exhibition intellectual property disputes legal fees insurance, and reduce the cost of overseas intellectual property rights protection for enterprises. We will promote the establishment and improvement of overseas IPR protection and mutual assistance mechanisms, encourage enterprises to set up overseas IPR protection and mutual assistance funds, and ease the pressure on overseas IPR protection funds.

Fourth, strengthen information services and optimize the dynamic release mechanism of overseas intellectual property rights.

(nine) to carry out overseas intellectual property legal system tracking research. Establish and improve the dynamic tracking mechanism, strengthen the tracking research on the revision of intellectual property laws, regulations and policies in key countries (regions), and timely release the information on the adjustment and change of intellectual property protection legal system and policy environment in key countries (regions). Continue to issue national guides for intellectual property protection in key countries (regions). Regularly update the official fee information of intellectual property rights in key countries (regions).

(ten) to strengthen the analysis and research of major typical cases. Collect and sort out typical cases of overseas intellectual property disputes, and gradually establish and enrich case databases in the fields of patents, trademarks, geographical indications, trade secrets and unfair competition. Strengthen the study of typical cases and release risk warning or early warning information in time. Strengthen the statistics, analysis and judgment of overseas trade information data of key countries (regions) to provide basic support for enterprises to deal with intellectual property-related trade investigations.

(eleven) to carry out environmental assessment of overseas intellectual property protection. In view of the intellectual property difficulties encountered by enterprises in China in the process of "going global", a survey report on the business environment of key countries (regions) was released. Improve the evaluation index system of intellectual property protection index and publish the annual global intellectual property protection index report.

Five, strengthen the professional construction, improve the ability of market players to deal with overseas disputes.

(twelve) to enhance the awareness and ability of overseas intellectual property protection of enterprises. Focus on the intellectual property protection needs of China enterprises in the process of "going global", focus on the key areas and key links of overseas intellectual property disputes, and carry out special training for enterprises and other market entities to comprehensively enhance their awareness of overseas intellectual property protection and their ability to deal with disputes. Establish a contact mechanism with overseas intellectual property and legal service institutions, select a number of qualified and powerful domestic and foreign intellectual property and legal service institutions, publish a list of service institutions that meet the needs of enterprises’ foreign trade development, and provide professional and high-quality services for enterprises. Explore the establishment of a "1+1" cooperation mechanism between domestic service agencies and overseas legal service agencies to provide enterprises with professional and high-quality services with controllable costs.

(XIII) Improve the information communication mechanism for overseas intellectual property protection. Establish and improve the communication mechanism for overseas intellectual property protection of China enterprises, understand the demands of enterprises, and strengthen information exchange and experience sharing among all parties. To carry out overseas intellectual property protection work, we should focus on enterprise cultivation projects and build a network of overseas intellectual property observation enterprises. Improve the information notification and emergency response mechanism for major overseas intellectual property disputes. Explore the establishment of feedback channels for Chinese enterprises to encounter unfair treatment of intellectual property rights and give targeted support and guidance. Organize local and industry associations for the promotion of international trade to build an overseas intellectual property rights protection assistance platform for enterprises, open a service hotline, and rely on overseas intellectual property expert consultants to provide public welfare consulting services.

(14) Strengthen foreign cooperation and exchanges on intellectual property protection. Actively promote the coordination and response of overseas intellectual property disputes and improve the overseas law enforcement cooperation mechanism. Give full play to the functions of the overseas representative offices of the China Council for the Promotion of International Trade, strengthen communication with relevant institutions in the host countries, and support and guide "going global" enterprises to do a good job in overseas intellectual property protection. Timely convey China’s intellectual property protection policy trends to overseas foreign associations, relevant institutions and enterprises, comprehensively use various international exchange and cooperation platforms, and actively publicize China’s intellectual property protection development achievements.

Six, strengthen organizational guarantee, and lay a solid foundation for the construction of overseas dispute response mechanism.

(15) Strengthen organizational leadership. China National Intellectual Property Administration and the China Council for the Promotion of International Trade will strengthen the top-level design of overseas intellectual property disputes, and make overall planning and coordination. The provincial intellectual property management departments, together with the local and trade promotion councils, will make overall plans to promote the response to overseas intellectual property disputes within their respective jurisdictions, strengthen coordination and linkage, establish working mechanisms, integrate regional resources, form joint efforts, and comprehensively promote all work. Major issues arising in the work should be reported to the China National Intellectual Property Administration and China Committees for the Promotion of International Trade in a timely manner.

(sixteen) do a good job in the implementation of the work. All provincial intellectual property management departments, local and industry CCPIT should improve their sense of responsibility and strictly implement their responsibilities in accordance with the division of functions. It is necessary to respond to the actual demand in combination with overseas intellectual property disputes in the region and the industry, refine the work objectives and implementation plans, increase resource input, strengthen team building, strengthen comprehensive security, and ensure the effectiveness of the work.

(seventeen) to strengthen publicity and guidance. All provincial intellectual property management departments, local and industry CCPIT should make full use of various platform channels, innovate ways and means, and increase the publicity of overseas intellectual property disputes. Select typical cases for key publicity and interpretation, so that more enterprises can understand overseas intellectual property protection work, create a good social environment for the detailed implementation of various tasks, and give full play to the role of overseas intellectual property dispute response mechanism.

China National Intellectual Property Administration　　　　　　　　　　　　　　　

China Council for the Promotion of International Trade　　　　　　　　　　　　　　　

November 30, 2021